Hmdb loader
Identification
HMDB Protein ID HMDBP09067
Secondary Accession Numbers
  • 14809
Name Regulator of differentiation 1
Synonyms
  1. Rod1
Gene Name ROD1
Protein Type Unknown
Biological Properties
General Function Involved in nucleotide binding
Specific Function May play a role in regulation of differentiation. In vitro, binds RNA, preferentially to both poly(G) and poly(U). Overexpressed, blocks differentiation of K562 leukemia cells following treatment with phorbol esters or sodium butyrate without affecting proliferation
Pathways Not Available
Reactions Not Available
GO Classification
Component
organelle
membrane-bounded organelle
intracellular membrane-bounded organelle
nucleus
Function
binding
nucleotide binding
nucleic acid binding
rna binding
Process
rna metabolic process
metabolic process
macromolecule metabolic process
cellular macromolecule metabolic process
rna processing
mrna processing
Cellular Location
  1. Cytoplasmic
Gene Properties
Chromosome Location Chromosome:9
Locus 9q32
SNPs ROD1
Gene Sequence
>1659 bp
ATGGATGGTGTTGTTACAGATCTTATAACAGTCGGTTTAAAGCGGGGATCTGATGAGCTT
CTTTCTTCTGGCATCATTAACGGACCTTTTACCATGAATAGTTCTACTCCTTCTACAGCT
AATGGGAATGACAGCAAGAAATTTAAACGAGATAGACCTCCCTGTTCGCCTTCCCGTGTT
CTCCATCTTCGAAAAATTCCATGTGATGTCACCGAAGCAGAGATCATATCATTAGGTCTA
CCATTTGGCAAAGTAACTAATCTTTTGATGTTGAAAGGAAAAAGCCAGGCTTTCTTAGAA
ATGGCTTCTGAGGAAGCTGCCGTTACTATGGTGAATTATTACACTCCTATTACTCCTCAC
CTTCGAAGCCAGCCTGTTTATATTCAGTATTCCAATCACAGAGAACTTAAGACTGACAAT
CTACCTAATCAAGCTCGAGCCCAAGCTGCACTGCAGGCTGTCAGTGCCGTCCAATCAGGA
AGCCTGGCCCTTTCTGGAGGTCCTTCCAATGAAGGCACAGTCCTACCTGGGCAGAGCCCT
GTGCTTCGAATAATTATTGAAAACCTCTTTTACCCTGTTACCCTGGAAGTTCTTCATCAG
ATATTTTCTAAATTTGGCACAGTCTTGAAGATTATCACCTTTACAAAGAATAATCAGTTT
CAAGCCTTGCTTCAGTATGCTGACCCAGTAAATGCACATTATGCCAAAATGGCTCTGGAT
GGCCAGAATATCTATAATGCATGCTGCACTCTGCGCATTGACTTCTCCAAGCTCACCAGC
CTTAATGTGAAATATAATAATGACAAAAGCAGAGACTTCACTCGCTTAGACCTTCCTACT
GGTGATGGCCAGCCATCCCTTGAACCCCCTATGGCTGCTGCTTTTGGTGCACCGGGTATA
ATTTCTTCACCATATGCAGGGGCTGCTGGATTTGCCCCAGCCATTGGATTTCCTCAAGCT
ACAGGTCTATCAGTTCCAGCTGTTCCTGGAGCTCTTGGTCCTCTCACAATCACCTCTTCT
GCTGTCACTGGAAGGATGGCCATTCCTGGGGCTAGTGGTATACCAGGAAATTCTGTTCTA
CTCGTCACAAATCTCAATCCTGATCTTATCACACCACATGGGCTTTTTATCCTATTTGGA
GTCTATGGTGATGTACATCGAGTGAAGATTATGTTTAATAAGAAAGAAAATGCCTTGGTT
CAGATGGCGGATGCAAATCAAGCTCAGCTAGCAATGAACCATCTAAGTGGTCAGAGACTT
TATGGGAAAGTGCTTCGTGCTACACTGTCCAAACATCAAGCAGTACAGCTTCCTCGAGAG
GGACAAGAAGACCAAGGTCTGACTAAGGATTTCAGCAATAGTCCTTTGCATCGCTTTAAA
AAGCCGGGCTCTAAAAACTTCCAGAATATCTTTCCACCATCAGCCACTCTGCATCTTTCC
AACATTCCCCCTTCTGTTACAGTGGATGATCTGAAGAACCTTTTCATAGAAGCTGGATGT
TCAGTGAAGGCTTTTAAATTCTTTCAGAAAGATCGCAAAATGGCGCTCATTCAATTGGGA
TCTGTGGAAGAAGCAATTCAGGCCCTCATTGAGCTTCATAACCATGACCTTGGAGAAAAT
CACCACCTCAGAGTTTCCTTCTCAAAATCTACAATCTGA
Protein Properties
Number of Residues 552
Molecular Weight 59689.0
Theoretical pI 9.46
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Regulator of differentiation 1
MDGVVTDLITVGLKRGSDELLSSGIINGPFTMNSSTPSTANGNDSKKFKRDRPPCSPSRV
LHLRKIPCDVTEAEIISLGLPFGKVTNLLMLKGKSQAFLEMASEEAAVTMVNYYTPITPH
LRSQPVYIQYSNHRELKTDNLPNQARAQAALQAVSAVQSGSLALSGGPSNEGTVLPGQSP
VLRIIIENLFYPVTLEVLHQIFSKFGTVLKIITFTKNNQFQALLQYADPVNAHYAKMALD
GQNIYNACCTLRIDFSKLTSLNVKYNNDKSRDFTRLDLPTGDGQPSLEPPMAAAFGAPGI
ISSPYAGAAGFAPAIGFPQATGLSVPAVPGALGPLTITSSAVTGRMAIPGASGIPGNSVL
LVTNLNPDLITPHGLFILFGVYGDVHRVKIMFNKKENALVQMADANQAQLAMNHLSGQRL
YGKVLRATLSKHQAVQLPREGQEDQGLTKDFSNSPLHRFKKPGSKNFQNIFPPSATLHLS
NIPPSVTVDDLKNLFIEAGCSVKAFKFFQKDRKMALIQLGSVEEAIQALIELHNHDLGEN
HHLRVSFSKSTI
GenBank ID Protein 38569466
UniProtKB/Swiss-Prot ID O95758
UniProtKB/Swiss-Prot Entry Name ROD1_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_005156.5
GeneCard ID ROD1
GenAtlas ID ROD1
HGNC ID HGNC:10253
References
General References
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  2. Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M: Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science. 2009 Aug 14;325(5942):834-40. doi: 10.1126/science.1175371. Epub 2009 Jul 16. [PubMed:19608861 ]
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  5. Yamamoto H, Tsukahara K, Kanaoka Y, Jinno S, Okayama H: Isolation of a mammalian homologue of a fission yeast differentiation regulator. Mol Cell Biol. 1999 May;19(5):3829-41. [PubMed:10207106 ]