| Identification |
|---|
| HMDB Protein ID
| HMDBP08947 |
| Secondary Accession Numbers
| |
| Name
| Receptor-type tyrosine-protein phosphatase mu |
| Synonyms
|
- Protein-tyrosine phosphatase mu
- R-PTP-mu
|
| Gene Name
| PTPRM |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in phosphatase activity |
| Specific Function
| Involved in cell-cell adhesion through homophilic interactions. May play a key role in signal transduction and growth control.
|
| Pathways
|
- Adherens junction
- Cell adhesion molecules
|
| Reactions
|
| Protein tyrosine phosphate + Water → protein tyrosine + Phosphate |
details
|
|
| GO Classification
|
| Biological Process |
| positive regulation of vasodilation |
| response to drug |
| homophilic cell adhesion |
| negative regulation of endothelial cell migration |
| negative regulation of endothelial cell proliferation |
| retina layer formation |
| retinal ganglion cell axon guidance |
| negative regulation of angiogenesis |
| Cellular Component |
| perinuclear region of cytoplasm |
| lamellipodium |
| cell-cell adherens junction |
| integral to plasma membrane |
| Component |
| membrane |
| cell part |
| Function |
| phosphoprotein phosphatase activity |
| protein tyrosine phosphatase activity |
| hydrolase activity, acting on ester bonds |
| catalytic activity |
| hydrolase activity |
| phosphoric ester hydrolase activity |
| phosphatase activity |
| Molecular Function |
| transmembrane receptor protein tyrosine phosphatase activity |
| cadherin binding |
| Process |
| phosphorus metabolic process |
| phosphate metabolic process |
| dephosphorylation |
| protein amino acid dephosphorylation |
| metabolic process |
| cellular metabolic process |
|
| Cellular Location
|
- Membrane
- Single-pass type I membrane protein
|
| Gene Properties |
|---|
| Chromosome Location
| 18 |
| Locus
| 18p11.2 |
| SNPs
| PTPRM |
| Gene Sequence
|
>4359 bp
ATGAGGACACTTGGGACTTGCCTGGCGACTTTGGCCGGACTTTTGCTAACTGCGGCGGGC
GAGACGTTCTCAGGTGGCTGCCTCTTTGATGAGCCGTATAGCACATGTGGATATAGTCAA
TCTGAAGGTGATGACTTCAATTGGGAGCAAGTGAACACCTTGACTAAACCGACTTCTGAT
CCATGGATGCCATCAGGTTCTCTCATGCTGGTGAATGCCTCTGGGAGACCTGAGGGGCAG
AGAGCCCACCTGCTCTTACCCCAACTTAAGGAAAATGACACCCACTGCATCGATTTTCAC
TATTTTGTGTCCAGCAAGAGTAATTCTCCTCCGGGGTTACTCAATGTCTACGTGAAGGTC
AATAACGGGCCACTGGGGAATCCTATCTGGAATATATCTGGAGACCCAACACGTACATGG
AACAGGGCAGAACTGGCCATTAGTACTTTCTGGCCTAACTTTTATCAGGTGATTTTTGAA
GTGATAACTTCTGGACATCAAGGCTATCTCGCTATCGATGAGGTGAAGGTGTTAGGACAT
CCATGTACCAGGACTCCTCACTTCCTGCGGATTCAGAATGTGGAAGTTAATGCTGGCCAG
