Hmdb loader
Identification
HMDB Protein ID HMDBP08756
Secondary Accession Numbers
  • 14479
Name Microtubule-associated serine/threonine-protein kinase 3
Synonyms Not Available
Gene Name MAST3
Protein Type Unknown
Biological Properties
General Function Involved in protein serine/threonine kinase activity
Specific Function ATP + a protein = ADP + a phosphoprotein
Pathways Not Available
Reactions Not Available
GO Classification
Function
ion binding
cation binding
metal ion binding
binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
magnesium ion binding
protein binding
protein kinase activity
protein serine/threonine kinase activity
Process
phosphorus metabolic process
phosphate metabolic process
metabolic process
cellular metabolic process
protein amino acid phosphorylation
phosphorylation
Cellular Location Not Available
Gene Properties
Chromosome Location Chromosome:1
Locus 19p13.11
SNPs MAST3
Gene Sequence
>3930 bp
ATGGACGAGTCGAGCCTCCTGCGGCGCCGCGGGCTCCAGAAGGAGCTGAGCCTGCCACGC
CGAGGACGTGGCTGCCGCAGCGGGAACCGCAAGAGCTTGGTGGTAGGAACGCCCTCCCCG
ACCCTCTCCCGGCCCCTGTCGCCATTGTCGGTCCCAACGGCAGGCAGCAGCCCCTTGGAT
AGTCCTCGGAATTTCTCGGCTGCCTCTGCCCTAAATTTCCCCTTTGCCCGGAGGGCAGAC
GGCAGAAGATGGTCCCTCGCGTCTCTCCCATCTTCCGGCTATGGAACCAACACACCCAGC
TCCACCCTCTCGTCAAGCTCATCCTCCCGGGAACGTCTCCACCAGCTTCCCTTCCAGCCG
ACGCCGGACGAGCTGCACTTCCTGTCCAAGCACTTCCGCAGCTCAGAGAATGTGCTTGAT
GAGGAAGGCGGCCGGTCACCCCGCCTCCGACCCCGCTCTCGCAGTCTCAGCCCGGGCCGT
GCAACGGGGACCTTCGACAATGAGATTGTCATGATGAATCACGTGTACCGGGAGAGGTTC
CCCAAGGCCACAGCACAGATGGAGGGCCGTCTGCAGGAGTTCCTGACGGCCTACGCGCCC
GGCGCCCGGCTGGCGCTGGCTGATGGCGTCTTGGGCTTCATCCACCACCAGATCGTCGAG
CTGGCCCGAGACTGCTTGGCCAAGTCTGGCGAGAACCTCGTCACCTCCCGCTACTTCCTA
GAGATGCAGGAGAAGCTGGAGCGGCTTCTGCAGGATGCCCATGAGCGTTCGGACAGTGAG
GAGGTCAGCTTCATCGTCCAGCTTGTCCGGAAACTGCTGATCATCATCTCACGGCCAGCT
CGGCTGCTGGAGTGTCTGGAGTTTGACCCTGAGGAATTTTACCACCTGCTGGAGGCGGCT
GAGGGCCATGCGCGGGAGGGCCAAGGCATTAAGACTGACCTTCCACAGTACATCATTGGG
CAGCTGGGCCTGGCCAAGGACCCCCTGGAGGAGATGGTGCCACTGAGTCACCTCGAAGAA
GAACAGCCCCCAGCACCTGAGTCCCCAGAGAGCCGCGCCCTGGTCGGCCAGTCACGGAGG
AAGCCATGCGAAAGCGACTTTGAGACCATCAAACTCATTAGCAACGGAGCCTATGGGGCC
GTCTACCTGGTGCGGCACCGTGACACACGGCAGCGCTTTGCCATCAAGAAGATCAACAAA
CAGAACTTGATCCTGCGTAACCAGATCCAGCAGGTCTTTGTGGAGCGTGACATTCTCACC
TTTGCCGAGAACCCCTTTGTGGTCAGCATGTTCTGCTCCTTTGAGACCCGGCGCCACCTA
TGTATGGTCATGGAATACGTGGAAGGCGGCGACTGCGCCACGCTCCTGAAGAACATGGGC
CCGCTGCCCGTGGACATGGCCCGCCTGTACTTCGCCGAGACGGTGTTGGCGCTGGAGTAC
CTGCATAACTATGGCATCGTGCACCGTGACCTCAAACCAGACAATCTGCTCATCACCTCG
