Hmdb loader
Survey
Identification
HMDB Protein ID HMDBP09170
Secondary Accession Numbers
  • 14926
Name Queuine tRNA-ribosyltransferase subunit QTRTD1
Synonyms
  1. Queuine tRNA-ribosyltransferase domain-containing protein 1
Gene Name QTRTD1
Protein Type Enzyme
Biological Properties
General Function Involved in queuine tRNA-ribosyltransferase activity
Specific Function Interacts with QTRT1 to form an active queuine tRNA-ribosyltransferase. This enzyme exchanges queuine for the guanine at the wobble position of tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), thereby forming the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity).
Pathways
  • tRNA-queuosine biosynthesis
Reactions
Guanine(34) in tRNA + Queuine → queuosine(34) in tRNA + Guanine details
tRNA guanine + Queuine → tRNA queuine + Guanine details
tRNA guanine + 7-Aminomethyl-7-carbaguanine → tRNA 7-aminomethyl-7-carbaguanine + Guanine details
GO Classification
Biological Process
queuosine biosynthetic process
Cellular Component
mitochondrion
Function
catalytic activity
transferase activity
transferase activity, transferring pentosyl groups
transferase activity, transferring glycosyl groups
queuine trna-ribosyltransferase activity
Molecular Function
metal ion binding
queuine tRNA-ribosyltransferase activity
Process
rna metabolic process
ncrna metabolic process
trna metabolic process
trna processing
metabolic process
macromolecule metabolic process
cellular macromolecule metabolic process
trna modification
queuosine biosynthetic process
Cellular Location
  1. Cytoplasm
  2. Mitochondrion
Gene Properties
Chromosome Location 3
Locus 3q13.31
SNPs QTRTD1
Gene Sequence
>1248 bp
ATGAAGCTGAGTCTTACCAAGGTAGTTAATGGCTGTCGCCTAGGAAAAATAAAAAACCTG
GGCAAAACAGGGGACCACACCATGGATATTCCAGGCTGCCTTCTGTATACCAAGACTGGC
TCCGCCCCACACCTCACCCATCACACGCTGCATAATATCCACGGGGTTCCTGCCATGGCT
CAGCTTACGCTGTCATCCCTAGCAGAACATCATGAAGTCTTGACAGAATATAAAGAAGGA
GTTGGAAAGTTTATAGGCATGCCAGAATCACTCTTGTACTGCTCCCTGCACGATCCAGTC
AGCCCCTGCCCGGCTGGTTATGTAACAAACAAGTCTGTGTCTGTGTGGAGTGTTGCAGGA
CGAGTGGAAATGACTGTTTCCAAGTTCATGGCAATTCAGAAGGCCCTTCAGCCAGACTGG
TTCCAGTGCCTCTCCGATGGAGAAGTATCTTGTAAGGAAGCAACTTCCATAAAAAGGGTC
AGAAAGTCTGTTGACCGATCACTTCTTTTCTTGGATAACTGTCTGCGGCTGCAGGAAGAG
TCAGAGGTTCTTCAGAAGAGTGTGATCATTGGAGTGATTGAAGGTGGAGATGTGATGGAA
GAGAGGCTGAGGTCAGCACGAGAGACAGCCAAGCGGCCTGTGGGTGGCTTCCTTCTGGAT
GGTTTTCAAGGAAATCCAACAACCCTGGAGGCTAGACTACGCTTGCTGTCATCAGTCACT
GCAGAGCTGCCGGAGGACAAGCCAAGGCTCATATCTGGTGTTAGTCGGCCAGATGAGGTG
CTCGAGTGTATTGAAAGAGGAGTGGACTTATTTGAGAGTTTTTTCCCTTATCAAGTAACA
GAGCGGGGATGTGCCCTGACTTTCAGTTTTGATTACCAGCCGAATCCTGAAGAGACACTA
