Hmdb loader
Identification
HMDB Protein ID HMDBP08842
Secondary Accession Numbers
  • 14569
Name Galactose-3-O-sulfotransferase 4
Synonyms
  1. Beta-galactose-3-O-sulfotransferase 4
  2. Gal-beta-1,3-GalNAc 3'-sulfotransferase
  3. Gal3ST-4
Gene Name GAL3ST4
Protein Type Unknown
Biological Properties
General Function Involved in galactosylceramide sulfotransferase activity
Specific Function Catalyzes the transfer of sulfate to beta-1,3-linked galactose residues in O-linked glycoproteins. Good substrates include asialofetuin, Gal-beta-1,3-GalNAc and Gal-beta-1,3 (GlcNAc-beta-1,6)GalNAc
Pathways Not Available
Reactions Not Available
GO Classification
Component
golgi apparatus
cell part
membrane part
intrinsic to membrane
organelle
membrane-bounded organelle
intracellular membrane-bounded organelle
integral to membrane
Function
catalytic activity
transferase activity
transferase activity, transferring sulfur-containing groups
sulfotransferase activity
galactose 3-o-sulfotransferase activity
galactosylceramide sulfotransferase activity
Process
metabolic process
biosynthetic process
Cellular Location
  1. Golgi apparatus
  2. Golgi stack membrane
  3. Single-pass type II membrane protein (Probable)
Gene Properties
Chromosome Location Chromosome:7
Locus 7q22.1
SNPs GAL3ST4
Gene Sequence
>1461 bp
ATGGGCCCTCTCTCTCCTGCCAGGACGCTGCGGCTCTGGGGACCTCGGAGCCTGGGGGTG
GCTCTGGGAGTCTTCATGACCATTGGCTTTGCACTCCAGCTCTTGGGAGGGCCCTTCCAG
AGGAGGCTACCTGGGCTACAGCTCCGACAGCCCTCGGCCCCATCCCTACGACCAGCCCTT
CCGTCCTGCCCACCCCGGCAGCGACTGGTGTTCCTGAAGACACATAAATCCGGGAGCAGC
TCTGTGCTGAGCCTGCTTCACCGCTATGGGGACCAGCACGGGCTGCGCTTCGCCCTCCCT
GCCCGCTACCAGTTTGGCTACCCAAAGCTCTTCCAGGCCTCTAGGGTAAAAGGCTACCGC
CCACAGGGTGGAGGCACCCAGCTCCCCTTCCACATCCTCTGTCACCACATGAGGTTCAAC
CTGAAAGAGGTACTTCAGGTCATGCCTTCTGACAGCTTCTTTTTTTCCATTGTCCGAGAC
CCAGCGGCTCTGGCTCGCTCTGCCTTCTCCTACTATAAATCCACCTCATCAGCCTTCCGC
AAGTCACCATCTTTGGCTGCCTTCCTGGCCAATCCTCGAGGCTTCTACAGGCCTGGGGCC
GTGGGGACCACTTACGCTCGCAACTTACTATGGTTTGACTTTGGCCTGCCCTTTCCCCCA
GAGAAGAGGGCCAAGAGAGGGAATATTCATCCCCCCAGAGACCCCAACCCCCCACAGCTG
CAGGTCTTGCCTTCTGGTGCTGGCCCTCGAGCCCAAACCCTCAATCCCAATGCCCTCATC
CATCCTGTTTCCACTGTTACTGATCATCGCAGCCAGATATCAAGCCCTGCCTCTTTCGAT
TTGGGGTCTTCATCCTTCATCCAGTGGGGTCTGGCCTGGCTGGACTCTGTCTTTGACCTG
GTCATGGTGGCTGAGTACTTCGATGAGTCATTGGTTCTGCTGGCAGATGCCCTGTGCTGG
GGTCTAGATGACGTGGTGGGCTTCATGCACAATGCCCAGGCTGGACATAAGCAGGGCCTC
AGCACTGTCAGCAACAGTGGACTGACTGCGGAGGACCGGCAGCTGACTGCACGGGCCCGA
GCCTGGAACAACCTGGACTGGGCTCTCTATGTCCACTTCAACCGCAGTCTCTGGGCACGG
ATAGAGAAATACGGCCAGGGCCGGCTGCAGACAGCTGTGGCCGAGCTCCGGGCTCGCCGA
GAGGCCCTAGCGAAACATTGTCTGGTAGGGGGTGAGGCTTCTGACCCCAAATACATCACT
GATCGCCGGTTCCGCCCCTTCCAGTTTGGGTCAGCTAAGGTTTTGGGCTATATACTTCGG
AGTGGATTGAGCCCCCAAGACCAAGAGGAATGTGAGCGCCTAGCTACCCCTGAGCTCCAG
TACAAGGACAAGCTGGATGTCAAGCAGTTCCCCCCTACCGTCTCACTGCCCCTCAAGACT
TCAAGGCCACTCTCCCCATAA
Protein Properties
Number of Residues 486
