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Identification
HMDB Protein ID HMDBP08828
Secondary Accession Numbers
  • 14553
Name Three prime repair exonuclease 2
Synonyms
  1. 3'-5' exonuclease TREX2
Gene Name TREX2
Protein Type Unknown
Biological Properties
General Function Involved in exonuclease activity
Specific Function Exonuclease with a preference for double stranded DNA with mismatched 3' termini. May play a role in DNA repair
Pathways Not Available
Reactions Not Available
GO Classification
Component
cell part
intracellular
Function
hydrolase activity, acting on ester bonds
binding
catalytic activity
hydrolase activity
exonuclease activity
nucleic acid binding
nuclease activity
Cellular Location
  1. Nucleus (Probable)
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs TREX2
Gene Sequence
>840 bp
ATGGGGCGGGCAGGAAGCCCTCTCCCAAGATCGAGTTGGCCGAGGATGGATGATTGTGGC
AGCAGAAGCCGTTGCAGCCCCACGTTGTGCTCTAGTTTGAGGACTTGCTATCCCCGTGGG
AACATCACCATGTCCGAGGCACCCCGGGCCGAGACCTTTGTCTTCCTGGACCTGGAAGCC
ACTGGGCTCCCCAGTGTGGAGCCCGAGATTGCCGAGCTGTCCCTCTTTGCTGTCCACCGC
TCCTCCCTGGAGAACCCGGAGCACGACGAGTCTGGTGCCCTAGTATTGCCCCGGGTCCTG
GACAAGCTCACGCTGTGCATGTGCCCGGAGCGCCCCTTCACTGCCAAGGCCAGCGAGATC
ACCGGCCTGAGCAGTGAGGGCCTGGCGCGATGCCGGAAGGCTGGCTTTGATGGCGCCGTG
GTGCGGACGCTGCAGGCCTTCCTGAGCCGCCAGGCAGGGCCCATCTGCCTTGTGGCCCAC
AATGGCTTTGATTATGATTTCCCCCTGCTGTGTGCCGAGCTGCGGCGCCTGGGTGCCCGC
CTGCCCCGGGACACTGTCTGCCTGGACACGCTGCCGGCCCTGCGGGGCCTGGACCGCGCC
CACAGCCACGGCACCCGGGCCCGGGGCCGCCAGGGTTACAGCCTCGGCAGCCTCTTCCAC
CGCTACTTCCGGGCAGAGCCAAGCGCAGCCCACTCAGCCGAGGGCGACGTGCACACCCTG
CTCCTGATCTTCCTGCACCGCGCCGCAGAGCTGCTCGCCTGGGCCGATGAGCAGGCCCGT
GGGTGGGCCCACATCGAGCCCATGTACTTGCCGCCTGATGACCCCAGCCTGGAGGCCTGA
Protein Properties
Number of Residues 279
Molecular Weight 30620.4
Theoretical pI 6.83
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Three prime repair exonuclease 2
MGRAGSPLPRSSWPRMDDCGSRSRCSPTLCSSLRTCYPRGNITMSEAPRAETFVFLDLEA
TGLPSVEPEIAELSLFAVHRSSLENPEHDESGALVLPRVLDKLTLCMCPERPFTAKASEI
TGLSSEGLARCRKAGFDGAVVRTLQAFLSRQAGPICLVAHNGFDYDFPLLCAELRRLGAR
LPRDTVCLDTLPALRGLDRAHSHGTRARGRQGYSLGSLFHRYFRAEPSAAHSAEGDVHTL
LLIFLHRAAELLAWADEQARGWAHIEPMYLPPDDPSLEA
GenBank ID Protein 12751319
UniProtKB/Swiss-Prot ID Q9BQ50
UniProtKB/Swiss-Prot Entry Name TREX2_HUMAN
PDB IDs
GenBank Gene ID AF319571
GeneCard ID TREX2
GenAtlas ID TREX2
HGNC ID HGNC:12270
References
General References
  1. Mazur DJ, Perrino FW: Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3'-->5' exonucleases. J Biol Chem. 1999 Jul 9;274(28):19655-60. [PubMed:10391904 ]
  2. Mazur DJ, Perrino FW: Structure and expression of the TREX1 and TREX2 3' --> 5' exonuclease genes. J Biol Chem. 2001 May 4;276(18):14718-27. Epub 2001 Jan 29. [PubMed:11278605 ]
  3. Mazur DJ, Perrino FW: Excision of 3' termini by the Trex1 and TREX2 3'-->5' exonucleases. Characterization of the recombinant proteins. J Biol Chem. 2001 May 18;276(20):17022-9. Epub 2001 Mar 6. [PubMed:11279105 ]
  4. Perrino FW, Harvey S, McMillin S, Hollis T: The human TREX2 3' -> 5'-exonuclease structure suggests a mechanism for efficient nonprocessive DNA catalysis. J Biol Chem. 2005 Apr 15;280(15):15212-8. Epub 2005 Jan 19. [PubMed:15661738 ]