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Identification
HMDB Protein ID HMDBP08962
Secondary Accession Numbers
  • 14696
Name Pyruvate kinase
Synonyms Not Available
Gene Name Not Available
Protein Type Unknown
Biological Properties
General Function Involved in magnesium ion binding
Specific Function ATP + pyruvate = ADP + phosphoenolpyruvate
Pathways Not Available
Reactions Not Available
GO Classification
Function
ion binding
cation binding
metal ion binding
binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
magnesium ion binding
alkali metal ion binding
potassium ion binding
pyruvate kinase activity
Process
metabolic process
small molecule metabolic process
alcohol metabolic process
monosaccharide metabolic process
hexose metabolic process
glucose metabolic process
glucose catabolic process
glycolysis
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence
>1701 bp
ATGCCTCTGACAACCCAACAGTGTGGAGCAGACCCACAGAGAGGGAGACCCAGAGAGGTG
TGCAGTGGCATGGAAGGGCCAGCGGGGTATCTGCGGCGGGCCAGTGTGGCCCAACTGACC
CAGGAGCTGGGCACTGCCTTCTTCCAGCAGCAGCAGCTGCCAGCTGCTATGGCAGACACC
TTCCTGGAACACCTCTGCCTACTGGACATTGACTCCGAGCCCGTGGCTGCTCGCAGTACC
AGCATCATTGCCACCATCGGGCCAGCATCTCGCTCCGTGGAGCGCCTCAAGGAGATGATC
AAGGCCGGGATGAACATTGCGCGACTCAACTTCTCCCACGGCTCCCACGAGTACCATGCT
GAGTCCATCGCCAACGTCCGGGAGGCGGTGGAGAGCTTTGCAGGTTCCCCACTCAGCTAC
CGGCCCGTGGCCATCGCCCTGGACACCAAGGGACCGGAGATCCGCACTGGGATCCTGCAG
GGGGGTCCAGAGTCGGAAGTGGAGCTGGTGAAGGGCTCCCAGGTGCTGGTGACTGTGGAC
CCCGCGTTCCGGACGCGGGGGAACGCGAACACCGTGTGGGTGGACTACCCCAATATTGTC
CGGGTCGTGCCGGTGGGGGGCCGCATCTACATTGACGACGGGCTCATCTCCCTAGTGGTC
CAGAAAATCGGCCCAGAGGGACTGGTGACCCAAGTGGAGAACGGCGGCGTCCTGGGCAGC
CGGAAGGGCGTGAACTTGCCAGGGGCCCAGGTGGACTTGCCCGGGCTGTCCGAGCAGGAC
GTCCGAGACCTGCGCTTCGGGGTGGAGCATGGGGTGGACATCGTCTTTGCCTCCTTTGTG
CGGAAAGCCAGCGACGTGGCTGCCGTCAGGGCTGCTCTGGGTCCGGAAGGACACGGCATC
AAGATCATCAGCAAAATTGAGAACCACGAAGGCGTGAAGAGGTTTGATGAAATCCTGGAG
GTGAGCGACGGCATCATGGTGGCACGGGGGGACCTAGGCATCGAGATCCCAGCAGAGAAG
GTTTTCCTGGCTCAGAAGATGATGATTGGGCGCTGCAACTTGGCGGGCAAGCCTGTTGTC
TGTGCCACACAGATGCTGGAGAGCATGATTACCAAGCCCCGGCCAACGAGGGCAGAGACA
AGCGATGTCGCCAATGCTGTGCTGGATGGGGCTGACTGCATCATGCTGTCAGGGGAGACT
GCCAAGGGCAACTTCCCTGTGGAAGCGGTGAAGATGCAGCATGCGATTGCCCGGGAGGCA
GAGGCCGCAGTGTACCACCGGCAGCTGTTTGAGGAGCTACGTCGGGCAGCGCCACTAAGC
CGTGATCCCACTGAGGTCACCGCCATTGGTGCTGTGGAGGCTGCCTTCAAGTGCTGTGCT
GCTGCCATCATTGTGCTGACCACAACTGGCCGCTCAGCCCAGCTTCTGTCTCGGTACCGA
CCTCGGGCAGCAGTCATTGCTGTCACCCGCTCTGCCCAGGCTGCCCGCCAGGTCCACTTA
TGCCGAGGAGTCTTCCCCTTGCTTTACCGTGAACCTCCAGAAGCCATCTGGGCAGATGAT
GTAGATCGCCGGGTGCAATTTGGCATTGAAAGTGGAAAGCTCCGTGGCTTCCTCCGTGTT
GGAGACCTGGTGATTGTGGTGACAGGCTGGCGACCTGGCTCCGGCTACACCAACATCATG
CGGGTGCTAAGCATATCCTGA
Protein Properties
Number of Residues 566
Molecular Weight 60963.6
Theoretical pI 7.25
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Pyruvate kinase
MPLTTQQCGADPQRGRPREVCSGMEGPAGYLRRASVAQLTQELGTAFFQQQQLPAAMADT
FLEHLCLLDIDSEPVAARSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHA
ESIANVREAVESFAGSPLSYRPVAIALDTKGPEIRTGILQGGPESEVELVKGSQVLVTVD
PAFRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENGGVLGS
RKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGPEGHGI
KIISKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVV
CATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGNFPVEAVKMQHAIAREA
EAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYR
PRAAVIAVTRSAQAARQVHLCRGVFPLLYREPPEAIWADDVDRRVQFGIESGKLRGFLRV
GDLVIVVTGWRPGSGYTNIMRVLSIS
GenBank ID Protein 1230590
UniProtKB/Swiss-Prot ID Q16716
UniProtKB/Swiss-Prot Entry Name Q16716_HUMAN
PDB IDs
GenBank Gene ID U47654
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID HGNC:9020
References
General References
  1. Lenzner C, Nurnberg P, Jacobasch G, Thiele BJ: Complete genomic sequence of the human PK-L/R-gene includes four intragenic polymorphisms defining different haplotype backgrounds of normal and mutant PK-genes. DNA Seq. 1997;8(1-2):45-53. [PubMed:9522120 ]