Hmdb loader
Identification
HMDB Protein ID HMDBP08748
Secondary Accession Numbers
  • 14471
Name Mitogen-activated protein kinase kinase kinase 13
Synonyms
  1. Leucine zipper-bearing kinase
  2. MLK
  3. Mixed lineage kinase
Gene Name MAP3K13
Protein Type Unknown
Biological Properties
General Function Involved in magnesium ion binding
Specific Function Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B
Pathways Not Available
Reactions Not Available
GO Classification
Function
ion binding
cation binding
metal ion binding
binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
magnesium ion binding
protein binding
protein kinase activity
protein serine/threonine kinase activity
identical protein binding
protein homodimerization activity
receptor signaling protein serine/threonine kinase activity
map kinase kinase kinase activity
Process
phosphorus metabolic process
phosphate metabolic process
metabolic process
protein amino acid autophosphorylation
cellular metabolic process
protein amino acid phosphorylation
phosphorylation
Cellular Location
  1. Cytoplasm
  2. Peripheral membrane protein
  3. Membrane
Gene Properties
Chromosome Location Chromosome:3
Locus 3q27
SNPs MAP3K13
Gene Sequence
>2901 bp
ATGGCCAACTTTCAGGAGCACCTGAGCTGCTCCTCTTCTCCACACTTACCCTTCAGTGAA
AGCAAAACCTTCAATGGACTACAAGATGAGCTCACAGCTATGGGGAACCACCCTTCTCCC
AAGCTGCTCGAGGACCAGCAGGAAAAGGGGATGGTACGAACAGAGCTAATCGAGAGCGTG
CACAGCCCCGTCACCACAACAGTGTTGACGAGCGTAAGTGAGGATTCCAGGGACCAGTTT
GAGAACAGCGTTCTTCAGCTAAGGGAACACGATGAATCAGAGACGGCGGTGTCTCAGGGG
AACAGCAACACGGTGGACGGAGAGAGCACAAGCGGAACTGAAGACATAAAGATTCAGTTC
AGCAGGTCAGGCAGTGGCAGTGGTGGGTTTCTTGAAGGACTATTTGGATGCTTAAGGCCT
GTATGGAATATCATTGGGAAGGCATATTCCACTGATTACAAATTGCAGCAGCAAGATACT
TGGGAAGTGCCATTTGAGGAGATCTCAGAGCTGCAGTGGCTGGGTAGTGGAGCCCAAGGA
GCGGTCTTCTTGGGCAAGTTCCGGGCGGAAGAGGTGGCCATCAAGAAAGTGAGAGAACAG
AATGAGACGGATATCAAGCATTTGAGGAAGTTGAAGCACCCTAACATCATCGCATTCAAG
GGTGTTTGTACTCAGGCCCCATGTTATTGTATTATCATGGAATACTGTGCCCATGGACAA
CTCTACGAGGTCTTACGAGCTGGCAGGAAGATCACACCTCGATTGCTAGTAGACTGGTCC
ACAGGAATTGCAAGTGGAATGAATTATTTGCACCTCCATAAAATTATTCATCGTGATCTC
AAATCACCTAATGTTTTAGTGACCCACACAGATGCGGTAAAAATTTCAGATTTTGGTACA
TCTAAGGAACTCAGTGACAAAAGTACCAAGATGTCATTTGCTGGCACGGTCGCATGGATG
GCGCCAGAGGTGATACGGAATGAACCTGTCTCTGAAAAAGTTGATATATGGTCTTTTGGA
GTGGTGCTTTGGGAGCTGCTGACAGGAGAGATCCCTTACAAAGATGTAGATTCTTCAGCC
ATTATCTGGGGTGTTGGAAGCAACAGCCTCCACCTTCCAGTTCCTTCCACTTGCCCTGAT
GGATTCAAAATCCTTATGAAACAGACGTGGCAGAGTAAACCTCGAAACCGACCTTCTTTT
CGGCAGACACTCATGCATTTAGACATTGCCTCTGCAGATGTACTTGCCACCCCACAAGAA
ACTTACTTCAAGTCTCAGGCTGAATGGAGAGAAGAAGTGAAAAAACATTTTGAGAAGATC
AAAAGTGAAGGAACTTGTATACACCGGTTAGATGAAGAACTGATTCGAAGGCGCAGAGAA
GAGCTCAGGCATGCGCTGGATATTCGTGAACACTATGAGCGGAAGCTTGAGCGGGCGAAT
AATTTATACATGGAATTGAGTGCCATCATGCTGCAGCTAGAAATGCGGGAGAAGGAGCTC
ATTAAGCGTGAGCAAGCAGTGGAAAAGAAGTATCCTGGGACCTACAAACGACACCCTGTT
