Hmdb loader
Identification
HMDB Protein ID HMDBP08876
Secondary Accession Numbers
  • 14603
Name TCDD-inducible poly [ADP-ribose] polymerase
Synonyms
  1. PARP-7
  2. Poly [ADP-ribose] polymerase 7
  3. ADP-ribosyltransferase diphtheria toxin-like 14
  4. ARTD14
Gene Name TIPARP
Protein Type Unknown
Biological Properties
General Function Involved in NAD+ ADP-ribosyltransferase activity
Specific Function Poly [ADP-ribose] polymerase using NAD(+) as a substrate to transfer ADP-ribose onto glutamic acid residues of a protein acceptor; repeated rounds of ADP-ribosylation leads to the formation of poly(ADPribose) chains on the protein, thereby altering the function of the target protein. May play a role in the adaptative response to chemical exposure (TCDD) and thereby mediates certain effects of the chemicals (By similarity).
Pathways Not Available
Reactions
NAD + (ADP-D-ribosyl)(n)-acceptor → Niacinamide + (ADP-D-ribosyl)(n+1)-acceptor details
GO Classification
Biological Process
estrogen metabolic process
face morphogenesis
palate development
protein ADP-ribosylation
hemopoiesis
skeletal system morphogenesis
nitrogen compound metabolic process
female gonad development
multicellular organismal metabolic process
platelet-derived growth factor receptor signaling pathway
smooth muscle tissue development
vasculogenesis
androgen metabolic process
kidney development
post-embryonic development
Function
ion binding
cation binding
metal ion binding
binding
catalytic activity
transition metal ion binding
zinc ion binding
transferase activity
nad+ adp-ribosyltransferase activity
transferase activity, transferring pentosyl groups
nucleic acid binding
transferase activity, transferring glycosyl groups
Molecular Function
nucleic acid binding
metal ion binding
NAD+ ADP-ribosyltransferase activity
zinc ion binding
Cellular Location
  1. Cytoplasmic
Gene Properties
Chromosome Location 3
Locus 3q25.31
SNPs TIPARP
Gene Sequence
>1974 bp
ATGGAAATGGAAACCACCGAACCTGAGCCAGACTGTGTAGTGCAGCCTCCCTCTCCTCCT
GATGACTTTTCATGCCAAATGAGACTCTCTGAGAAGATCACTCCATTGAAGACTTGTTTT
AAGAAAAAGGATCAGAAAAGATTGGGAACTGGAACCCTGAGGTCTTTGAGGCCAATATTA
AACACTCTTCTAGAATCTGGCTCACTTGATGGGGTTTTTAGATCTAGGAACCAGAGTACA
GATGAGAACAGCTTACATGAACCTATGATGAAGAAAGCCATGGAAATCAATTCATCATGC
CCACCAGCAGAAAATAATATGTCTGTTCTGATTCCTGATAGGACAAATGTTGGGGACCAG
ATACCGGAAGCCCATCCTTCCACTGAAGCTCCAGAACGAGTGGTTCCAATCCAAGATCAC
AGCTTTCCATCAGAAACCCTCAGTGGGACGGTGGCAGATTCCACACCAGCTCACTTCCAG
ACTGATCTTTTGCACCCAGTTTCAAGTGATGTTCCTACTAGTCCTGACTGCTTAGACAAA
GTCATAGATTATGTTCCAGGCATTTTCCAAGAAAACAGTTTTACAATCCAATACATTCTG
GACACCAGTGATAAGCTGAGTACTGAGCTCTTTCAGGACAAAAGTGAAGAGGCTTCCCTT
