Hmdb loader
Identification
HMDB Protein ID HMDBP09215
Secondary Accession Numbers
  • 14997
Name N-acetylated-alpha-linked acidic dipeptidase-like protein
Synonyms
  1. 100 kDa ileum brush border membrane protein
  2. I100
  3. Ileal dipeptidylpeptidase
  4. NAALADase L
Gene Name NAALADL1
Protein Type Enzyme
Biological Properties
General Function Involved in peptidase activity
Specific Function NAALADase-like activity unknown. Has no NAAG hydrolyzing activity. Exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC
Pathways Not Available
Reactions Not Available
GO Classification
Function
catalytic activity
hydrolase activity
peptidase activity
Process
metabolic process
macromolecule metabolic process
protein metabolic process
proteolysis
Cellular Location
  1. Single-pass type II membrane protein
  2. Apical cell membrane
Gene Properties
Chromosome Location Chromosome:1
Locus 11q12
SNPs NAALADL1
Gene Sequence
>2223 bp
ATGCAGTGGACGAAGGTGTTGGGGCTGGGGCTGGGGGCTGCTGCCCTCTTGGGGCTGGGG
ATCATCCTCGGCCACTTTGCCATCCCCAAAAAAGCCAACTCACTGGCCCCCCAGGACCTG
GACCTGGAGATCCTGGAGACCGTCATGGGGCAGCTGGATGCCCACAGGATCCGGGAGAAC
CTCAGAGAACTCTCCAGGGAGCCACACCTGGCCTCCAGCCCTCGGGATGAGGACCTGGTG
CAGCTGCTGCTGCAGCGCTGGAAGGACCCAGAGTCAGGCCTGGACTCGGCCGAGGCCTCC
ACGTACGAAGTGCTGCTGTCCTTCCCTAGCCAGGAGCAGCCCAACGTCGTGGACATCGTG
GGCCCCACTGGGGGCATCATCCACTCCTGCCACCGGACTGAGGAGAACGTGACCGGGGAG
CAAGGGGGGCCAGATGTGGTACAACCCTATGCTGCCTATGCTCCTTCTGGAACCCCACAG
GGCCTCCTCGTCTATGCCAACCGGGGCGCGGAAGAAGACTTTAAGGAGCTACAGACTCAG
GGCATCAAACTTGAAGGCACCATTGCCCTGACTCGATATGGGGGTGTAGGGCGTGGGGCC
AAGGCTGTGAACGCTGCCAAGCACGGGGTAGCTGGGGTGCTGGTGTACACAGACCCTGCC
GACATCAACGATGGGCTGAGCTCACCCGACGAAACCTTTCCCAACTCCTGGTACCTGCCC
CCCTCAGGAGTGGAGCGAGGCTCCTACTACGAGTATTTTGGGGACCCTCTGACTCCCTAC
CTTCCAGCCGTCCCCTCTTCCTTCCGCGTGGACCTTGCCAATGTCTCCGGATTTCCCCCA
ATTCCTACACAGCCCATTGGCTTCCAGGATGCAAGAGACCTGCTCTGTAACCTCAACGGA
ACTTTGGCCCCAGCCACCTGGCAGGGAGCACTGGGCTGCCACTACAGGTTGGGTCCCGGC
TTCCGGCCTGACGGAGACTTCCCAGCAGACAGCCAGGTGAATGTGAGCGTCTACAACCGC
CTGGAGCTGAGGAACTCTTCCAACGTCCTGGGCATCATCCGTGGGGCTGTGGAGCCTGAT