CGTCCTATCATCCATCCCAATGCCATGGAGAAACTCATGAAAAGGAAAGGAGTGCCTCAC
AAATCTGGGATGCAGACCAAACGGCCAGACTTGTTGAGATCAGAAGGGATCCCCACCACA
GAAGTGGCTCCCACTGCATCCCCTTTGTCCGGAAGTCCCAAAATGTCCACTTCTAGCAGC
AAGAGCCGATATCGAAGCAAACCACGCCACCGCCGAGGGAATAGCAGAGGCAGCCATAGT
GACTTTGCCGCAATCTTGAAAAACCAGCCAGCCCAGGAAAATTCACCCCATCCCACTTAC
CTGCACCAAGCTCAATCCCAATACCCTTCTCTTCATCACCATAATTCTCTGCAGCAGCAA
TACCAGCAGCCCCCTCCTGCCATGTCCCAGAGTCACCATCCCAGACTCAATATGCACGGA
CAGGACATAGCAACCTGCGCCAACAACCTGAGGTATTTCGGCCCAGCAGCAGCCCTGCGG
AGCCCACTCAGCAACCATGCTCAGAGACAGCTGCCCGGCTCGAGCCCTGACCTCATCTCC
ACAGCCATGGCTGCAGACTGCTGGAGAAGTTCTGAGCCTGACAAGGGCCAAGCTGGTCCC
TGGGGCTGTTGCCAGGCTGACGCTTATGACCCCTGCCTTCAGTGCAGGCCAGAACAGTAT
GGGTCCTTAGACATACCCTCTGCTGAGCCAGTGGGGAGGAGCCCTGACCTTTCCAAGTCA
CCAGCACATAATCCTCTCTTGGAAAACGCCCAGAGTTCTGAGAAAACGGAAGAAAATGAA
TTCAGCGGCTGTAGGTCTGAGTCATCCCTCGGCACCTCTCATCTCGGCACCCCTCCAGCG
CTACCTCGAAAAACAAGGCCTCTGCAGAAGAGTGGAGATGACTCCTCAGAAGAGGAAGAA
GGGGAAGTAGATAGTGAAGTTGAATTTCCACGAAGACAGAGGCCCCATCGCTGTATCAGC
AGCTGCCAGTCATATTCAACCTTTAGCTCTGAGAATTTCTCTGTGTCTGATGGAGAAGAG
GGAAATACCAGTGACCACTCAAACAGTCCTGATGAGTTAGCTGATAAACTTGAAGACCGC
TTGGCAGAGAAGCTAGACGACCTGCTGTCCCAGACGCCAGAGATTCCCATTGACATATCC
TCACACTCGGATGGGCTCTCTGACAAGGAGTGTGCCGTGCGCCGTGTGAAGACTCAGATG
TCTCTGGGCAAGCTGTGTGTGGAGGAACGTGGCTATGAGAACCCCATGCAGTTTGAAGAA
TCGGACTGTGACTCTTCAGATGGGGAGTGTTCTGATGCCACAGTTAGGACCAATAAACAC
TACAGCTCTGCTACCTGGTAA
Protein Properties
Number of Residues 966
Molecular Weight 108295.1
Theoretical pI 6.47
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Mitogen-activated protein kinase kinase kinase 13
MANFQEHLSCSSSPHLPFSESKTFNGLQDELTAMGNHPSPKLLEDQQEKGMVRTELIESV
HSPVTTTVLTSVSEDSRDQFENSVLQLREHDESETAVSQGNSNTVDGESTSGTEDIKIQF
SRSGSGSGGFLEGLFGCLRPVWNIIGKAYSTDYKLQQQDTWEVPFEEISELQWLGSGAQG
AVFLGKFRAEEVAIKKVREQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQ
LYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGT
SKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSA
IIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQTLMHLDIASADVLATPQE
TYFKSQAEWREEVKKHFEKIKSEGTCIHRLDEELIRRRREELRHALDIREHYERKLERAN
NLYMELSAIMLQLEMREKELIKREQAVEKKYPGTYKRHPVRPIIHPNAMEKLMKRKGVPH
KSGMQTKRPDLLRSEGIPTTEVAPTASPLSGSPKMSTSSSKSRYRSKPRHRRGNSRGSHS
DFAAILKNQPAQENSPHPTYLHQAQSQYPSLHHHNSLQQQYQQPPPAMSQSHHPRLNMHG
QDIATCANNLRYFGPAAALRSPLSNHAQRQLPGSSPDLISTAMAADCWRSSEPDKGQAGP
WGCCQADAYDPCLQCRPEQYGSLDIPSAEPVGRSPDLSKSPAHNPLLENAQSSEKTEENE
FSGCRSESSLGTSHLGTPPALPRKTRPLQKSGDDSSEEEEGEVDSEVEFPRRQRPHRCIS
SCQSYSTFSSENFSVSDGEEGNTSDHSNSPDELADKLEDRLAEKLDDLLSQTPEIPIDIS
SHSDGLSDKECAVRRVKTQMSLGKLCVEERGYENPMQFEESDCDSSDGECSDATVRTNKH
YSSATW
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID O43283
UniProtKB/Swiss-Prot Entry Name M3K13_HUMAN
PDB IDs Not Available
GenBank Gene ID AB001872
GeneCard ID MAP3K13
GenAtlas ID MAP3K13
HGNC ID HGNC:6852
References
General References
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