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Identification
HMDB Protein ID HMDBP08846
Secondary Accession Numbers
  • 14573
Name GDP-fucose protein O-fucosyltransferase 1
Synonyms
  1. O-FucT-1
  2. Peptide-O-fucosyltransferase 1
Gene Name POFUT1
Protein Type Unknown
Biological Properties
General Function Involved in peptide-O-fucosyltransferase activity
Specific Function Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in EGF domains. Plays a crucial role in Notch signaling
Pathways Not Available
Reactions Not Available
GO Classification Not Available
Cellular Location
  1. Endoplasmic reticulum
Gene Properties
Chromosome Location Chromosome:2
Locus 20q11
SNPs POFUT1
Gene Sequence
>1167 bp
ATGGGCGCCGCCGCGTGGGCACGGCCGCTGAGCGTGTCTTTCCTGCTGCTGCTTCTGCCG
CTCCCGGGGATGCCCGCGGGCTCCTGGGACCCGGCCGGTTACCTGCTCTACTGCCCCTGC
ATGGGGCGCTTTGGGAACCAGGCCGATCACTTCTTGGGCTCTCTGGCATTTGCAAAGCTG
CTAAACCGTACCTTGGCTGTCCCTCCTTGGATTGAGTACCAGCATCACAAGCCTCCTTTC
ACCAACCTCCATGTGTCCTACCAGAAGTACTTCAAGCTGGAGCCCCTCCAGGCTTACCAT
CGGGTCATCAGCTTGGAGGATTTCATGGAGAAGCTGGCACCCACCCACTGGCCCCCTGAG
AAGCGGGTGGCATACTGCTTTGAGGTGGCAGCCCAGCGAAGCCCAGATAAGAAGACGTGC
CCCATGAAGGAAGGAAACCCCTTTGGCCCATTCTGGGATCAGTTTCATGTGAGTTTCAAC
AAGTCGGAGCTTTTTACAGGCATTTCCTTCAGTGCTTCCTACAGAGAACAATGGAGCCAG
AGATTTTCTCCAAAGGAACATCCGGTGCTTGCCCTGCCAGGAGCCCCAGCCCAGTTCCCC
GTCCTAGAGGAACACAGGCCACTACAGAAGTACATGGTATGGTCAGACGAAATGGTGAAG
ACGGGAGAGGCCCAGATTCATGCCCACCTTGTCCGGCCCTATGTGGGCATTCATCTGCGC
ATTGGCTCTGACTGGAAGAACGCCTGTGCCATGCTGAAGGACGGGACTGCAGGCTCGCAC
TTCATGGCCTCTCCGCAGTGTGTGGGCTACAGCCGCAGCACAGCGGCCCCCCTCACGATG
ACTATGTGCCTGCCTGACCTGAAGGAGATCCAGAGGGCTGTGAAGCTCTGGGTGAGGTCG
CTGGATGCCCAGTCGGTCTACGTTGCTACTGATTCCGAGAGTTATGTGCCTGAGCTCCAA
CAGCTCTTCAAAGGGAAGGTGAAGGTGGTGAGCCTGAAGCCTGAGGTGGCCCAGGTCGAC
CTGTACATCCTCGGCCAAGCCGACCACTTTATTGGCAACTGTGTCTCCTCCTTCACTGCC
TTTGTGAAGCGGGAGCGGGACCTCCAGGGGAGGCCGTCTTCTTTCTTCGGCATGGACAGG
CCCCCTAAGCTGCGGGACGAGTTCTGA
Protein Properties
Number of Residues 388
Molecular Weight 43955.4
Theoretical pI 8.69
Pfam Domain Function
Signals
  • 1-26
Transmembrane Regions
  • None
Protein Sequence
>GDP-fucose protein O-fucosyltransferase 1
MGAAAWARPLSVSFLLLLLPLPGMPAGSWDPAGYLLYCPCMGRFGNQADHFLGSLAFAKL
LNRTLAVPPWIEYQHHKPPFTNLHVSYQKYFKLEPLQAYHRVISLEDFMEKLAPTHWPPE
KRVAYCFEVAAQRSPDKKTCPMKEGNPFGPFWDQFHVSFNKSELFTGISFSASYREQWSQ
RFSPKEHPVLALPGAPAQFPVLEEHRPLQKYMVWSDEMVKTGEAQIHAHLVRPYVGIHLR
IGSDWKNACAMLKDGTAGSHFMASPQCVGYSRSTAAPLTMTMCLPDLKEIQRAVKLWVRS
LDAQSVYVATDSESYVPELQQLFKGKVKVVSLKPEVAQVDLYILGQADHFIGNCVSSFTA
FVKRERDLQGRPSSFFGMDRPPKLRDEF
GenBank ID Protein 15825114
UniProtKB/Swiss-Prot ID Q9H488
UniProtKB/Swiss-Prot Entry Name OFUT1_HUMAN
PDB IDs Not Available
GenBank Gene ID AF375884
GeneCard ID POFUT1
GenAtlas ID POFUT1
HGNC ID HGNC:14988
References
General References
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