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Identification
HMDB Protein ID HMDBP09060
Secondary Accession Numbers
  • 14802
Name Sodium-dependent glucose transporter 1
Synonyms Not Available
Gene Name NAGLT1
Protein Type Unknown
Biological Properties
General Function Involved in transmembrane transport
Specific Function May function as a sodium-dependent glucose transporter (By similarity).
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
sodium ion transport
carbohydrate transport
Cellular Component
apical plasma membrane
integral to membrane
Molecular Function
symporter activity
Process
establishment of localization
transport
transmembrane transport
Cellular Location
  1. Multi-pass membrane protein
  2. Apical cell membrane
Gene Properties
Chromosome Location 6
Locus 6q22
SNPs NAGLT1
Gene Sequence
>1557 bp
ATGCTGTGTGCCTCCTTCCTGGGGCTGGGATTGAGTGTTGCTATAGTGGGACCCACGTTT
CAAGATTTGGCAACAAACGTGAACCGAAATATCAGTAGTCTGTCTTTCATTTTTGTGGGT
CGTGCCTTGGGATATTTGAGTGGCTCTGTGATTGGTGGATTTCTTGTCGATGTCATGAAT
TATTTTTTACTTTTGGGAATCTCAATGTCGGCTACCACCGTTGGTCTTTATCTTGTTCCT
TTTTGCAAGACAGCAATATTACTCACTGTCATGATGTCTATCTTCGGTGTTTCAATTGGC
ATTCTGGATACAGGTGGTAACGTCCTTATCTTGGCTATTTGGGGGGACAAAGGAGCCCCA
CATATGCAGGCCTTACACTTCTCTTTTGCCTTGGGTGCCTTTTTGGCTCCACTGCTAGCT
AAACTGGCTTTGGGTCCGACAGCGTCTGCTGAAAACCACACAGAGTCTGACTTCCATCCT
GCACTCAACCAATCATCTGATGCTGACTCAGAAGCTCTGTTTGGAGTACCTAATGATAAG
AATTTACTGTGGGCTTATGCTGTTATCGGTACTTACATGTTCTTAGTTTCTGTCATTTTT
TTTTGTCTGTTTTTAAAGAATAGCTCAAAGCAAGAAAAAGCAAGAGCATCTGCTGAGACA
TTTCGAAGAGCAAAATATCACAACGCCCTTCTTTGTCTCCTTTTTCTGTTCTTCTTTTTT
TATGTTGGAGCTGAGGTAACATATGGCTCTTATGTTTTCTCATTTGCAACCACCCATGCT
GGCATGAAAGAAAGTGAAGCTGCTGGGTTGAACTCCATCTTCTGGGGGACATTTGCAGCC
TGCAGGGGCCTGGCAATCTTTTTTGCTACCTGTTTACAGCCTGGAACCATGATTGTGTTG
AGCAACATTGGCAGCCTGACTTCATCTTTATTTCTGGTGCTTTTTGACAAGAACCCAATT
TGTCTCTGGATAGCAACTTCAGTGTATGGGGCTTCAATGGCAACCACATTTCCGAGTGGT
GTTTCTTGGATTGAGCAGTACACGACCATCCATGGGAAATCTGCAGCATTTTTTGTAATT
GGTGCTTCCCTGGGAGAAATGGCTATTCCTGCAGTCATTGGAATTCTTCAAGGAAAATAC
CCTGATTTGCCTGTAGTTCTGTATACCTCTTTGGGAGCATCAATAGCTACTGGTATTTTA
TTTCCTGTGCTATATAAATTAGCCACTTCACCTCTTGATCGCCAGCGAAAAGAAGACAGA
AAGAGTGAGGACCAGAAAGCTCTGCTCTCTAGCTCCGGGCTAAATGAATATGAGGAAGAG
AATGAAGAGGAGGATGCAGAAAAATGGAATGAAATGGATTTTGAAATGATTGAAACGAAT
GATACAATGAGGCATTCTATAATAGAGACATCTAGAAGTAGTCTGACGGAGCCCACAGCT
GAAGTCTATAATCAATACCCATCAAATGCACTGGTGTTTGAGTCTTCTCCTTTTAATACT
GGCAGTGCCCATGTGAAGCACTTGCCAGAAACCAGGACAAAAGGGACTAACGTTTAG
Protein Properties
Number of Residues 518
Molecular Weight 56217.055
Theoretical pI 5.427
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Sodium-dependent glucose transporter 1
MLCASFLGLGLSVAIVGPTFQDLATNVNRNISSLSFIFVGRALGYLSGSVIGGFLVDVMN
YFLLLGISMSATTVGLYLVPFCKTAILLTVMMSIFGVSIGILDTGGNVLILAIWGDKGAP
HMQALHFSFALGAFLAPLLAKLALGPTASAENHTESDFHPALNQSSDADSEALFGVPNDK
NLLWAYAVIGTYMFLVSVIFFCLFLKNSSKQEKARASAETFRRAKYHNALLCLLFLFFFF
