Hmdb loader
Identification
HMDB Protein ID HMDBP08769
Secondary Accession Numbers
  • 14492
Name Serine/threonine-protein kinase Nek5
Synonyms
  1. Never in mitosis A-related kinase 5
  2. NimA-related protein kinase 5
Gene Name NEK5
Protein Type Unknown
Biological Properties
General Function Involved in protein kinase activity
Specific Function ATP + a protein = ADP + a phosphoprotein
Pathways Not Available
Reactions Not Available
GO Classification
Function
binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
protein kinase activity
protein serine/threonine kinase activity
Process
phosphorus metabolic process
phosphate metabolic process
metabolic process
cellular metabolic process
protein amino acid phosphorylation
phosphorylation
Cellular Location Not Available
Gene Properties
Chromosome Location Chromosome:1
Locus 13q14.3
SNPs NEK5
Gene Sequence
>2127 bp
ATGGATAAGTACGATGTGATTAAGGCCATCGGGCAAGGTGCCTTCGGGAAAGCATACTTA
GCTAAAGGGAAATCAGATAGCAAGCACTGTGTCATAAAAGAGATCAATTTTGAAAAGATG
CCCATACAAGAAAAAGAAGCTTCAAAGAAAGAAGTGATTCTTCTGGAAAAGATGAAACAT
CCCAACATTGTAGCCTTCTTCAATTCATTTCAAGAGAATGGCAGGCTGTTTATTGTAATG
GAATATTGTGATGGAGGGGATCTCATGAAAAGGATCAATAGACAACGGGGTGTGTTATTT
AGTGAAGATCAGATCCTCGGTTGGTTTGTACAGATTTCTCTAGGACTAAAACATATTCAT
GACAGGAAGATATTACACAGGGACATAAAAGCTCAGAACATTTTTCTTAGCAAGAACGGA
ATGGTGGCAAAGCTTGGGGACTTTGGTATAGCAAGAGTCCTGAATAATTCCATGGAACTT
GCTCGAACTTGTATTGGAACACCTTACTACCTGTCCCCAGAGATCTGTCAGAATAAACCC
TACAACAATAAAACGGATATTTGGTCTCTTGGCTGTGTCTTATATGAGCTCTGCACACTT
AAACATCCTTTTGAGGGTAACAACTTACAGCAGCTGGTTCTGAAGATTTGTCAAGCACAT
TTTGCCCCAATATCTCCGGGGTTTTCTCGTGAGCTCCATTCCTTGATATCTCAGCTCTTT
CAAGTATCTCCTCGAGACCGACCATCCATAAATTCCATTTTGAAAAGGCCCTTTTTAGAG
AATCTTATTCCCAAATATTTGACTCCTGAGGTCATTCAGGAAGAATTCAGTCACATGCTT
ATATGCAGAGCAGGAGCGCCAGCTTCTCGACATGCTGGGAAGGTGGTCCAGAAGTGTAAA
ATACAAAAAGTGAGATTCCAGGGAAAGTGCCCACCAAGATCAAGGATATCTGTGCCAATT
AAAAGGAATGCTATATTGCATAGAAATGAATGGAGACCACCAGCTGGAGCCCAGAAGGCC
AGATCTATAAAAATGATAGAAAGACCCAAAATTGCTGCTGTCTGTGGACATTATGATTAT
TATTATGCTCAACTTGATATGCTGAGGAGGAGAGCCCACAAACCAAGTTATCACCCTATT
CCTCAAGAAAATACTGGAGTTGAGGATTACGGTCAGGAAACGAGGCATGGTCCATCCCCA
AGTCAATGGCCTGCTGAGTACCTTCAGAGAAAATTTGAAGCTCAACAATATAAGTTGAAA
GTGGAGAAGCAATTGGGTCTTCGTCCATCTTCTGCCGAGCCAAATTACAACCAGAGACAA
GAGCTAAGAAGTAATGGAGAAGAGCCTAGATTCCAGGAGCTGCCATTTAGGAAAAACGAA
ATGAAGGAACAGGAATATTGGAAGCAGTTAGAGGAAATACGCCAACAGTACCACAATGAC
ATGAAAGAAATTAGAAAGAAGATGGGGAGAGAACCAGAGGAGAACTCAAAAATAAGTCAT
AAAACCTATTTGGTGAAGAAGAGTAACCTGCCTGTCCATCAAGATGCATCTGAGGGAGAA
GCACCTGTGCAGATGGAATTTCGCTCTTGTTGCCCAGGCTGGAGTGCAATGGCACGATCT
TGGCTCACCGCAACCTCCGCCTCCCAGGACATTGAAAAAGACTTGAAACAAATGAGGCTT
CAGAACACAAAGGAAAGTAAAAATCCAGAACAGAAATATAAAGCTAAGAAGGGGGTAAAA