TTTGCTACCTTCCAGTGCAGTGCCATCGGCAGGACCGTGGCAGGAGACAGGCTCTGGTTA
CAGGGCATTGATGTGCGAGATGCTCCTCTGAAGGAAATCAAGGTGACCAGCTCCCGACGC
TTCATTGCTTCATTTAATGTTGTGAATACCACCAAACGAGATGCTGGAAAGTACCGCTGC
ATGATTCGCACTGAAGGAGGTGTTGGAATATCAAACTATGCAGAGTTGGTAGTTAAAGAA
CCACCCGTTCCTATTGCCCCACCTCAGCTCGCCTCTGTAGGAGCCACCTACCTGTGGATA
CAGCTCAACGCCAACTCCATCAATGGGGATGGGCCCATTGTGGCCCGAGAGGTGGAGTAC
TGCACGGCCAGTGGGAGCTGGAATGACCGGCAGCCAGTCGATTCCACGAGCTATAAAATT
GGACACCTTGACCCAGATACAGAATATGAGATTAGTGTGCTCCTGACCAGGCCAGGGGAG
GGTGGCACTGGCTCTCCTGGTCCAGCTCTCAGGACAAGAACAAAGTGTGCTGATCCCATG
CGAGGCCCAAGAAAACTAGAAGTAGTGGAGGTCAAATCTCGGCAAATCACTATCCGCTGG
GAGCCATTTGGATATAATGTAACTCGTTGCCACAGTTATAATCTCACTGTCCACTACTGT
TACCAAGTTGGAGGACAAGAACAAGTGCGAGAAGAAGTAAGCTGGGATACAGAAAATTCA
CACCCTCAACACACGATCACTAACCTGTCACCATACACCAATGTCAGTGTGAAACTGATC
CTCATGAACCCAGAGGGCCGGAAGGAAAGCCAAGAACTCATAGTGCAGACAGATGAAGAC
CTCCCAGGTGCTGTTCCCACTGAATCCATACAAGGAAGTACCTTTGAAGAGAAGATATTT
CTTCAGTGGAGAGAACCAACTCAAACATATGGTGTAATCACTTTATATGAGATCACCTAC
AAAGCAGTCAGTTCCTTTGACCCAGAAATAGATTTATCCAATCAGAGTGGAAGAGTTTCA
AAGCTGGGAAATGAAACCCATTTTCTGTTTTTTGGACTGTATCCGGGGACCACATACTCC
TTTACCATCCGAGCTAGCACAGCTAAGGGTTTTGGGCCTCCAGCAACAAACCAGTTCACC
ACCAAAATATCAGCACCCTCTATGCCAGCTTATGAACTTGAGACACCTTTGAATCAAACT
GACAATACCGTGACAGTCATGCTGAAACCTGCCCACAGCAGAGGAGCACCTGTCAGTGTC
TATCAAATAGTTGTTGAGGAAGAACGTCCTCGAAGAACTAAAAAGACGACAGAAATCTTA
AAGTGCTACCCAGTGCCAATTCACTTCCAGAATGCTTCTCTGCTGAACTCACAGTACTAC
TTTGCTGCAGAATTTCCTGCAGACAGCCTCCAAGCTGCGCAGCCTTTTACAATTGGTGAT
AATAAGACATATAATGGATACTGGAACACTCCCCTTCTCCCCTATAAAAGCTACAGAATT
TATTTCCAAGCTGCTAGTAGAGCCAATGGGGAAACCAAAATAGACTGTGTCCAAGTGGCC
ACAAAAGGAGCTGCCACTCCGAAACCAGTCCCAGAACCCGAGAAACAGACAGACCATACA
GTTAAAATTGCTGGAGTCATCGCGGGCATCTTGCTGTTCGTGATTATATTTCTTGGAGTT
GTGTTGGTAATGAAGAAAAGGAAACTGGCCAAGAAGCGGAAAGAGACCATGAGCAGCACC
CGACAGGAGATGACTGTGATGGTGAACTCAATGGACAAGAGCTATGCTGAGCAGGGCACA
AACTGCGACGAGGCTTTCTCATTCATGGACACGCACAATCTGAATGGGAGATCTGTGTCT
TCACCATCGTCCTTCACAATGAAAACAAATACACTGAGCACATCGGTGCCTAATTCCTAT
TACCCAGATGAAACCCACACAATGGCCAGCGATACCAGCAGCCTGGTGCAGTCCCATACT
TACAAGAAGCGAGAGCCGGCCGACGTGCCCTATCAGACTGGGCAGCTCCACCCCGCCATC
CGGGTGGCAGACCTCCTTCAGCACATCACACAGATGAAGTGTGCGGAGGGCTACGGCTTC
AAGGAGGAATACGAGAGCTTCTTTGAAGGGCAGTCTGCACCATGGGACTCGGCTAAGAAA
GATGAGAACAGAATGAAGAACAGATACGGGAATATCATTGCATACGATCATTCCCGAGTG
AGGCTGCAGACAATAGAAGGAGACACAAACTCAGACTATATCAATGGCAATTATATCGAT
GGTTATCATCGACCCAATCATTACATTGCTACCCAAGGGCCAATGCAGGAAACCATCTAT
GACTTCTGGAGGATGGTGTGGCACGAAAACACTGCAAGTATCATCATGGTGACCAATCTT
GTGGAAGTGGGAAGGGTCAAATGCTGCAAATACTGGCCAGATGACACAGAGATATATAAA
GACATTAAAGTTACCCTAATAGAAACAGAACTACTGGCAGAATATGTGATAAGAACATTT
