Hmdb loader
Identification
HMDB Protein ID HMDBP09096
Secondary Accession Numbers
  • 14840
Name Sorbin and SH3 domain-containing protein 2
Synonyms
  1. Arg/Abl-interacting protein 2
  2. ArgBP2
  3. Sorbin
Gene Name SORBS2
Protein Type Unknown
Biological Properties
General Function Involved in zinc ion binding
Specific Function Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1 or with AKT1 and PAK1, thus mediating AKT1-mediated activation of PAK1. Isoform 6 increases water and sodium absorption in the intestine and gall-bladder
Pathways Not Available
Reactions Not Available
GO Classification
Component
cell part
intracellular
Function
ion binding
cation binding
metal ion binding
binding
transition metal ion binding
zinc ion binding
Cellular Location
  1. Cytoplasm
  2. perinuclear region
Gene Properties
Chromosome Location Chromosome:4
Locus 4q35.1
SNPs SORBS2
Gene Sequence
>3303 bp
ATGAGTTACTATCAGAGGCCGTTTTCCCCCTCGGCATATTCTCTCCCAGCCTCACTCAAC
TCCAGCATTGTCATGCAGCACGGCACATCCCTCGATTCCACAGACACATATCCCCAGCAT
GCGCAGTCTCTGGATGGCACCACCAGCAGCTCTATCCCCCTGTACCGATCCTCAGAGGAA
GAGAAGAGAGTGACAGTCATCAAAGCCCCGCATTACCCAGGGATCGGGCCCGTGGATGAA
TCCGGAATCCCCACAGCAATTAGAACGACAGTCGACCGGCCCAAGGACTGGTACAAGACG
ATGTTTAAGCAAATTCACATGGTGCACAAGCCGGATGATGACACAGACATGTATAATACT
CCTTATACATACAATGCAGGTCTGTACAACCCACCCTACAGTGCTCAGTCACACCCTGCT
GCAAAGACCCAAACCTACAGACCTCTTTCCAAAAGCCACTCCGACAACAGCCCCAATGCC
TTTAAGGATGCGTCCTCCCCAGTGCCTCCCCCACATGTTCCACCTCCAGTCCCGCCGCTT
CGACCAAGAGATCGGTCTTCAACAGAAAAGCATGACTGGGATCCTCCAGACAGAAAAGTG
GACACAAGAAAATTTCGGTCTGAGCCAAGGAGTATTTTTGAATATGAACCTGGCAAGTCA
TCAATTCTTCAGCATGAAAGACCAGCCTCCTTGTATCAGTCCTCTATAGACAGAAGCCTG
GAAAGACCCATGAGTTCTGCAAGCATGGCCAGTGACTTCAGGAAGCGGAGGAAGAGCGAG
CCTGCAGTGGGTCCACCACGGGGCTTGGGAGATCAAAGTGCGAGCAGGACTAGCCCAGGC
CGAGTGGACCTCCCAGGATCAAGCACCACTCTTACAAAGTCTTTCACTAGCTCTTCTCCT
TCTTCCCCATCAAGAGCAAAAGGTGGGGATGATAGCAAAATATGTCCATCCCTTTGCAGT
TACTCAGGGCTCAACGGCAACCCCTCCAGTGAGTTAGATTACTGTAGCACTTACAGACAG
CACTTGGATGTCCCTCGGGACTCACCAAGAGCCATTAGTTTCAAGAACGGCTGGCAAATG
GCCCGGCAAAACGCAGAAATCTGGAGCAGCACGGAAGAAACCGTCTCTCCCAAAATCAAA
TCCCGGAGCTGTGACGATCTCCTAAACGACGACTGCGATAGCTTCCCGGACCCGAAAGTC
AAGTCGGAAAGCATGGGCTCCCTGTTATGTGAGGAGGACTCCAAGGAGAGCTGCCCCATG
GCGTGGGGGTCCCCCTACGTCCCGGAGGTTCGCAGTAACGGCAGATCAAGGATCAGACAC
AGGTCAGCCCGCAACGCCCCGGGGTTCCTGAAGATGTACAAGAAAATGCACCGCATCAAC
CGCAAGGACCTGATGAACTCCGAGGTGATCTGCTCCGTGAAGTCCAGGATTCTGCAGTAC
GAGAGCGAGCAGCAGCACAAGGACCTGCTGCGCGCCTGGAGCCAGTGCTCCACGGAGGAG
GTGCCCCGGGACATGGTGCCCACACGCATCTCCGAATTCGAAAAGCTGATCCAGAAGTCC
AAATCCATGCCAAATTTAGGGGATGACATGCTGTCTCCCGTAACCCTAGAACCACCGCAA
AATGGCCTATGTCCCAAGAGGCGGTTTTCCATTGAGTATTTGCTGGAGGAAGAAAATCAA
AGCGGCCCCCCCGCTCGGGGCCGGCGAGGCTGCCAGTCTAACGCCCTGGTGCCCATTCAC
ATTGAAGTCACCAGCGATGAGCAGCCCCGAGCACACGTGGAGTTTTCCGACAGCGACCAG
GACGGGGTTGTGTCCGACCACAGTGACTACATTCACCTAGAGGGGTCATCCTTCTGCAGT
GAAAGTGACTTTGATCACTTTTCCTTCACATCCTCCGAAAGCTTTTACGGATCCAGCCAC
CACCACCACCATCACCACCACCACCACCACCGCCACCTCATCAGCTCCTGCAAAGGCAGG
TGCCCGGCCTCCTACACTCGATTTACCACAATGTTAAAACACGAAAGAGCCAGACACGAA
AACACCGAGGAGCCCAGAAGGCAAGAAATGGACCCTGGCCTTTCTAAACTTGCTTTTCTA
GTCAGTCCTGTGCCTTTCCGGAGGAAAAAAAATTCGGCTCCTAAGAAACAGACTGAAAAG
GCAAAATGTAAAGCATCTGTGTTTGAGGCTCTGGACTCTGCCCTTAAAGACATCTGTGAC
CAAATTAAAGCTGAAAAGAAAAGGGGGAGCTTGCCGGACAACAGCATCCTGCACCGCCTC
ATCAGTGAGCTGCTGCCAGATGTTCCCGAGAGGAACTCATCCCTGAGAGCGCTGAGGAGG
