Hmdb loader
Identification
HMDB Protein ID HMDBP08923
Secondary Accession Numbers
  • 14652
Name Myotubularin-related protein 14
Synonyms
  1. HCV NS5A-transactivated protein 4 splice variant A-binding protein 1
  2. NS5ATP4ABP1
  3. hJumpy
Gene Name MTMR14
Protein Type Enzyme
Biological Properties
General Function Involved in protein tyrosine phosphatase activity
Specific Function Lipid phosphatase which efficiently dephosphorylates phosphatidylinositol 3-phosphate (PtdIns3P) and PtdIns(3,5)P2; inactive toward PtdIns4P, PtdIns(3,4)P2, PtdIns(4,5)P2 and PtdIns(3,4,5)P3
Pathways Not Available
Reactions Not Available
GO Classification
Function
phosphoprotein phosphatase activity
protein tyrosine phosphatase activity
hydrolase activity, acting on ester bonds
catalytic activity
hydrolase activity
phosphoric ester hydrolase activity
phosphatase activity
Process
phosphorus metabolic process
phosphate metabolic process
dephosphorylation
metabolic process
cellular metabolic process
Cellular Location
  1. Cytoplasm
Gene Properties
Chromosome Location Chromosome:3
Locus 3p26
SNPs MTMR14
Gene Sequence
>1953 bp
ATGGCCGGCGCTCGGGCCGCCGCCGCCGCTGCCTCGGCGGGGTCCTCGGCCTCTTCAGGC
AACCAGCCGCCTCAGGAGCTGGGGCTTGGGGAGCTGCTGGAGGAGTTCTCCCGGACTCAG
TACCGGGCCAAGGATGGCAGCGGGACCGGCGGCTCTAAGGTTGAGCGCATTGAGAAGAGA
TGTCTGGAGCTGTTTGGCCGAGACTACTGTTTCAGCGTGATTCCAAACACGAATGGGGAT
ATCTGTGGCCACTATCCCCGGCACATCGTGTTCCTGGAGTATGAGAGTTCTGAGAAGGAG
AAAGACACGTTTGAGAGTACCGTACAGGTGAGCAAGTTGCAAGACCTCATCCACCGCAGC
AAGATGGCCCGGTGCAGAGGACGGTTTGTCTGCCCAGTAATCCTGTTCAAGGGCAAGCAC
ATTTGCAGGTCGGCCACACTGGCTGGATGGGGAGAGCTGTATGGACGCTCAGGCTACAAC
TATTTTTTCTCAGGGGGTGCAGATGATGCCTGGGCAGATGTGGAGGACGTCACGGAGGAG
GACTGTGCTCTTCGAAGTGGTGACACGCATCTTTTTGATAAGGTCAGAGGCTATGACATC
AAGCTGCTTCGATACCTGTCAGTCAAATACATCTGTGACCTGATGGTGGAGAACAAGAAG
GTGAAGTTTGGCATGAATGTAACCTCCTCTGAGAAGGTGGACAAAGCCCAGCGCTATGCC
GACTTCACTCTCCTCTCCATCCCGTATCCAGGCTGTGAATTTTTCAAGGAATATAAAGAT
CGGGATTACATGGCAGAAGGGCTCATATTTAACTGGAAGCAGGACTACGTTGATGCCCCA
TTGAGCATCCCCGACTTCCTGACTCACTCTCTGAACATTGACTGGAGCCAGTATCAGTGT
TGGGATCTGGTGCAACAAACACAAAACTACCTGAAGCTGCTGCTTTCCTTAGTTAACAGT
GATGATGACAGCGGGCTGCTGGTACACTGTATCTCAGGCTGGGATCGGACCCCCCTCTTC
ATCTCCCTCCTGCGCCTTTCCTTGTGGGCTGATGGGCTCATCCACACGTCCCTGAAGCCC
ACTGAGATCCTCTACCTCACTGTGGCCTATGACTGGTTCCTCTTCGGGCACATGTTGGTA
GATCGGCTCAGCAAAGGGGAGGAGATTTTCTTCTTCTGCTTCAATTTTTTGAAGCATATT
ACCTCCGAGGAGTTCTCTGCTCTGAAGACCCAGAGGAGGAAGAGTTTGCCAGCCCGGGAT
GGAGGCTTCACCCTGGAAGACATCTGCATGCTGAGACGAAAGGACCGTGGCAGCACCACC
AGCCTTGGCAGCGACTTCTCCCTGGTCATGGAGAGTTCCCCAGGAGCCACTGGGAGCTTC
