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Identification
HMDB Protein ID HMDBP08850
Secondary Accession Numbers
  • 14577
Name PH domain leucine-rich repeat-containing protein phosphatase 1
Synonyms
  1. PH domain-containing family E member 1
  2. Pleckstrin homology domain-containing family E member 1
  3. Suprachiasmatic nucleus circadian oscillatory protein
  4. hSCOP
Gene Name PHLPP1
Protein Type Unknown
Biological Properties
General Function Involved in protein binding
Specific Function Protein phosphatase that mediates dephosphorylation of 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of AKT1 triggers apoptosis and suppression of tumor growth. Controls the phosphorylation of AKT2 and AKT3 more efficiently than that of AKT1. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Inhibits cancer cell proliferation and may act as a tumor suppressor. May act as a negative regulator of K-Ras signaling in membrane rafts.
Pathways
  • PI3K-Akt signaling pathway
Reactions
A phosphoprotein + Water → a protein + Phosphate details
GO Classification
Biological Process
apoptotic process
phosphatidylinositol-mediated signaling
entrainment of circadian clock
circadian rhythm
epidermal growth factor receptor signaling pathway
fibroblast growth factor receptor signaling pathway
nerve growth factor receptor signaling pathway
Cellular Component
cytosol
nucleus
membrane
Function
binding
catalytic activity
protein binding
Molecular Function
protein serine/threonine phosphatase activity
metal ion binding
phospholipid binding
Cellular Location
  1. Nucleus
  2. Cytoplasm
  3. Peripheral membrane protein
  4. Membrane
Gene Properties
Chromosome Location 18
Locus 18q21.33
SNPs PHLPP1
Gene Sequence
>5154 bp
ATGGAGCCCGCCGCCGCGGCCACGGTACAGCGACTCCCCGAGCTCGGCAGGGAGGACCGA
GCTTCGGCTCCGGCGGCCGCCGCTGCGGCAGCAGCAGCAGCAGCGGCGGCCGCGGCGGCT
CTGGCGGCGGCGGCCGGGGGCGGCCGGAGTCCGGAGCCCGCGCTGACCCCGGCGGCCCCG
AGCGGCGGGAACGGCAGCGGCAGCGGGGCGCGGGAAGAGGCCCCAGGCGAGGCGCCGCCG
GGGCCGCTGCCGGGCAGAGCGGGGGGTGCCGGGCGCAGGAGGCGGCGCGGGGCGCCCCAG
CCCATTGCCGGCGGGGCTGCCCCCGTACCCGGGGCCGGCGGCGGCGCCAACTCCCTCCTG
CTGAGGAGAGGGCGGCTGAAGAGGAATCTGTCCGCGGCCGCCGCGGCCGCCTCCTCGTCG
TCGTCGTCCTCGGCCGCTGCTGCCTCGCACTCCCCCGGCGCTGCCGGCCTCCCCGCCTCC
