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Identification
HMDB Protein ID HMDBP08859
Secondary Accession Numbers
  • 14586
Name Aldehyde dehydrogenase family 8 member A1
Synonyms
  1. Aldehyde dehydrogenase 12
Gene Name ALDH8A1
Protein Type Unknown
Biological Properties
General Function Involved in oxidoreductase activity
Specific Function Converts 9-cis-retinal to 9-cis-retinoic acid. Has lower activity towards 13-cis-retinal. Has much lower activity towards all-trans-retinal. Has highest activity with benzaldehyde and decanal (in vitro). Has a preference for NAD, but shows considerable activity with NADP (in vitro)
Pathways Not Available
Reactions Not Available
GO Classification
Function
catalytic activity
oxidoreductase activity
Process
metabolic process
oxidation reduction
Cellular Location
  1. Cytoplasm
Gene Properties
Chromosome Location Chromosome:6
Locus 6q23.2
SNPs ALDH8A1
Gene Sequence
>1464 bp
ATGGCTGGAACAAACGCACTTTTGATGCTGGAAAACTTCATAGATGGAAAATTTTTACCT
TGTAGCTCATATATAGATTCTTACGACCCATCAACAGGGGAAGTGTATTGCAGAGTGCCA
AATAGTGGAAAAGACGAGATCGAAGCCGCGGTCAAGGCCGCCAGAGAAGCCTTTCCCAGC
TGGTCATCCCGCAGCCCCCAGGAGCGCTCACGGGTCCTGAACCAGGTGGCGGATTTGCTG
GAGCAGTCCCTGGAGGAGTTTGCCCAGGCCGAGTCTAAAGACCAAGGGAAAACCTTAGCA
CTGGCAAGAACCATGGACATTCCCCGGTCTGTGCAGAACTTCAGGTTCTTCGCTTCCTCC
AGCCTGCACCACACGTCAGAGTGCACGCAGATGGACCACCTGGGCTGCATGCACTACACG
GTGCGGGCCCCGGTGGGAGTCGCTGGTCTGATCAGCCCCTGGAATTTGCCACTCTACTTG
CTGACCTGGAAGATAGCTCCAGCGATGGCTGCAGGGAACACTGTGATAGCCAAGCCCAGT
GAGCTGACTTCAGTGACTGCGTGGATGTTGTGCAAACTCCTGGATAAAGCAGGTGTTCCA
CCAGGTGTGGTCAATATTGTGTTTGGAACCGGGCCCAGGGTGGGTGAGGCCCTGGTGTCC
CACCCAGAGGTGCCCCTGATCTCCTTCACCGGGAGCCAGCCCACCGCTGAGCGGATCACC
CAGCTGAGCGCTCCCCACTGCAAAAAGCTCTCCCTGGAGCTGGGGGGCAAGAATCCTGCC
ATCATCTTTGAGGACGCCAACCTGGATGAGTGCATTCCGGCAACCGTCAGGTCCAGCTTT
GCCAACCAGGGTGAAATCTGTCTCTGTACCAGCAGGATCTTTGTCCAGAAGAGCATCTAT
AGTGAATTTTTAAAGAGATTTGTAGAAGCTACCAGAAAGTGGAAAGTCGGCATTCCCTCT
GATCCACTGGTGAGCATAGGTGCTCTGATAAGTAAAGCACATTTGGAGAAAGTCAGAAGT
TACGTCAAGAGAGCTCTTGCTGAAGGTGCCCAAATTTGGTGCGGTGAGGGAGTGGATAAG
TTGAGCCTCCCTGCCAGGAACCAGGCAGGCTACTTTATGCTTCCCACGGTGATAACAGAC
ATTAAGGATGAATCCTGCTGCATGACGGAAGAGATATTTGGTCCAGTGACGTGTGTCGTC
CCCTTTGATAGTGAAGAGGAGGTGATTGAAAGAGCCAACAACGTTAAGTATGGGCTGGCG
GCTACCGTGTGGTCCAGCAATGTGGGGCGCGTCCACCGGGTGGCTAAGAAGCTGCAGTCT
GGCTTGGTCTGGACCAACTGCTGGCTCATCAGGGAGCTGAACCTTCCTTTCGGGGGGATG
AAGAGTTCTGGAATAGGTAGAGAGGGAGCCAAGGACTCTTACGACTTCTTCACTGAGATC
AAAACCATCACCGTTAAACACTGA
Protein Properties
Number of Residues 487
Molecular Weight 53400.9
Theoretical pI 7.16
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Aldehyde dehydrogenase family 8 member A1
MAGTNALLMLENFIDGKFLPCSSYIDSYDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPS
WSSRSPQERSRVLNQVADLLEQSLEEFAQAESKDQGKTLALARTMDIPRSVQNFRFFASS
SLHHTSECTQMDHLGCMHYTVRAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPS
ELTSVTAWMLCKLLDKAGVPPGVVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERIT
QLSAPHCKKLSLELGGKNPAIIFEDANLDECIPATVRSSFANQGEICLCTSRIFVQKSIY
SEFLKRFVEATRKWKVGIPSDPLVSIGALISKAHLEKVRSYVKRALAEGAQIWCGEGVDK
LSLPARNQAGYFMLPTVITDIKDESCCMTEEIFGPVTCVVPFDSEEEVIERANNVKYGLA
ATVWSSNVGRVHRVAKKLQSGLVWTNCWLIRELNLPFGGMKSSGIGREGAKDSYDFFTEI
KTITVKH
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q9H2A2
UniProtKB/Swiss-Prot Entry Name AL8A1_HUMAN
PDB IDs Not Available
GenBank Gene ID AF303134
GeneCard ID ALDH8A1
GenAtlas ID ALDH8A1
HGNC ID HGNC:15471
References
General References
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