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Identification
HMDB Protein ID HMDBP08912
Secondary Accession Numbers
  • 14641
Name Dual specificity protein phosphatase 5
Synonyms
  1. Dual specificity protein phosphatase hVH3
Gene Name DUSP5
Protein Type Enzyme
Biological Properties
General Function Involved in phosphatase activity
Specific Function Displays phosphatase activity toward several substrates. The highest relative activity is toward ERK1.
Pathways
  • MAPK signaling pathway
Reactions
Protein tyrosine phosphate + Water → protein tyrosine + Phosphate details
A phosphoprotein + Water → a protein + Phosphate details
GO Classification
Biological Process
negative regulation of transcription, DNA-dependent
endoderm formation
Cellular Component
nucleoplasm
Function
phosphoprotein phosphatase activity
protein tyrosine phosphatase activity
hydrolase activity, acting on ester bonds
catalytic activity
hydrolase activity
phosphoric ester hydrolase activity
phosphatase activity
map kinase tyrosine/serine/threonine phosphatase activity
protein tyrosine/serine/threonine phosphatase activity
Molecular Function
MAP kinase tyrosine/serine/threonine phosphatase activity
protein tyrosine phosphatase activity
Process
phosphorus metabolic process
phosphate metabolic process
dephosphorylation
protein amino acid dephosphorylation
metabolic process
cellular metabolic process
Cellular Location
  1. Nucleus (Potential)
Gene Properties
Chromosome Location 10
Locus 10q25
SNPs DUSP5
Gene Sequence
>1155 bp
ATGAAGGTCACGTCGCTCGACGGGCGCCAGCTGCGCAAGATGCTCCGCAAGGAGGCGGCG
GCGCGCTGCGTGGTGCTCGACTGCCGGCCCTATCTGGCCTTCGCTGCCTCGAACGTGCGC
GGCTCGCTCAACGTCAACCTCAACTCGGTGGTGCTGCGGCGGGCCCGGGGCGGCGCGGTG
TCGGCGCGCTACGTGCTGCCCGACGAGGCGGCGCGCGCGCGGCTCCTGCAGGAGGGCGGC
GGCGGCGTCGCGGCCGTGGTGGTGCTGGACCAGGGCAGCCGCCACTGGCAGAAGCTGCGA
GAGGAGAGCGCCGCGCGTGTCGTCCTCACCTCGCTACTCGCTTGCCTACCCGCCGGCCCG
CGGGTCTACTTCCTCAAAGGGGGATATGAGACTTTCTACTCGGAATATCCTGAGTGTTGC
GTGGATGTAAAACCCATTTCACAAGAGAAGATTGAGAGTGAGAGAGCCCTCATCAGCCAG
TGTGGAAAACCAGTGGTAAATGTCAGCTACAGGCCAGCTTATGACCAGGGTGGCCCAGTT
GAAATCCTTCCCTTCCTCTACCTTGGAAGTGCCTACCATGCATCCAAGTGCGAGTTCCTC
GCCAACCTGCACATCACAGCCCTGCTGAATGTCTCCCGACGGACCTCCGAGGCCTGCGCG
ACCCACCTACACTACAAATGGATCCCTGTGGAAGACAGCCACACGGCTGACATTAGCTCC
CACTTTCAAGAAGCAATAGACTTCATTGACTGTGTCAGGGAAAAGGGAGGCAAGGTCCTG
GTCCACTGTGAGGCTGGGATCTCCCGTTCACCCACCATCTGCATGGCTTACCTTATGAAG
ACCAAGCAGTTCCGCCTGAAGGAGGCCTTCGATTACATCAAGCAGAGGAGGAGCATGGTC
TCGCCCAACTTTGGCTTCATGGGCCAGCTCCTGCAGTACGAATCTGAGATCCTGCCCTCC
ACGCCCAACCCCCAGCCTCCCTCCTGCCAAGGGGAGGCAGCAGGCTCTTCACTGATAGGC
CATTTGCAGACACTGAGCCCTGACATGCAGGGTGCCTACTGCACATTCCCTGCCTCGGTG
CTGGCACCGGTGCCTACCCACTCAACAGTCTCAGAGCTCAGCAGAAGCCCTGTGGCAACG
GCCACATCCTGCTAA
Protein Properties
Number of Residues 384
Molecular Weight 42046.885
Theoretical pI 8.346
