Hmdb loader
Identification
HMDB Protein ID HMDBP08779
Secondary Accession Numbers
  • 14502
Name 8-oxo-dGDP phosphatase NUDT18
Synonyms
  1. Nudix motif 18
  2. 2-hydroxy-dADP phosphatase
  3. 7,8-dihydro-8-oxoguanine phosphatase
  4. MutT homolog 3
  5. Nucleoside diphosphate-linked moiety X motif 18
Gene Name NUDT18
Protein Type Unknown
Biological Properties
General Function Involved in hydrolase activity
Specific Function Mediates the hydrolyzis of oxidized nucleoside diphosphate derivatives. Hydrolyzes 8-oxo-7,8-dihydroguanine (8-oxo-Gua)-containing deoxyribo- and ribonucleoside diphosphates to the monophosphates. Hydrolyzes 8-oxo-dGDP and 8-oxo-GDP with the same efficiencies. Hydrolyzes also 8-OH-dADP and 2-OH-dADP. Exhibited no or minimal hydrolyzis activity against 8-oxo-dGTP, 8-oxo-GTP, dGTP, GTP, dGDP and GDP. Probably removes oxidized guanine nucleotides from both the DNA and RNA precursor pools.
Pathways Not Available
Reactions
8-oxo-dGDP + Water → 8-Oxo-dGMP + Phosphate details
GO Classification
Biological Process
dADP catabolic process
dGDP catabolic process
GDP catabolic process
Function
catalytic activity
hydrolase activity
Molecular Function
magnesium ion binding
8-hydroxy-dADP phosphatase activity
8-oxo-dGDP phosphatase activity
8-oxo-GDP phosphatase activity
Cellular Location
  1. Cytoplasmic
Gene Properties
Chromosome Location 8
Locus 8p21.3
SNPs NUDT18
Gene Sequence
>972 bp
ATGGCCTCGGAGGGCCTGGCGGGGGCGCTGGCTTCCGTGCTGGCTGGCCAGGGGTCCAGC
GTGCACAGCTGCGACTCGGCGCCGGCCGGGGAGCCGCCGGCGCCCGTGCGGCTGCGGAAG
AACGTGTGCTACGTGGTGCTGGCCGTGTTCCTCAGCGAGCAGGATGAGGTGCTACTGATC
CAGGAGGCCAAGAGGGAGTGCCGGGGGTCGTGGTACCTGCCTGCGGGGAGAATGGAGCCA
GGGGAGACCATCGTGGAGGCGCTGCAGCGGGAGGTGAAGGAGGAGGCGGGGCTGCACTGT
GAGCCCGAGACACTGCTGTCCGTGGAGGAGCGGGGCCCCTCCTGGGTCCGCTTCGTGTTC
CTCGCTCGCCCCACAGGTGGAATTCTCAAGACTTCCAAGGAGGCCGATGCGGAGTCCCTG
CAGGCTGCCTGGTACCCACGGACCTCCCTGCCCACTCCGCTGCGAGCCCATGACATCCTG
CACCTGGTTGAACTAGCCGCCCAGTATCGCCAGCAAGCCAGGCACCCTCTCATTCTGCCC
CAAGAGCTACCCTGTGATCTGGTCTGCCAGCGGCTCGTGGCTACCTTTACCAGCGCCCAG
ACAGTGTGGGTGTTAGTGGGCACAGTGGGGATGCCTCACTTGCCTGTCACTGCCTGTGGC
CTCGACCCTATGGAGCAGAGGGGTGGCATGAAGATGGCCGTCCTGCGGCTGCTGCAGGAG
TGTCTGACCCTGCACCACTTGGTGGTGGAGATCAAGGGGTTGCTTGGACTGCAGCACCTG
GGCCGAGATCACAGTGATGGCATCTGTTTGAATGTGCTGGTGACCGTGGCTTTTCGGAGC
CCAGGGATCCAGGATGAACCCCCAAAAGTTCGGGGTGAGAACTTCTCTTGGTGGAAGGTG
ATGGAGGAAGACCTGCAAAGCCAGCTCCTCCAGCGGCTTCAGGGATCCTCTGTTGTCCCA
GTGAACAGATAG
Protein Properties
Number of Residues 323
Molecular Weight 35500.76
Theoretical pI 6.227
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Nucleoside diphosphate-linked moiety X motif 18
MASEGLAGALASVLAGQGSSVHSCDSAPAGEPPAPVRLRKNVCYVVLAVFLSEQDEVLLI
QEAKRECRGSWYLPAGRMEPGETIVEALQREVKEEAGLHCEPETLLSVEERGPSWVRFVF
LARPTGGILKTSKEADAESLQAAWYPRTSLPTPLRAHDILHLVELAAQYRQQARHPLILP
QELPCDLVCQRLVATFTSAQTVWVLVGTVGMPHLPVTACGLDPVEQRGGMKMAVLRLLQE
CLTLHHLVVEIKGLLGLQHLGRDHSDGICLNVLVTVAFRSPGIQDEPPKVRGENFSWWKV
MEEDLQSQLLQRLQGSSVVPVNR
GenBank ID Protein 118026927
UniProtKB/Swiss-Prot ID Q6ZVK8
UniProtKB/Swiss-Prot Entry Name NUD18_HUMAN
PDB IDs
GenBank Gene ID NM_024815.3
GeneCard ID NUDT18
GenAtlas ID NUDT18
HGNC ID HGNC:26194
References
General References
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