| Identification |
|---|
| HMDB Protein ID
| HMDBP09056 |
| Secondary Accession Numbers
| |
| Name
| Amiloride-sensitive cation channel 5 |
| Synonyms
|
- HINaC
- Human intestine Na(+) channel
|
| Gene Name
| ACCN5 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Involved in sodium channel activity |
| Specific Function
| Cation channel that gives rise to very low constitutive currents in the absence of activation. The activated channel exhibits selectivity for sodium, and is inhibited by amiloride |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Component |
| membrane |
| cell part |
| Function |
| transmembrane transporter activity |
| substrate-specific transmembrane transporter activity |
| ion transmembrane transporter activity |
| sodium channel activity |
| transporter activity |
| ion channel activity |
| cation channel activity |
| Process |
| sodium ion transport |
| establishment of localization |
| transport |
| monovalent inorganic cation transport |
| ion transport |
| cation transport |
|
| Cellular Location
|
- Cell membrane
- Multi-pass membrane protein
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:4 |
| Locus
| 4q31.3-q32 |
| SNPs
| ACCN5 |
| Gene Sequence
|
>1515 bp
ATGGAGCAGACAGAAAAATCAAAAGTATATGCTGAGAACGGACTCTTAGAAAAGATAAAG
CTTTGCCTTTCAAAGAAACCACTGCCATCTCCCACTGAGCGAAAGAAGTTTGACCATGAC
TTTGCCATCTCCACTTCCTTTCATGGGATACACAATATTGTTCAGAACCGGAGCAAAATT
CGCAGGGTGCTCTGGTTGGTGGTGGTTCTGGGCTCAGTCTCACTTGTGACATGGCAGATC
TACATTCGCTTGCTCAACTACTTCACATGGCCAACCACAACGTCCATTGAGGTTCAATAT
GTGGAAAAGATGGAGTTCCCAGCTGTGACATTTTGTAATTTGAATAGGTTCCAAACAGAT
GCTGTAGCCAAATTTGGTGTTATTTTTTTCTTATGGCACATTGTATCCAAAGTCCTCCAT
CTTCAAGAAATTACTGCCAATTCCACTGGCTCTAGAGAGGCTACTGATTTTGCTGCAAGT
CACCAAAACTTCAGCATTGTGGAATTTATCAGGAACAAAGGTTTTTATCTCAACAATAGC
ACTTTGTTGGACTGTGAGTTTTTTGGAAAGCCATGTAGCCCAAAGGATTTTGCACATGTC
TTCACTGAATATGGAAATTGTTTTACTTTTAATCATGGTGAAACTCTCCAAGCAAAGAGA
AAAGTGAGTGTCTCTGGAAGAGGTTTGAGCTTACTCTTCAATGTGAATCAGGAGGCATTC
ACTGATAACCCAGCCCTTGGTTTCGTTGATGCTGGGATCATCTTTGTTATCCATTCACCA
AAGAAGGTGCCACAGTTTGATGGGTTAGGCTTGTTGTCACCTGTGGGAATGCACGCAAGG
GTAACCATCCGCCAAGTGAAGACAGTTCATCAAGAATACCCTTGGGGAGAATGCAATCCT
AACATCAAGCTGCAGAATTTTAGCAGCTACAGCACTTCTGGTTGCTTGAAGGAATGCAAA
GCCCAGCACATAAAAAAGCAATGTGGATGTGTGCCTTTTCTTCTTCCTGGATATGGGATA
GAATGTGACCTACAAAAGTACTTCAGCTGTGTTTCTCCTGTACTTGACCACATTGAATTT
AAGGATTTATGTACAGTAGGAACACATAACTCTAGCTGCCCCGTTTCTTGTGAAGAAATA
GAATACCCGGCCACTATTTCTTATTCCTCTTTTCCAAGTCAAAAAGCTTTGAAATATCTT
TCCAAGAAGTTGAATCAAAGCCGGAAATACATCAGGGAGAATCTTGTAAAAATTGAAATT
AACTATAGTGACCTAAACTATAAGATAACCCAGCAGCAAAAGGCGGTGAGTGTGTCTGAG
TTACTTGCAGATCTTGGTGGTCAGCTGGGTCTATTTTGTGGGGCCAGTCTGATCACGATC
ATAGAAATTATTGAATATCTATTCACCAATTTCTACTGGATATGCATTTTCTTTTTGCTG
AAGATATCTGAAATGACCCAGTGGACTCCTCCACCTCAGAATCATCTGGGAAATAAAAAT
AGGATAGAGGAGTGT
|
| Protein Properties |
|---|
| Number of Residues
| 505 |
| Molecular Weight
| 57463.8 |
| Theoretical pI
| 8.26 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Amiloride-sensitive cation channel 5
MEQTEKSKVYAENGLLEKIKLCLSKKPLPSPTERKKFDHDFAISTSFHGIHNIVQNRSKI
RRVLWLVVVLGSVSLVTWQIYIRLLNYFTWPTTTSIEVQYVEKMEFPAVTFCNLNRFQTD
AVAKFGVIFFLWHIVSKVLHLQEITANSTGSREATDFAASHQNFSIVEFIRNKGFYLNNS
TLLDCEFFGKPCSPKDFAHVFTEYGNCFTFNHGETLQAKRKVSVSGRGLSLLFNVNQEAF
TDNPALGFVDAGIIFVIHSPKKVPQFDGLGLLSPVGMHARVTIRQVKTVHQEYPWGECNP
NIKLQNFSSYSTSGCLKECKAQHIKKQCGCVPFLLPGYGIECDLQKYFSCVSPVLDHIEF
KDLCTVGTHNSSCPVSCEEIEYPATISYSSFPSQKALKYLSKKLNQSRKYIRENLVKIEI
NYSDLNYKITQQQKAVSVSELLADLGGQLGLFCGASLITIIEIIEYLFTNFYWICIFFLL
KISEMTQWTPPPQNHLGNKNRIEEC
|
| External Links |
|---|
| GenBank ID Protein
| 7406623 |
| UniProtKB/Swiss-Prot ID
| Q9NY37 |
| UniProtKB/Swiss-Prot Entry Name
| ACCN5_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AJ252011 |
| GeneCard ID
| ACCN5 |
| GenAtlas ID
| ACCN5 |
| HGNC ID
| HGNC:17537 |
| References |
|---|
| General References
| - Schaefer L, Sakai H, Mattei M, Lazdunski M, Lingueglia E: Molecular cloning, functional expression and chromosomal localization of an amiloride-sensitive Na(+) channel from human small intestine. FEBS Lett. 2000 Apr 14;471(2-3):205-10. [PubMed:10767424 ]
|
