Hmdb loader
Identification
HMDB Protein ID HMDBP08716
Secondary Accession Numbers
  • 14438
Name Enolase-phosphatase E1
Synonyms
  1. 2,3-diketo-5-methylthio-1-phosphopentane phosphatase
  2. MASA homolog
Gene Name ENOPH1
Protein Type Unknown
Biological Properties
General Function Involved in catalytic activity
Specific Function Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
Pathways
  • Cysteine and methionine metabolism
  • L-methionine biosynthesis via salvage pathway
Reactions
5-(Methylthio)-2,3-dioxopentyl phosphate + Water → 1,2-Dihydroxy-3-keto-5-methylthiopentene + Phosphate details
GO Classification
Biological Process
L-methionine salvage from methylthioadenosine
polyamine metabolic process
Cellular Component
cytosol
nucleus
Function
phosphoglycolate phosphatase activity
ion binding
cation binding
metal ion binding
hydrolase activity, acting on ester bonds
binding
catalytic activity
hydrolase activity
phosphoric ester hydrolase activity
phosphatase activity
acireductone synthase activity
Molecular Function
magnesium ion binding
acireductone synthase activity
phosphoglycolate phosphatase activity
Process
cellular amino acid biosynthetic process
metabolic process
cellular metabolic process
amino acid salvage
l-methionine salvage from methylthioadenosine
cellular amino acid and derivative metabolic process
cellular amino acid metabolic process
Cellular Location
  1. Nucleus
  2. Cytoplasm
Gene Properties
Chromosome Location 4
Locus 4q21.22
SNPs ENOPH1
Gene Sequence
>786 bp
ATGGTCGTGCTTTCGGTCCCCGCCGAAGTCACCGTGATCCTGTTAGATATCGAAGGTACC
ACAACCCCGATTGCTTTCGTGAAGGACATTTTATTTCCTTACATCGAAGAAAATGTTAAA
GAGTATCTGCAGACACATTGGGAAGAAGAGGAGTGCCAGCAGGATGTCAGTCTTTTGAGG
AAACAGGCTGAAGAGGACGCCCACCTGGATGGGGCTGTTCCTATCCCTGCAGCATCTGGG
AATGGAGTGGATGATCTGCAACAGATGATCCAGGCCGTGGTAGATAATGTGTGCTGGCAG
ATGTCCCTGGATCGAAAGACCACTGCACTCAAACAGCTGCAGGGCCACATGTGGAGGGCG
GCATTCACAGCTGGGCGCATGAAAGCAGAGTTCTTTGCAGATGTAGTTCCAGCAGTCAGG
AAGTGGAGAGAGGCCGGAATGAAGGTGTACATCTATTCCTCAGGGAGTGTGGAGGCACAG
AAACTGTTATTCGGGCATTCTACGGAGGGAGATATTCTTGAGCTTGTTGATGGTCACTTT
GATACCAAGATTGGACACAAAGTAGAGAGTGAAAGTTACCGAAAGATTGCAGACAGCATT
GGGTGCTCAACCAACAACATTTTGTTTCTGACAGATGTTACTCGAGAGGCCAGTGCTGCT
GAGGAAGCAGATGTGCACGTAGCTGTGGTGGTGAGACCAGGCAACGCAGGATTAACAGAT
GATGAGAAGACTTACTACAGCCTCATCACATCCTTCAGTGAACTATACCTGCCTTCCTCA
ACCTAG
Protein Properties
Number of Residues 261
Molecular Weight 28932.44
Theoretical pI 4.778
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Enolase-phosphatase E1
MVVLSVPAEVTVILLDIEGTTTPIAFVKDILFPYIEENVKEYLQTHWEEEECQQDVSLLR
KQAEEDAHLDGAVPIPAASGNGVDDLQQMIQAVVDNVCWQMSLDRKTTALKQLQGHMWRA
AFTAGRMKAEFFADVVPAVRKWREAGMKVYIYSSGSVEAQKLLFGHSTEGDILELVDGHF
DTKIGHKVESESYRKIADSIGCSTNNILFLTDVTREASAAEEADVHVAVVVRPGNAGLTD
DEKTYYSLITSFSELYLPSST
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q9UHY7
UniProtKB/Swiss-Prot Entry Name ENOPH_HUMAN
PDB IDs
GenBank Gene ID AF113125
GeneCard ID ENOPH1
GenAtlas ID ENOPH1
HGNC ID HGNC:24599
References
General References
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  3. Hu RM, Han ZG, Song HD, Peng YD, Huang QH, Ren SX, Gu YJ, Huang CH, Li YB, Jiang CL, Fu G, Zhang QH, Gu BW, Dai M, Mao YF, Gao GF, Rong R, Ye M, Zhou J, Xu SH, Gu J, Shi JX, Jin WR, Zhang CK, Wu TM, Huang GY, Chen Z, Chen MD, Chen JL: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9543-8. [PubMed:10931946 ]
  4. Wang H, Pang H, Bartlam M, Rao Z: Crystal structure of human E1 enzyme and its complex with a substrate analog reveals the mechanism of its phosphatase/enolase activity. J Mol Biol. 2005 May 13;348(4):917-26. [PubMed:15843022 ]