| Identification |
|---|
| HMDB Protein ID
| HMDBP09074 |
| Secondary Accession Numbers
| |
| Name
| Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5 |
| Synonyms
|
- Solute carrier family 6 member 16
|
| Gene Name
| SLC6A16 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Involved in neurotransmitter:sodium symporter activity |
| Specific Function
| Not Available |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Component |
| integral to plasma membrane |
| membrane |
| cell part |
| membrane part |
| intrinsic to membrane |
| integral to membrane |
| Function |
| neurotransmitter transporter activity |
| neurotransmitter:sodium symporter activity |
| transmembrane transporter activity |
| transporter activity |
| Process |
| establishment of localization |
| transport |
| neurotransmitter transport |
|
| Cellular Location
|
- Membrane
- Multi-pass membrane protein
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 19q13.1-q13.4 |
| SNPs
| SLC6A16 |
| Gene Sequence
|
>2211 bp
ATGAAGACAGAGGCCCAGCCTTCGACATCCTTGCTGGCAAACACCTCATGGACTGGCACA
GTGATTTCTGACAGTGTCCCAGGAAGTCAAACGTGGGAAGACAAGGGTTCATTGACCCGG
TCTGCAACATCTTGGACCTCAGAGGCCCAAGTTTCAGCAGCCCGGGTTGCAGAGGCTCAG
GCCAGGACCAGTCAGCCCAAGCAAATTTCTGTATTGGAGGCGTTAACTGCCTCAGCCCTG
AACCAGAAACCCACGCATGAGAAGGTGCAGATGACAGAGAAGAAAGAGAGTGAGGTCCTC
CTTGCCCGTCCGTTCTGGTCCAGCAAAACTGAGTATATTCTGGCTCAGGTGGGCTTCTCT
ATGAAGCCATCTTGTCTCTGGCGCTTTGCCTACCTGTGGCTTAACAGTGGAGGCTGCAGT
TTCGCTGCCATCTACATCTTCATGCTGTTCCTGGTCGGGGTTCCTCTTCTCTTCCTGGAG
ATGGCAGCTGGTCAGAGCATGCGTCAGGGTGGCATGGGTGTATGGAAGATCATTGCCCCC
TGGATTGGTGGTGTGGGGTATTCTAGCTTCATGGTGTGCTTCATCCTCGGCCTGTACTTC
AATGTGGTCAATTCCTGGATCATCTTCTACATGAGCCAGTCCTTCCAGTTTCCCGTTCCA
TGGGAGAAATGTCCCTTAACGATGAACTCTAGTGGCTTTGATCCTGAATGTGAACGGACA
ACACCCTCCATATACTTCTGGTACCAGCAGGCCTTGAAGGCCTCAGACAGAATCGAGGAT
GGCGGGTCACCAGTCTACAGTCTGGTCCTGCCCTTCTTTCTTTGCTGGTGTCTTGTTGGT
GCTTTCATGATCAATGGGCTCAAGTCCACTGGGAAGGTAATCTATGTCTTGGTACTGCTC
CCCTGTTTCATCATTGTCGGTTTCTTCATCCGGACTCTACTCCTGGAAGGGGCAAAATTT
GGCCTTCAACAGTTGGTGGTTGCCAAGATATCGGATGTGTACAATATGAGTGTGTGGTCT
CTAGCAGGGGGTCAAGTTTTGTCTAACACAGGCATAGGCCTTGGCTCCGTTGCCTCCTTA
GCCTCCTACATGCCCCAGTCCAACAACTGTCTCAGTGATGCCTTTCTCGTGTCTGTGATA
AACCTGCTCACTTTGTTGGTTTTCACATCTTTCAACTTCTGTGTCCTGGGCTTCTGGGCG
ACAGTCATCACACATCGCTGCTGTGAGAGGAATGCTGAAATACTTTTAAAGCTGATAAAC
CTAGGGAAACTGCCTCCTGATGCCAAGCCCCCTGTCAACCTGCTTTACAACCCAACCTCC
ATCTACAATGCCTGGCTCAGTGGCCTTCCCCAGCACATCAAAAGCATGGTTCTCCGCGAG
GTGACTGAGTGCAACATAGAGACTCAGTTTCTTAAGGCTAGCGAGGGCCCAAAGTTTGCA
TTCCTGTCCTTTGTTGAAGCCATGTCCTTCCTTCCTCCGTCTGTCTTCTGGTCTTTTATC
TTCTTCCTGATGTTGCTGGCCATGGGGCTGAGCAGCGCAATAGGGATTATGCAGGGCATC
ATTACTCCACTCCAGGACACCTTCTCTTTCTTCAGGAAACATACAAAGCTGCTCATAGTG
GGAGTCTTTTTGCTCATGTTCGTGTGCGGCCTCTTCTTCACTCGACCTTCAGGCAGCTAC
