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Identification
HMDB Protein ID HMDBP09151
Secondary Accession Numbers
  • 14906
Name Beta-1,4-N-acetylgalactosaminyltransferase 3
Synonyms
  1. Beta-1,4-N-acetylgalactosaminyltransferase III
  2. Beta4GalNAc-T3
  3. Beta4GalNAcT3
  4. NGalNAc-T2
  5. B4GalNAcT3
  6. N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 2
Gene Name B4GALNT3
Protein Type Enzyme
Biological Properties
General Function Involved in transferase activity, transferring hexosyl groups
Specific Function Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans. Mediates the N,N'-diacetyllactosediamine formation on gastric mucosa.
Pathways Not Available
Reactions
UDP-N-acetyl-alpha-D-galactosamine + N-acetyl-beta-D-glucosaminyl group → Uridine 5'-diphosphate + N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl group details
UDP-N-acetyl-D-galactosamine + → UDP + details
UDP-N-acetyl-D-galactosamine + → UDP + details
GO Classification
Cellular Component
Golgi cisterna membrane
integral to membrane
Component
golgi membrane
membrane
cell part
organelle membrane
golgi cisterna membrane
Function
catalytic activity
transferase activity
transferase activity, transferring hexosyl groups
transferase activity, transferring glycosyl groups
Molecular Function
acetylgalactosaminyltransferase activity
N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity
Cellular Location
  1. Single-pass type II membrane protein
  2. Golgi apparatus
  3. Golgi stack membrane
Gene Properties
Chromosome Location 12
Locus 12p13.33
SNPs B4GALNT3
Gene Sequence
>2997 bp
ATGGGGAGCCCCCGGGCCGCGCGGCCCCCGCTGCTCCTGCGCCCGGTGAAGCTGCTGCGG
AGGCGCTTCCGGCTGCTGCTGGCGCTCGCCGTGGTGTCTGTGGGGCTCTGGACTCTGTAT
CTGGAACTGGTGGCGTCGGCCCAGGTCGGCGGGAACCCCCTGAACCGGAGGTACGGCAGC
TGGAGAGAACTAGCCAAGGCTCTGGCCAGCAGGAACATTCCAGCTGTGGATCCACACCTC
CAGTTCTACCATCCCCAGAGGCTGAGCCTCGAGGACCACGACATTGACCAAGGGGTGAGC
AGTAACAGCAGCTACTTGAAGTGGAACAAGCCTGTCCCCTGGCTCTCAGAGTTCCGGGGC
CGTGCCAACCTGCATGTGTTTGAAGACTGGTGTGGCAGCTCTATCCAGCAGCTCAGGAGG
AACCTGCATTTCCCACTGTACCCCCATATTCGCACAACCCTGAGGAAGCTTGCTGTGTCC
CCCAAATGGACCAACTATGGCCTCCGCATCTTTGGCTACCTGCACCCCTTTACTGATGGG
AAAATCCAGTTTGCCATTGCTGCAGATGACAACGCGGAGTTCTGGCTGAGCCTCGATGAC
CAGGTCTCAGGCCTCCAGCTGCTGGCCAGTGTGGGCAAGACTGGAAAGGAGTGGACCGCC
CCGGGAGAGTTTGGGAAATTTCGGAGCCAAATTTCCAAGCCGGTGAGCCTGTCAGCCTCC
