Hmdb loader
Survey
You are using an unsupported browser. Please upgrade your browser to a newer version to get the best experience on Human Metabolome Database.
Identification
HMDB Protein ID HMDBP08858
Secondary Accession Numbers
  • 14585
Name Probable Xaa-Pro aminopeptidase 3
Synonyms
  1. APP3
  2. Aminopeptidase P3
  3. X-Pro aminopeptidase 3
Gene Name XPNPEP3
Protein Type Unknown
Biological Properties
General Function Involved in cellular process
Specific Function Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide
Pathways Not Available
Reactions Not Available
GO Classification
Function
manganese ion binding
exopeptidase activity
aminopeptidase activity
ion binding
cation binding
metal ion binding
binding
catalytic activity
hydrolase activity
transition metal ion binding
peptidase activity
peptidase activity, acting on l-amino acid peptides
Process
cellular process
Cellular Location
  1. Cytoplasmic
Gene Properties
Chromosome Location Chromosome:2
Locus 22q13.2
SNPs XPNPEP3
Gene Sequence
>1524 bp
ATGCCTTGGCTGCTCTCAGCCCCCAAGCTGGTTCCCGCTGTAGCAAACGTCCGCGGCCTC
TCAGGATGTATGTTGTGTTCACAGCGAAGGTACTCCCTTCAGCCTGTCCCAGAAAGGAGG
ATTCCAAACCGATACTTAGGCCAGCCCAGCCCCTTTACACACCCACACCTCCTCAGACCA
GGGGAGGTAACTCCAGGACTATCTCAGGTGGAATATGCACTTCGCAGACACAAACTAATG
TCTCTGATCCAGAAGGAAGCTCAAGGGCAGAGTGGGACAGACCAGACAGTGGTTGTGCTC
TCCAACCCTACATACTACATGAGCAACGATATTCCCTATACTTTCCACCAAGACAACAAT
TTCCTGTACCTATGTGGATTCCAAGAGCCTGATAGCATTCTTGTCCTTCAGAGCCTCCCT
GGCAAACAATTACCATCACACAAAGCCATACTTTTTGTGCCTCGGCGAGATCCCAGTCGA
GAACTTTGGGATGGTCCGCGATCTGGCACTGATGGAGCAATAGCTCTAACTGGAGTAGAC
GAAGCCTATACGCTAGAAGAATTTCAACATCTTCTACCAAAAATGAAAGCTGAGACGAAC
ATGGTTTGGTATGACTGGATGAGGCCCTCACATGCACAGCTTCACTCTGACTATATGCAG
CCCCTGACTGAGGCCAAAGCCAAGAGCAAGAACAAGGTTCGGGGTGTTCAGCAGCTGATA
CAGCGCCTCCGGCTGATCAAGTCTCCTGCAGAAATTGAACGAATGCAGATTGCTGGGAAG
CTGACATCACAGGCTTTCATAGAAACCATGTTCACCAGTAAAGCCCCTGTGGAAGAAGCC
TTTCTTTATGCTAAGTTTGAATTTGAATGCCGGGCTCGTGGCGCAGACATTTTAGCCTAT
CCACCTGTGGTGGCTGGTGGTAATCGGTCAAACACTTTGCACTATGTGAAAAATAATCAA
CTCATCAAGGATGGGGAAATGGTGCTTCTGGATGGAGGTTGTGAGTCTTCCTGCTATGCG
AGTGACATCACACGTACGTGGCCAGTCAATGGCAGGTTCACCGCACCTCAGGCAGAACTC
TATGAAGCCGTTCTAGAGATCCAAAGAGATTGTTTGGCCCTCTGCTTCCCTGGGACAAGC
TTGGAGAACATCTACAGCATGATGCTGACCCTGATAGGACAGAAGCTTAAAGACTTGGGG
ATCATGAAGAACATTAAGGAAAATAATGCCTTCAAGGCTGCTCGAAAATACTGTCCTCAT
CATGTTGGCCACTACCTCGGGATGGATGTCCATGACACTCCAGACATGCCCCGTTCCCTC
CCTCTGCAGCCTGGGATGGTAATCACAATTGAGCCCGGCATTTATATTCCAGAGGATGAC
AAAGATGCCCCAGAGAAGTTTCGGGGTCTTGGTGTACGAATTGAGGATGATGTAGTGGTG
ACTCAGGACTCACCTCTCATCCTTTCTGCAGACTGTCCCAAAGAGATGAATGACATTGAA
CAGATATGCAGCCAGGCTTCTTAA
Protein Properties
Number of Residues 507
Molecular Weight 57033.1
Theoretical pI 6.83
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Probable Xaa-Pro aminopeptidase 3
MPWLLSAPKLVPAVANVRGLSGCMLCSQRRYSLQPVPERRIPNRYLGQPSPFTHPHLLRP
GEVTPGLSQVEYALRRHKLMSLIQKEAQGQSGTDQTVVVLSNPTYYMSNDIPYTFHQDNN
FLYLCGFQEPDSILVLQSLPGKQLPSHKAILFVPRRDPSRELWDGPRSGTDGAIALTGVD
EAYTLEEFQHLLPKMKAETNMVWYDWMRPSHAQLHSDYMQPLTEAKAKSKNKVRGVQQLI
QRLRLIKSPAEIERMQIAGKLTSQAFIETMFTSKAPVEEAFLYAKFEFECRARGADILAY
PPVVAGGNRSNTLHYVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVNGRFTAPQAEL
YEAVLEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLGIMKNIKENNAFKAARKYCPH
HVGHYLGMDVHDTPDMPRSLPLQPGMVITIEPGIYIPEDDKDAPEKFRGLGVRIEDDVVV
TQDSPLILSADCPKEMNDIEQICSQAS
GenBank ID Protein 48146909
UniProtKB/Swiss-Prot ID Q9NQH7
UniProtKB/Swiss-Prot Entry Name XPP3_HUMAN
PDB IDs Not Available
GenBank Gene ID CR457396
GeneCard ID XPNPEP3
GenAtlas ID XPNPEP3
HGNC ID HGNC:28052
References
General References
  1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [PubMed:14702039 ]
  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  3. Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al.: The DNA sequence of human chromosome 22. Nature. 1999 Dec 2;402(6761):489-95. [PubMed:10591208 ]
  4. Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. [PubMed:17974005 ]
  5. Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, Goward ME, Aguado B, Mallya M, Mokrab Y, Huckle EJ, Beare DM, Dunham I: A genome annotation-driven approach to cloning the human ORFeome. Genome Biol. 2004;5(10):R84. Epub 2004 Sep 30. [PubMed:15461802 ]
  6. Ersahin C, Szpaderska AM, Orawski AT, Simmons WH: Aminopeptidase P isozyme expression in human tissues and peripheral blood mononuclear cell fractions. Arch Biochem Biophys. 2005 Mar 15;435(2):303-10. [PubMed:15708373 ]