Hmdb loader
Identification
HMDB Protein ID HMDBP08918
Secondary Accession Numbers
  • 14647
Name Lipid phosphate phosphatase-related protein type 3
Synonyms
  1. PAP-2-like protein 2
  2. PRG-2
  3. Plasticity-related gene 2 protein
Gene Name LPPR3
Protein Type Enzyme
Biological Properties
General Function Involved in catalytic activity
Specific Function Not Available
Pathways Not Available
Reactions
A 1,2-diacylglycerol 3-phosphate + Water → a 1,2-diacyl-sn-glycerol + Phosphate details
GO Classification
Biological Process
metabolic process
Cellular Component
integral to membrane
Component
membrane
cell part
Function
catalytic activity
Molecular Function
phosphatidate phosphatase activity
Cellular Location
  1. Membrane
  2. Multi-pass membrane protein (Potential)
Gene Properties
Chromosome Location 19
Locus 19p13.3
SNPs LPPR3
Gene Sequence
>2157 bp
ATGATCTCCACCAAGGAGAAGAACAAGATCCCGAAGGACAGCATGACGCTTCTGCCCTGC
TTCTACTTCGTGGAGCTGCCCATAGTGGCTTCTTCCATCGTATCCTTGTACTTCCTGGAG
CTGACCGACCTCTTCAAGCCGGCCAAGGTGGGCTTCCAGTGCTATGACCGCACTCTCTCC
ATGCCCTACGTGGAGACCAACGAGGAGCTCATCCCGCTGCTGATGCTGCTCAGCTTGGCC
TTCGCGGCCCCTGCCGCCTCGATCATGGTGGCCGAGGGCATGTTGTACTGTCTGCAGTCC
CGGCTGTGGGGCCGTGCCGGGGGGCCCGCCGGGGCGGAGGGCAGCATCAACGCCGGCGGC
TGCAACTTCAACTCCTTCCTGCGGCGTACGGTGCGGTTTGTGGGTGTCCACGTGTTCGGC
CTGTGTGCCACAGCCCTGGTGACGGACGTGATCCAGCTGGCCACGGGTTACCACACTCCC
TTCTTCCTCACCGTCTGCAAGCCCAACTACACTCTCCTGGGCACGTCCTGCGAGGTCAAC
CCCTACATCACGCAGGACATCTGCTCCGGCCACGACATCCACGCCATCCTGTCTGCACGG
AAGACCTTCCCGTCCCAGCACGCCACGCTGTCAGCCTTCGCCGCGGTCTATGTGTCGATG
TACTTCAACTCGGTCATCTCGGACACCACCAAGCTGCTGAAGCCCATCCTGGTCTTCGCC
TTTGCCATCGCCGCGGGCGTATGCGGGCTCACGCAGATCACGCAGTACCGCAGCCACCCT
GTGGACGTGTATGCCGGCTTCCTCATCGGGGCGGGCATCGCTGCCTACCTGGCCTGCCAC
GCGGTGGGCAACTTCCAGGCCCCACCTGCAGAGAAGCCCGCGGCCCCGGCCCCCGCCAAG
GACGCGCTGCGGGCCCTGACGCAGCGGGGCCACGACTCGGTTTATCAGCAGAATAAGTCG
GTGAGCACCGACGAGCTGGGGCCCCCAGGGCGGCTGGAGGGCGCGCCCCGGCCCGTGGCC
CGCGAGAAGACCTCGCTGGGCAGCCTGAAGCGCGCCAGCGTGGACGTGGACCTGCTGGCC
CCGCGCAGCCCCATGGCCAAGGAGAACATGGTGACCTTCAGCCACACGCTGCCCAGGGCC
AGCGCGCCCTCGCTGGACGACCCCGCGCGCCGCCACATGACCATCCACGTGCCGCTGGAC
GCCTCGCGCTCCAAGCAGCTCATCAGCGAGTGGAAGCAGAAGAGCCTGGAGGGCCGCGGC
CTGGGGCTGCCCGACGACGCCAGCCCCGGGCACCTGCGCGCGCCCGCCGAACCCATGGCG
GAGGAGGAGGAAGAGGAGGAGGACGAAGAGGAAGAGGAGGAGGAGGAAGAGGAGGAGGAC