CACAGGTACTACTTCGAGGTGCTGCACAAGCAGAATGAGGAGGGCACCGACCACGTGGAA
GTTGCATGGCGACGGAACGACCCTGGAGCCAAGTTCACCATCATTGACTCCCTCTCCCTG
TCCCTCTTCACAAATGAGACGTTCCTACAGATGGATGAGGTGGGCCACATCCCACAGACA
GCAGCCAGCCACGTGGACTCCTCCAACGCTCTTCCCAGGGATGAGCAGCCGCCCGCTGAC
ATGCTTCGGCCTGACCCCCGGGACACCCTCTATCGAGTGCCTCTGATCCCCAAGTCGCAT
CTCCGCCACGTCCTGCCTGACTGTCCCTACAAACCCAGCTATCTGGTGGATGGGCTTCCT
CTGCAGCGCTACCAGGGACTCCGGTTTGTTCATCTGTCTTTTGTTTACCCCAATGACTAT
ACCCGCCTGAGCCACATGGAGACCCACAATAAATGTTTCTACCAGGAAAACGCCTACTAC
CAAGACCGGTTCAGCTTTCAGGAGTACATCAGGATTGACCAGCCTGAGAAGCAGGGGCTG
GAGCAGCCAGGTTTTGAGGAAAACCTTCTAGAAGAGTCCCAGTATGGGGAAGTGGCAGAG
GAGACCCCTGCCTCCAACAACCAGAATGCCAGGATGCTTGAGGGAAGACAGACACCTGCC
TCCACCCTGGAGCAAGATGCCACTGACTACCGCCTCCGAAGCCTGCGGAAACTCCTGGCT
CAGCCCCGGGAGGGCCTGCTGGCCCCCTTCTCCAAGCGGAACTCCACAGCGTCCTTCCCA
GGGAGGACCAGCCACATTCCAGTGCAGCAGCCAGAGAAGAGGAAGCAAAAACCCAGCCCT
GAGCCCAGCCAAGATTCACCTCATTCCGACAAGTGGCCTCCTGGGCACCCTGTGAAGAAC
CTGCCTCAGATGAGGGGGCCCAGGCCCAGGCCCGCTGGTGACAGCCCCAGGAAGACTCAG
TGGCTGAACCAGGTGGAGTCGTACATCGCAGAGCAGAGACGGGGTGACAGGATGCGGCCT
CAGGCCCCCGGAAGGGGCTGGCATGGGGAGGAGGAAGTGGTGGCGGCCGCAGGCCAGGAA
GGACAAGTGGAGGGAGAGGAAGAGGGGGAAGAAGAGGAGGAGGAAGAGGATATGAGTGAG
GTGTTCGAGTACGTACCTGTGTTTGACCCGGTAGTAAACTGGGACCAGACCTTCAGTGCC
CGGAATCTCGACTTCCAAGCCCTGAGGACTGACTGGATCGATCTGAGCTGTAACACATCT
GGCAACCTGCTGCTTCCAGAGCAGGAAGCTCTGGAGGTCACGCGAGTCTTCTTGAAGAAG
CTCAACCAGAGGAGCCGGGGGAGGTACCAGCTACAGCGCATTGTGAACGTGGAAAAGCGT
CAGGACCAGCTACGTGGGGGTCGCTACCTCCTGGAGCTTGAACTGTTGGAACAAGGCCAG
CGCGTGGTGCGGCTCTCGGAGTATGTGTCTGCACGAGGCTGGCAGGGCATCGATCCAGCT
GGTGGGGAGGAGGTCGAGGCCCGGAACCTGCAAGGCCTGGTCTGGGACCCACACAACCGT
AGGAGACAGGTCCTGAATACCCGGGCCCAAGAGCCCAAGCTGTGCTGGCCTCAGGGTTTC
TCCTGGAGTCACCGAGCCGTGGTCCACTTCGTCGTGCCTGTGAAGAACCAGGCACGCTGG
GTACAGCAATTCATCAAAGACATGGAAAACCTGTTCCAGGTCACCGGTGACCCACACTTC
AACATCGTCATCACTGACTATAGCAGTGAGGACATGGATGTTGAGATGGCACTGAAGAGG
TCCAAGCTGCGGAGCTACCAGTACGTGAAGCTAAGTGGAAACTTTGAACGCTCAGCTGGA
CTTCAGGCTGGCATAGACCTCGTGAAGGACCCGCACAGCATCATCTTCCTCTGTGACCTC
CACATCCACTTCCCAGCTGGAGTCATCGATGCCATTCGGAAGCACTGTGTGGAGGGAAAG
ATGGCCTTTGCCCCCATGGTGATGAGGCTGCATTGTGGGGCCACCCCCCAGTGGCCTGAG
GGCTACTGGGAGGTGAATGGGTTCGGGCTGCTTGGCATCTACAAGTCTGACCTGGACAGG
ATTGGGGGCATGAACACCAAGGAGTTCCGAGACCGCTGGGGCGGGGAAGACTGGGAGCTG
CTGGACAGGATACTCCAAGCGGGCCTGGACGTGGAGCGTCTCTCCCTCAGGAATTTCTTC
CATCATTTCCATTCCAAGCGAGGCATGTGGAGCCGTCGCCAGATGAAGACGCTGTAG
Protein Properties
Number of Residues 998