TGCTCGGCCTCGGCGTCGCTGTGCACCCGGAGCCTGGACAGGAAGACGCTGCTTCTGAAG
CACCGGCAGACGCTGCAGCTGCAGCCGTCGGACCGGGACTGGGTGAGGCACCAGCTCCAG
CGCGGCTGCGTGCACGTCTTCGACCGCCACATGGCCTCGACCTACCTGCGCCCGGTGCTC
TGCACACTGGACACCACGGCCGGCGAGGTGGCCGCCCGCCTGCTGCAGCTGGGCCACAAA
GGCGGCGGCGTGGTGAAGGTGCTGGGCCAGGGGCCCGGAGCCGCCGCCGCCCGGGAGCCC
GCTGAACCGCCCCCCGAGGCCGGCCCCCGGCTGGCGCCCCCGGAGCCGCGGGACTCGGAG
GTACCGCCCGCGAGGAGCGCGCCGGGTGCCTTCGGGGGGCCTCCGCGCGCGCCCCCCGCC
GACCTACCCCTGCCCGTCGGCGGCCCGGGCGGGTGGTCGCGCCGCGCCAGCCCAGCGCCC
TCGGACTCCAGCCCCGGCGAGCCGTTCGTTGGGGGCCCTGTCTCTTCGCCCCGCGCCCCA
CGGCCTGTGGTCTCCGACACCGAGAGCTTCAGTCTGAGTCCCAGCGCCGAGAGCGTGTCT
GACCGGTTGGACCCCTACAGCAGCGGCGGCGGCTCCTCGTCGTCGTCGGAAGAGCTCGAG
GCCGACGCAGCCTCGGCCCCGACGGGGGTCCCGGGCCAGCCCCGCCGTCCCGGCCACCCC
GCGCAGCCCCTCCCGCTTCCCCAGACGGCTTCCTCGCCTCAGCCGCAGCAGAAAGCCCCG
AGGGCCATTGACAGCCCGGGCGGGGCCGTCCGCGAGGGGTCGTGCGAGGAGAAGGCAGCG
GCAGCCGTGGCCCCGGGAGGCCTCCAGTCTACCCCCGGGAGGAGCGGGGTGACCGCGGAG
AAGGCGCCTCCGCCGCCCCCGCCGCCCACCCTGTACGTGCAGCTCCACGGAGAGACCACC
CGGCGCTTGGAGGCGGAGGAGAAGCCATTGCAGATCCAAAATGACTACCTCTTCCAACTG
GGATTTGGGGAGCTGTGGAGGGTGCAGGAGGAAGGCATGGACTCGGAGATTGGCTGCCTC
ATCCGCTTCTATGCAGGAAAACCTCACAGCACGGGTAGCTCTGAACGGATTCAGCTCTCA
GGAATGTATAATGTCCGTAAAGGCAAGATGCAGTTGCCAGTGAACCGATGGACAAGACGC
CAAGTCATCCTATGTGGGACCTGCCTGATAGTATCATCTGTGAAAGACAGCTTGACCGGA
AAGATGCATGTTCTGCCACTAATTGGTGGAAAAGTAGAAGAAGTGAAAAAGCACCAACAC
TGTTTAGCATTTAGCTCCTCTGGACCCCAAAGCCAGACTTACTACATTTGCTTTGATACT
TTCACAGAATACTTAAGGTGGCTGCGACAAGTCTCCAAGGTTGCATCCCAGCGCATTAGC
TCAGTGGACCTCTCGTGTTGTAGCCTGGAACATCTGCCTGCCAACCTCTTCTACAGCCAA
GACCTCACTCATCTCAATTTAAAACAAAACTTCCTAAGGCAGAACCCTAGCCTTCCAGCT
GCCAGGGGGCTTAATGAACTGCAAAGGTTCACCAAGTTGAAGAGTCTTAACCTTTCCAAT
AATCATTTAGGGGACTTCCCACTGGCAGTCTGCAGTATTCCAACCCTGGCAGAGCTGAAC
GTGTCCTGCAATGCCCTGCGATCAGTCCCGGCAGCCGTTGGAGTGATGCACAACTTACAG
ACATTTTTGTTGGATGGAAACTTTCTCCAATCCCTTCCTGCTGAGTTGGAGAACATGAAG
CAGCTTAGTTATCTGGGTCTTTCTTTCAATGAATTTACTGACATTCCCGAAGTATTGGAG
AAATTGACTGCTGTGGATAAACTTTGTATGTCTGGAAACTGTGTGGAGACCCTTAGGCTA
CAGGCTTTAAGAAAAATGCCTCACATTAAACATGTGGATCTAAGGTTGAACGTAATTAGG
AAGCTGATAGCAGATGAAGTGGACTTTCTACAGCATGTTACTCAGCTTGACCTACGAGAC
AATAAGCTTGGTGATCTAGATGCTATGATTTTCAACAACATTGAAGTTTTACACTGTGAA
AGGAATCAACTGGTCACATTAGACATCTGTGGCTATTTCCTAAAAGCGCTCTATGCCTCT
TCTAATGAACTTGTTCAACTTGATGTTTACCCAGTTCCAAATTATCTGTCCTACATGGAT
