Hmdb loader
Identification
HMDB Protein ID HMDBP09197
Secondary Accession Numbers
  • 14971
Name Pseudouridylate synthase 7 homolog-like protein
Synonyms Not Available
Gene Name PUS7L
Protein Type Enzyme
Biological Properties
General Function Involved in RNA binding
Specific Function tRNA uridine = tRNA pseudouridine
Pathways Not Available
Reactions Not Available
GO Classification
Function
binding
catalytic activity
nucleic acid binding
isomerase activity
pseudouridine synthase activity
intramolecular transferase activity
rna binding
Process
rna metabolic process
metabolic process
macromolecule metabolic process
cellular macromolecule metabolic process
rna modification
pseudouridine synthesis
Cellular Location
  1. Cytoplasmic
Gene Properties
Chromosome Location Chromosome:1
Locus 12q12
SNPs PUS7L
Gene Sequence
>2106 bp
ATGGAAGAAGATACAGATTATAGAATCAGGTTTAGTTCTTTGTGTTTCTTTAATGATCAC
GTTGGATTTCATGGCACTATAAAAAGCTCACCAAGTGACTTTATTGTTATTGAAATTGAT
GAACAGGGACAGTTAGTTAATAAGACCATCGATGAGCCTATTTTCAAGATTAGTGAAATA
CAACTTGAGCCAAATAATTTTCCCAAAAAACCAAAACTAGATCTTCAAAATCTGTCCTTA
GAAGATGGAAGAAACCAAGAAGTTCATACTTTGATTAAGTACACTGATGGTGACCAAAAT
CATCAGTCTGGTTCAGAAAAGGAAGATACTATCGTTGATGGAACTTCCAAATGTGAAGAA
AAAGCTGATGTTTTAAGCTCCTTTTTGGATGAAAAAACTCATGAGTTACTGAATAATTTT
GCCTGTGATGTAAGAGAGAAGTGGCTTTCTAAAACAGAGCTAATTGGACTACCTCCTGAA
TTCTCAATAGGCAGAATCCTTGACAAAAACCAGAGGGCTAGTTTACACAGTGCCATTAGG
CAGAAATTTCCATTTTTAGTAACTGTAGGAAAAAACAGTGAAATTGTTGTAAAACCAAAT
CTTGAATATAAAGAACTTTGTCATTTGGTATCTGAAGAGGAAGCATTTGACTTTTTTAAA
TATTTGGATGCAAAGAAAGAAAATTCCAAATTTACCTTTAAACCTGATACAAACAAAGAC
CACAGAAAAGCTGTCCACCATTTTGTCAACAAAAAGTTTGGAAACCTTGTGGAAACCAAA
TCTTTTTCTAAAATGAATTGCAGTGCTGGTAATCCGAATGTGGTGGTAACAGTAAGATTT
CGGGAAAAAGCACACAAACGTGGGAAAAGGCCTCTTTCTGAATGCCAAGAAGGAAAAGTT
ATATATACAGCTTTTACCCTACGAAAGGAAAACCTGGAAATGTTTGAAGCGATTGGTTTT
TTAGCTATCAAACTTGGTGTTATTCCTTCGGATTTTAGTTATGCAGGCCTTAAAGACAAG
AAAGCCATCACCTATCAAGCAATGGTTGTTAGAAAAGTGACTCCAGAGAGGTTGAAAAAT
ATTGAAAAAGAAATTGAAAAGAAAAGAATGAATGTCTTTAATATTCGGTCTGTAGATGAT
TCCCTGAGACTTGGTCAGCTCAAAGGAAATCACTTTGATATTGTCATTAGAAATTTAAAA
AAACAAATAAATGATTCTGCAAACCTGAGGGAGAGAATTATGGAAGCAATAGAAAATGTT
AAGAAAAAAGGCTTTGTGAATTACTATGGACCACAGAGATTTGGGAAGGGAAGGAAAGTT
