Hmdb loader
Identification
HMDB Protein ID HMDBP09152
Secondary Accession Numbers
  • 14907
Name Probable allantoicase
Synonyms
  1. Allantoate amidinohydrolase
Gene Name ALLC
Protein Type Enzyme
Biological Properties
General Function Involved in allantoicase activity
Specific Function The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals.
Pathways
  • Purine metabolism
Reactions
Allantoic acid + Water → (S)-Ureidoglycolic acid + Urea details
GO Classification
Biological Process
allantoin catabolic process
Function
catalytic activity
hydrolase activity
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
allantoicase activity
Molecular Function
allantoicase activity
Cellular Location
  1. Cytoplasmic
Gene Properties
Chromosome Location 2
Locus 2q35
SNPs ALLC
Gene Sequence
>1176 bp
ATGGACATGGCATCTGAATCCGTAGGAGGAAAAATTTTATTTGCAACAGATGACTTTTTT
GCTCCTGCAGAAAACCTCATAAAGAGTGACAGCCCGTGCTTCAAAGAGCATGAATATACG
GAGTTTGGGAAATGGATGGATGGCTGGGAGACCAGGAGGAAAAGGATTCCAGGTCACGAC
TGGTGTGTCCTCAGGCTGGGGATCCAAGGAGTCATCCGGGGCTTCGACGTGGACGTTTCT
TACTTCACGGGAGATTACGCTCCTCGAGTGTCCATTCAAGCAGCAAACTTGGAAGAAGAT
AAACTACCAGAAATCCCAGAAAGAGGAACCAGGACAGGAGCTGCAGCCACTCCTGAGGAG
TTTGAAGCCATTGCTGAGCTAAAATCCGACGACTGGAGTTACTTGGTTCCCATGACTGAG
CTTAAGCCAGGAAACCCTGCTTCCGGCCACAACTATTTTCTTGTCAATTCCCAGCAGAGA
TGGACTCATATCAGACTCAACATTTTCCCAGATGGTGGAATTGCACGACTTAGAGTATTC
GGTACTGGACAAAAAGACTGGACTGCAACTGACCCCAAAGAACCTGCAGACCTAGTGGCC
ATCGCTTTTGGGGGTGTCTGTGTAGGATTTAGTAATGCTAAGTTTGGGCACCCAAACAAT
ATAATAGGAGTTGGCGGGGCAAAGTCTATGGCGGATGGTTGGGAAACTGCAAGAAGGCTG
GACCGGCCACCAATATTAGAAAATGATGAGAATGGCATTCTCTTGGTTCCGGGTTGTGAA
TGGGCAGTTTTCCGATTGGCACATCCTGGAGTAATAACTCGAATTGAAATTGACACAAAA
TATTTTGAAGGCAATGCTCCTGACAGCTGTAAAGTGGATGGGTGCATCCTGACAACTCAG
GAAGAAGAAGCCGTGATCAGGCAAAAGTGGATTCTCCCGGCCCACAAGTGGAAACCACTG
CTTCCAGTGACCAAGTTGTCTCCCAACCAAAGTCATCTGTTCGATAGCCTGACCCTAGAG
CTCCAAGATGTCATCACTCACGCCAGGCTCACCATCGTCCCCGACGGGGGAGTGAGCCGC
CTTCGGCTCCGGGGCTTCCCCAGCTCCATCTGCCTCCTGAGGCCCCGGGAGAAGCCCATG
TTGAAGTTCTCGGTGAGCTTCAAAGCAAACCCTTAA
Protein Properties
Number of Residues 410
Molecular Weight 43558.25
Theoretical pI 6.162
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Probable allantoicase
MADAPKEGRLTRFLDFTQLMDMASESVGGKILFATDDFFAPAENLIKSDSPCFKEHEYTE
FGKWMDGWETRRKRIPGHDWCVLRLGIQGVIRGFDVDVSYFTGDYAPRVSIQAANLEEDK
LPEIPERGIRTGAAATPEEFEAIAELKSDDWSYLVPMTELKPGNPASGHNYFLVNSQQRW
THIRLNIFPDGGIARLRVFGTGQKDWTATDPKEPADLVAIAFGGVCVGFSNAKFGHPNNI
IGVGGAKSMADGWETARRLDRPPILENDENGILLVPGCEWAVFRLAHPGVITRIEIDTKY
FEGNAPDSCKVDGCILTTQEEEAVIRQKWILPAHKWKPLLPVTKLSPNQSHLFDSLTLEL
QDVITHARLTIVPDGGVSRLRLRGFPSSICLLRPREKPMLKFSVSFKANP
GenBank ID Protein 144953901
UniProtKB/Swiss-Prot ID Q8N6M5
UniProtKB/Swiss-Prot Entry Name ALLC_HUMAN
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID ALLC
GenAtlas ID ALLC
HGNC ID HGNC:17377
References
General References
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  3. Vigetti D, Monetti C, Acquati F, Taramelli R, Bernardini G: Human allantoicase gene: cDNA cloning, genomic organization and chromosome localization. Gene. 2000 Oct 3;256(1-2):253-60. [PubMed:11054555 ]
  4. Vigetti D, Monetti C, Prati M, Gornati R, Bernardini G: Genomic organization and chromosome localization of the murine and human allantoicase gene. Gene. 2002 May 1;289(1-2):13-7. [PubMed:12036579 ]