You are using an unsupported browser. Please upgrade your browser to a newer version to get the best experience on Human Metabolome Database.
Showing Protein Histone-lysine N-methyltransferase SUV420H2 (HMDBP09039)
Identification | |||||||||
---|---|---|---|---|---|---|---|---|---|
HMDB Protein ID | HMDBP09039 | ||||||||
Secondary Accession Numbers |
|
||||||||
Name | Histone-lysine N-methyltransferase SUV420H2 | ||||||||
Synonyms |
|
||||||||
Gene Name | SUV420H2 | ||||||||
Protein Type | Unknown | ||||||||
Biological Properties | |||||||||
General Function | Involved in protein binding | ||||||||
Specific Function | Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). | ||||||||
Pathways |
|
||||||||
Reactions |
|
||||||||
GO Classification |
|
||||||||
Cellular Location |
|
||||||||
Gene Properties | |||||||||
Chromosome Location | 19 | ||||||||
Locus | 19q13.42 | ||||||||
SNPs | SUV420H2 | ||||||||
Gene Sequence |
>1389 bp ATGGGGCCCGACAGAGTGACAGCACGAGAACTGTGCGAGAACGACGACCTGGCCACCAGC CTCGTCCTGGACCCCTACCTCGGTTTCCGCACCCATAAGATGAACGTCAGCCCTGTGCCC CCCCTGCGGCGACAGCAGCACCTGCGCTCAGCGCTGGAAACTTTCCTGAGGCAGCGGGAC CTGGAGGCTGCGTACCGGGCCCTGACGCTGGGAGGCTGGACGGCCCGCTACTTCCAGAGC CGGGGCCCGCGGCAGGAGGCTGCCCTCAAGACCCACGTCTATCGCTACCTCCGTGCCTTC CTGCCGGAAAGTGGCTTTACCATCCTGCCCTGCACGCGCTACTCCATGGAGACCAACGGG GCCAAGATCGTGTCCACTCGTGCTTGGAAAAAGAATGAGAAGCTGGAGCTGCTGGTGGGC TGCATTGCAGAGCTGCGGGAGGCAGATGAGGGGCTGCTGAGGGCCGGTGAGAATGACTTC AGCATCATGTACTCAACCCGCAAGCGGAGTGCTCAGCTGTGGCTGGGCCCAGCCGCCTTC ATCAACCATGACTGCAAACCCAACTGCAAGTTTGTGCCTGCAGATGGGAACGCAGCCTGC GTGAAGGTGCTCCGGGACATTGAGCCTGGGGACGAGGTGACATGCTTCTACGGCGAGGGC TTCTTCGGCGAGAAGAATGAGCACTGTGAATGCCACACCTGTGAGAGGAAAGGTGAAGGA GCTTTCCGAACCAGGCCTAGGGAGCCCGCGTTGCCACCACGGCCCCTGGACAAGTACCAG CTGCGTGAGACCAAGCGGCGGCTGCAGCAAGGCCTGGACAGTGGCAGCCGACAGGGCCTG CTGGGCCCTCGGGCCTGCGTGCACCCATCCCCGCTGCGCCGGGACCCATTCTGCGCCGCC TGCCAGCCCCTGCGCCTGCCAGCCTGCAGCGCCCGCCCAGACACCTCACCCCTCTGGCTC CAGTGGCTGCCTCAGCCCCAGCCCCGAGTGCGGCCCCGGAAGCGCCGACGCCCCCGGCCC CGGAGGGCCCCAGTGCTCTCCACCCACCACGCTGCCCGCGTCTCCCTGCACCGATGGGGA GGCTGTGGCCCCCACTGCCGCCTGCGAGGAGAGGCCCTGGTGGCCCTGGGCCAGCCCCCC CACGCCCGCTGGGCCCCTCAGCAGGACTGGCACTGGGCCCGGCGCTATGGGCTGCCTTAC GTGGTGCGTGTGGACCTTCGTCGCCTGGCCCCAGCCCCACCAGCTACCCCAGCCCCTGCT GGGACCCCAGGCCCCATCCTGATCCCGAAGCAGGCCCTCGCCTTCGCCCCCTTCTCCCCA CCCAAGCGCCTACGGCTGGTGGTCAGCCACGGCTCCATCGACCTGGATGTCGGCGGTGAA GAGCTGTGA |
||||||||
Protein Properties | |||||||||
Number of Residues | 462 | ||||||||
Molecular Weight | 52112.445 | ||||||||
Theoretical pI | 9.834 | ||||||||
Pfam Domain Function |
|
||||||||
Signals | Not Available | ||||||||
Transmembrane Regions | Not Available | ||||||||
Protein Sequence |
>Histone-lysine N-methyltransferase SUV420H2 MGPDRVTARELCENDDLATSLVLDPYLGFRTHKMNVSPVPPLRRQQHLRSALETFLRQRD LEAAYRALTLGGWTARYFQSRGPRQEAALKTHVYRYLRAFLPESGFTILPCTRYSMETNG AKIVSTRAWKKNEKLELLVGCIAELREADEGLLRAGENDFSIMYSTRKRSAQLWLGPAAF INHDCKPNCKFVPADGNAACVKVLRDIEPGDEVTCFYGEGFFGEKNEHCECHTCERKGEG AFRTRPREPALPPRPLDKYQLRETKRRLQQGLDSGSRQGLLGPRACVHPSPLRRDPFCAA CQPLRLPACSARPDTSPLWLQWLPQPQPRVRPRKRRRPRPRRAPVLSTHHAARVSLHRWG GCGPHCRLRGEALVALGQPPHARWAPQQDWHWARRYGLPYVVRVDLRRLAPAPPATPAPA GTPGPILIPKQALAFAPFSPPKRLRLVVSHGSIDLDVGGEEL |
||||||||
External Links | |||||||||
GenBank ID Protein | 31543169 | ||||||||
UniProtKB/Swiss-Prot ID | Q86Y97 | ||||||||
UniProtKB/Swiss-Prot Entry Name | SV422_HUMAN | ||||||||
PDB IDs | |||||||||
GenBank Gene ID | NM_032701.3 | ||||||||
GeneCard ID | SUV420H2 | ||||||||
GenAtlas ID | SUV420H2 | ||||||||
HGNC ID | HGNC:28405 | ||||||||
References | |||||||||
General References |
|