ACCTATGAGGCCGTGGAGCTGGTCCCAGCAGGAGCGCCAACTCAGGCAGCTTGGAGGAAG
AGCCACTCATCCTCTCCACAGAGTGTCCTCTGGAACCGGCCACAACCCTCAGAGGACCGC
TTGCCTTCCCAGCAGGGGCTGGCGGAAGCCAGGTCTTCCAGCTCCTCTTCCTCAAACCAT
TCTGATAACTTTTTCAGGATGGGTAGCAGTCCCCTGGAGGTCCCCAAACCCAGATCAGTG
GACCATCCCCTGCCCGGATCCTCTCTCTCCACAGACTATGGCAGCTGGCAGATGGTAACG
GGCTGTGGCAGTATTCAGGAGCGGGCTGTCCTGCACACAGACTCCTCTCTCCCTTTCAGC
TTCCCGGATGAGCTCCCTAACAGTTGTCTGCTTGCAGCCCTGAGTGATCGAGAGACTCGG
CTGCAGGAGGTGCGCTCAGCCTTCTTGGCTGCGTACAGCAGCACAGTGGGGCTTCGGGCA
GTAGCCCCCAGTCCTTCCGGTGCCATCGGGGGCCTGCTGGAGCAATTTGCCCGTGGTGTT
GGACTCCGGAGCATCAGCAGCAATGCCTTGTGA
Protein Properties
Number of Residues 650
Molecular Weight 72202.6
Theoretical pI 6.17
Pfam Domain Function Not Available
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Myotubularin-related protein 14
MAGARAAAAAASAGSSASSGNQPPQELGLGELLEEFSRTQYRAKDGSGTGGSKVERIEKR
CLELFGRDYCFSVIPNTNGDICGHYPRHIVFLEYESSEKEKDTFESTVQVSKLQDLIHRS
KMARCRGRFVCPVILFKGKHICRSATLAGWGELYGRSGYNYFFSGGADDAWADVEDVTEE
DCALRSGDTHLFDKVRGYDIKLLRYLSVKYICDLMVENKKVKFGMNVTSSEKVDKAQRYA
DFTLLSIPYPGCEFFKEYKDRDYMAEGLIFNWKQDYVDAPLSIPDFLTHSLNIDWSQYQC
WDLVQQTQNYLKLLLSLVNSDDDSGLLVHCISGWDRTPLFISLLRLSLWADGLIHTSLKP
TEILYLTVAYDWFLFGHMLVDRLSKGEEIFFFCFNFLKHITSEEFSALKTQRRKSLPARD
GGFTLEDICMLRRKDRGSTTSLGSDFSLVMESSPGATGSFTYEAVELVPAGAPTQAAWRK
SHSSSPQSVLWNRPQPSEDRLPSQQGLAEARSSSSSSSNHSDNFFRMGSSPLEVPKPRSV
DHPLPGSSLSTDYGSWQMVTGCGSIQERAVLHTDSSLPFSFPDELPNSCLLAALSDRETR
LQEVRSAFLAAYSSTVGLRAVAPSPSGAIGGLLEQFARGVGLRSISSNAL
GenBank ID Protein 117938270
UniProtKB/Swiss-Prot ID Q8NCE2
UniProtKB/Swiss-Prot Entry Name MTMRE_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_001077525.2
GeneCard ID MTMR14
GenAtlas ID MTMR14
HGNC ID HGNC:26190
References
General References
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  3. Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M: Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science. 2009 Aug 14;325(5942):834-40. doi: 10.1126/science.1175371. Epub 2009 Jul 16. [PubMed:19608861 ]
  4. Yu LR, Zhu Z, Chan KC, Issaq HJ, Dimitrov DS, Veenstra TD: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra. J Proteome Res. 2007 Nov;6(11):4150-62. Epub 2007 Oct 9. [PubMed:17924679 ]
  5. Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. [PubMed:17974005 ]
  6. Cantin GT, Yi W, Lu B, Park SK, Xu T, Lee JD, Yates JR 3rd: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. J Proteome Res. 2008 Mar;7(3):1346-51. doi: 10.1021/pr0705441. Epub 2008 Jan 26. [PubMed:18220336 ]
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