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Survey
Identification
HMDB Protein ID HMDBP08774
Secondary Accession Numbers
  • 14497
Name Endonuclease G, mitochondrial
Synonyms
  1. Endo G
Gene Name ENDOG
Protein Type Unknown
Biological Properties
General Function Involved in nucleic acid binding
Specific Function Cleaves DNA at double-stranded (DG)n.(DC)n and at single-stranded (DC)n tracts. In addition to deoxyribonuclease activities, also has ribonuclease (RNase) and RNase H activities. Capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA
Pathways Not Available
Reactions Not Available
GO Classification
Function
ion binding
cation binding
metal ion binding
binding
catalytic activity
hydrolase activity
nucleic acid binding
Cellular Location
  1. Mitochondrion
Gene Properties
Chromosome Location Chromosome:9
Locus 9q34.1
SNPs ENDOG
Gene Sequence
>894 bp
ATGCGGGCGCTGCGGGCCGGCCTGACCCTGGCGTCGGGCGCGGGGCTGGGTGCGGTCGTC
GAGGGCTGGCGGCGGCGGCGGGAGGACGCGCGGGCGGCGCCGGGACTGCTGGGCCGGCTG
CCCGTGCTGCCCGTGGCGGCGGCAGCCGAGTTGCCCCCTGTGCCCGGGGGACCCCGCGGC
CCGGGCGAGCTGGCCAAGTACGGGCTGCCGGGGCTGGCGCAGCTCAAGAGCCGCGAGTCG
TACGTGCTGTGCTACGACCCGCGCACCCGCGGCGCGCTCTGGGTGGTGGAGCAGCTGCGA
CCCGAGCGTCTCCGCGGCGACGGCGACCGGCGCGAGTGCGACTTCCGCGAGGACGACTCG
GTGCACGCGTACCACCGTGCCACCAACGCCGACTACCGCGGCAGTGGCTTCGACCGCGGT
CACCTGGCCGCCGCCGCCAACCACCGCTGGAGCCAGAAGGCCATGGACGACACGTTCTAC
CTGAGCAACGTCGCGCCCCAGGTGCCCCACCTCAACCAGAATGCCTGGAACAACCTGGAG
AAATATAGCCGCAGCTTGACCCGCAGCTACCAAAACGTCTATGTCTGCACAGGGCCACTC
TTCCTGCCCAGGACAGAGGCTGATGGGAAATCCTACGTAAAGTACCAGGTCATCGGCAAG
AACCACGTGGCAGTGCCCACACACTTCTTCAAGGTGCTGATCCTGGAGGCAGCAGGTGGG
CAAATTGAGCTCCGCACCTACGTGATGCCCAACGCACCTGTGGATGAGGCCATCCCACTG
GAGCGCTTCCTGGTGCCCATCGAGAGCATTGAGCGGGCTTCGGGGCTGCTCTTTGTGCCA
AACATCCTGGCGCGGGCAGGCAGCCTCAAGGCCATCACGGCGGGCAGTAAGTGA
Protein Properties
Number of Residues 297
Molecular Weight 32646.0
Theoretical pI 9.83
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Endonuclease G, mitochondrial
MRALRAGLTLALGAGLGAVVEGWRRRREDARAAPGLLGRLPVLPVAAAAELPPVPGGPRG
PGELAKYGLPGLAQLKSRESYVLCYDPRTRGALWVVEQLRPERLRGDGDRRECDFREDDS
VHAYHRATNADYRGSGFDRGHLAAAANHRWSQKAMDDTFYLSNVAPQVPHLNQNAWNNLE
KYSRSLTRSYQNVYVCTGPLFLPRTEADGKSYVKYQVIGKNHVAVPTHFFKVLILEAAGG
QIELRTYVMPNAPVDEAIPLERFLVPIESIERASGLLFVPNILARAGSLKAITAGSK
GenBank ID Protein 55960038
UniProtKB/Swiss-Prot ID Q14249
UniProtKB/Swiss-Prot Entry Name NUCG_HUMAN
PDB IDs Not Available
GenBank Gene ID AL441992
GeneCard ID ENDOG
GenAtlas ID ENDOG
HGNC ID HGNC:3346
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Humphray SJ, Oliver K, Hunt AR, Plumb RW, Loveland JE, Howe KL, Andrews TD, Searle S, Hunt SE, Scott CE, Jones MC, Ainscough R, Almeida JP, Ambrose KD, Ashwell RI, Babbage AK, Babbage S, Bagguley CL, Bailey J, Banerjee R, Barker DJ, Barlow KF, Bates K, Beasley H, Beasley O, Bird CP, Bray-Allen S, Brown AJ, Brown JY, Burford D, Burrill W, Burton J, Carder C, Carter NP, Chapman JC, Chen Y, Clarke G, Clark SY, Clee CM, Clegg S, Collier RE, Corby N, Crosier M, Cummings AT, Davies J, Dhami P, Dunn M, Dutta I, Dyer LW, Earthrowl ME, Faulkner L, Fleming CJ, Frankish A, Frankland JA, French L, Fricker DG, Garner P, Garnett J, Ghori J, Gilbert JG, Glison C, Grafham DV, Gribble S, Griffiths C, Griffiths-Jones S, Grocock R, Guy J, Hall RE, Hammond S, Harley JL, Harrison ES, Hart EA, Heath PD, Henderson CD, Hopkins BL, Howard PJ, Howden PJ, Huckle E, Johnson C, Johnson D, Joy AA, Kay M, Keenan S, Kershaw JK, Kimberley AM, King A, Knights A, Laird GK, Langford C, Lawlor S, Leongamornlert DA, Leversha M, Lloyd C, Lloyd DM, Lovell J, Martin S, Mashreghi-Mohammadi M, Matthews L, McLaren S, McLay KE, McMurray A, Milne S, Nickerson T, Nisbett J, Nordsiek G, Pearce AV, Peck AI, Porter KM, Pandian R, Pelan S, Phillimore B, Povey S, Ramsey Y, Rand V, Scharfe M, Sehra HK, Shownkeen R, Sims SK, Skuce CD, Smith M, Steward CA, Swarbreck D, Sycamore N, Tester J, Thorpe A, Tracey A, Tromans A, Thomas DW, Wall M, Wallis JM, West AP, Whitehead SL, Willey DL, Williams SA, Wilming L, Wray PW, Young L, Ashurst JL, Coulson A, Blocker H, Durbin R, Sulston JE, Hubbard T, Jackson MJ, Bentley DR, Beck S, Rogers J, Dunham I: DNA sequence and analysis of human chromosome 9. Nature. 2004 May 27;429(6990):369-74. [PubMed:15164053 ]
  3. Tiranti V, Rossi E, Ruiz-Carrillo A, Rossi G, Rocchi M, DiDonato S, Zuffardi O, Zeviani M: Chromosomal localization of mitochondrial transcription factor A (TCF6), single-stranded DNA-binding protein (SSBP), and endonuclease G (ENDOG), three human housekeeping genes involved in mitochondrial biogenesis. Genomics. 1995 Jan 20;25(2):559-64. [PubMed:7789991 ]