Hmdb loader
Survey
Identification
HMDB Protein ID HMDBP09018
Secondary Accession Numbers
  • 14760
Name 7SK snRNA methylphosphate capping enzyme
Synonyms
  1. Bicoid-interacting protein 3 homolog
  2. Bin3 homolog
  3. MePCE
Gene Name MEPCE
Protein Type Unknown
Biological Properties
General Function Involved in methyltransferase activity
Specific Function S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA, leading to stabilize it
Pathways Not Available
Reactions Not Available
GO Classification
Function
catalytic activity
transferase activity
transferase activity, transferring one-carbon groups
methyltransferase activity
Cellular Location Not Available
Gene Properties
Chromosome Location Chromosome:7
Locus 7q22.1
SNPs MEPCE
Gene Sequence
>2070 bp
ATGATCGAGATGGCGGCGGAGAAGGAGCCGTTTCTGGTGCCGGCCCCGCCGCCGCCGCTC
AAAGATGAGTCGGGCGGAGGGGGCGGCCCCACGGTGCCACCGCACCAAGAGGCCGCCTCT
GGGGAGCTCCGCGGCGGGACGGAGCGTGGTCCGGGTCGTTGCGCGCCATCTGCGGGGTCC
CCAGCCGCTGCGGTCGGTCGGGAAAGCCCCGGGGCCGCGGCCACCTCCTCCAGTGGTCCC
CAGGCGCAGCAGCACCGAGGGGGCGGCCCCCAGGCGCAGTCGCATGGGGAGGCCCGCCTG
TCGGATCCCCCGGGGCGAGCCGCTCCCCCGGACGTGGGGGAGGAGCGCCGGGGAGGGGGC
GGGACAGAGCTGGGTCCCCCTGCTCCTCCTCGACCCCGCAATGGCTATCAGCCCCACCGG
CCACCTGGGGGGGGCGGGGGCAAGAGGAGAAATAGCTGTAATGTAGGGGGAGGCGGGGGA
GGCTTCAAACATCCGGCCTTCAAGAGGCGCAGGCGGGTGAATTCGGACTGTGACTCTGTG
TTACCCTCCAACTTCCTCCTGGGGGGCAATATCTTTGATCCCCTGAACCTGAATAGCCTC
CTGGATGAGGAAGTGAGCCGCACTCTCAACGCGGAGACCCCTAAGTCATCCCCCCTTCCG
GCCAAAGGGCGAGATCCGGTGGAGATCCTCATCCCCAAAGATATTACTGACCCGCTCAGT
CTCAATACTTGCACTGATGAGGGCCATGTAGTTCTTGCTTCGCCACTCAAGACTGGTCGG
AAGCGGCATAGACACCGGGGACAGCACCACCAGCAGCAGCAGGCAGCCGGAGGGAGTGAG
AGTCACCCCGTGCCGCCCACAGCCCCTCTCACCCCCTTACTCCACGGGGAGGGCGCCTCA
CAGCAGCCGCGGCACAGGGGCCAGAACCGGGATGCCCCCCAACCCTATGAACTCAACACA
GCCATCAACTGCAGGGATGAAGTGGTGTCTCCCCTTCCATCTGCTCTGCAGGGTCCCTCA
GGCTCCCTATCAGCCCCTCCAGCTGCCTCAGTTATCTCTGCACCCCCATCTTCCTCCTCC
CGACATCGCAAACGTCGCAGGACTTCCAGCAAGTCGGAGGCAGGGGCTAGGGGTGGAGGC
CAGGGTTCCAAGGAAAAGGGCCGAGGGAGTTGGGGAGGCCGCCACCACCACCACCACCCA
CTGCCTGCAGCAGGCTTCAAAAAGCAACAGCGCAAGTTCCAGTATGGGAATTATTGCAAA
TACTATGGGTACCGCAATCCTTCCTGTGAGGATGGGCGCCTTCGGGTGTTGAAGCCTGAG
TGGTTTCGGGGCCGGGACGTCCTAGATCTGGGCTGCAATGTGGGCCATCTGACCCTGAGC
ATTGCCTGCAAGTGGGGCCCGTCCCGCATGGTGGGCCTGGATATCGATTCCCGGCTCATC
CATTCTGCCCGCCAAAACATCCGACACTACCTTTCCGAGGAGCTGCGTCTCCCACCCCAG