CTTGGCCACATCAAGCTCACGGACTTCGGCCTGTCCAAGATCGGCCTCATGAGCATGGCC
ACCAACCTCTATGAGGGCCACATCGAGAAGGACGCCCGAGAGTTCATCGACAAGCAGGTG
TGTGGGACGCCGGAGTACATAGCCCCCGAGGTGATCTTCCGCCAGGGCTATGGGAAGCCA
GTGGACTGGTGGGCCATGGGCGTCGTCCTCTATGAGTTTCTGGTGGGCTGCGTGCCTTTC
TTTGGAGATACCCCCGAGGAACTCTTCGGTCAGGTGGTCAGCGATGAGATCATGTGGCCA
GAGGGAGATGAGGCCCTTCCAGCAGACGCCCAGGACCTCATCACCAGGTTGCTCCGGCAG
AGCCCGCTGGACCGTCTGGGCACTGGTGGCACCCACGAAGTGAAGCAGCACCCCTTTTTC
CTGGCCCTGGACTGGGCAGGGCTTCTCCGACACAAAGCCGAGTTCGTGCCCCAGCTCGAA
GCTGAGGATGATACCAGCTACTTTGACACACGTTCGGAACGTTACCGCCATCTGGGCTCC
GAGGACGACGAGACCAATGATGAAGAATCGTCCACAGAGATCCCCCAGTTCTCCTCCTGC
TCCCACCGGTTCAGCAAGGTCTACAGCAGCTCTGAGTTCCTGGCCGTCCAGCCCACTCCT
ACCTTCGCTGAAAGGAGCTTCAGTGAAGACCGGGAGGAGGGGTGGGAGCGCAGCGAAGTG
GACTATGGCCGCCGGCTGAGTGCTGACATCCGGCTGAGGTCCTGGACATCCTCTGGATCC
TCCTGTCAGTCATCTTCGTCCCAGCCCGAGCGGGGTCCCAGCCCATCTCTCCTGAATACC
ATCAGCCTGGACACAATGCCCAAGTTTGCCTTCTCATCAGAGGATGAGGGGGTAGGCCCA
GGCCCTGCAGGCCCCAAGAGGCCCGTCTTCATTCTAGGGGAGCCTGACCCCCCACCAGCG
GCCACCCCAGTGATGCCCAAGCCCTCGAGCCTTTCTGCCGACACAGCTGCTCTCAGCCAC
GCCCGCCTACGGAGCAATAGCATCGGCGCCCGACACTCCACACCAAGGCCTCTGGATGCC
GGCCGGGGCCGCCGCCTTGGGGGCCCAAGAGACCCAGCCCCTGAGAAGTCCAGAGCCTCC
TCCAGCGGTGGCAGTGGTGGCGGCAGTGGGGGCCGCGTGCCCAAGTCAGCCTCTGTCTCT
GCCCTGTCCCTCATCATCACGGCAGATGATGGCAGCGGCGGCCCCCTCATGAGCCCCCTT
TCCCCGCGCTCTCTGTCCTCGAACCCGTCGTCCCGTGACTCTTCGCCGAGCCGAGACCCG
TCCCCCGTGTGTGGCAGCCTGCGGCCCCCCATCGTTATCCACAGCTCTGGCAAGAAGTAC
GGCTTCAGCCTGCGGGCGATCCGCGTCTACATGGGTGATAGCGACGTCTACACTGTGCAC
CACGTCGTCTGGAGTGTGGAGGACGGAAGCCCCGCCCAGGAGGCGGGCCTGCGGGCTGGG
GACCTCATCACCCACATCAACGGGGAGTCAGTGCTGGGGCTGGTGCACATGGACGTCGTG
GAGCTGCTGCTGAAGAGCGGCAACAAGATATCCCTGCGGACCACAGCCCTGGAGAACACC
TCCATCAAGGTGGGCCCCGCCCGGAAGAATGTGGCCAAGGGCCGCATGGCACGCAGGAGC
AAGAGGAGCCGTCGGCGGGAGACCCAGGATCGGCGGAAGTCACTTTTCAAGAAGATCTCC
AAGCAGACCTCCGTGCTGCACACCAGCCGCAGCTTCTCCTCCGGACTCCACCACTCACTG
TCATCCAGTGAGAGCCTCCCCGGCTCGCCCACCCACAGCCTCTCCCCCAGCCCCACCACT
CCCTGCCGAAGCCCAGCCCCTGATGTCCCAGCAGATACCACTGCATCCCCACCCAGCGCA
TCCCCGAGCTCCAGCAGCCCCGCCTCCCCAGCTGCTGCTGGCCACACCCGCCCCAGCTCC
CTGCACGGCCTGGCTGCCAAGCTTGGGCCACCCCGCCCCAAGACTGGCCGCCGCAAGTCC
ACCAGCAGCATCCCGCCCTCCCCGCTGGCCTGCCCGCCCATCTCCGCGCCCCCACCCCGC
TCGCCCTCGCCCCTGCCCGGGCACCCGCCCGCACCTGCCCGATCCCCGCGGCTGCGCCGG
GGCCAGTCAGCTGACAAGCTGGGCACAGGGGAGCGGCTGGATGGGGAGGCGGGGCGGCGC
ACTCGTGGGCCAGAGGCCGAGCTCGTGGTCATGCGGCGGCTGCACCTGTCCGAGCGCCGA
GACTCCTTCAAGAAGCAGGAGGCCGTGCAGGAGGTTAGCTTCGATGAGCCGCAGGAGGAG
GCCACTGGGCTGCCCACCTCAGTGCCACAGATCGCCGTGGAGGGCGAGGAAGCCGTGCCA
