Human Metabolome Database: Showing Protein Histone-lysine N-methyltransferase MLL4 (HMDBP09020)

Identification Biological properties Gene properties Protein properties External links References XML Show 3 metabolites

Identification

HMDB Protein ID

HMDBP09020

Secondary Accession Numbers

14762

Name

Histone-lysine N-methyltransferase MLL4

Synonyms

KMT2D
Lysine N-methyltransferase 2D
Myeloid/lymphoid or mixed-lineage leukemia protein 4
Trithorax homolog 2
WBP-7
WW domain-binding protein 7
Lysine N-methyltransferase 2B
KMT2B

Gene Name

WBP7

Protein Type

Unknown

Biological Properties

General Function

Involved in DNA binding

Specific Function

Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2. Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development. Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation.

Pathways

Lysine degradation

Reactions

S-Adenosylmethionine + L-lysine-[histone] → S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone]	details
Protein lysine + S-Adenosylmethionine → Protein N6-methyl-L-lysine + S-Adenosylhomocysteine	details
S-Adenosylmethionine + Protein N6-methyl-L-lysine → S-Adenosylhomocysteine + Protein N6,N6-dimethyl-L-lysine	details
S-Adenosylmethionine + Protein N6,N6-dimethyl-L-lysine → S-Adenosylhomocysteine + Protein N6,N6,N6-trimethyl-L-lysine	details

GO Classification

Biological Process
ovulation
gene silencing
transcription, DNA-dependent
histone H3-K4 trimethylation
chromatin-mediated maintenance of transcription
oocyte differentiation
ovarian follicle development
regulation of histone H3-K4 methylation
Cellular Component
histone methyltransferase complex
Component
macromolecular complex
protein complex
organelle
membrane-bounded organelle
intracellular membrane-bounded organelle
nucleus
methyltransferase complex
histone methyltransferase complex
Function
ion binding
cation binding
metal ion binding
binding
catalytic activity
transition metal ion binding
zinc ion binding
transferase activity
protein binding
protein methyltransferase activity
protein-lysine n-methyltransferase activity
histone-lysine n-methyltransferase activity
nucleic acid binding
dna binding
histone methyltransferase activity (h3-k4 specific)
transferase activity, transferring one-carbon groups
methyltransferase activity
Molecular Function
metal ion binding
sequence-specific DNA binding transcription factor activity
zinc ion binding
DNA binding
histone methyltransferase activity (H3-K4 specific)
Process
cellular process
cellular component organization at cellular level
organelle organization
chromosome organization
chromatin organization
chromatin modification
biological regulation
regulation of biological process
regulation of metabolic process
regulation of macromolecule metabolic process
regulation of gene expression
regulation of transcription
regulation of transcription, dna-dependent