YVGAEVTYGSYVFSFATTHAGMKESEAAGLNSIFWGTFAACRGLAIFFATCLQPGTMIVL
SNIGSLTSSLFLVLFDKNPICLWIATSVYGASMATTFPSGVSWIEQYTTIHGKSAAFFVI
GASLGEMAIPAVIGILQGKYPDLPVVLYTSLGASIATGILFPVLYKLATSPLDRQRKEDR
KSEDQKALLSSSGLNEYEEENEEEDAEKWNEMDFEMIETNDTMRHSIIETSRSSLTEPTA
EVYNQYPSNALVFESSPFNTGSAHVKHLPETRTKGTNV
GenBank ID Protein 154937330
UniProtKB/Swiss-Prot ID Q5TF39
UniProtKB/Swiss-Prot Entry Name NAGT1_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_153369.2
GeneCard ID NAGLT1
GenAtlas ID NAGLT1
HGNC ID HGNC:21053
References
General References
  1. Mungall AJ, Palmer SA, Sims SK, Edwards CA, Ashurst JL, Wilming L, Jones MC, Horton R, Hunt SE, Scott CE, Gilbert JG, Clamp ME, Bethel G, Milne S, Ainscough R, Almeida JP, Ambrose KD, Andrews TD, Ashwell RI, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Barker DJ, Barlow KF, Bates K, Beare DM, Beasley H, Beasley O, Bird CP, Blakey S, Bray-Allen S, Brook J, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Carder C, Carter NP, Chapman JC, Clark SY, Clark G, Clee CM, Clegg S, Cobley V, Collier RE, Collins JE, Colman LK, Corby NR, Coville GJ, Culley KM, Dhami P, Davies J, Dunn M, Earthrowl ME, Ellington AE, Evans KA, Faulkner L, Francis MD, Frankish A, Frankland J, French L, Garner P, Garnett J, Ghori MJ, Gilby LM, Gillson CJ, Glithero RJ, Grafham DV, Grant M, Gribble S, Griffiths C, Griffiths M, Hall R, Halls KS, Hammond S, Harley JL, Hart EA, Heath PD, Heathcott R, Holmes SJ, Howden PJ, Howe KL, Howell GR, Huckle E, Humphray SJ, Humphries MD, Hunt AR, Johnson CM, Joy AA, Kay M, Keenan SJ, Kimberley AM, King A, Laird GK, Langford C, Lawlor S, Leongamornlert DA, Leversha M, Lloyd CR, Lloyd DM, Loveland JE, Lovell J, Martin S, Mashreghi-Mohammadi M, Maslen GL, Matthews L, McCann OT, McLaren SJ, McLay K, McMurray A, Moore MJ, Mullikin JC, Niblett D, Nickerson T, Novik KL, Oliver K, Overton-Larty EK, Parker A, Patel R, Pearce AV, Peck AI, Phillimore B, Phillips S, Plumb RW, Porter KM, Ramsey Y, Ranby SA, Rice CM, Ross MT, Searle SM, Sehra HK, Sheridan E, Skuce CD, Smith S, Smith M, Spraggon L, Squares SL, Steward CA, Sycamore N, Tamlyn-Hall G, Tester J, Theaker AJ, Thomas DW, Thorpe A, Tracey A, Tromans A, Tubby B, Wall M, Wallis JM, West AP, White SS, Whitehead SL, Whittaker H, Wild A, Willey DJ, Wilmer TE, Wood JM, Wray PW, Wyatt JC, Young L, Younger RM, Bentley DR, Coulson A, Durbin R, Hubbard T, Sulston JE, Dunham I, Rogers J, Beck S: The DNA sequence and analysis of human chromosome 6. Nature. 2003 Oct 23;425(6960):805-11. [PubMed:14574404 ]
  2. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [PubMed:14702039 ]
  3. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  4. Nagase T, Kikuno R, Ohara O: Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. DNA Res. 2001 Aug 31;8(4):179-87. [PubMed:11572484 ]