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Showing Protein Galactose-3-O-sulfotransferase 3 (HMDBP08727)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 2 metabolites
Identification
HMDB Protein ID HMDBP08727
Secondary Accession Numbers
  • 14450
Name Galactose-3-O-sulfotransferase 3
Synonyms
  1. Beta-galactose-3-O-sulfotransferase 3
  2. Gal-beta-1, 3-GalNAc 3'-sulfotransferase 3
  3. Gal3ST-3
  4. Gal3ST3
Gene Name GAL3ST3
Protein Type Unknown
Biological Properties
General Function Involved in galactosylceramide sulfotransferase activity
Specific Function Transfers a sulfate to position 3 of non-reducing beta- galactosyl residues in N-glycans and core2-branched O-glycans. Has high activity towards Gal-beta-1,4-GlcNAc, Gal-beta-1,4(Fuc-alpha- 1,3)GlcNAc and lower activity towards Gal-beta-1,3(Fuc-alpha- 1,4)GlcNAc
Pathways Not Available
Reactions Not Available
GO Classification
Component
golgi apparatus
cell part
membrane part
intrinsic to membrane
organelle
membrane-bounded organelle
intracellular membrane-bounded organelle
integral to membrane
Function
catalytic activity
transferase activity
transferase activity, transferring sulfur-containing groups
sulfotransferase activity
galactose 3-o-sulfotransferase activity
galactosylceramide sulfotransferase activity
Process
metabolic process
biosynthetic process
Cellular Location
  1. Golgi apparatus
  2. Golgi stack membrane
  3. Single-pass type II membrane protein (Probable)
Gene Properties
Chromosome Location Chromosome:1
Locus 11q13.1
SNPs GAL3ST3
Gene Sequence 
>1296 bp
ATGCCACCCATCCTCCAGCGCCTGCAGCAGGCCACCAAGATGATGAGCCGCCGGAAAATC
CTGCTGCTGGTGCTAGGGTGCAGCACCGTAAGCCTTCTCATCCACCAGGGGGCGCAGCTC
AGCTGGTACCCCAAGCTGTTCCCCTTGAGCTGCCCTCCTCTGCGGAACTCGCCGCCGCGC
CCCAAGCACATGACTGTGGCCTTCCTGAAGACTCACAAGACGGCAGGCACGACGGTGCAG
AACATCCTGTTTCGCTTTGCCGAGCGCCACAACCTGACGGTGGCCCTGCCGCACCCGAGC
TGCGAGCACCAGTTCTGCTACCCCCGCAACTTCTCGGCGCACTTCGTGCACCCGGCCACG
CGGCCGCCGCACGTGCTGGCCAGCCACCTGCGCTTCGACCGTGCGGAGCTGGAGCGCCTC
ATGCCGCCCAGCACCGTCTATGTCACCATCCTGCGCGAGCCGGCCGCCATGTTCGAGTCG
CTCTTCAGCTACTACAACCAGTACTGCCCGGCCTTCCGGCGCGTGCCCAACGCCTCGCTC
GAGGCCTTCCTGCGCGCGCCCGAGGCATACTACCGCGCTGGCGAGCACTTCGCCATGTTC
GCACACAACACGCTGGCCTACGACCTGGGCGGCGACAATGAGCGCAGCCCGCGCGACGAC
GCCGCCTACCTGGCGGGCCTCATCCGCCAGGTGGAGGAGGTTTTCTCGCTCGTCATGATC
GCCGAGTACTTCGACGAGTCGCTAGTGCTGCTGCGGCGCCTACTGGCCTGGGACCTGGAC
GACGTGCTCTACGCCAAGCTCAACGCGCGCGCCGCCAGCTCGCGCCTGGCCGCCATCCCC
GCGGCGCTGGCGCGGGCGGCGCGCACCTGGAACGCCCTGGACGCCGGCCTCTACGACCAC
TTCAACGCCACCTTCTGGCGCCACGTGGCGCGCGCGGGCCGCGCGTGCGTGGAGCGCGAG
GCGCGCGAGCTGCGCGAGGCCCGCCAGCGCCTACTGCGGCGCTGCTTCGGGGACGAGCCA
CTGCTGCGGCCTGCCGCGCAGATCCGCACCAAGCAGCTGCAGCCATGGCAGCCCAGCCGC
AAGGTGGACATTATGGGCTATGACCTGCCCGGCGGCGGCGCCGGCCCGGCCACCGAGGCC
TGCCTCAAGCTGGCCATGCCCGAGGTCCAGTACTCGAACTACCTGTTGCGCAAGCAGAAG
CGCCGGGGCGGTGCGCGGGCTCGGCCCGAGCCCGTCCTGGACAATCCCCCGCCTCGGCCC
ATCCGAGTGCTGCCTCGCGGCCCTCAAGGTCCCTGA
Protein Properties
Number of Residues 431
Molecular Weight 48955.1
Theoretical pI 10.31
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • 20-40
Protein Sequence 
>Galactose-3-O-sulfotransferase 3
MPPILQRLQQATKMMSRRKILLLVLGCSTVSLLIHQGAQLSWYPKLFPLSCPPLRNSPPR
PKHMTVAFLKTHKTAGTTVQNILFRFAERHNLTVALPHPSCEHQFCYPRNFSAHFVHPAT
RPPHVLASHLRFDRAELERLMPPSTVYVTILREPAAMFESLFSYYNQYCPAFRRVPNASL
EAFLRAPEAYYRAGEHFAMFAHNTLAYDLGGDNERSPRDDAAYLAGLIRQVEEVFSLVMI
AEYFDESLVLLRRLLAWDLDDVLYAKLNARAASSRLAAIPAALARAARTWNALDAGLYDH
FNATFWRHVARAGRACVEREARELREARQRLLRRCFGDEPLLRPAAQIRTKQLQPWQPSR
KVDIMGYDLPGGGAGPATEACLKLAMPEVQYSNYLLRKQKRRGGARARPEPVLDNPPPRP
IRVLPRGPQGP
GenBank ID Protein 14625435
UniProtKB/Swiss-Prot ID Q96A11
UniProtKB/Swiss-Prot Entry Name G3ST3_HUMAN
PDB IDs Not Available
GenBank Gene ID AB053232
GeneCard ID GAL3ST3
GenAtlas ID GAL3ST3
HGNC ID HGNC:24144
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. El-Fasakhany FM, Uchimura K, Kannagi R, Muramatsu T: A novel human Gal-3-O-sulfotransferase: molecular cloning, characterization, and its implications in biosynthesis of (SO(4)-3)Galbeta1-4(Fucalpha1-3)GlcNAc. J Biol Chem. 2001 Jul 20;276(29):26988-94. Epub 2001 May 16. [PubMed:11356829 ]
  3. Suzuki A, Hiraoka N, Suzuki M, Angata K, Misra AK, McAuliffe J, Hindsgaul O, Fukuda M: Molecular cloning and expression of a novel human beta-Gal-3-O-sulfotransferase that acts preferentially on N-acetyllactosamine in N- and O-glycans. J Biol Chem. 2001 Jun 29;276(26):24388-95. Epub 2001 Apr 25. [PubMed:11323440 ]