CACACAGACCAAATTGGACTAGCTTTGCTGAAGAATGAAATGATGAAAGCCATAAAATTG
TTTCTTACACCAGAAGACTTGGATGATCCTGTAAATAGAGCAAAGAAGTATTTTCTTCAA
ACTGAGGATGCTAAAGGCACACTTTCATTGATGCCTGAATTCAAAGTGCGTGAGAGAGCA
TTGTTGGAGGCATTGCACCGCTTTGGCATGACCGAGGAAGGTTGTATCCAGGCATGGTTC
TCTTTACCCCATTCCATGCGCATATTCTATGTTCACGCATATACCAGCAAAATTTGGAAT
GAGGCAGTATCTTACAGACTTGAAACCTATGGAGCAAGAGTAGTGCAGGGTGATTTGGTC
TGTTTGGATGAAGACATTGATGACGAGAATTTCCCAAATAGTAAAATTCACCTGGTAACT
GAAGAGGAGGGATCAGCTAATATGTATGCAATACATCAGGTGGTTCTTCCAGTACTTGGA
TACAATATTCAGTACCCGAAGAACAAAGTAGGGCAGTGGTACCATGACATACTTAGCAGA
GATGGACTACAGACATGTAGGTTTAAAGTACCTACTCTGAAACTGAATATACCAGGTTGC
TATAGACAGATTTTGAAACATCCCTGTAATCTCTCATACCAACTAATGGAAGATCATGAC
ATTGATGTCAAAACGAAAGGTTCCCACATTGATGAAACAGCTTTGTCTCTTTTGATCTCT
TTTGATCTTGATGCTTCATGCTATGCTACCGTTTGTCTGAAGGAAATAATGAAGCATGAC
GTTTAA
Protein Properties
Number of Residues 701
Molecular Weight 80699.9
Theoretical pI 7.61
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Pseudouridylate synthase 7 homolog-like protein
MEEDTDYRIRFSSLCFFNDHVGFHGTIKSSPSDFIVIEIDEQGQLVNKTIDEPIFKISEI
QLEPNNFPKKPKLDLQNLSLEDGRNQEVHTLIKYTDGDQNHQSGSEKEDTIVDGTSKCEE
KADVLSSFLDEKTHELLNNFACDVREKWLSKTELIGLPPEFSIGRILDKNQRASLHSAIR
QKFPFLVTVGKNSEIVVKPNLEYKELCHLVSEEEAFDFFKYLDAKKENSKFTFKPDTNKD
HRKAVHHFVNKKFGNLVETKSFSKMNCSAGNPNVVVTVRFREKAHKRGKRPLSECQEGKV
IYTAFTLRKENLEMFEAIGFLAIKLGVIPSDFSYAGLKDKKAITYQAMVVRKVTPERLKN
IEKEIEKKRMNVFNIRSVDDSLRLGQLKGNHFDIVIRNLKKQINDSANLRERIMEAIENV
KKKGFVNYYGPQRFGKGRKVHTDQIGLALLKNEMMKAIKLFLTPEDLDDPVNRAKKYFLQ
TEDAKGTLSLMPEFKVRERALLEALHRFGMTEEGCIQAWFSLPHSMRIFYVHAYTSKIWN
EAVSYRLETYGARVVQGDLVCLDEDIDDENFPNSKIHLVTEEEGSANMYAIHQVVLPVLG
YNIQYPKNKVGQWYHDILSRDGLQTCRFKVPTLKLNIPGCYRQILKHPCNLSYQLMEDHD
IDVKTKGSHIDETALSLLISFDLDASCYATVCLKEIMKHDV
GenBank ID Protein 12053035
UniProtKB/Swiss-Prot ID Q9H0K6
UniProtKB/Swiss-Prot Entry Name PUS7L_HUMAN
PDB IDs Not Available
GenBank Gene ID AL136759
GeneCard ID PUS7L
GenAtlas ID PUS7L
HGNC ID HGNC:25276
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A: Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. Genome Res. 2001 Mar;11(3):422-35. [PubMed:11230166 ]
  3. Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. [PubMed:17974005 ]