TTTGAAATTAATTTAGACAAATGTATTTCTGATGAAAACATCCTCCAAGAGGAAGAGGCA
ATGGATATACCAAATGAAACTTTGACCTTTGAGGATGGCATGAAGTTTAAGGAATATGAA
TGTGTAAAGGAGCATGGAGATTATACAGACAAAGCATTTGAAAAACTTCACTGCCCAGAA
GCAGGGTTTTCCACGCAGACTGTAGCTGCTGTGGGAAACAGGAGGCAGTGGGATGGAGGA
GCGCCTCAGACTCTGCTGCAGATGATGGCAGTGGCCGACATCACCTCCACCTGCCCCACG
GGGCCTGACAGTGAGTCTGTGCTTAGCGTCAGTCGTCAGGAAGGGAAGACCAAGGACCCG
TACAGCCCAGTGCTCATCCTGATGTGA
Protein Properties
Number of Residues 708
Molecular Weight 81444.9
Theoretical pI 9.18
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Serine/threonine-protein kinase Nek5
MDKYDVIKAIGQGAFGKAYLAKGKSDSKHCVIKEINFEKMPIQEKEASKKEVILLEKMKH
PNIVAFFNSFQENGRLFIVMEYCDGGDLMKRINRQRGVLFSEDQILGWFVQISLGLKHIH
DRKILHRDIKAQNIFLSKNGMVAKLGDFGIARVLNNSMELARTCIGTPYYLSPEICQNKP
YNNKTDIWSLGCVLYELCTLKHPFEGNNLQQLVLKICQAHFAPISPGFSRELHSLISQLF
QVSPRDRPSINSILKRPFLENLIPKYLTPEVIQEEFSHMLICRAGAPASRHAGKVVQKCK
IQKVRFQGKCPPRSRISVPIKRNAILHRNEWRPPAGAQKARSIKMIERPKIAAVCGHYDY
YYAQLDMLRRRAHKPSYHPIPQENTGVEDYGQETRHGPSPSQWPAEYLQRKFEAQQYKLK
VEKQLGLRPSSAEPNYNQRQELRSNGEEPRFQELPFRKNEMKEQEYWKQLEEIRQQYHND
MKEIRKKMGREPEENSKISHKTYLVKKSNLPVHQDASEGEAPVQMEFRSCCPGWSAMARS
WLTATSASQDIEKDLKQMRLQNTKESKNPEQKYKAKKGVKFEINLDKCISDENILQEEEA
MDIPNETLTFEDGMKFKEYECVKEHGDYTDKAFEKLHCPEAGFSTQTVAAVGNRRQWDGG
APQTLLQMMAVADITSTCPTGPDSESVLSVSRQEGKTKDPYSPVLILM
GenBank ID Protein 123247885
UniProtKB/Swiss-Prot ID Q6P3R8
UniProtKB/Swiss-Prot Entry Name NEK5_HUMAN
PDB IDs Not Available
GenBank Gene ID AL139082
GeneCard ID NEK5
GenAtlas ID NEK5
HGNC ID HGNC:7748
References
General References
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  2. Molina H, Horn DM, Tang N, Mathivanan S, Pandey A: Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry. Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2199-204. Epub 2007 Feb 7. [PubMed:17287340 ]
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  4. Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, Davies H, Teague J, Butler A, Stevens C, Edkins S, O'Meara S, Vastrik I, Schmidt EE, Avis T, Barthorpe S, Bhamra G, Buck G, Choudhury B, Clements J, Cole J, Dicks E, Forbes S, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jenkinson A, Jones D, Menzies A, Mironenko T, Perry J, Raine K, Richardson D, Shepherd R, Small A, Tofts C, Varian J, Webb T, West S, Widaa S, Yates A, Cahill DP, Louis DN, Goldstraw P, Nicholson AG, Brasseur F, Looijenga L, Weber BL, Chiew YE, DeFazio A, Greaves MF, Green AR, Campbell P, Birney E, Easton DF, Chenevix-Trench G, Tan MH, Khoo SK, Teh BT, Yuen ST, Leung SY, Wooster R, Futreal PA, Stratton MR: Patterns of somatic mutation in human cancer genomes. Nature. 2007 Mar 8;446(7132):153-8. [PubMed:17344846 ]