ACTTTGGAAGGGGACCCGGGGGCAGAGGGTGAGGAAGGGACCACCACCGTTCGAAAGAGG
AGCTGCTTCCCAGCCTCGCTGACTGCCAGCCGGGGTCCCATCGCTGCCCCCCAAGTGCCC
TTGGATGGAGCGGACACATCAGTCTTCCCCAACAATGTTGTCTTCGTCACGGGTAATTAT
GTGCTGGATCGAGATGACCTGGTGGAGGCCCAAACACCTGAGTATGATGTGGTGCTCTGC
CTCAGCCTCACCAAGTGGGTGCATCTGAACTGGGGAGACGAGGGCCTGAAGCGCATGTTT
CGCCGGATCTACCGGCACCTACGCCCTGGGGGCATCCTGGTCCTAGAGCCCCAACCCTGG
TCGTCGTATGGCAAGAGAAAGACTCTTACAGAAACGATCTACAAGAACTACTACCGAATC
CAATTGAAGCCAGAGCAGTTCAGTTCCTACCTGACATCCCCAGACGTGGGCTTCTCCAGC
TATGAGCTTGTGGCCACACCCCACAACACCTCTAAAGGCTTCCAGCGTCCTGTGTACCTG
TTCCACAAGGCCCGATCCCCCAGCCACTAA
Protein Properties
Number of Residues 689
Molecular Weight 74354.7
Theoretical pI 10.01
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>7SK snRNA methylphosphate capping enzyme
MIEMAAEKEPFLVPAPPPPLKDESGGGGGPTVPPHQEAASGELRGGTERGPGRCAPSAGS
PAAAVGRESPGAAATSSSGPQAQQHRGGGPQAQSHGEARLSDPPGRAAPPDVGEERRGGG
GTELGPPAPPRPRNGYQPHRPPGGGGGKRRNSCNVGGGGGGFKHPAFKRRRRVNSDCDSV
LPSNFLLGGNIFDPLNLNSLLDEEVSRTLNAETPKSSPLPAKGRDPVEILIPKDITDPLS
LNTCTDEGHVVLASPLKTGRKRHRHRGQHHQQQQAAGGSESHPVPPTAPLTPLLHGEGAS
QQPRHRGQNRDAPQPYELNTAINCRDEVVSPLPSALQGPSGSLSAPPAASVISAPPSSSS
RHRKRRRTSSKSEAGARGGGQGSKEKGRGSWGGRHHHHHPLPAAGFKKQQRKFQYGNYCK
YYGYRNPSCEDGRLRVLKPEWFRGRDVLDLGCNVGHLTLSIACKWGPSRMVGLDIDSRLI
HSARQNIRHYLSEELRLPPQTLEGDPGAEGEEGTTTVRKRSCFPASLTASRGPIAAPQVP
LDGADTSVFPNNVVFVTGNYVLDRDDLVEAQTPEYDVVLCLSLTKWVHLNWGDEGLKRMF
RRIYRHLRPGGILVLEPQPWSSYGKRKTLTETIYKNYYRIQLKPEQFSSYLTSPDVGFSS
YELVATPHNTSKGFQRPVYLFHKARSPSH
GenBank ID Protein 47271406
UniProtKB/Swiss-Prot ID Q7L2J0
UniProtKB/Swiss-Prot Entry Name MEPCE_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_019606.5
GeneCard ID MEPCE
GenAtlas ID MEPCE
HGNC ID HGNC:20247
References
General References
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  4. Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. [PubMed:18669648 ]
  5. Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal. 2009 Aug 18;2(84):ra46. doi: 10.1126/scisignal.2000007. [PubMed:19690332 ]
  6. Daub H, Olsen JV, Bairlein M, Gnad F, Oppermann FS, Korner R, Greff Z, Keri G, Stemmann O, Mann M: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol Cell. 2008 Aug 8;31(3):438-48. doi: 10.1016/j.molcel.2008.07.007. [PubMed:18691976 ]
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