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Identification
HMDB Protein ID HMDBP09121
Secondary Accession Numbers
  • 14867
Name Glycine receptor subunit alpha-4
Synonyms Not Available
Gene Name GLRA4
Protein Type Unknown
Biological Properties
General Function Involved in ion transport
Specific Function The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing)
Pathways Not Available
Reactions Not Available
GO Classification
Component
integral to plasma membrane
membrane
cell part
membrane part
intrinsic to membrane
integral to membrane
postsynaptic membrane
Function
binding
transmitter-gated ion channel activity
glycine binding
transmembrane transporter activity
substrate-specific transmembrane transporter activity
ion transmembrane transporter activity
carboxylic acid binding
amino acid binding
transporter activity
ion channel activity
ligand-gated ion channel activity
extracellular ligand-gated ion channel activity
Process
establishment of localization
transport
ion transport
Cellular Location
  1. Cell membrane
  2. Multi-pass membrane protein
  3. Multi-pass membrane protein
  4. Cell junction
  5. synapse
  6. postsynaptic cell membrane
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs GLRA4
Gene Sequence
>1254 bp
ATGACAACTCTTGTTCCTGCAACCCTCTCCTTCCTTCTTCTCTGGACCCTGCCAGGGCAG
GTCCTCCTCAGGGTGGCCTTGGCAAAAGAGGAAGTCAAATCTGGAACCAAGGGGTCCCAG
CCCATGTCCCCCTCTGATTTCCTAGACAAACTTATGGGGCGAACATCTGGATATGATGCC
AGGATTCGGCCCAATTTTAAAGGCCCACCCGTGAACGTGACCTGCAACATCTTCATCAAC
AGTTTCAGCTCCATCACCAAGACCACAATGGACTACCGGGTGAATGTCTTCTTGCGGCAA
CAGTGGAATGACCCACGCCTGTCCTACCGAGAATATCCTGATGACTCTCTGGACCTCGAT
CCCTCCATGCTGGACTCTATCTGGAAGCCAGACCTCTTCTTTGCTAATGAGAAAGGGGCC
AACTTCCATGAGGTGACCACGGACAACAAGTTACTGCGCATCTTCAAGAATGGGAATGTG
CTGTACAGCATCAGGCTGACCCTCATTTTGTCCTGCCTGATGGACCTCAAGAACTTCCCC
ATGGACATCCAGACCTGCACGATGCAGCTTGAGAGCTTTGGCTACACCATGAAAGACCTC
GTGTTTGAGTGGCTGGAAGATGCTCCTGCTGTCCAAGTGGCTGAGGGGCTGACTCTGCCC
CAGTTTATCTTGCGGGATGAGAAGGATCTAGGCTGTTGTACCAAGCACTACAACACAGGG
AAATTCACCTGCATCGAGGTAAAGTTTCACCTGGAACGGCAGATGGGCTACTATCTGATT
CAGATGTACATCCCCAGCCTACTCATCGTCATCCTGTCCTGGGTCTCCTTCTGGATCAAC
ATGGATGCTGCCCCTGCCCGTGTGGGCCTGGGCATCACCACCGTGCTCACCATGACCACC
CAGAGCTCTGGCTCCCGGGCCTCTTTGCCTAAGGTGTCCTACGTGAAGGCAATCGACATC
TGGATGGCTGTGTGTCTGCTCTTTGTGTTCGCTGCCTTGCTGGAGTATGCTGCCATAAAT
TTTGTTTCTCGTCAGCATAAAGAATTCATACGACTTCGAAGAAGGCAGAGGCGCCAACGC
TTGGAGGAAGATATCATCCAAGAAAGTCGTTTCTATTTCCGTGGCTATGGCTTGGGCCAC
TGCCTGCAGGCAAGAGATGGAGGTCCAATGGAAGGTTCTGGCATTTATAGTCCCCAACCT
CCAGCCCCTCTTCTAAGGGAAGGAGAAACCACGCGGAAACTCTACGTGGACTGA
Protein Properties
Number of Residues 417
Molecular Weight 47727.9
Theoretical pI 8.36
Pfam Domain Function
Signals
  • 1-28
Transmembrane Regions
  • 259-279
  • 322-342
Protein Sequence
>Glycine receptor subunit alpha-4
MTTLVPATLSFLLLWTLPGQVLLRVALAKEEVKSGTKGSQPMSPSDFLDKLMGRTSGYDA
RIRPNFKGPPVNVTCNIFINSFSSITKTTMDYRVNVFLRQQWNDPRLSYREYPDDSLDLD
PSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLILSCLMDLKNFP
MDIQTCTMQLESFGYTMKDLVFEWLEDAPAVQVAEGLTLPQFILRDEKDLGCCTKHYNTG
KFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVGLGITTVLTMTT
QSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAINFVSRQHKEFIRLRRRQRRQR
LEEDIIQESRFYFRGYGLGHCLQARDGGPMEGSGIYSPQPPAPLLREGETTRKLYVD
GenBank ID Protein 220732272
UniProtKB/Swiss-Prot ID Q5JXX5
UniProtKB/Swiss-Prot Entry Name GLRA4_HUMAN
PDB IDs Not Available
GenBank Gene ID AL049610
GeneCard ID GLRA4
GenAtlas ID GLRA4
HGNC ID HGNC:31715
References
General References
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