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Identification
HMDB Protein ID HMDBP08873
Secondary Accession Numbers
  • 14600
Name Poly [ADP-ribose] polymerase 6
Synonyms
  1. PARP-6
  2. ADP-ribosyltransferase diphtheria toxin-like 17
  3. ARTD17
Gene Name PARP6
Protein Type Unknown
Biological Properties
General Function Involved in NAD+ ADP-ribosyltransferase activity
Specific Function Not Available
Pathways Not Available
Reactions
NAD + (ADP-D-ribosyl)(n)-acceptor → Niacinamide + (ADP-D-ribosyl)(n+1)-acceptor details
GO Classification
Function
catalytic activity
transferase activity
nad+ adp-ribosyltransferase activity
transferase activity, transferring pentosyl groups
transferase activity, transferring glycosyl groups
Molecular Function
NAD+ ADP-ribosyltransferase activity
Cellular Location Not Available
Gene Properties
Chromosome Location 15
Locus 15q23
SNPs PARP6
Gene Sequence
>1893 bp
ATGGACATCAAAGGCCAGTTCTGGAATGATGACGACTCGGAGGGAGATAATGAATCAGAG
GAATTTCTCTATGGCGTTCAGGGGAGCTGTGCAGCTGACCTGTATCGACACCCACAGCTT
GATGCAGACATTGAAGCCGTGAAGGAGATCTACAGTGAGAACTCTGTATCCATCAGAGAA
TATGGAACTATCGATGACGTGGACATTGACCTCCACATCAACATCAGCTTCCTCGATGAG
GAAGTCTCTACAGCCTGGAAGGTCCTCCGGACAGAACCTATTGTGTTGAGGCTGCGATTT
TCTCTCTCCCAGTACCTAGATGGACCAGAACCATCCATTGAGGTTTTCCAGCCATCAAAT
AAGGAAGGATTTGGGCTGGGTCTTCAGTTGAAAAAGATCCTGGGTATGTTTACATCCCAA
CAATGGAAACATCTGAGCAATGATTTCTTGAAGACCCAGCAGGAGAAGAGGCACAGTTGG
TTCAAGGCAAGTGGTACCATCAAGAAGTTCCGAGCTGGCCTCAGCATCTTTTCACCCATC
CCCAAGTCTCCCAGTTTCCCTATCATACAGGACTCCATGCTGAAAGGCAAACTAGGTGTA
CCAGAGCTTCGGGTTGGGCGCCTCATGAACCGTTCCATCTCCTGTACCATGAAGAACCCC
AAAGTGGAAGTGTTTGGCTACCCTCCCAGCCCCCAGGCAGGTCTCCTGTGCCCTCAGCAC
GTGGGCCTCCCTCCCCCAGCACGGACCTCTCCTTTGGTCAGTGGTCACTGCAAGAACATT
CCCACTCTGGAGTATGGATTCCTCGTTCAGATCATGAAGTATGCAGAACAGAGGATTCCA
ACATTGAATGAGTACTGTGTGGTGTGTGATGAGCAGCATGTCTTCCAAAATGGATCTATG
CTGAAGCCAGCTGTCTGTACTCGTGAACTATGCGTTTTCTCCTTCTACACACTGGGCGTC
ATGTCTGGAGCTGCAGAGGAGGTGGCCACTGGAGCAGAGGTGGTGGATCTGCTGGTGGCC
ATGTGTAGGGCAGCTTTAGAGTCCCCTAGAAAGAGCATCATCTTTGAGCCTTATCCCTCT
GTGGTGGACCCCACTGATCCCAAGACTCTGGCCTTTAACCCTAAGAAGAAGAATTATGAG
CGGCTTCAGAAAGCTCTGGATAGTGTGATGTCTATTCGGGAGATGACCCAGGGCTCATAT
TTGGAAATCAAGAAACAGATGGACAAGTTGGATCCCCTGGCCCATCCTCTCCTGCAGTGG
ATCATCTCTAGCAACAGGTCACACATTGTCAAACTACCTCTCAGCAGGCTGAAGTTCATG
CACACCTCACACCAGTTCCTCCTGCTGAGCAGCCCTCCTGCCAAGGAGGCTCGGTTCCGG
ACCGCCAAGAAGCTCTATGGCAGCACCTTTGCCTTCCATGGGTCCCACATTGAGAACTGG
CATTCGATCCTGCGCAATGGGCTGGTCAATGCATCCTACACCAAACTGCAGCTGCATGGA
GCAGCCTATGGCAAAGGCATCTACCTGAGCCCCATCTCCAGTATTTCCTTTGGATACTCA
GGAATGGGAAAAGGACAGCACAGGATGCCCTCCAAGGATGAGCTGGTCCAGAGATACAAC
AGGATGAATACCATCCCCCAGACCCGATCCATTCAGTCACGGTTCCTGCAGAGTCGGAAT
CTAAACTGTATAGCACTTTGTGAAGTGATTACATCTAAGGACCTCCAGAAGCATGGGAAC
ATCTGGGTGTGCCCTGTGTCCGACCATGTCTGCACAAGATTCTTCTTTGTATATGAGGAT
GGTCAGGTGGGCGATGCCAACATTAATACTCAGGACCCCAAGATACAGAAGGAAATCATG
CGTGTGATCGGAACTCAGGTTTACACAAACTGA
Protein Properties
Number of Residues 630
Molecular Weight 71114.175
Theoretical pI 8.332
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Poly [ADP-ribose] polymerase 6
MDIKGQFWNDDDSEGDNESEEFLYGVQGSCAADLYRHPQLDADIEAVKEIYSENSVSIRE
YGTIDDVDIDLHINISFLDEEVSTAWKVLRTEPIVLRLRFSLSQYLDGPEPSIEVFQPSN
KEGFGLGLQLKKILGMFTSQQWKHLSNDFLKTQQEKRHSWFKASGTIKKFRAGLSIFSPI
PKSPSFPIIQDSMLKGKLGVPELRVGRLMNRSISCTMKNPKVEVFGYPPSPQAGLLCPQH
VGLPPPARTSPLVSGHCKNIPTLEYGFLVQIMKYAEQRIPTLNEYCVVCDEQHVFQNGSM
LKPAVCTRELCVFSFYTLGVMSGAAEEVATGAEVVDLLVAMCRAALESPRKSIIFEPYPS
VVDPTDPKTLAFNPKKKNYERLQKALDSVMSIREMTQGSYLEIKKQMDKLDPLAHPLLQW
IISSNRSHIVKLPLSRLKFMHTSHQFLLLSSPPAKEARFRTAKKLYGSTFAFHGSHIENW
HSILRNGLVNASYTKLQLHGAAYGKGIYLSPISSISFGYSGMGKGQHRMPSKDELVQRYN
RMNTIPQTRSIQSRFLQSRNLNCIALCEVITSKDLQKHGNIWVCPVSDHVCTRFFFVYED
GQVGDANINTQDPKIQKEIMRVIGTQVYTN
GenBank ID Protein 94536838
UniProtKB/Swiss-Prot ID Q2NL67
UniProtKB/Swiss-Prot Entry Name PARP6_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_020214.2
GeneCard ID PARP6
GenAtlas ID PARP6
HGNC ID HGNC:26921
References
General References
  1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [PubMed:14702039 ]
  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  3. Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. [PubMed:17974005 ]