Cellular Location

Nucleus

Gene Properties

Chromosome Location

Locus

19q13.1

SNPs

WBP7

Gene Sequence

>8148 bp
ATGGCGGCGGCGGCGGGCGGCGGCAGTTGCCCCGGGCCTGGCTCCGCGCGGGGCCGCTTC
CCGGGCCGGCCGCGGGGCGCCGGCGGGGGCGGGGGCCGCGGCGGACGGGGCAACGGGGCC
GAAAGAGTGCGGGTAGCTCTGCGGCGCGGCGGTGGCGCGACGGGGCCGGGCGGAGCCGAG
CCCGGGGAGGACACGGCCCTGCTCCGTTTGCTGGGGCTCCGCCGGGGCCTGCGCCGGCTC
CGCCGCCTGTGGGCCGGCCCGCGGGTCCAGCGGGGCCGGGGACGGGGTCGGGGCCGGGGC
TGGGGCCCGAGTCGAGGCTGCGTGCCGGAGGAGGAGAGCAGTGACGGGGAATCCGACGAG
GAGGAGTTTCAGGGTTTTCATTCAGATGAAGATGTGGCCCCCAGTTCCCTGCGCTCTGCG
CTCCGATCCCAGCGAGGTCGAGCGCCCCGAGGTCGGGGTCGCAAGCATAAGACGACCCCC
CTTCCTCCTCCTCGCCTAGCAGATGTGGCTCCTACCCCCCCAAAGACCCCTGCCCGGAAA
CGGGGTGAGGAAGGCACAGAACGGATGGTGCAGGCACTGACTGAACTTCTCCGGCGGGCC
CAGGCACCCCAAGCACCCCGGAGCCGGGCATGTGAGCCCTCCACCCCCCGGCGGTCTCGG
GGACGGCCCCCAGGACGGCCAGCAGGCCCCTGCAGGAGGAAGCAGCAAGCAGTAGTGGTG
GCAGAAGCAGCTGTGACAATCCCCAAACCTGAGCCCCCACCTCCTGTGGTTCCAGTGAAA
CATCAGACTGGCAGCTGGAAATGCAAGGAGGGGCCCGGTCCAGGACCTGGGACCCCCAGG
CGTGGAGGACAGTCAAGCCGTGGAGGCCGTGGAGGCAGGGGCCGCGGCCGAGGTGGTGGG
CTCCCCTTTGTGATCAAGTTTGTTTCAAGGGCCAAAAAAGTAAAGATGGGACAATTGTCC
TTGGGACTCGAATCAGGTCAAGGTCAAGGTCAACATGAGGAAAGTTGGCAGGATGTCCCC
CAAAGAAGAGTTGGATCTGGACAGGGAGGGAGCCCTTGCTGGAAAAAGCAGGAACAGAAG
CTGGATGACGAGGAAGAAGAGAAGAAAGAAGAAGAAGAAAAAGACAAGGAGGGAGAAGAG
AAGGAAGAAAGAGCTGTAGCTGAGGAGATGATGCCAGCTGCGGAAAAGGAAGAGGCAAAG
CTGCCACCACCGCCTCTGACTCCTCCAGCCCCTTCACCTCCTCCACCCCTCCCACCCCCT
TCGACATCTCCTCCACCCCCACTCTGCCCTCCACCACCACCCCCAGTGTCCCCACCACCT
CTACCATCCCCTCCACCGCCTCCTGCCCAAGAGGAGCAGGAGGAATCCCCTCCTCCTGTG
GTCCCAGCTACGTGCTCCAGGAAGAGGGGCCGGCCTCCCCTGACTCCCAGCCAGCGGGCG
GAGCGGGAAGCTGCTCGGGCAGGGCCAGAGGGCACCTCTCCTCCCACTCCAACCCCCAGC
ACCGCCACGGGAGGCCCTCCGGAAGACAGTCCCACCGTGGCCCCCAAAAGCACCACCTTC
CTGAAGAATATCCGGCAGTTTATTATGCCTGTGGTGAGTGCCCGCTCCTCCCGTGTCATC
AAGACACCCCGGCGATTTATGGATGAAGACCCCCCCAAACCCCCAAAGGTGGAGGTCTCA
CCTGTCCTGCGACCTCCCATTACCACCTCCCCACCTGTTCCCCAGGAGCCAGCACCAGTC
CCCTCTCCACCACGTGCCCCAACTCCTCCATCTACCCCAGTTCCACTCCCTGAGAAGAGA
CGGTCCATCCTAAGGGAACCCACATTTCGCTGGACCTCACTGACCCGGGAGCTGCCCCCT
CCTCCCCCAGCCCCTCCACCTCCCCCGGCCCCCTCCCCACCCCCTGCTCCTGCCACCTCC
TCCCGGAGGCCCCTACTCCTTCGGGCCCCTCAGTTTACCCCAAGCGAAGCCCACCTGAAG
