Hmdb loader
Identification
HMDB Protein ID HMDBP08773
Secondary Accession Numbers
  • 14496
Name NUAK family SNF1-like kinase 2
Synonyms
  1. SNARK
  2. SNF1/AMP kinase-related kinase
Gene Name NUAK2
Protein Type Unknown
Biological Properties
General Function Involved in protein kinase activity
Specific Function Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95- activated tumor cells
Pathways Not Available
Reactions Not Available
GO Classification
Function
binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
protein kinase activity
protein serine/threonine kinase activity
Process
phosphorus metabolic process
phosphate metabolic process
metabolic process
cellular metabolic process
protein amino acid phosphorylation
phosphorylation
Cellular Location Not Available
Gene Properties
Chromosome Location Chromosome:1
Locus 1q32.1
SNPs NUAK2
Gene Sequence
>1887 bp
ATGGAGTCGCTGGTTTTCGCGCGGCGCTCCGGCCCCACTCCCTCGGCCGCAGAGCTAGCC
CGGCCGCTGGCGGAAGGGCTGATCAAGTCGCCCAAGCCCCTAATGAAGAAGCAGGCGGTG
AAGCGGCACCACCACAAGCACAACCTGCGGCACCGCTACGAGTTCCTGGAGACCCTGGGC
AAAGGCACCTACGGGAAGGTGAAGAAGGCGCGGGAGAGCTCGGGGCGCCTGGTGGCCATC
AAGTCAATCCGGAAGGACAAAATCAAAGATGAGCAAGATCTGATGCACATACGGAGGGAG
ATTGAGATCATGTCATCACTCAACCACCCTCACATCATTGCCATCCATGAAGTGTTTGAG
AACAGCAGCAAGATCGTGATCGTCATGGAGTATGCCAGCCGGGGCGACCTTTATGACTAC
ATCAGCGAGCGGCAGCAGCTCAGTGAGCGCGAAGCTAGGCATTTCTTCCGGCAGATCGTC
TCTGCCGTGCACTATTGCCATCAGAACAGAGTTGTCCACCGAGATCTCAAGCTGGAGAAC
ATCCTCTTGGATGCCAATGGGAATATCAAGATTGCTGACTTCGGCCTCTCCAACCTCTAC
CATCAAGGCAAGTTCCTGCAGACATTCTGTGGGAGCCCCCTCTATGCCTCGCCAGAGATT
GTCAATGGGAAGCCCTACACAGGCCCAGAGGTGGACAGCTGGTCCCTGGGTGTTCTCCTC
TACATCCTGGTGCATGGCACCATGCCCTTTGATGGGCATGACCATAAGATCCTAGTGAAA
CAGATCAGCAACGGGGCCTACCGGGAGCCACCTAAACCCTCTGATGCCTGTGGCCTGATC
CGGTGGCTGTTGATGGTGAACCCCACCCGCCGGGCCACCCTGGAGGATGTGGCCAGTCAC
TGGTGGGTCAACTGGGGCTACGCCACCCGAGTGGGAGAGCAGGAGGCTCCGCATGAGGGT
GGGCACCCTGGCAGTGACTCTGCCCGCGCCTCCATGGCTGACTGGCTCCGGCGTTCCTCC
CGCCCCCTCCTGGAGAATGGGGCCAAGGTGTGCAGCTTCTTCAAGCAGCATGCACCTGGT
GGGGGAAGCACCACCCCTGGCCTGGAGCGCCAGCATTCGCTCAAGAAGTCCCGCAAGGAG
AATGACATGGCCCAGTCTCTCCACAGTGACACGGCTGATGACACTGCCCATCGCCCTGGC
AAGAGCAACCTCAAGCTGCCAAAGGGCATTCTCAAGAAGAAGGTGTCAGCCTCTGCAGAA
GGGGTACAGGAGGACCCTCCGGAGCTCAGCCCAATCCCTGCGAGCCCAGGGCAGGCTGCC
CCCCTGCTCCCCAAGAAGGGCATTCTCAAGAAGCCCCGACAGCGCGAGTCTGGCTACTAC
TCCTCTCCCGAGCCCAGTGAATCTGGGGAGCTCTTGGACGCAGGCGACGTGTTTGTGAGT
GGGGATCCCAAGGAGCAGAAGCCTCCGCAAGCTTCAGGGCTGCTCCTCCATCGCAAAGGC
ATCCTCAAACTCAATGGCAAGTTCTCCCAGACAGCCTTGGAGCTCGCGGCCCCCACCACC
TTCGGCTCCCTGGATGAACTCGCCCCACCTCGCCCCCTGGCCCGGGCCAGCCGACCCTCA
GGGGCTGTGAGCGAGGACAGCATCCTGTCCTCTGAGTCCTTTGACCAGCTGGACTTGCCT
GAACGGCTCCCAGAGCCCCCACTGCGGGGCTGTGTGTCTGTGGACAACCTCACGGGGCTT
GAGGAGCCCCCCTCAGAGGGCCCTGGAAGCTGCCTGAGGCGCTGGCGGCAGGATCCTTTG
GGGGACAGCTGCTTTTCCCTGACAGACTGCCAGGAGGTGACAGCGACCTACCGACAGGCA
CTGAGGGTCTGCTCAAAGCTCACCTGA
Protein Properties
Number of Residues 628
Molecular Weight 69611.5
Theoretical pI 9.2
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>NUAK family SNF1-like kinase 2
MESLVFARRSGPTPSAAELARPLAEGLIKSPKPLMKKQAVKRHHHKHNLRHRYEFLETLG
KGTYGKVKKARESSGRLVAIKSIRKDKIKDEQDLMHIRREIEIMSSLNHPHIIAIHEVFE
NSSKIVIVMEYASRGDLYDYISERQQLSEREARHFFRQIVSAVHYCHQNRVVHRDLKLEN
ILLDANGNIKIADFGLSNLYHQGKFLQTFCGSPLYASPEIVNGKPYTGPEVDSWSLGVLL
YILVHGTMPFDGHDHKILVKQISNGAYREPPKPSDACGLIRWLLMVNPTRRATLEDVASH
WWVNWGYATRVGEQEAPHEGGHPGSDSARASMADWLRRSSRPLLENGAKVCSFFKQHAPG
GGSTTPGLERQHSLKKSRKENDMAQSLHSDTADDTAHRPGKSNLKLPKGILKKKVSASAE
GVQEDPPELSPIPASPGQAAPLLPKKGILKKPRQRESGYYSSPEPSESGELLDAGDVFVS
GDPKEQKPPQASGLLLHRKGILKLNGKFSQTALELAAPTTFGSLDELAPPRPLARASRPS
GAVSEDSILSSESFDQLDLPERLPEPPLRGCVSVDNLTGLEEPPSEGPGSCLRRWRQDPL
GDSCFSLTDCQEVTATYRQALRVCSKLT
GenBank ID Protein 22760532
UniProtKB/Swiss-Prot ID Q9H093
UniProtKB/Swiss-Prot Entry Name NUAK2_HUMAN
PDB IDs Not Available
GenBank Gene ID AK074830
GeneCard ID NUAK2
GenAtlas ID NUAK2
HGNC ID HGNC:29558
References
General References
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  6. Lizcano JM, Goransson O, Toth R, Deak M, Morrice NA, Boudeau J, Hawley SA, Udd L, Makela TP, Hardie DG, Alessi DR: LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. EMBO J. 2004 Feb 25;23(4):833-43. Epub 2004 Feb 19. [PubMed:14976552 ]
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