AGCCCCCTGCACCAGCCTCTCCACCCACTGCCTCCCGATGGTGCTATTCATTGTCCACCC
TACCAGAATGACTGCGGGAGAATGCCCCGCAGTGCCTCTTTCCAAGACGTGGACACAGCC
AACAGCAGCTGCCACCACCAAGACCGTGGCGGTGCACTCCAAGACCGTGAGTCCCCTAGA
AGTTACTCATCCACTTTGACTGACATGGGGAGAAGTGCACCAAGGGAAAGAAGAGGAACT
CCAGAAAAAGAGAAATTGCCTGCAAAAGCTGTTTATGATTTTAAGGCTCAGACATCTAAG
GAGTTGTCATTTAAGAAAGGAGATACTGTCTACATCCTCAGGAAAATTGATCAAAATTGG
TATGAGGGAGAACACCACGGGAGAGTGGGCATCTTCCCGATCTCATACGTAGAGAAACTC
ACACCTCCTGAGAAAGCACAGCCTGCAAGACCACCTCCGCCAGCCCAGCCCGGAGAAATC
GGAGAAGCTATAGCCAAATACAACTTCAACGCAGACACAAATGTGGAGCTGTCACTGAGA
AAGGGAGATAGAGTTATTCTTCTTAAAAGAGTTGATCAAAACTGGTATGAAGGTAAAATC
CCAGGAACCAACAGACAAGGCATCTTCCCTGTTTCCTATGTGGAGGTCGTCAAGAAGAAC
ACAAAAGGTGCTGAGGACTACCCTGACCCTCCAATACCCCACAGCTATTCTAGTGATAGG
ATTCACAGCTTGAGCTCAAATAAGCCACAGCGTCCTGTGTTTACTCATGAAAATATTCAA
GGTGGGGGGGAACCGTTTCAGGCTCTGTATAACTATACTCCCAGGAATGAAGATGAGCTG
GAGCTCAGAGAAAGTGATGTCATTGATGTCATGGAAAAGTGTGATGACGGCTGGTTTGTG
GGGACCTCAAGAAGAACCAAATTCTTTGGTACTTTCCCCGGAAACTACGTCAAGAGGCTG
TGA
Protein Properties
Number of Residues 1100
Molecular Weight 124106.3
Theoretical pI 8.42
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Sorbin and SH3 domain-containing protein 2
MSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEE
EKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNT
PYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPL
RPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPASLYQSSIDRSL
ERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSP
SSPSRAKGGDDSKICPSLCSYSGLNGNPSSELDYCSTYRQHLDVPRDSPRAISFKNGWQM
ARQNAEIWSSTEETVSPKIKSRSCDDLLNDDCDSFPDPKVKSESMGSLLCEEDSKESCPM
AWGSPYVPEVRSNGRSRIRHRSARNAPGFLKMYKKMHRINRKDLMNSEVICSVKSRILQY
ESEQQHKDLLRAWSQCSTEEVPRDMVPTRISEFEKLIQKSKSMPNLGDDMLSPVTLEPPQ
NGLCPKRRFSIEYLLEEENQSGPPARGRRGCQSNALVPIHIEVTSDEQPRAHVEFSDSDQ
DGVVSDHSDYIHLEGSSFCSESDFDHFSFTSSESFYGSSHHHHHHHHHHHRHLISSCKGR
CPASYTRFTTMLKHERARHENTEEPRRQEMDPGLSKLAFLVSPVPFRRKKNSAPKKQTEK
AKCKASVFEALDSALKDICDQIKAEKKRGSLPDNSILHRLISELLPDVPERNSSLRALRR
SPLHQPLHPLPPDGAIHCPPYQNDCGRMPRSASFQDVDTANSSCHHQDRGGALQDRESPR
SYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNW
YEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLR
KGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDR
IHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFV
GTSRRTKFFGTFPGNYVKRL
GenBank ID Protein 10947118
UniProtKB/Swiss-Prot ID O94875
UniProtKB/Swiss-Prot Entry Name SRBS2_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_021069.4
GeneCard ID SORBS2
GenAtlas ID SORBS2
HGNC ID HGNC:24098
References
General References
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  4. Yu LR, Zhu Z, Chan KC, Issaq HJ, Dimitrov DS, Veenstra TD: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra. J Proteome Res. 2007 Nov;6(11):4150-62. Epub 2007 Oct 9. [PubMed:17924679 ]
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  7. Wang B, Golemis EA, Kruh GD: ArgBP2, a multiple Src homology 3 domain-containing, Arg/Abl-interacting protein, is phosphorylated in v-Abl-transformed cells and localized in stress fibers and cardiocyte Z-disks. J Biol Chem. 1997 Jul 11;272(28):17542-50. [PubMed:9211900 ]
  8. Wahbi K, Magaud JP, Pansu D, Descroix-Vagne M: Coding region of the sorbin gene in different species. Peptides. 2001 Dec;22(12):2045-53. [PubMed:11786189 ]
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