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Dual specificity protein phosphatase 5
MKVTSLDGRQLRKMLRKEAAARCVVLDCRPYLAFAASNVRGSLNVNLNSVVLRRARGGAV
SARYVLPDEAARARLLQEGGGGVAAVVVLDQGSRHWQKLREESAARVVLTSLLACLPAGP
RVYFLKGGYETFYSEYPECCVDVKPISQEKIESERALISQCGKPVVNVSYRPAYDQGGPV
EILPFLYLGSAYHASKCEFLANLHITALLNVSRRTSEACATHLHYKWIPVEDSHTADISS
HFQEAIDFIDCVREKGGKVLVHCEAGISRSPTICMAYLMKTKQFRLKEAFDYIKQRRSMV
SPNFGFMGQLLQYESEILPSTPNPQPPSCQGEAAGSSLIGHLQTLSPDMQGAYCTFPASV
LAPVPTHSTVSELSRSPVATATSC
GenBank ID Protein 55958676
UniProtKB/Swiss-Prot ID Q16690
UniProtKB/Swiss-Prot Entry Name DUS5_HUMAN
PDB IDs
GenBank Gene ID AL355512
GeneCard ID DUSP5
GenAtlas ID DUSP5
HGNC ID HGNC:3071
References
General References
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  2. Deloukas P, Earthrowl ME, Grafham DV, Rubenfield M, French L, Steward CA, Sims SK, Jones MC, Searle S, Scott C, Howe K, Hunt SE, Andrews TD, Gilbert JG, Swarbreck D, Ashurst JL, Taylor A, Battles J, Bird CP, Ainscough R, Almeida JP, Ashwell RI, Ambrose KD, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Bates K, Beasley H, Bray-Allen S, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Cahill P, Camire D, Carter NP, Chapman JC, Clark SY, Clarke G, Clee CM, Clegg S, Corby N, Coulson A, Dhami P, Dutta I, Dunn M, Faulkner L, Frankish A, Frankland JA, Garner P, Garnett J, Gribble S, Griffiths C, Grocock R, Gustafson E, Hammond S, Harley JL, Hart E, Heath PD, Ho TP, Hopkins B, Horne J, Howden PJ, Huckle E, Hynds C, Johnson C, Johnson D, Kana A, Kay M, Kimberley AM, Kershaw JK, Kokkinaki M, Laird GK, Lawlor S, Lee HM, Leongamornlert DA, Laird G, Lloyd C, Lloyd DM, Loveland J, Lovell J, McLaren S, McLay KE, McMurray A, Mashreghi-Mohammadi M, Matthews L, Milne S, Nickerson T, Nguyen M, Overton-Larty E, Palmer SA, Pearce AV, Peck AI, Pelan S, Phillimore B, Porter K, Rice CM, Rogosin A, Ross MT, Sarafidou T, Sehra HK, Shownkeen R, Skuce CD, Smith M, Standring L, Sycamore N, Tester J, Thorpe A, Torcasso W, Tracey A, Tromans A, Tsolas J, Wall M, Walsh J, Wang H, Weinstock K, West AP, Willey DL, Whitehead SL, Wilming L, Wray PW, Young L, Chen Y, Lovering RC, Moschonas NK, Siebert R, Fechtel K, Bentley D, Durbin R, Hubbard T, Doucette-Stamm L, Beck S, Smith DR, Rogers J: The DNA sequence and comparative analysis of human chromosome 10. Nature. 2004 May 27;429(6990):375-81. [PubMed:15164054 ]
  3. Ishibashi T, Bottaro DP, Michieli P, Kelley CA, Aaronson SA: A novel dual specificity phosphatase induced by serum stimulation and heat shock. J Biol Chem. 1994 Nov 25;269(47):29897-902. [PubMed:7961985 ]
  4. Kwak SP, Dixon JE: Multiple dual specificity protein tyrosine phosphatases are expressed and regulated differentially in liver cell lines. J Biol Chem. 1995 Jan 20;270(3):1156-60. [PubMed:7836374 ]