GTTTCAAGGAACCGCTTAGAAAATGTGCCTGAGTGGGTATGTGAAAGCCGAAAGCTAGAA
GTTTTGGATATTGGCCATAATCAAATATGTGAACTTCCTGCCCGCTTATTTTGTAATAGC
AGTCTCCGGAAACTACTGGCAGGACACAACCAGTTGGCAAGGCTGCCTGAAAGGCTAGAA
AGAACCTCGGTGGAGGTCTTGGATGTGCAACACAACCAGCTCCTTGAGCTCCCACCTAAC
CTTCTGATGAAGGCTGACAGCCTGAGATTCCTGAACGCCTCTGCGAACAAACTGGAAAGC
CTTCCTCCAGCCACGCTTTCCGAAGAGACAAACAGTATCTTACAAGAGTTGTATTTGACA
AATAACAGCCTCACAGACAAATGTGTGCCCTTGTTAACGGGACACCCCCATTTGAAGATC
CTTCACATGGCCTATAACCGACTTCAGAGTTTTCCAGCAAGTAAAATGGCGAAACTGGAG
GAACTTGAAGAAATTGATCTCAGTGGGAATAAGCTGAAAGCCATCCCAACAACGATCATG
AATTGCAGGCGCATGCACACCGTGATTGCTCACTCCAACTGCATCGAGGTCTTTCCCGAA
GTTATGCAGCTCCCAGAGATCAAGTGTGTGGACCTGAGCTGTAATGAGCTAAGTGAAGTC
ACATTACCAGAAAACCTGCCTCCCAAACTGCAGGAGCTAGACCTGACTGGAAACCCGCGC
CTTGTCCTTGATCACAAAACCCTGGAACTACTGAATAATATCCGCTGTTTCAAGATTGAT
CAGCCTTCTACAGGAGACGCTTCCGGAGCCCCAGCTGTATGGAGTCATGGTTACACTGAA
GCTTCGGGGGTAAAAAACAAGTTGTGTGTCGCAGCCCTGTCGGTGAATAACTTCTGTGAC
AACCGCGAAGCCCTGTATGGTGTGTTTGACGGAGACCGGAATGTGGAGGTGCCCTACCTT
CTCCAGTGCACTATGAGTGACATTTTGGCTGAAGAGCTGCAAAAAACAAAAAACGAAGAA
GAATACATGGTCAATACATTCATTGTCATGCAAAGGAAACTTGGAACTGCTGGGCAGAAG
CTTGGTGGTGCCGCTGTCCTTTGTCATATCAAGCATGACCCTGTGGATCCAGGAGGATCC
TTCACCTTGACCTCTGCTAATGTGGGCAAGTGCCAAACAGTTCTCTGTCGAAATGGAAAG
CCGCTGCCTCTGTCCAGATCTTACATCATGAGCTGTGAAGAAGAGCTGAAGAGGATTAAA
CAGCACAAGGCCATTATCACTGAGGATGGCAAGGTGAACGGAGTGACTGAGTCCACGCGC
ATCCTGGGCTACACCTTCCTCCATCCCAGTGTGGTGCCTCGCCCCCACGTGCAGTCCGTG
CTCCTGACTCCCCAGGATGAGTTCTTCATCCTAGGCAGTAAGGGGTTGTGGGACAGCCTG
TCCGTCGAGGAGGCCGTGGAAGCCGTGCGCAACGTGCCCGATGCCCTGGCTGCTGCCAAG
AAGCTGTGTACCCTGGCCCAGAGCTACGGCTGCCACGACAGCATCAGCGCTGTGGTGGTG
CAGCTCAGTGTCACTGAGGACAGCTTCTGCTGCTGCGAGCTCAGCGCCGGTGGGGCTGTG
CCACCACCCAGTCCTGGCATCTTTCCTCCCTCAGTGAACATGGTGATCAAGGATCGGCCC
TCAGATGGGCTGGGCGTGCCGTCCTCCAGCAGCGGCATGGCTTCCGAGATTAGCAGTGAG
CTCTCCACTTCTGAGATGAGCAGCGAGGTGGGGTCAACAGCCTCCGATGAGCCCCCGCCC
GGAGCCCTAAGCGAGAACAGCCCTGCCTACCCCAGTGAGCAGCGCTGCATGCTCCACCCC
ATCTGTCTGTCCAACTCCTTCCAGCGCCAGCTATCCAGCGCCACGTTCTCTAGCGCCTTC
TCCGACAACGGCCTTGACAGTGACGATGAGGAGCCCATCGAGGGCGTCTTCACCAACGGC
AGCCGGGTGGAGGTGGAGGTGGACATCCACTGCAGCCGGGCCAAGGAGAAGGAGAAACAG
CAGCACCTGCTTCAGGTGCCAGCAGAGGCCAGTGATGAGGGCATTGTCATCAGCGCCAAC
GAGGATGAGCCAGGTCTGCCCAGGAAGGCAGACTTCTCTGCCGTTGGGACCATTGGGCGC
CGGAGGGCCAATGGCTCTGTTGCGCCCCAGGAAAGGAGCCACAATGTGATAGAGGTGGCT