GCTGTTGAAAAGAGAGGTGTGCATGAAATCCGAGAGATCAGACAGTTTCACTTCACTGGC
TGGCCGGATCATGGGGTCCCCTACCATGCCACCGGCCTGCTGGGATTCGTGCGGCAAGTC
AAGTCCAAGAGCCCGCCCAGTGCAGGCCCACTGGTGGTGCACTGCAGTGCTGGTGCAGGG
AGGACTGGCTGTTTCATCGTCATTGATATCATGTTGGACATGGCCGAAAGGGAAGGGGTC
GTAGACATCTACAACTGCGTCAGGGAGCTGCGGTCACGGAGGGTGAACATGGTGCAAACA
GAGGAGCAGTATGTGTTTATCCACGATGCGATCCTGGAAGCCTGTCTTTGTGGGGACACC
TCTGTGCCTGCTTCCCAAGTTAGGTCTCTGTATTATGACATGAACAAACTGGATCCACAG
ACAAACTCAAGCCAGATTAAAGAGGAATTCCGGACGCTAAACATGGTGACACCAACGCTG
CGAGTAGAGGACTGCAGCATCGCACTGTTGCCCCGGAACCATGAGAAAAACCGGTGCATG
GACATCCTGCCCCCAGACCGCTGCCTGCCCTTCCTCATCACCATCGATGGGGAGAGCAGC
AACTACATCAATGCTGCCCTCATGGACAGCTATAAACAGCCTTCAGCTTTTATAGTCACC
CAGCATCCTTTGCCAAACACAGTGAAAGACTTTTGGAGACTGGTCCTGGATTATCACTGC
ACATCCGTAGTTATGCTAAATGATGTGGATCCTGCCCAGTTGTGTCCACAGTACTGGCCA
GAAAACGGAGTACACAGACACGGCCCCATCCAGGTGGAATTTGTCTCTGCTGACCTGGAA
GAGGACATCATCAGCAGGATATTCCGCATTTACAATGCCGCCAGACCCCAAGATGGATAT
CGGATGGTGCAGCAATTCCAGTTCCTGGGCTGGCCGATGTACAGGGACACACCAGTGTCT
AAGCGCTCCTTCTTGAAGCTCATTCGCCAGGTGGACAAGTGGCAAGAGGAATACAATGGC
GGGGAAGGCCCGACCGTTGTGCACTGCTTGAACGGGGGAGGCCGCAGTGGGACGTTCTGC
GCCATCAGCATCGTATGTGAGATGCTCCGGCACCAGAGAACCGTGGATGTCTTTCACGCT
GTGAAGACACTGAGGAACAACAAGCCCAACATGGTCGACCTCCTGGATCAGTACAAGTTC
TGCTACGAGGTGGCCCTGGAATACTTGAATTCTGGCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 1452 |
| Molecular Weight
| 165058.91 |
| Theoretical pI
| 6.615 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Receptor-type tyrosine-protein phosphatase mu
MRGLGTCLATLAGLLLTAAGETFSGGCLFDEPYSTCGYSQSEGDDFNWEQVNTLTKPTSD
PWMPSGSFMLVNASGRPEGQRAHLLLPQLKENDTHCIDFHYFVSSKSNSPPGLLNVYVKV
NNGPLGNPIWNISGDPTRTWNRAELAISTFWPNFYQVIFEVITSGHQGYLAIDEVKVLGH
PCTRTPHFLRIQNVEVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRR
FIASFNVVNTTKRDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWI
QLNANSINGDGPIVAREVEYCTASGSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGE
GGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYC
YQVGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDED
LPGAVPTESIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVS
KLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPSMPAYELETPLNQT
DNTVTVMLKPAHSRGAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNSQYY
FAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQVA
TKGAATPKPVPEPEKQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKRKLAKKRKETMSST
RQEMTVMVNSMDKSYAEQGTNCDEAFSFMDTHNLNGRSVSSPSSFTMKTNTLSTSVPNSY
YPDETHTMASDTSSLVQSHTYKKREPADVPYQTGQLHPAIRVADLLQHITQMKCAEGYGF
KEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYID
GYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEIYK
DIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQV
KSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQT
EEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTLNMVTPTL
RVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGESSNYINAALMDSYKQPSAFIVT
QHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQLCPQYWPENGVHRHGPIQVEFVSADLE
EDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNG
GEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKF
CYEVALEYLNSG
|
| External Links |
|---|
| GenBank ID Protein
| 32456 |
| UniProtKB/Swiss-Prot ID
| P28827 |
| UniProtKB/Swiss-Prot Entry Name
| PTPRM_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| X58288 |
| GeneCard ID
| PTPRM |
| GenAtlas ID
| PTPRM |
| HGNC ID
| HGNC:9675 |
| References |
|---|
| General References
| - Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. [PubMed:18669648 ]
- Liu T, Qian WJ, Gritsenko MA, Camp DG 2nd, Monroe ME, Moore RJ, Smith RD: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. J Proteome Res. 2005 Nov-Dec;4(6):2070-80. [PubMed:16335952 ]
- Nusbaum C, Zody MC, Borowsky ML, Kamal M, Kodira CD, Taylor TD, Whittaker CA, Chang JL, Cuomo CA, Dewar K, FitzGerald MG, Yang X, Abouelleil A, Allen NR, Anderson S, Bloom T, Bugalter B, Butler J, Cook A, DeCaprio D, Engels R, Garber M, Gnirke A, Hafez N, Hall JL, Norman CH, Itoh T, Jaffe DB, Kuroki Y, Lehoczky J, Lui A, Macdonald P, Mauceli E, Mikkelsen TS, Naylor JW, Nicol R, Nguyen C, Noguchi H, O'Leary SB, O'Neill K, Piqani B, Smith CL, Talamas JA, Topham K, Totoki Y, Toyoda A, Wain HM, Young SK, Zeng Q, Zimmer AR, Fujiyama A, Hattori M, Birren BW, Sakaki Y, Lander ES: DNA sequence and analysis of human chromosome 18. Nature. 2005 Sep 22;437(7058):551-5. [PubMed:16177791 ]
- Gebbink MF, van Etten I, Hateboer G, Suijkerbuijk R, Beijersbergen RL, Geurts van Kessel A, Moolenaar WH: Cloning, expression and chromosomal localization of a new putative receptor-like protein tyrosine phosphatase. FEBS Lett. 1991 Sep 23;290(1-2):123-30. [PubMed:1655529 ]
- Hoffmann KM, Tonks NK, Barford D: The crystal structure of domain 1 of receptor protein-tyrosine phosphatase mu. J Biol Chem. 1997 Oct 31;272(44):27505-8. [PubMed:9346878 ]
- Aricescu AR, Hon WC, Siebold C, Lu W, van der Merwe PA, Jones EY: Molecular analysis of receptor protein tyrosine phosphatase mu-mediated cell adhesion. EMBO J. 2006 Feb 22;25(4):701-12. Epub 2006 Feb 2. [PubMed:16456543 ]
|