TTCATCAGACTGCTGAGTGACTACTGGATAGTCTTCCCCATCATCGTCGTTGTCGTATTT
GAAACCATGGCTGTATCCTGGGCCTATGGGGCCAGGAGGTTCCTTGCAGACCTGACGATC
CTGTTGGGCCACCCCATCTCTCCCATCTTTGGTTGGCTGTGGCCCCATCTGTGTCCAGTT
GTGCTGCTAATCATCTTTGTGACCATGATGGTTCATCTTTGTATGAAGCCGATCACCTAC
ATGTCCTGGGACTCAAGCACCTCAAAAGAGGTGCTTCGACCATACCCACCGTGGGCACTG
CTCTTGATGATCACCCTTTTTGCCATTGTCATCCTCCCCATCCCTGCATACTTTGTATAC
TGCCGCATACATAGGATTCCCTTCAGGCCCAAGAGCGGAGACGGGCCTATGACAGCCTCC
ACATCCCTACCCCTAAGTCACCAGCTAACACCCAGTAAAGAGGTTCAAAAGGAAGAAATT
CTACAAGTTGATGAAACAAAGTACCCATCAACTTGTAATGTGACTTCCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 736 |
| Molecular Weight
| 82199.1 |
| Theoretical pI
| 8.33 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- 139-159
- 177-197
- 199-219
- 264-284
- 290-310
- 338-358
- 383-403
- 496-516
- 534-554
- 568-588
- 609-629
- 659-679
|
| Protein Sequence
|
>Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5
MKTEAQPSTSLLANTSWTGTVISDSVPGSQTWEDKGSLTRSATSWTSEAQVSAARVAEAQ
ARTSQPKQISVLEALTASALNQKPTHEKVQMTEKKESEVLLARPFWSSKTEYILAQVGFS
MKPSCLWRFAYLWLNSGGCSFAAIYIFMLFLVGVPLLFLEMAAGQSMRQGGMGVWKIIAP
WIGGVGYSSFMVCFILGLYFNVVNSWIIFYMSQSFQFPVPWEKCPLTMNSSGFDPECERT
TPSIYFWYQQALKASDRIEDGGSPVYSLVLPFFLCWCLVGAFMINGLKSTGKVIYVLVLL
PCFIIVGFFIRTLLLEGAKFGLQQLVVAKISDVYNMSVWSLAGGQVLSNTGIGLGSVASL
ASYMPQSNNCLSDAFLVSVINLLTLLVFTSFNFCVLGFWATVITHRCCERNAEILLKLIN
LGKLPPDAKPPVNLLYNPTSIYNAWLSGLPQHIKSMVLREVTECNIETQFLKASEGPKFA
FLSFVEAMSFLPPSVFWSFIFFLMLLAMGLSSAIGIMQGIITPLQDTFSFFRKHTKLLIV
GVFLLMFVCGLFFTRPSGSYFIRLLSDYWIVFPIIVVVVFETMAVSWAYGARRFLADLTI
LLGHPISPIFGWLWPHLCPVVLLIIFVTMMVHLCMKPITYMSWDSSTSKEVLRPYPPWAL
LLMITLFAIVILPIPAYFVYCRIHRIPFRPKSGDGPMTASTSLPLSHQLTPSKEVQKEEI
LQVDETKYPSTCNVTS
|
| External Links |
|---|
| GenBank ID Protein
| 55749589 |
| UniProtKB/Swiss-Prot ID
| Q9GZN6 |
| UniProtKB/Swiss-Prot Entry Name
| S6A16_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_014037.2 |
| GeneCard ID
| SLC6A16 |
| GenAtlas ID
| SLC6A16 |
| HGNC ID
| HGNC:13622 |
| References |
|---|
| General References
| - Yu LR, Zhu Z, Chan KC, Issaq HJ, Dimitrov DS, Veenstra TD: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra. J Proteome Res. 2007 Nov;6(11):4150-62. Epub 2007 Oct 9. [PubMed:17924679 ]
- Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A: Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. Genome Res. 2001 Mar;11(3):422-35. [PubMed:11230166 ]
- Farmer MK, Robbins MJ, Medhurst AD, Campbell DA, Ellington K, Duckworth M, Brown AM, Middlemiss DN, Price GW, Pangalos MN: Cloning and characterization of human NTT5 and v7-3: two orphan transporters of the Na+/Cl- -dependent neurotransmitter transporter gene family. Genomics. 2000 Dec 1;70(2):241-52. [PubMed:11112352 ]
|