Molecular Weight 114974.105
Theoretical pI 7.489
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 2
MGSPRAARPPLLLRPVKLLRRRFRLLLALAVVSVGLWTLYLELVASAQVGGNPLNRRYGS
WRELAKALASRNIPAVDPHLQFYHPQRLSLEDHDIDQGVSSNSSYLKWNKPVPWLSEFRG
RANLHVFEDWCGSSIQQLRRNLHFPLYPHIRTTLRKLAVSPKWTNYGLRIFGYLHPFTDG
KIQFAIAADDNAEFWLSLDDQVSGLQLLASVGKTGKEWTAPGEFGKFRSQISKPVSLSAS
HRYYFEVLHKQNEEGTDHVEVAWRRNDPGAKFTIIDSLSLSLFTNETFLQMDEVGHIPQT
AASHVDSSNALPRDEQPPADMLRPDPRDTLYRVPLIPKSHLRHVLPDCPYKPSYLVDGLP
LQRYQGLRFVHLSFVYPNDYTRLSHMETHNKCFYQENAYYQDRFSFQEYIKIDQPEKQGL
EQPGFEENLLEESQYGEVAEETPASNNQNARMLEGRQTPASTLEQDATDYRLRSLRKLLA
QPREGLLAPFSKRNSTASFPGRTSHIPVQQPEKRKQKPSPEPSQDSPHSDKWPPGHPVKN
LPQMRGPRPRPAGDSPRKTQWLNQVESYIAEQRRGDRMRPQAPGRGWHGEEEVVAAAGQE
GQVEGEEEGEEEEEEEDMSEVFEYVPVFDPVVNWDQTFSARNLDFQALRTDWIDLSCNTS
GNLLLPEQEALEVTRVFLKKLNQRSRGRYQLQRIVNVEKRQDQLRGGRYLLELELLEQGQ
RVVRLSEYVSARGWQGIDPAGGEEVEARNLQGLVWDPHNRRRQVLNTRAQEPKLCWPQGF
SWSHRAVVHFVVPVKNQARWVQQFIKDMENLFQVTGDPHFNIVITDYSSEDMDVEMALKR
SKLRSYQYVKLSGNFERSAGLQAGIDLVKDPHSIIFLCDLHIHFPAGVIDAIRKHCVEGK
MAFAPMVMRLHCGATPQWPEGYWEVNGFGLLGIYKSDLDRIGGMNTKEFRDRWGGEDWEL
LDRILQAGLDVERLSLRNFFHHFHSKRGMWSRRQMKTL
GenBank ID Protein 38564141
UniProtKB/Swiss-Prot ID Q6L9W6
UniProtKB/Swiss-Prot Entry Name B4GN3_HUMAN
PDB IDs Not Available
GenBank Gene ID AB089940
GeneCard ID B4GALNT3
GenAtlas ID B4GALNT3
HGNC ID HGNC:24137
References
General References
  1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [PubMed:14702039 ]
  2. Scherer SE, Muzny DM, Buhay CJ, Chen R, Cree A, Ding Y, Dugan-Rocha S, Gill R, Gunaratne P, Harris RA, Hawes AC, Hernandez J, Hodgson AV, Hume J, Jackson A, Khan ZM, Kovar-Smith C, Lewis LR, Lozado RJ, Metzker ML, Milosavljevic A, Miner GR, Montgomery KT, Morgan MB, Nazareth LV, Scott G, Sodergren E, Song XZ, Steffen D, Lovering RC, Wheeler DA, Worley KC, Yuan Y, Zhang Z, Adams CQ, Ansari-Lari MA, Ayele M, Brown MJ, Chen G, Chen Z, Clerc-Blankenburg KP, Davis C, Delgado O, Dinh HH, Draper H, Gonzalez-Garay ML, Havlak P, Jackson LR, Jacob LS, Kelly SH, Li L, Li Z, Liu J, Liu W, Lu J, Maheshwari M, Nguyen BV, Okwuonu GO, Pasternak S, Perez LM, Plopper FJ, Santibanez J, Shen H, Tabor PE, Verduzco D, Waldron L, Wang Q, Williams GA, Zhang J, Zhou J, Allen CC, Amin AG, Anyalebechi V, Bailey M, Barbaria JA, Bimage KE, Bryant NP, Burch PE, Burkett CE, Burrell KL, Calderon E, Cardenas