Human Metabolome Database: Showing Protein Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial (HMDBP08887)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 metabolite

Identification
HMDB Protein ID	HMDBP08887
Secondary Accession Numbers	14615
Name	Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial
Synonyms	Protein SITPEC
Gene Name	ECSIT
Protein Type	Enzyme
Biological Properties
General Function	Involved in oxidoreductase activity, acting on NADH or
Specific Function	Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B via MAP3K1. Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development. Required for efficient assembly of mitochondrial NADH:ubiquinone oxidoreductase
Pathways	Not Available
Reactions	Not Available
GO Classification	Not Available
Cellular Location	Nucleus Cytoplasm Mitochondrion
Gene Properties
Chromosome Location	Chromosome:1
Locus	19p13.2
SNPs	ECSIT
Gene Sequence	>1296 bp ATGAGCTGGGTCCAGGCCACCCTACTGGCCCGAGGCCTCTGTAGGGCCTGGGGAGGCACC TGCGGGGCCGCCCTCACAGGAACCTCCATCTCTCAGGTCCCTCGCCGGCTCCCTCGGGGC CTCCACTGCAGCGCAGCTGCCCATAGCTCTGAACAGTCCCTGGTTCCCAGCCCACCGGAA CCCCGGCAGAGGCCCACCAAGGCTCTGGTGCCCTTTGAGGACCTGTTTGGGCAGGCGCCT GGTGGGGAACGGGACAAGGCGAGCTTCCTGCAGACGGTGCAGAAATTTGCGGAGCACAGC GTGCGTAAGCGGGGCCACATTGACTTCATCTACCTGGCCCTGCGCAAGATGCGGGAGTAT GGTGTCGAGCGGGACCTGGCTGTGTACAACCAGCTGCTCAACATCTTCCCCAAGGAGGTC TTCCGGCCTCGCAACATCATCCAGCGCATCTTCGTCCACTACCCTCGGCAGCAGGAGTGT GGGATTGCTGTCCTGGAGCAGATGGAGAACCACGGTGTGATGCCCAACAAGGAGACGGAG TTCCTGCTGATTCAGATCTTTGGACGCAAAAGCTACCCCATGCTCAAGTTGGTGCGCCTG AAGCTGTGGTTCCCTCGATTCATGAACGTCAACCCCTTCCCAGTGCCCCGGGACCTGCCC CAGGACCCTGTGGAGCTGGCCATGTTTGGCCTGCGGCACATGGAGCCTGACCTTAGTGCC AGGGTCACCATCTACCAGGTTCCTTTGCCCAAAGACTCAACAGGTGCAGCAGATCCCCCC CAGCCCCACATCGTAGGAATCCAGAGTCCCGATCAGCAGGCCGCCCTGGCCTGCCACAAT CCAGCCCGGCCTGTCTTTGTTGAGGGCCCCTTCTCCCTGTGGCTCCGCAACAAGTGTGTG TATTACCACATCCTCAGAGCTGACTTGCTGCCCCCGGAGGAGAGGGAAGTGGAAGAGACG CCGGAGGAGTGGAACCTCTACTACCCGATGCAGCTGGACCTGGAGTATGTGAGGAGTGGC TGGGACAACTACGAGTTTGACATCAATGAAGTGGAGGAAGGCCCTGTCTTCGCCATGTGC ATGGCGGGTGCTCATGACCAGGCGACGATGGCTAAGTGGATCCAGGGCCTGCAGGAGACC AACCCAACCCTGGCCCAGATCCCCGTGGTCTTCCGCCTCGCCGGGTCCACCCGGGAGCTC CAGACATCCTCTGCAGGGCTGGAGGAGCCGCCCCTGCCCGAGGACCACCAGGAAGAAGAC GACAACCTGCAGCGACAGCAGCAGGGCCAGAGCTAG
Protein Properties
Number of Residues	431
Molecular Weight	49147.8
Theoretical pI	6.25
Pfam Domain Function	ECSIT (PF06239 )
Signals	None
Transmembrane Regions	None
Protein Sequence	>Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial MSWVQATLLARGLCRAWGGTCGAALTGTSISQVPRRLPRGLHCSAAAHSSEQSLVPSPPE PRQRPTKALVPFEDLFGQAPGGERDKASFLQTVQKFAEHSVRKRGHIDFIYLALRKMREY GVERDLAVYNQLLNIFPKEVFRPRNIIQRIFVHYPRQQECGIAVLEQMENHGVMPNKETE FLLIQIFGRKSYPMLKLVRLKLWFPRFMNVNPFPVPRDLPQDPVELAMFGLRHMEPDLSA RVTIYQVPLPKDSTGAADPPQPHIVGIQSPDQQAALARHNPARPVFVEGPFSLWLRNKCV YYHILRADLLPPEEREVEETPEEWNLYYPMQLDLEYVRSGWDNYEFDINEVEEGPVFAMC MAGAHDQATMAKWIQGLQETNPTLAQIPVVFRLAGSTRELQTSSAGLEEPPLPEDHQEED DNLQRQQQGQS
External Links
GenBank ID Protein	7407498
UniProtKB/Swiss-Prot ID	Q9BQ95
UniProtKB/Swiss-Prot Entry Name	ECSIT_HUMAN
PDB IDs	Not Available
GenBank Gene ID	AF243044
GeneCard ID	ECSIT
GenAtlas ID	ECSIT
HGNC ID	HGNC:29548
References
General References	Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ] Vogel RO, Janssen RJ, van den Brand MA, Dieteren CE, Verkaart S, Koopman WJ, Willems PH, Pluk W, van den Heuvel LP, Smeitink JA, Nijtmans LG: Cytosolic signaling protein Ecsit also localizes to mitochondria where it interacts with chaperone NDUFAF1 and functions in complex I assembly. Genes Dev. 2007 Mar 1;21(5):615-24. [PubMed:17344420 ]