GTAGCTCTCGGGCCCACCGGAAGAGACTGA
Protein Properties
Number of Residues 1309
Molecular Weight 143135.6
Theoretical pI 8.13
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Microtubule-associated serine/threonine-protein kinase 3
MDESSLLRRRGLQKELSLPRRGRGCRSGNRKSLVVGTPSPTLSRPLSPLSVPTAGSSPLD
SPRNFSAASALNFPFARRADGRRWSLASLPSSGYGTNTPSSTLSSSSSSRERLHQLPFQP
TPDELHFLSKHFRSSENVLDEEGGRSPRLRPRSRSLSPGRATGTFDNEIVMMNHVYRERF
PKATAQMEGRLQEFLTAYAPGARLALADGVLGFIHHQIVELARDCLAKSGENLVTSRYFL
EMQEKLERLLQDAHERSDSEEVSFIVQLVRKLLIIISRPARLLECLEFDPEEFYHLLEAA
EGHAREGQGIKTDLPQYIIGQLGLAKDPLEEMVPLSHLEEEQPPAPESPESRALVGQSRR
KPCESDFETIKLISNGAYGAVYLVRHRDTRQRFAIKKINKQNLILRNQIQQVFVERDILT
FAENPFVVSMFCSFETRRHLCMVMEYVEGGDCATLLKNMGPLPVDMARLYFAETVLALEY
LHNYGIVHRDLKPDNLLITSLGHIKLTDFGLSKIGLMSMATNLYEGHIEKDAREFIDKQV
CGTPEYIAPEVIFRQGYGKPVDWWAMGVVLYEFLVGCVPFFGDTPEELFGQVVSDEIMWP
EGDEALPADAQDLITRLLRQSPLDRLGTGGTHEVKQHPFFLALDWAGLLRHKAEFVPQLE
AEDDTSYFDTRSERYRHLGSEDDETNDEESSTEIPQFSSCSHRFSKVYSSSEFLAVQPTP
TFAERSFSEDREEGWERSEVDYGRRLSADIRLRSWTSSGSSCQSSSSQPERGPSPSLLNT
ISLDTMPKFAFSSEDEGVGPGPAGPKRPVFILGEPDPPPAATPVMPKPSSLSADTAALSH
ARLRSNSIGARHSTPRPLDAGRGRRLGGPRDPAPEKSRASSSGGSGGGSGGRVPKSASVS
ALSLIITADDGSGGPLMSPLSPRSLSSNPSSRDSSPSRDPSPVCGSLRPPIVIHSSGKKY
GFSLRAIRVYMGDSDVYTVHHVVWSVEDGSPAQEAGLRAGDLITHINGESVLGLVHMDVV
ELLLKSGNKISLRTTALENTSIKVGPARKNVAKGRMARRSKRSRRRETQDRRKSLFKKIS
KQTSVLHTSRSFSSGLHHSLSSSESLPGSPTHSLSPSPTTPCRSPAPDVPADTTASPPSA
SPSSSSPASPAAAGHTRPSSLHGLAAKLGPPRPKTGRRKSTSSIPPSPLACPPISAPPPR
SPSPLPGHPPAPARSPRLRRGQSADKLGTGERLDGEAGRRTRGPEAELVVMRRLHLSERR
DSFKKQEAVQEVSFDEPQEEATGLPTSVPQIAVEGEEAVPVALGPTGRD
GenBank ID Protein 150170729
UniProtKB/Swiss-Prot ID O60307
UniProtKB/Swiss-Prot Entry Name MAST3_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_015016.1
GeneCard ID MAST3
GenAtlas ID MAST3
HGNC ID HGNC:19036
References
General References
  1. Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. [PubMed:18669648 ]
  2. Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal. 2009 Aug 18;2(84):ra46. doi: 10.1126/scisignal.2000007. [PubMed:19690332 ]
  3. Oppermann FS, Gnad F, Olsen JV, Hornberger R, Greff Z, Keri G, Mann M, Daub H: Large-scale proteomics analysis of the human kinome. Mol Cell Proteomics. 2009 Jul;8(7):1751-64. doi: 10.1074/mcp.M800588-MCP200. Epub 2009 Apr 15. [PubMed:19369195 ]
  4. Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal Chem. 2009 Jun 1;81(11):4493-501. doi: 10.1021/ac9004309. [PubMed:19413330 ]