ATCTACGAATCGGTGCTTACTCCTCCTCCTCTTGGGGCTCCTGAAGCCCCTGAGCCAGAG
CCTCCTCCTGCCGATGACTCTCCAGCTGAGCCTGAGCCTCGGGCAGTGGGCCGCACCAAC
CACCTCAGCCTGCCTCGATTCGCCCCTGTGGTCACCACTCCTGTTAAGGCCGAGGTGTCC
CCTCACGGGGCTCCAGCTCTGAGCAACGGGCCACAGACACAGGCTCAGCTACTGCAGCCC
CTGCAGGCCTTGCAAACCCAGCTCCTGCCCCAGGCACTACCGCCACCACAGCCACAGCTG
CAGCCACCGCCGTCACCACAGCAGATGCCTCCCCTGGAAAAAGCCCGGATTGCGGGCGTG
GGTTCCTTGCCGCTGTCTGGGGTAGAGGAGAAGATGTTCAGCCTCCTCAAGAGAGCCAAA
GTGCAGCTATTCAAGATCGATCAGCAGCAGCAGCAGAAGGTGGCAGCTTCCATGCCGCTG
AGCCCTGGAGGGCAGATGGAGGAGGTGGCCGGGGCTGTCAAGCAGATCTCCGACAGAGGC
CCTGTCCGGTCTGAAGATGAGTCGGTGGAAGCTAAGAGAGAGCGGCCCTCAGGTCCCGAG
TCCCCTGTGCAAGGTCCCCGCATCAAACATGTCTGCCGTCATGCTGCTGTGGCCCTGGGT
CAGGCCCGGGCCATGGTGCCTGAAGATGTCCCTCGCCTCAGTGCCCTCCCTCTCCGGGAT
CGGCAGGACCTCGCCACAGAGGATACATCATCGGCGTCCGAGACTGAGAGTGTCCCGTCA
CGGTCCCGGCGGGGAAAGGTGGAGGCAGCAGGCCCTGGGGGAGAATCAGAGCCCACAGGT
TCTGGAGGGACCCTGGCCCACACACCCCGGCGCTCACTGCCCTCCCATCACGGCAAGAAG
ATGCGCATGGCTCGATGTGGACACTGTCGGGGCTGCCTACGTGTGCAGGACTGTGGGTCC
TGTGTCAACTGCCTAGACAAGCCCAAGTTTGGGGGCCCTAACACCAAGAAGCAGTGCTGT
GTATACCGGAAGTGTGACAAAATAGAGGCTCGGAAGATGGAACGACTGGCTAAAAAAGGC
CGGACGATAGTGAAGACGCTGTTGCCCTGGGATTCCGATGAATCTCCTGAGGCCTCCCCT
GGTCCTCCAGGCCCACGCCGGGGGGCGGGAGCTGGGGGGCCCCGGGAGGAGGTGGTGGCC
CACCCAGGGCCCGAGGAGCAGGACTCCCTCCTGCAGCGCAAGTCAGCTCGGCGCTGCGTC
AAACAGCGACCCTCCTATGATATCTTCGAGGATTCGGATGACTCGGAGCCCGGGGGCCCC
CCTGCTCCTCGGCGTCGGACCCCCCGAGAAAATGAGCTGCCACTGCCAGAACCTGAGGAG
CAGAGCCGGCCCCGCAAACCTACCCTGCAGCCTGTGTTGCAGCTCAAGGCCCGAAGGCGC
CTGGACAAGGATGCTTTGGCCCCTGGCCCCTTTGCTTCTTTTCCCAATGGCTGGACTGGA
AAGCAGAAGTCTCCCGATGGTGTGCACCGCGTCCGTGTGGATTTTAAGGAGGATTGTGAT
TTAGAGAACGTGTGGCTGATGGGGGGCCTGAGTGTGCTCACCTCTGTGCCAGGGGGCCCC
CCGATGGTGTGCTTGCTGTGTGCCAGCAAAGGACTCCACGAGCTGGTGTTCTGTCAAGTC
TGCTGTGACCCATTCCACCCATTCTGCCTGGAGGAGGCCGAGCGGCCCCTGCCCCAGCAT
CACGACACCTGGTGCTGCCGTCGCTGCAAATTCTGCCACGTCTGTGGACGCAAAGGTCGT
GGATCCAAGCACCTCCTGGAGTGCGAGCGCTGCCGCCATGCATACCACCCGGCCTGTCTG
GGGCCCAGCTATCCAACCCGGGCCACGCGCAAACGGCGCCACTGGATCTGTTCAGCCTGT
GTGCGCTGTAAGAGCTGTGGGGCAACTCCAGGCAAGAACTGGGACGTCGAGTGGTCTGGA
GATTACAGCCTCTGCCCCAGGTGCACCCAGCTATATGAGAAAGGAAACTACTGCCCGATC