ACAGACGCACCTCTTCGAAAGCCTGGAGGCTATTTTGCTGCCCCGGCTCAGCCGGATCCT
GATGATCAGTTTATCATACCCCCGGAGCTGGAAGAGGAGGTCAAAGAAATCATGAAGCAT
CACCAGGAGCAACAGCAGCAGCAGCAGCCGCCACCACCCCCTCAGCTCCAGCCGCAGCTG
CCGCGGCACTACCAGCTGGACCAGCTGCCAGATTATTACGACACGCCACTATGA
Protein Properties
Number of Residues 1717
Molecular Weight 184670.48
Theoretical pI 6.281
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>PH domain leucine-rich repeat-containing protein phosphatase 1
MEPAAAATVQRLPELGREDRASAPAAAAAAAAAAAAAAAALAAAAGGGRSPEPALTPAAP
SGGNGSGSGAREEAPGEAPPGPLPGRAGGAGRRRRRGAPQPIAGGAAPVPGAGGGANSLL
LRRGRLKRNLSAAAAAASSSSSSSAAAASHSPGAAGLPASCSASASLCTRSLDRKTLLLK
HRQTLQLQPSDRDWVRHQLQRGCVHVFDRHMASTYLRPVLCTLDTTAGEVAARLLQLGHK
GGGVVKVLGQGPGAAAAREPAEPPPEAGPRLAPPEPRDSEVPPARSAPGAFGGPPRAPPA
DLPLPVGGPGGWSRRASPAPSDSSPGEPFVGGPVSSPRAPRPVVSDTESFSLSPSAESVS
DRLDPYSSGGGSSSSSEELEADAASAPTGVPGQPRRPGHPAQPLPLPQTASSPQPQQKAP
RAIDSPGGAVREGSCEEKAAAAVAPGGLQSTPGRSGVTAEKAPPPPPPPTLYVQLHGETT
RRLEAEEKPLQIQNDYLFQLGFGELWRVQEEGMDSEIGCLIRFYAGKPHSTGSSERIQLS
GMYNVRKGKMQLPVNRWTRRQVILCGTCLIVSSVKDSLTGKMHVLPLIGGKVEEVKKHQH
CLAFSSSGPQSQTYYICFDTFTEYLRWLRQVSKVASQRISSVDLSCCSLEHLPANLFYSQ
DLTHLNLKQNFLRQNPSLPAARGLNELQRFTKLKSLNLSNNHLGDFPLAVCSIPTLAELN
VSCNALRSVPAAVGVMHNLQTFLLDGNFLQSLPAELENMKQLSYLGLSFNEFTDIPEVLE
KLTAVDKLCMSGNCVETLRLQALRKMPHIKHVDLRLNVIRKLIADEVDFLQHVTQLDLRD
NKLGDLDAMIFNNIEVLHCERNQLVTLDICGYFLKALYASSNELVQLDVYPVPNYLSYMD
VSRNRLENVPEWVCESRKLEVLDIGHNQICELPARLFCNSSLRKLLAGHNQLARLPERLE
RTSVEVLDVQHNQLLELPPNLLMKADSLRFLNASANKLESLPPATLSEETNSILQELYLT
NNSLTDKCVPLLTGHPHLKILHMAYNRLQSFPASKMAKLEELEEIDLSGNKLKAIPTTIM
NCRRMHTVIAHSNCIEVFPEVMQLPEIKCVDLSCNELSEVTLPENLPPKLQELDLTGNPR
LVLDHKTLELLNNIRCFKIDQPSTGDASGAPAVWSHGYTEASGVKNKLCVAALSVNNFCD
NREALYGVFDGDRNVEVPYLLQCTMSDILAEELQKTKNEEEYMVNTFIVMQRKLGTAGQK
LGGAAVLCHIKHDPVDPGGSFTLTSANVGKCQTVLCRNGKPLPLSRSYIMSCEEELKRIK
QHKAIITEDGKVNGVTESTRILGYTFLHPSVVPRPHVQSVLLTPQDEFFILGSKGLWDSL
SVEEAVEAVRNVPDALAAAKKLCTLAQSYGCHDSISAVVVQLSVTEDSFCCCELSAGGAV
PPPSPGIFPPSVNMVIKDRPSDGLGVPSSSSGMASEISSELSTSEMSSEVGSTASDEPPP
GALSENSPAYPSEQRCMLHPICLSNSFQRQLSSATFSSAFSDNGLDSDDEEPIEGVFTNG
SRVEVEVDIHCSRAKEKEKQQHLLQVPAEASDEGIVISANEDEPGLPRKADFSAVGTIGR
RRANGSVAPQERSHNVIEVATDAPLRKPGGYFAAPAQPDPDDQFIIPPELEEEVKEIMKH
HQEQQQQQQPPPPPQLQPQLPRHYQLDQLPDYYDTPL
GenBank ID Protein 291219891
UniProtKB/Swiss-Prot ID O60346