  5. Grimwood J, Gordon LA, Olsen A, Terry A, Schmutz J, Lamerdin J, Hellsten U, Goodstein D, Couronne O, Tran-Gyamfi M, Aerts A, Altherr M, Ashworth L, Bajorek E, Black S, Branscomb E, Caenepeel S, Carrano A, Caoile C, Chan YM, Christensen M, Cleland CA, Copeland A, Dalin E, Dehal P, Denys M, Detter JC, Escobar J, Flowers D, Fotopulos D, Garcia C, Georgescu AM, Glavina T, Gomez M, Gonzales E, Groza M, Hammon N, Hawkins T, Haydu L, Ho I, Huang W, Israni S, Jett J, Kadner K, Kimball H, Kobayashi A, Larionov V, Leem SH, Lopez F, Lou Y, Lowry S, Malfatti S, Martinez D, McCready P, Medina C, Morgan J, Nelson K, Nolan M, Ovcharenko I, Pitluck S, Pollard M, Popkie AP, Predki P, Quan G, Ramirez L, Rash S, Retterer J, Rodriguez A, Rogers S, Salamov A, Salazar A, She X, Smith D, Slezak T, Solovyev V, Thayer N, Tice H, Tsai M, Ustaszewska A, Vo N, Wagner M, Wheeler J, Wu K, Xie G, Yang J, Dubchak I, Furey TS, DeJong P, Dickson M, Gordon D, Eichler EE, Pennacchio LA, Richardson P, Stubbs L, Rokhsar DS, Myers RM, Rubin EM, Lucas SM: The DNA sequence and biology of human chromosome 19. Nature. 2004 Apr 1;428(6982):529-35. [PubMed:15057824 ]
  6. Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O: Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. DNA Res. 1998 Feb 28;5(1):31-9. [PubMed:9628581 ]
  7. Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, Davies H, Teague J, Butler A, Stevens C, Edkins S, O'Meara S, Vastrik I, Schmidt EE, Avis T, Barthorpe S, Bhamra G, Buck G, Choudhury B, Clements J, Cole J, Dicks E, Forbes S, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jenkinson A, Jones D, Menzies A, Mironenko T, Perry J, Raine K, Richardson D, Shepherd R, Small A, Tofts C, Varian J, Webb T, West S, Widaa S, Yates A, Cahill DP, Louis DN, Goldstraw P, Nicholson AG, Brasseur F, Looijenga L, Weber BL, Chiew YE, DeFazio A, Greaves MF, Green AR, Campbell P, Birney E, Easton DF, Chenevix-Trench G, Tan MH, Khoo SK, Teh BT, Yuen ST, Leung SY, Wooster R, Futreal PA, Stratton MR: Patterns of somatic mutation in human cancer genomes. Nature. 2007 Mar 8;446(7132):153-8. [PubMed:17344846 ]
  8. Valiente M, Andres-Pons A, Gomar B, Torres J, Gil A, Tapparel C, Antonarakis SE, Pulido R: Binding of PTEN to specific PDZ domains contributes to PTEN protein stability and phosphorylation by microtubule-associated serine/threonine kinases. J Biol Chem. 2005 Aug 12;280(32):28936-43. Epub 2005 Jun 10. [PubMed:15951562 ]