TGTACACGCTGCTATGAAGACAACGACTATGAGAGCAAGATGATGCAGTGCGCACAGTGC
GATCACTGGGTGCATGCCAAGTGCGAGGGGCTCTCAGATGAAGACTACGAGATCCTTTCA
GGACTGCCAGACTCGGTGCTGTACACCTGCGGACCGTGTGCTGGGGCAGCGCAGCCCCGC
TGGCGAGAGGCCCTGAGCGGGGCCCTCCAGGGGGGCCTGCGCCAGGTGCTCCAGGGCCTG
CTGAGCTCCAAGGTGGTGGGCCCACTGCTGCTCTGCACCCAGTGTGGGCCAGATGGGAAG
CAACTGCACCCAGGACCCTGCGGCCTGCAAGCTGTGAGTCAGCGCTTCGAGGATGGCCAC
TACAAGTCTGTGCACAGCTTCATGGAGGACATGGTGGGCATCCTCATGCGGCACTCGGAG
GAGGGAGAGACCCCGGACCGCCGGGCTGGAGGCCAGATGAAGGGGCTCCTGCTGAAGCTG
CTAGAATCTGCGTTCGGCTGGTTCGACGCCCACGACCCCAAGTACTGGCGACGGAGTACC
CGGCTGCCAAACGGAGTCCTTCCCAATGCGGTGTTGCCCCCATCCCTGGATCATGTCTAT
GCGCAGTGGAGACAGCAGGAACCAGAGACCCCAGAATCAGGGCAGCCTCCAGGGGATCCC
TCAGCAGCATTCCAGGGCAAGGATCCGGCTGCCTTCTCACACCTGGAGGACCCCCGTCAG
TGTGCACTCTGCCTCAAATACGGGGATGCAGACTCCAAGGAGGCGGGGCGGCTCTTGTAC
ATCGGGCAGAACGAGTGGACACACGTCAACTGTGCCATCTGGTCGGCGGAAGTCTTCGAG
GAGAACGACGGCTCCCTCAAGAATGTGCATGCTGCTGTGGCCCGAGGGAGGCAGATGCGC
TGCGAGCTCTGCCTGAAGCCTGGCGCCACGGTGGGCTGCTGCCTGTCCTCCTGCCTCAGC
AACTTCCACTTCATGTGTGCCCGGGCCAGCTACTGCATCTTCCAGGATGACAAGAAAGTC
TTCTGCCAGAAACACACTGATCTCCTGGATGGCAAGGAAATTGTGAACCCCGATGGTTTT
GATGTTCTCCGCCGAGTCTATGTGGACTTCGAGGGCATCAACTTCAAGCGGAAGTTCTTG
ACGGGGCTTGAACCCGATGCCATCAACGTGCTCATTGGTTCCATCCGCATTGACTCCCTG
GGTACTCTGTCTGATCTCTCGGACTGCGAGGGACGGCTCTTCCCCATTGGCTACCAGTGC
TCCCGTCTGTACTGGAGCACAGTGGATGCTCGGAGGCGCTGCTGGTATCGGTGCCGAATT
CTGGAGTATCGGCCATGGGGGCCGAGGGAAGAGCCAGCTCACCTGGAGGCTGCAGAGGAG
AACCAGACCATTGTGCACAGCCCCGCCCCTTCCTCAGAGCCCCCAGGTGGTGAGGACCCC
CCACTGGACACAGATGTTCTTGTCCCTGGAGCTCCTGAGCGCCACTCGCCCATTCAGAAC
CTGGACCCTCCACTGCGGCCAGATTCAGGCAGCGCCCCTCCTCCAGCCCCCCGTTCTTTT
TCGGGGGCTCGAATCAAAGTGCCCAACTACTCGCCATCCCGGAGGCCCTTGGGGGGTGTC
TCCTTTGGCCCCCTGCCCTCCCCTGGAAGTCCATCTTCACTGACCCACCACATCCCCACA
GTGGGAGACCCGGACTTCCCAGCTCCCCCCAGACGTTCCCGTCGTCCCAGCCCTTTGGCT
CCCAGGCCGCCTCCATCACGGTGGGCCTCCCCTCCTCTAAAAACCTCCCCTCAGCTCAGG
GTGCCCCCTCCTACCTCAGTCGTCACAGCCCTCACACCTACCTCAGGGGAGCTGGCTCCC
CCTGGCCCGGCCCCATCTCCACCACCCCCTGAAGACCTGGGCCCAGACTTCGAGGACATG
GAGGTGGTGTCAGGACTGAGTGCTGCTGACCTGGACTTCGCGGCCAGCCTGCTGGGGACT
GAGCCCTTCCAGGAAGAGATTGTAGCCGCTGGGGCCATGGGGAGCAGCCACGGGGGCCCG