GACCTCGTGTTTGAGCTGGTGAACCAGTTGCAGTACCACACTCACCAAGAGAACGGAATT
GAAATTTGCATGGACTTTCTGCAAGGCACTTGTATTTATGGCAGGGATTGTTTGAAGCAC
CACACTGTCTTGCCATATCATTGGCAGATCAAAAGGACAACTACTCAAAAGTGGCAGAGT
GTATTCAATGATTCTCAGGAGCACTTGGAAAGATTTTACTGTAACCCAGAAAATGATAGA
ATGAGAATGAAGTATGGAGGACAAGAATTTTGGGCAGATTTGAATGCCATGAACGTGTAT
GAAACAACTGAATTTGACCAACTACGAAGGCTGTCCACACCACCCTCTAGCAATGTCAAC
TCTATTTACCACACAGTCTGGAAATTCTTCTGTAGGGACCACTTTGGATGGAGAGAGTAT
CCCGAGTCTGTCATTCGATTGATTGAAGAAGCCAACTCTCGGGGTCTGAAAGAGGTTCGA
TTTATGATGTGGAATAACCACTACATCCTCCACAATTCATTCTTCAGGAGAGAGATAAAA
AGGAGACCCCTCTTCCGCTCCTGTTTTATACTGCTTCCATATTTACAGACACTTGGTGGG
GTTCCCACACAAGCTCCTCCACCTCTTGAAGCAACTTCATCATCACAAATTATCTGCCCA
GATGGGGTCACTTCAGCAAACTTTTACCCTGAAACTTGGGTTTATATGCATCCATCTCAG
GACTTCATCCAAGTCCCTGTTTCTGCAGAGGATAAAAGTTATCGGATCATTTACAATCTT
TTTCATAAGACTGTGCCTGAGTTTAAATACAGAATTTTGCAGATATTGAGAGTCCAAAAC
CAGTTTCTTTGGGAGAAATATAAAAGGAAAAAGGAATATATGAACAGGAAAATGTTTGGC
CGTGACAGGATAATAAATGAGAGACATTTATTTCATGGAACATCCCAGGATGTGGTAGAT
GGAATCTGCAAACACAACTTTGACCCTCGAGTCTGTGGAAAGCATGCTACAATGTTTGGA
CAAGGCAGTTATTTTGCAAAGAAGGCAAGCTACTCTCATAACTTTTCTAAGAAGTCCTCC
AAAGGAGTCCACTTCATGTTTCTGGCCAAAGTGCTGACGGGCAGATACACAATGGGCAGT
CATGGCATGAGAAGGCCCCCGCCAGTCAATCCTGGCAGTGTCACCAGTGACCTTTATGAC
TCTTGTGTGGATAATTTCTTTGAGCCTCAGATTTTTGTCATTTTTAATGATGACCAGAGT
TACCCTTATTTTGTTATCCAATATGAAGAAGTCAGTAACACTGTTTCCATTTGA
Protein Properties
Number of Residues 657
Molecular Weight 76226.74
Theoretical pI 6.658
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>TCDD-inducible poly [ADP-ribose] polymerase
MEMETTEPEPDCVVQPPSPPDDFSCQMRLSEKITPLKTCFKKKDQKRLGTGTLRSLRPIL
NTLLESGSLDGVFRSRNQSTDENSLHEPMMKKAMEINSSCPPAENNMSVLIPDRTNVGDQ
IPEAHPSTEAPERVVPIQDHSFPSETLSGTVADSTPAHFQTDLLHPVSSDVPTSPDCLDK
VIDYVPGIFQENSFTIQYILDTSDKLSTELFQDKSEEASLDLVFELVNQLQYHTHQENGI
EICMDFLQGTCIYGRDCLKHHTVLPYHWQIKRTTTQKWQSVFNDSQEHLERFYCNPENDR
MRMKYGGQEFWADLNAMNVYETTEFDQLRRLSTPPSSNVNSIYHTVWKFFCRDHFGWREY
PESVIRLIEEANSRGLKEVRFMMWNNHYILHNSFFRREIKRRPLFRSCFILLPYLQTLGG
VPTQAPPPLEATSSSQIICPDGVTSANFYPETWVYMHPSQDFIQVPVSAEDKSYRIIYNL
FHKTVPEFKYRILQILRVQNQFLWEKYKRKKEYMNRKMFGRDRIINERHLFHGTSQDVVD
GICKHNFDPRVCGKHATMFGQGSYFAKKASYSHNFSKKSSKGVHFMFLAKVLTGRYTMGS
HGMRRPPPVNPGSVTSDLYDSCVDNFFEPQIFVIFNDDQSYPYFVIQYEEVSNTVSI
GenBank ID Protein 296080688
UniProtKB/Swiss-Prot ID Q7Z3E1
UniProtKB/Swiss-Prot Entry Name PARPT_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_001184717.1
GeneCard ID TIPARP
GenAtlas ID TIPARP
HGNC ID HGNC:23696
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. [PubMed:17974005 ]
  3. Katoh M, Katoh M: Identification and characterization of human TIPARP gene within the CCNL amplicon at human chromosome 3q25.31. Int J Oncol. 2003 Aug;23(2):541-7. [PubMed:12851707 ]