GAGGGCCCGGCCCCGCCCTCGCTCTACCCCACCGTGCAGGCGCGGCCGGGGCTGGGGCCT
CGGGTCATCCTCCCACCGCGCGCGGGGCCGCCGCCGCTGGTGCACATCCCGGAGGAGGGC
GCGCAGACGGGGGCCGGCCTGTCCCCCAAAAGCGGCGCCGGGGTGCGCGCCAAGTGGCTC
ATGATGGCCGAGAAGAGCGGGGCGGCAGTGGCCAACCCTCCGCGGCTGCTGCAGGTCATC
GCCATGTCCAAGGCTCCGGGCGCGCCGGGCCCCAAGGCGGCCGAGACGGCGTCGTCGTCC
AGCGCCAGCTCCGACTCCTCGCAGTACCGGTCGCCGTCGGACCGCGACTCCGCCAGCATC
GTGACCATCGACGCGCACGCGCCGCACCACCCCGTGGTGCACCTGTCGGCCGGCGGCGCG
CCCTGGGAGTGGAAGGCGGCGGGCGGCGGGGCCAAGGCGGAGGCCGACGGCGGCTACGAG
CTGGGGGACCTGGCGCGCGGCTTCCGCGGCGGGGCCAAGCCCCCGGGCGTGTCCCCCGGC
TCGTCGGTCAGCGACGTGGACCAGGAGGAGCCGCGGTTCGGGGCCGTGGCCACCGTCAAC
CTGGCCACGGGCGAGGGGCTGCCCCCGCTGGGCGCGGCCGATGGGGCGCTGGGCCCGGGC
AGCCGGGAGTCCACGCTGCGGCGCCACGCGGGCGGCCTGGGGCTGGCGGAGCGCGAGGCG
GAGGCGGAGGCCGAGGGCTACTTCCGCAAGATGCAGGCGCGCCGCTTCCCCGACTAG
Protein Properties
Number of Residues 718
Molecular Weight 76036.385
Theoretical pI 5.97
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Lipid phosphate phosphatase-related protein type 3
MISTKEKNKIPKDSMTLLPCFYFVELPIVASSIVSLYFLELTDLFKPAKVGFQCYDRTLS
MPYVETNEELIPLLMLLSLAFAAPAASIMVAEGMLYCLQSRLWGRAGGPAGAEGSINAGG
CNFNSFLRRTVRFVGVHVFGLCATALVTDVIQLATGYHTPFFLTVCKPNYTLLGTSCEVN
PYITQDICSGHDIHAILSARKTFPSQHATLSAFAAVYVSMYFNSVISDTTKLLKPILVFA
FAIAAGVCGLTQITQYRSHPVDVYAGFLIGAGIAAYLACHAVGNFQAPPAEKPAAPAPAK
DALRALTQRGHDSVYQQNKSVSTDELGPPGRLEGAPRPVAREKTSLGSLKRASVDVDLLA
PRSPMAKENMVTFSHTLPRASAPSLDDPARRHMTIHVPLDASRSKQLISEWKQKSLEGRG
LGLPDDASPGHLRAPAEPMAEEEEEEEDEEEEEEEEEEEDEGPAPPSLYPTVQARPGLGP
RVILPPRAGPPPLVHIPEEGAQTGAGLSPKSGAGVRAKWLMMAEKSGAAVANPPRLLQVI
AMSKAPGAPGPKAAETASSSSASSDSSQYRSPSDRDSASIVTIDAHAPHHPVVHLSAGGA
PWEWKAAGGGAKAEADGGYELGDLARGFRGGAKPPGVSPGSSVSDVDQEEPRFGAVATVN
LATGEGLPPLGAADGALGPGSRESTLRRHAGGLGLAEREAEAEAEGYFRKMQARRFPD
GenBank ID Protein 38073393
UniProtKB/Swiss-Prot ID Q6T4P5
UniProtKB/Swiss-Prot Entry Name LPPR3_HUMAN
PDB IDs Not Available
GenBank Gene ID AY436785
GeneCard ID LPPR3
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  3. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A: Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. Genome Res. 2001 Mar;11(3):422-35. [PubMed:11230166 ]
  4. Brauer AU, Savaskan NE, Kuhn H, Prehn S, Ninnemann O, Nitsch R: A new phospholipid phosphatase, PRG-1, is involved in axon growth and regenerative sprouting. Nat Neurosci. 2003 Jun;6(6):572-8. [PubMed:12730698 ]