GGGGACAGCTCCGAGGAGGAGTCCAGCCCCACCTCCCGCTACATCCACTTCCCTGTGACT
GTGGTGTCCGCCCCTGGTCTGGCCCCCAGCGCTACCCCTGGAGCCCCCCGCATTGAACAG
CTGGACGGCGTGGACGACGGCACTGACAGTGAGGCTGAGGCGGTGCAGCAGCCTCGGGGC
CAGGGCACGCCTCCTTCGGGGCCAGGAGTAGTCCGGGCAGGGGTCCTTGGGGCTGCAGGG
GACAGGGCCCGGCCTCCTGAGGACCTGCCATCGGAAATTGTGGATTTTGTGTTGAAGAAC
CTAGGGGGTCCTGGGGATGGAGGTGCTGGCCCTAGAGAGGAGTCACTCCCCCCGGCGCCT
CCCCTGGCTAATGGCAGCCAGCCCTCCCAAGGCCTGACCGCCAGCCCAGCTGACCCCACC
CGCACATTTGCCTGGCTCCCAGGGGCCCCAGGGGTCCGGGTGTTAAGCCTTGGCCCTGCC
CCTGAGCCCCCCAAACCCGCCACATCCAAAATCATACTTGTCAACAAGCTGGGGCAAGTA
TTTGTGAAGATGGCTGGGGAGGGTGAACCTGTCCCACCCCCAGTGAAGCAGCCACCTTTG
CCCCCCACCATTTCCCCCACGGCTCCCACCTCCTGGACTCTGCCCCCAGGCCCCCTCCTC
GGCGTGCTGCCCGTGGTCGGAGTGGTCCGCCCTGCCCCGCCCCCGCCACCCCCTCCCCTG
ACGCTGGTGCTGAGCAGTGGGCCAGCCAGCCCGCCCCGCCAGGCCATCCGCGTCAAGAGG
GTGTCCACTTTCTCCGGCCGGTCCCCGCCAGCACCTCCCCCATACAAAGCCCCCCGGCTG
GATGAAGATGGAGAGGCCTCAGAGGATACCCCTCAGGTTCCAGGGCTTGGCAGTGGCGGG
TTTAGCCGTGTGAGGATGAAAACCCCCACAGTGCGTGGGGTCCTTGACCTGGATCGGCCT
GGGGAGCCCGCTGGGGAAGAAAGTCCTGGGCCCCTCCAGGAACGGTCCCCTTTGCTGCCA
CTTCCGGAAGATGGTCCTCCCCAGGTCCCCGATGGTCCCCCAGACCTGCTGCTTGAGTCC
CAGTGGCACCACTATTCAGGTGAGGCTTCGAGCTCTGAGGAAGAGCCTCCATCCCCAGAT
GATAAAGAGAACCAGGCCCCAAAACGGACTGGCCCACATCTGCGCTTCGAGATCAGCAGT
GAGGATGGGTTCAGCGTTGAGGCAGAGAGCTTGGAGGGGGCGTGGAGAACTCTGATCGAG
AAAGTGCAAGAGGCCCGAGGGCATGCCCGACTCAGACATCTCTCCTTTAGTGGAATGAGT
GGGGCGAGACTCCTGGGCATCCACCATGATGCTGTCATCTTCCTGGCCGAGCAGCTCCCC
GGAGCCCAGCGTTGCCAGCACTATAAGTTCCGTTACCACCAGCAGGGAGAGGGCCAGGAG
GAGCCGCCCCTGAATCCCCATGGGGCTGCTCGGGCAGAGGTCTATCTCCGGAAGTGCACC
TTTGACATGTTCAACTTCCTGGCCTCCCAGCACCGGGTGCTCCCTGAGGGGGCCACCTGT
GATGAGGAAGAGGATGAGGTGCAGCTCAGGTCAACCAGACGTGCCACCAGCCTGGAGCTG
CCCATGGCCATGCGTTTTCGTCACCTTAAGAAGACGTCCAAAGAAGCTGTGGGTGTCTAC
AGATCAGCCATCCACGGGCGAGGCCTGTTCTGTAAGCGCAACATCGACGCGGGGGAGATG
GTCATCGAGTACTCTGGCATTGTCATCCGCTCGGTGTTGACTGACAAGCGGGAGAAGTTC
TACGATGGGAAGGGCATCGGGTGCTATATGTTCCGCATGGATGACTTTGATGTAGTGGAC
GCCACGATGCATGGCAATGCCGCCCGCTTCATCAACCACTCCTGTGAGCCCAACTGCTTC
TCTCGGGTCATCCACGTGGAGGGCCAGAAACACATTGTTATCTTCGCCCTGCGCCGCATC
CTGCGTGGTGAGGAGCTCACCTACGACTACAAGTTCCCCATCGAGGATGCCAGCAACAAG
CTGCCCTGCAACTGTGGCGCCAAGCGCTGCCGTCGGTTCCTTAACTGA