V, Carter K, Casias K, Cavazos I, Cavazos SR, Ceasar H, Chacko J, Chan SN, Chavez D, Christopoulos C, Chu J, Cockrell R, Cox CD, Dang M, Dathorne SR, David R, Davis CM, Davy-Carroll L, Deshazo DR, Donlin JE, D'Souza L, Eaves KA, Egan A, Emery-Cohen AJ, Escotto M, Flagg N, Forbes LD, Gabisi AM, Garza M, Hamilton C, Henderson N, Hernandez O, Hines S, Hogues ME, Huang M, Idlebird DG, Johnson R, Jolivet A, Jones S, Kagan R, King LM, Leal B, Lebow H, Lee S, LeVan JM, Lewis LC, London P, Lorensuhewa LM, Loulseged H, Lovett DA, Lucier A, Lucier RL, Ma J, Madu RC, Mapua P, Martindale AD, Martinez E, Massey E, Mawhiney S, Meador MG, Mendez S, Mercado C, Mercado IC, Merritt CE, Miner ZL, Minja E, Mitchell T, Mohabbat F, Mohabbat K, Montgomery B, Moore N, Morris S, Munidasa M, Ngo RN, Nguyen NB, Nickerson E, Nwaokelemeh OO, Nwokenkwo S, Obregon M, Oguh M, Oragunye N, Oviedo RJ, Parish BJ, Parker DN, Parrish J, Parks KL, Paul HA, Payton BA, Perez A, Perrin W, Pickens A, Primus EL, Pu LL, Puazo M, Quiles MM, Quiroz JB, Rabata D, Reeves K, Ruiz SJ, Shao H, Sisson I, Sonaike T, Sorelle RP, Sutton AE, Svatek AF, Svetz LA, Tamerisa KS, Taylor TR, Teague B, Thomas N, Thorn RD, Trejos ZY, Trevino BK, Ukegbu ON, Urban JB, Vasquez LI, Vera VA, Villasana DM, Wang L, Ward-Moore S, Warren JT, Wei X, White F, Williamson AL, Wleczyk R, Wooden HS, Wooden SH, Yen J, Yoon L, Yoon V, Zorrilla SE, Nelson D, Kucherlapati R, Weinstock G, Gibbs RA: The finished DNA sequence of human chromosome 12. Nature. 2006 Mar 16;440(7082):346-51. [PubMed:16541075 ]
  3. Sato T, Gotoh M, Kiyohara K, Kameyama A, Kubota T, Kikuchi N, Ishizuka Y, Iwasaki H, Togayachi A, Kudo T, Ohkura T, Nakanishi H, Narimatsu H: Molecular cloning and characterization of a novel human beta 1,4-N-acetylgalactosaminyltransferase, beta 4GalNAc-T3, responsible for the synthesis of N,N'-diacetyllactosediamine, galNAc beta 1-4GlcNAc. J Biol Chem. 2003 Nov 28;278(48):47534-44. Epub 2003 Sep 9. [PubMed:12966086 ]
  4. Ikehara Y, Sato T, Niwa T, Nakamura S, Gotoh M, Ikehara SK, Kiyohara K, Aoki C, Iwai T, Nakanishi H, Hirabayashi J, Tatematsu M, Narimatsu H: Apical Golgi localization of N,N'-diacetyllactosediamine synthase, beta4GalNAc-T3, is responsible for LacdiNAc expression on gastric mucosa. Glycobiology. 2006 Sep;16(9):777-85. Epub 2006 May 25. [PubMed:16728562 ]