CTACAACAAAATGGAACACAAGAAGAAATAAAATGTATGGATCAAATAAAGAAAATTGAA
ACAACTGGTTGCAACCAAGAAATAACATCATTTGAAATTAATCTGAAGGAAAAAAAGTAC
CAGGAGGACTTTAACCCGCTGGTGAGAGGATGTTCCTGTTACTGCTGTAAGAATCACACT
CGGGCATACATCCACCATCTGCTGGTGACCAATGAGCTGCTGGCCGGAGTCCTGCTTATG
ATGCACAACTTTGAACACTACTTTGGGTTTTTCCATTACATCCGGGAAGCACTAAAAAGT
GACAAACTGGCACAGTTGAAAGAGCTCATCCACAGGCAAGCATCTTGA
Protein Properties
Number of Residues 415
Molecular Weight 48203.07
Theoretical pI 6.617
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Queuine tRNA-ribosyltransferase subunit QTRTD1
MKLSLTKVVNGCRLGKIKNLGKTGDHTMDIPGCLLYTKTGSAPHLTHHTLHNIHGVPAMA
QLTLSSLAEHHEVLTEYKEGVGKFIGMPESLLYCSLHDPVSPCPAGYVTNKSVSVWSVAG
RVEMTVSKFMAIQKALQPDWFQCLSDGEVSCKEATSIKRVRKSVDRSLLFLDNCLRLQEE
SEVLQKSVIIGVIEGGDVMEERLRSARETAKRPVGGFLLDGFQGNPTTLEARLRLLSSVT
AELPEDKPRLISGVSRPDEVLECIERGVDLFESFFPYQVTERGCALTFSFDYQPNPEETL
LQQNGTQEEIKCMDQIKKIETTGCNQEITSFEINLKEKKYQEDFNPLVRGCSCYCCKNHT
RAYIHHLLVTNELLAGVLLMMHNFEHYFGFFHYIREALKSDKLAQLKELIHRQAS
GenBank ID Protein 13375872
UniProtKB/Swiss-Prot ID Q9H974
UniProtKB/Swiss-Prot Entry Name QTRD1_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_024638.2
GeneCard ID QTRTD1
GenAtlas ID QTRTD1
HGNC ID HGNC:25771
References
General References
  1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [PubMed:14702039 ]
  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  3. Muzny DM, Scherer SE, Kaul R, Wang J, Yu J, Sudbrak R, Buhay CJ, Chen R, Cree A, Ding Y, Dugan-Rocha S, Gill R, Gunaratne P, Harris RA, Hawes AC, Hernandez J, Hodgson AV, Hume J, Jackson A, Khan ZM, Kovar-Smith C, Lewis LR, Lozado RJ, Metzker ML, Milosavljevic A, Miner GR, Morgan MB, Nazareth LV, Scott G, Sodergren E, Song XZ, Steffen D, Wei S, Wheeler DA, Wright MW, Worley KC, Yuan Y, Zhang Z, Adams CQ, Ansari-Lari MA, Ayele M, Brown MJ, Chen G, Chen Z, Clendenning J, Clerc-Blankenburg KP, Chen R, Chen Z, Davis C, Delgado O, Dinh HH, Dong W, Draper H, Ernst S, Fu G, Gonzalez-Garay ML, Garcia DK, Gillett W, Gu J, Hao B, Haugen E, Havlak P, He X, Hennig S, Hu S, Huang W, Jackson LR, Jacob LS, Kelly SH, Kube M, Levy R, Li Z, Liu B, Liu J, Liu W, Lu J, Maheshwari M, Nguyen BV, Okwuonu GO, Palmeiri A, Pasternak S, Perez LM, Phelps KA, Plopper FJ, Qiang B, Raymond C, Rodriguez R, Saenphimmachak C, Santibanez J, Shen H, Shen Y, Subramanian S, Tabor PE, Verduzco D, Waldron L, Wang J, Wang J, Wang Q, Williams GA, Wong GK, Yao Z, Zhang J, Zhang X, Zhao G, Zhou J, Zhou Y, Nelson D, Lehrach H, Reinhardt R, Naylor SL, Yang H, Olson M, Weinstock G, Gibbs RA: The DNA sequence, annotation and analysis of human chromosome 3. Nature. 2006 Apr 27;440(7088):1194-8. [PubMed:16641997 ]