Hmdb loader
Identification
HMDB Protein ID HMDBP08847
Secondary Accession Numbers
  • 14574
Name Oligoribonuclease, mitochondrial
Synonyms
  1. RNA exonuclease 2 homolog
  2. Small fragment nuclease
Gene Name REXO2
Protein Type Unknown
Biological Properties
General Function Involved in exonuclease activity
Specific Function 3'-to-5' exoribonuclease specific for small oligoribonucleotides. Active on small (primarily
Pathways Not Available
Reactions Not Available
GO Classification
Component
cell part
intracellular
Function
hydrolase activity, acting on ester bonds
binding
catalytic activity
hydrolase activity
exonuclease activity
nucleic acid binding
nuclease activity
Cellular Location
  1. Isoform 2:Nucleus
Gene Properties
Chromosome Location Chromosome:1
Locus 11q23.2
SNPs REXO2
Gene Sequence
>714 bp
ATGCTAGGCGGCTCCCTGGGCTCCAGGCTGTTGCGGGGTGTAGGTGGGAGTCACGGACGG
TTCGGGGCCCGAGGTGTCCGCGAAGGTGGCGCAGCCATGGCGGCAGGGGAGAGCATGGCT
CAGCGGATGGTCTGGGTGGACCTGGAGATGACAGGATTGGACATTGAGAAGGACCAGATT
ATTGAGATGGCCTGTCTGATAACTGACTCTGATCTCAACATTTTGGCTGAAGGTCCTAAC
CTGATTATAAAACAACCAGATGAGTTGCTGGACAGCATGTCAGATTGGTGTAAGGAGCAT
CACGGGAAGTCTGGCCTTACCAAGGCAGTGAAGGAGAGTACAATTACATTGCAGCAGGCA
GAGTATGAATTTCTGTCCTTTGTACGACAGCAGACTCCTCCAGGGCTCTGTCCACTTGCA
GGAAATTCAGTTCATGAAGATAAGAAGTTTCTTGACAAATACATGCCCCAGTTCATGAAA
CATCTTCATTATAGAATAATTGATGTGAGCACTGTTAAAGAACTGTGCAGACGCTGGTAT
CCAGAAGAATATGAATTTGCACCAAAGAAGGCTGCTTCTCATAGGGCACTTGATGACATT
AGTGAAAGCATCAAAGAGCTTCAGTTTTACCGAAATAACATCTTCAAGAAAAAAATAGAT
GAAAAGAAGAGGAAAATTATAGAAAATGGGGAAAATGAGAAGACCGTGAGTTGA
Protein Properties
Number of Residues 237
Molecular Weight 26832.5
Theoretical pI 6.88
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Oligoribonuclease, mitochondrial
MLGGSLGSRLLRGVGGSHGRFGARGVREGGAAMAAGESMAQRMVWVDLEMTGLDIEKDQI
IEMACLITDSDLNILAEGPNLIIKQPDELLDSMSDWCKEHHGKSGLTKAVKESTITLQQA
EYEFLSFVRQQTPPGLCPLAGNSVHEDKKFLDKYMPQFMKHLHYRIIDVSTVKELCRRWY
PEEYEFAPKKAASHRALDDISESIKELQFYRNNIFKKKIDEKKRKIIENGENEKTVS
GenBank ID Protein 224496106
UniProtKB/Swiss-Prot ID Q9Y3B8
UniProtKB/Swiss-Prot Entry Name ORN_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_015523.3
GeneCard ID REXO2
GenAtlas ID REXO2
HGNC ID HGNC:17851
References
General References
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  2. Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. Nat Biotechnol. 2005 Jan;23(1):94-101. Epub 2004 Dec 12. [PubMed:15592455 ]
  3. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A: Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. Genome Res. 2001 Mar;11(3):422-35. [PubMed:11230166 ]
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  5. Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. Genome Res. 2000 May;10(5):703-13. [PubMed:10810093 ]
  6. Nguyen LH, Erzberger JP, Root J, Wilson DM 3rd: The human homolog of Escherichia coli Orn degrades small single-stranded RNA and DNA oligomers. J Biol Chem. 2000 Aug 25;275(34):25900-6. [PubMed:10851236 ]