UniProtKB/Swiss-Prot Entry Name PHLP1_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_194449.2
GeneCard ID PHLPP1
GenAtlas ID PHLPP1
HGNC ID HGNC:20610
References
General References
  1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [PubMed:14702039 ]
  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  3. Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. DNA Res. 2002 Jun 30;9(3):99-106. [PubMed:12168954 ]
  4. Zhang Y, Wolf-Yadlin A, Ross PL, Pappin DJ, Rush J, Lauffenburger DA, White FM: Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules. Mol Cell Proteomics. 2005 Sep;4(9):1240-50. Epub 2005 Jun 11. [PubMed:15951569 ]
  5. Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O: Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. DNA Res. 1998 Feb 28;5(1):31-9. [PubMed:9628581 ]
  6. Nusbaum C, Zody MC, Borowsky ML, Kamal M, Kodira CD, Taylor TD, Whittaker CA, Chang JL, Cuomo CA, Dewar K, FitzGerald MG, Yang X, Abouelleil A, Allen NR, Anderson S, Bloom T, Bugalter B, Butler J, Cook A, DeCaprio D, Engels R, Garber M, Gnirke A, Hafez N, Hall JL, Norman CH, Itoh T, Jaffe DB, Kuroki Y, Lehoczky J, Lui A, Macdonald P, Mauceli E, Mikkelsen TS, Naylor JW, Nicol R, Nguyen C, Noguchi H, O'Leary SB, O'Neill K, Piqani B, Smith CL, Talamas JA, Topham K, Totoki Y, Toyoda A, Wain HM, Young SK, Zeng Q, Zimmer AR, Fujiyama A, Hattori M, Birren BW, Sakaki Y, Lander ES: DNA sequence and analysis of human chromosome 18. Nature. 2005 Sep 22;437(7058):551-5. [PubMed:16177791 ]
  7. Gao T, Brognard J, Newton AC: The phosphatase PHLPP controls the cellular levels of protein kinase C. J Biol Chem. 2008 Mar 7;283(10):6300-11. Epub 2007 Dec 27. [PubMed:18162466 ]
  8. Brognard J, Sierecki E, Gao T, Newton AC: PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms. Mol Cell. 2007 Mar 23;25(6):917-31. [PubMed:17386267 ]
  9. Liu J, Weiss HL, Rychahou P, Jackson LN, Evers BM, Gao T: Loss of PHLPP expression in colon cancer: role in proliferation and tumorigenesis. Oncogene. 2009 Feb 19;28(7):994-1004. doi: 10.1038/onc.2008.450. Epub 2008 Dec 15. [PubMed:19079341 ]
  10. Gao T, Furnari F, Newton AC: PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. Mol Cell. 2005 Apr 1;18(1):13-24. [PubMed:15808505 ]