Molecular Weight 54165.6
Theoretical pI 10.71
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • 19-39
Protein Sequence
>Galactose-3-O-sulfotransferase 4
MGPLSPARTLRLWGPRSLGVALGVFMTIGFALQLLGGPFQRRLPGLQLRQPSAPSLRPAL
PSCPPRQRLVFLKTHKSGSSSVLSLLHRYGDQHGLRFALPARYQFGYPKLFQASRVKGYR
PQGGGTQLPFHILCHHMRFNLKEVLQVMPSDSFFFSIVRDPAALARSAFSYYKSTSSAFR
KSPSLAAFLANPRGFYRPGARGDHYARNLLWFDFGLPFPPEKRAKRGNIHPPRDPNPPQL
QVLPSGAGPRAQTLNPNALIHPVSTVTDHRSQISSPASFDLGSSSFIQWGLAWLDSVFDL
VMVAEYFDESLVLLADALCWGLDDVVGFMHNAQAGHKQGLSTVSNSGLTAEDRQLTARAR
AWNNLDWALYVHFNRSLWARIEKYGQGRLQTAVAELRARREALAKHCLVGGEASDPKYIT
DRRFRPFQFGSAKVLGYILRSGLSPQDQEECERLATPELQYKDKLDAKQFPPTVSLPLKT
SRPLSP
GenBank ID Protein 18027354
UniProtKB/Swiss-Prot ID Q96RP7
UniProtKB/Swiss-Prot Entry Name G3ST4_HUMAN
PDB IDs Not Available
GenBank Gene ID AF289575
GeneCard ID GAL3ST4
GenAtlas ID GAL3ST4
HGNC ID HGNC:24145
References
General References
  1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [PubMed:14702039 ]
  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  3. Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. [PubMed:17974005 ]
  4. Scherer SW, Cheung J, MacDonald JR, Osborne LR, Nakabayashi K, Herbrick JA, Carson AR, Parker-Katiraee L, Skaug J, Khaja R, Zhang J, Hudek AK, Li M, Haddad M, Duggan GE, Fernandez BA, Kanematsu E, Gentles S, Christopoulos CC, Choufani S, Kwasnicka D, Zheng XH, Lai Z, Nusskern D, Zhang Q, Gu Z, Lu F, Zeesman S, Nowaczyk MJ, Teshima I, Chitayat D, Shuman C, Weksberg R, Zackai EH, Grebe TA, Cox SR, Kirkpatrick SJ, Rahman N, Friedman JM, Heng HH, Pelicci PG, Lo-Coco F, Belloni E, Shaffer LG, Pober B, Morton CC, Gusella JF, Bruns GA, Korf BR, Quade BJ, Ligon AH, Ferguson H, Higgins AW, Leach NT, Herrick SR, Lemyre E, Farra CG, Kim HG, Summers AM, Gripp KW, Roberts W, Szatmari P, Winsor EJ, Grzeschik KH, Teebi A, Minassian BA, Kere J, Armengol L, Pujana MA, Estivill X, Wilson MD, Koop BF, Tosi S, Moore GE, Boright AP, Zlotorynski E, Kerem B, Kroisel PM, Petek E, Oscier DG, Mould SJ, Dohner H, Dohner K, Rommens JM, Vincent JB, Venter JC, Li PW, Mural RJ, Adams MD, Tsui LC: Human chromosome 7: DNA sequence and biology. Science. 2003 May 2;300(5620):767-72. Epub 2003 Apr 10. [PubMed:12690205 ]
  5. Wan D, Gong Y, Qin W, Zhang P, Li J, Wei L, Zhou X, Li H, Qiu X, Zhong F, He L, Yu J, Yao G, Jiang H, Qian L, Yu Y, Shu H, Chen X, Xu H, Guo M, Pan Z, Chen Y, Ge C, Yang S, Gu J: Large-scale cDNA transfection screening for genes related to cancer development and progression. Proc Natl Acad Sci U S A. 2004 Nov 2;101(44):15724-9. Epub 2004 Oct 21. [PubMed:15498874 ]
  6. Seko A, Hara-Kuge S, Yamashita K: Molecular cloning and characterization of a novel human galactose 3-O-sulfotransferase that transfers sulfate to gal beta 1-->3galNAc residue in O-glycans. J Biol Chem. 2001 Jul 13;276(28):25697-704. Epub 2001 May 1. [PubMed:11333265 ]