Showing Protein Diphosphoinositol polyphosphate phosphohydrolase 1 (HMDBP08781)

• 14504

1. DIPP-1
2. Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 1
3. Nucleoside diphosphate-linked moiety X motif 3
4. Nudix motif 3

• Inositol Phosphate Metabolism

1. Cytoplasm (Probable)

>519 bp
ATGATGAAGCTCAAGTCGAACCAGACCCGCACCTACGACGGCGACGGCTACAAGAAGCGG
GCCGCATGCCTGTGTTTCCGCAGCGAGAGCGAGGAGGAGGTGCTACTCGTGAGCAGTAGT
CGCCATCCAGACAGATGGATTGTCCCTGGAGGAGGCATGGAGCCCGAGGAGGAGCCAAGT
GTGGCAGCAGTTCGTGAAGTCTGTGAGGAGGCTGGAGTAAAAGGGACATTGGGAAGATTA
GTTGGAATTTTTGAGAACCAGGAGAGGAAGCACAGGACGTATGTCTATGTGCTCATTGTC
ACTGAAGTGCTGGAAGACTGGGAAGATTCAGTTAACATTGGAAGGAAGAGGGAATGGTTT
AAAATAGAAGACGCCATAAAAGTGCTGCAGTATCACAAACCCGTGCAGGCATCATATTTT
GAAACATTGAGGCAAGGCTACTCAGCCAACAATGGCACCCCAGTCGTGGCCACCACATAC
TCGGTTTCTGCTCAGAGCTCGATGTCAGGCATCAGATGA

• NUDIX (PF00293 )

>Diphosphoinositol polyphosphate phosphohydrolase 1
MMKLKSNQTRTYDGDGYKKRAACLCFRSESEEEVLLVSSSRHPDRWIVPGGGMEPEEEPS
VAAVREVCEEAGVKGTLGRLVGIFENQERKHRTYVYVLIVTEVLEDWEDSVNIGRKREWF
KIEDAIKVLQYHKPVQASYFETLRQGYSANNGTPVVATTYSVSAQSSMSGIR

• 2FVV
• 2Q9P

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4. Fisher DI, Safrany ST, Strike P, McLennan AG, Cartwright JL: Nudix hydrolases that degrade dinucleoside and diphosphoinositol polyphosphates also have 5-phosphoribosyl 1-pyrophosphate (PRPP) pyrophosphatase activity that generates the glycolytic activator ribose 1,5-bisphosphate. J Biol Chem. 2002 Dec 6;277(49):47313-7. Epub 2002 Oct 4. [PubMed:12370170 ]
5. Safrany ST, Caffrey JJ, Yang X, Bembenek ME, Moyer MB, Burkhart WA, Shears SB: A novel context for the 'MutT' module, a guardian of cell integrity, in a diphosphoinositol polyphosphate phosphohydrolase. EMBO J. 1998 Nov 16;17(22):6599-607. [PubMed:9822604 ]
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7. Yang X, Safrany ST, Shears SB: Site-directed mutagenesis of diphosphoinositol polyphosphate phosphohydrolase, a dual specificity NUDT enzyme that attacks diadenosine polyphosphates and diphosphoinositol polyphosphates. J Biol Chem. 1999 Dec 10;274(50):35434-40. [PubMed:10585413 ]
8. Thorsell AG, Persson C, Graslund S, Hammarstrom M, Busam RD, Hallberg BM: Crystal structure of human diphosphoinositol phosphatase 1. Proteins. 2009 Oct;77(1):242-6. doi: 10.1002/prot.22489. [PubMed:19585659 ]