Protein Properties

Number of Residues

2715

Molecular Weight

293512.14

Theoretical pI

8.218

Pfam Domain Function

PHD (PF00628 )
SET (PF00856 )
FYRC (PF05965 )
FYRN (PF05964 )
zf-CXXC (PF02008 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Histone-lysine N-methyltransferase MLL4
MAAAAGGGSCPGPGSARGRFPGRPRGAGGGGGRGGRGNGAERVRVALRRGGGATGPGGAE
PGEDTALLRLLGLRRGLRRLRRLWAGPRVQRGRGRGRGRGWGPSRGCVPEEESSDGESDE
EEFQGFHSDEDVAPSSLRSALRSQRGRAPRGRGRKHKTTPLPPPRLADVAPTPPKTPARK
RGEEGTERMVQALTELLRRAQAPQAPRSRACEPSTPRRSRGRPPGRPAGPCRRKQQAVVV
AEAAVTIPKPEPPPPVVPVKHQTGSWKCKEGPGPGPGTPRRGGQSSRGGRGGRGRGRGGG
LPFVIKFVSRAKKVKMGQLSLGLESGQGQGQHEESWQDVPQRRVGSGQGGSPCWKKQEQK
LDDEEEEKKEEEEKDKEGEEKEERAVAEEMMPAAEKEEAKLPPPPLTPPAPSPPPPLPPP
STSPPPPLCPPPPPPVSPPPLPSPPPPPAQEEQEESPPPVVPATCSRKRGRPPLTPSQRA
EREAARAGPEGTSPPTPTPSTATGGPPEDSPTVAPKSTTFLKNIRQFIMPVVSARSSRVI
KTPRRFMDEDPPKPPKVEVSPVLRPPITTSPPVPQEPAPVPSPPRAPTPPSTPVPLPEKR
RSILREPTFRWTSLTRELPPPPPAPPPPPAPSPPPAPATSSRRPLLLRAPQFTPSEAHLK
IYESVLTPPPLGAPEAPEPEPPPADDSPAEPEPRAVGRTNHLSLPRFAPVVTTPVKAEVS
PHGAPALSNGPQTQAQLLQPLQALQTQLLPQALPPPQPQLQPPPSPQQMPPLEKARIAGV
GSLPLSGVEEKMFSLLKRAKVQLFKIDQQQQQKVAASMPLSPGGQMEEVAGAVKQISDRG
PVRSEDESVEAKRERPSGPESPVQGPRIKHVCRHAAVALGQARAMVPEDVPRLSALPLRD
RQDLATEDTSSASETESVPSRSRRGKVEAAGPGGESEPTGSGGTLAHTPRRSLPSHHGKK
MRMARCGHCRGCLRVQDCGSCVNCLDKPKFGGPNTKKQCCVYRKCDKIEARKMERLAKKG
RTIVKTLLPWDSDESPEASPGPPGPRRGAGAGGPREEVVAHPGPEEQDSLLQRKSARRCV
KQRPSYDIFEDSDDSEPGGPPAPRRRTPRENELPLPEPEEQSRPRKPTLQPVLQLKARRR
LDKDALAPGPFASFPNGWTGKQKSPDGVHRVRVDFKEDCDLENVWLMGGLSVLTSVPGGP
PMVCLLCASKGLHELVFCQVCCDPFHPFCLEEAERPLPQHHDTWCCRRCKFCHVCGRKGR
GSKHLLECERCRHAYHPACLGPSYPTRATRKRRHWICSACVRCKSCGATPGKNWDVEWSG
DYSLCPRCTQLYEKGNYCPICTRCYEDNDYESKMMQCAQCDHWVHAKCEGLSDEDYEILS
GLPDSVLYTCGPCAGAAQPRWREALSGALQGGLRQVLQGLLSSKVVGPLLLCTQCGPDGK
QLHPGPCGLQAVSQRFEDGHYKSVHSFMEDMVGILMRHSEEGETPDRRAGGQMKGLLLKL
LESAFGWFDAHDPKYWRRSTRLPNGVLPNAVLPPSLDHVYAQWRQQEPETPESGQPPGDP
SAAFQGKDPAAFSHLEDPRQCALCLKYGDADSKEAGRLLYIGQNEWTHVNCAIWSAEVFE
ENDGSLKNVHAAVARGRQMRCELCLKPGATVGCCLSSCLSNFHFMCARASYCIFQDDKKV
