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Identification
HMDB Protein ID HMDBP09203
Secondary Accession Numbers
  • 14977
Name Probable tRNA pseudouridine synthase 2
Synonyms Not Available
Gene Name TRUB2
Protein Type Enzyme
Biological Properties
General Function Involved in RNA processing
Specific Function May be responsible for synthesis of pseudouridine from uracil in transfer RNAs
Pathways Not Available
Reactions Not Available
GO Classification
Function
binding
catalytic activity
nucleic acid binding
isomerase activity
pseudouridine synthase activity
intramolecular transferase activity
rna binding
Process
rna metabolic process
metabolic process
macromolecule metabolic process
cellular macromolecule metabolic process
rna processing
rna modification
pseudouridine synthesis
Cellular Location
  1. Cytoplasmic
Gene Properties
Chromosome Location Chromosome:9
Locus 9q34.11
SNPs TRUB2
Gene Sequence
>996 bp
ATGGGGTCTGCTGGCTTGTCGCGGCTGCATGGGCTTTTCGCGGTCTATAAGCCCCCGGGG
CTAAAATGGAAGCACCTGCGGGATACAGTGGAGCTACAACTTCTGAAGGGTCTCAATGCC
AGGAAGCCTCCCGCTCCTAAACAGCGTGTTCGCTTCTTGCTGGGCCCCATGGAAGGCAGC
GAAGAGAAGGAGCTGACCCTCACAGCCACCAGCGTACCCTCTTTCATCAACCATCCACTG
GTATGTGGACCAGCATTCGCCCATCTCAAGGTTGGCGTGGGACATCGGTTGGATGCCCAG
GCTTCTGGAGTACTTGTGCTCGGCGTGGGACATGGATGCAGGCTCCTCACCGATATGTAC
AATGCTCATCTTACCAAGGATTACACAGTGCGTGGCCTCCTGGGCAAAGCTACAGATGAC
TTCCGTGAGGACGGGAGGCTGGTAGAGAAGACAACCTATGACCACGTGACCAGAGAGAAG
CTGGACCGCATTCTGGCCGTTATCCAAGGCTCCCATCAGAAGGCCCTGGTGATGTACTCC
AACCTCGACCTGAAGACCCAGGAGGCCTATGAGATGGCCGTGAGAGGCCTGATCCGGCCC
ATGAACAAGTCCCCGATGCTGATAACTGGCATCCGATGCCTCTACTTTGCACCTCCGGAA
TTCCTCTTAGAGGTGCAGTGCATGCATGAGACGCAGAAAGAGCTGCGGAAGTTGGTTCAT
GAAATCGGCCTGGAACTAAAGACCACTGCTGTCTGCACCCAAGTGCGGCGCACGCGCGAC
GGCTTCTTCACGCTAGACAGTGCCCTCCTGAGGACCCAGTGGGACCTAACCAACATCCAG
GATGCTATCCGGGCTGCTACCCCTCAGGTAGCTGCAGAGCTGGAGAAGAGCTTGAGCCCG
GGGCTGGACACCAAGCAGCTCCCCAGTCCGGGATGGTCCTGGGACTCCCAGGGCCCGAGC
TCTACCTTGGGGCTGGAGAGGGGTGCGGGGCAGTGA
Protein Properties
Number of Residues 331
Molecular Weight 36694.1
Theoretical pI 9.36
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Probable tRNA pseudouridine synthase 2
MGSAGLSRLHGLFAVYKPPGLKWKHLRDTVELQLLKGLNARKPPAPKQRVRFLLGPMEGS
EEKELTLTATSVPSFINHPLVCGPAFAHLKVGVGHRLDAQASGVLVLGVGHGCRLLTDMY
NAHLTKDYTVRGLLGKATDDFREDGRLVEKTTYDHVTREKLDRILAVIQGSHQKALVMYS
NLDLKTQEAYEMAVRGLIRPMNKSPMLITGIRCLYFAPPEFLLEVQCMHETQKELRKLVH
EIGLELKTTAVCTQVRRTRDGFFTLDSALLRTQWDLTNIQDAIRAATPQVAAELEKSLSP
GLDTKQLPSPGWSWDSQGPSSTLGLERGAGQ
GenBank ID Protein 4406691
UniProtKB/Swiss-Prot ID O95900
UniProtKB/Swiss-Prot Entry Name TRUB2_HUMAN
PDB IDs Not Available
GenBank Gene ID AF131848
GeneCard ID TRUB2
GenAtlas ID TRUB2
HGNC ID HGNC:17170
References
General References
  1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [PubMed:14702039 ]
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  3. Humphray SJ, Oliver K, Hunt AR, Plumb RW, Loveland JE, Howe KL, Andrews TD, Searle S, Hunt SE, Scott CE, Jones MC, Ainscough R, Almeida JP, Ambrose KD, Ashwell RI, Babbage AK, Babbage S, Bagguley CL, Bailey J, Banerjee R, Barker DJ, Barlow KF, Bates K, Beasley H, Beasley O, Bird CP, Bray-Allen S, Brown AJ, Brown JY, Burford D, Burrill W, Burton J, Carder C, Carter NP, Chapman JC, Chen Y, Clarke G, Clark SY, Clee CM, Clegg S, Collier RE, Corby N, Crosier M, Cummings AT, Davies J, Dhami P, Dunn M, Dutta I, Dyer LW, Earthrowl ME, Faulkner L, Fleming CJ, Frankish A, Frankland JA, French L, Fricker DG, Garner P, Garnett J, Ghori J, Gilbert JG, Glison C, Grafham DV, Gribble S, Griffiths C, Griffiths-Jones S, Grocock R, Guy J, Hall RE, Hammond S, Harley JL, Harrison ES, Hart EA, Heath PD, Henderson CD, Hopkins BL, Howard PJ, Howden PJ, Huckle E, Johnson C, Johnson D, Joy AA, Kay M, Keenan S, Kershaw JK, Kimberley AM, King A, Knights A, Laird GK, Langford C, Lawlor S, Leongamornlert DA, Leversha M, Lloyd C, Lloyd DM, Lovell J, Martin S, Mashreghi-Mohammadi M, Matthews L, McLaren S, McLay KE, McMurray A, Milne S, Nickerson T, Nisbett J, Nordsiek G, Pearce AV, Peck AI, Porter KM, Pandian R, Pelan S, Phillimore B, Povey S, Ramsey Y, Rand V, Scharfe M, Sehra HK, Shownkeen R, Sims SK, Skuce CD, Smith M, Steward CA, Swarbreck D, Sycamore N, Tester J, Thorpe A, Tracey A, Tromans A, Thomas DW, Wall M, Wallis JM, West AP, Whitehead SL, Willey DL, Williams SA, Wilming L, Wray PW, Young L, Ashurst JL, Coulson A, Blocker H, Durbin R, Sulston JE, Hubbard T, Jackson MJ, Bentley DR, Beck S, Rogers J, Dunham I: DNA sequence and analysis of human chromosome 9. Nature. 2004 May 27;429(6990):369-74. [PubMed:15164053 ]
  4. Zucchini C, Strippoli P, Biolchi A, Solmi R, Lenzi L, D'Addabbo P, Carinci P, Valvassori L: The human TruB family of pseudouridine synthase genes, including the Dyskeratosis Congenita 1 gene and the novel member TRUB1. Int J Mol Med. 2003 Jun;11(6):697-704. [PubMed:12736709 ]