FCQKHTDLLDGKEIVNPDGFDVLRRVYVDFEGINFKRKFLTGLEPDAINVLIGSIRIDSL
GTLSDLSDCEGRLFPIGYQCSRLYWSTVDARRRCWYRCRILEYRPWGPREEPAHLEAAEE
NQTIVHSPAPSSEPPGGEDPPLDTDVLVPGAPERHSPIQNLDPPLRPDSGSAPPPAPRSF
SGARIKVPNYSPSRRPLGGVSFGPLPSPGSPSSLTHHIPTVGDPDFPAPPRRSRRPSPLA
PRPPPSRWASPPLKTSPQLRVPPPTSVVTALTPTSGELAPPGPAPSPPPPEDLGPDFEDM
EVVSGLSAADLDFAASLLGTEPFQEEIVAAGAMGSSHGGPGDSSEEESSPTSRYIHFPVT
VVSAPGLAPSATPGAPRIEQLDGVDDGTDSEAEAVQQPRGQGTPPSGPGVVRAGVLGAAG
DRARPPEDLPSEIVDFVLKNLGGPGDGGAGPREESLPPAPPLANGSQPSQGLTASPADPT
RTFAWLPGAPGVRVLSLGPAPEPPKPATSKIILVNKLGQVFVKMAGEGEPVPPPVKQPPL
PPTISPTAPTSWTLPPGPLLGVLPVVGVVRPAPPPPPPPLTLVLSSGPASPPRQAIRVKR
VSTFSGRSPPAPPPYKAPRLDEDGEASEDTPQVPGLGSGGFSRVRMKTPTVRGVLDLDRP
GEPAGEESPGPLQERSPLLPLPEDGPPQVPDGPPDLLLESQWHHYSGEASSSEEEPPSPD
DKENQAPKRTGPHLRFEISSEDGFSVEAESLEGAWRTLIEKVQEARGHARLRHLSFSGMS
GARLLGIHHDAVIFLAEQLPGAQRCQHYKFRYHQQGEGQEEPPLNPHGAARAEVYLRKCT
FDMFNFLASQHRVLPEGATCDEEEDEVQLRSTRRATSLELPMAMRFRHLKKTSKEAVGVY
RSAIHGRGLFCKRNIDAGEMVIEYSGIVIRSVLTDKREKFYDGKGIGCYMFRMDDFDVVD
ATMHGNAARFINHSCEPNCFSRVIHVEGQKHIVIFALRRILRGEELTYDYKFPIEDASNK
LPCNCGAKRCRRFLN

External Links

GenBank ID Protein

7662046

UniProtKB/Swiss-Prot ID

Q9UMN6

UniProtKB/Swiss-Prot Entry Name

MLL4_HUMAN

PDB IDs

3UVM
4ERZ

GenBank Gene ID

NM_014727.1

GeneCard ID

WBP7

GenAtlas ID

Not Available

HGNC ID

Not Available

References

General References

Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M: Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science. 2009 Aug 14;325(5942):834-40. doi: 10.1126/science.1175371. Epub 2009 Jul 16. [PubMed:19608861 ]
Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. [PubMed:18669648 ]
Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal. 2009 Aug 18;2(84):ra46. doi: 10.1126/scisignal.2000007. [PubMed:19690332 ]
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villen J, Li J, Cohn MA, Cantley LC, Gygi SP: Large-scale characterization of HeLa cell nuclear phosphoproteins. Proc Natl Acad Sci U S A. 2004 Aug 17;101(33):12130-5. Epub 2004 Aug 9. [PubMed:15302935 ]
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