CGCTACGTGCTGTATGGGAACCACCGAGACAGCTGGGTGCACGGGGCTGTGGACCCCAGC
AGTGGCACCGCCGTCCTCCTGGAGCTCTCCCGTGTCCTGGGGACCCTGCTGAAGAAGGGC
ACCTGGCGTCCTCGCAGATCAATCGTGTTTGCGAGCTGGGGGGCTGAGGAGTTTGGGCTC
ATTGGCTCCACGGAATTCACAGAAGAGTTCTTCAACAAGCTGCAGGAGCGCACGGTGGCC
TACATCAACGTGGACATCTCGGTGTTTGCCAACGCTACCCTTAGGGTGCAGGGGACGCCC
CCTGTCCAGAGCGTCGTCTTCTCTGCAACCAAAGAGATCCGCTCACCAGGCCCTGGCGAC
CTGAGCATCTACGACAACTGGATCCGGTACTTCAACCGCAGCAGCCCGGTGTACGGCCTG
GTCCCCAGCTTGGGTTCTCTGGGTGCTGGCAGCGACTATGCACCCTTCGTTCACTTCCTG
GGCATCTCCTCCATGGACATTGCCTATACCTATGACCGGAGCAAGACTTCAGCCAGGATC
TACCCCACCTACCACACAGCCTTTGACACCTTTGACTATGTGGACAAGTTTTTGGACCCG
GGCTTCAGCAGCCATCAGGCTGTGGCCCGGACAGCGGGGAGTGTGATTCTCCGGCTCAGT
GACAGCTTCTTCCTGCCCCTCAAAGTCAGTGACTACAGTGAGACACTCCGCAGCTTCCTG
CAGGCAGCCCAGCAAGATCTTGGGGCCCTGCTGGAGCAGCACAGCATCAGCCTGGGGCCT
CTGGTGACTGCAGTGGAGAAGTTTGAGGCAGAAGCTGCAGCCTTGGGCCAACGCATATCA
ACACTGCAGAAGGGCAGCCCTGACCCCCTGCAGGTCCGGATGCTCAATGACCAGTTGATG
CTCTTGGAACGGACCTTTCTGAACCCTAGAGCCTTCCCAGAGGAACGCTACTACAGCCAT
GTGCTCTGGGCACCTCGCACGGGCTCCGTAGTCACATTCCCGGGCCTATCCAATGCCTGC
TCCAGGGCCAGGGACACAGCTTCTGGATCTGAAGCTTGGGCTGAGGTCCAGAGACAGCTC
AGCATTGTGGTGACAGCCCTGGAGGGTGCGGCAGCCACCCTGAGGCCTGTGGCTGACCTC
TGA
Protein Properties
Number of Residues 740
Molecular Weight 80566.9
Theoretical pI 5.14
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • 7-28
Protein Sequence
>N-acetylated-alpha-linked acidic dipeptidase-like protein
MQWTKVLGLGLGAAALLGLGIILGHFAIPKKANSLAPQDLDLEILETVMGQLDAHRIREN
LRELSREPHLASSPRDEDLVQLLLQRWKDPESGLDSAEAXTYEVLLSFPSQEQPNVVDIV
GPTGGIIHSCHRTEENVTGEQGGPDVVQPYAAYAPSGTPQGLLVYANRGAEEDFKELQTQ
GIKLEGTIALTRYGGVGRGAKAVNAAKHGVAGVLVYTDPADINDGLSSPDETFPNSWYLP
PSGVERGSYYEYFGDPLTPYLPAVPSSFRVDLANVSGFPPIPTQPIGFQDARDLLCNLNG
TLAPATWQGALGCHYRLGPGFRPDGDFPADSQVNVSVYNRLELRNSSNVLGIIRGAVEPD
RYVLYGNHRDSWVHGAVDPSSGTAVLLELSRVLGTLLKKGTWRPRRSIVFASWGAEEFGL
IGSTEFTEEFFNKLQERTVAYINVDISVFANATLRVQGTPPVQSVVFSATKEIRSPGPGD
LSIYDNWIRYFNRSSPVYGLVPSLGSLGAGSDYAPFVHFLGISSMDIAYTYDRSKTSARI
YPTYHTAFDTFDYVDKFLDPGFSSHQAVARTAGSVILRLSDSFFLPLKVSDYSETLRSFL
QAAQQDLGALLEQHSISLGPLVTAVEKFEAEAAALGQRISTLQKGSPDPLQVRMLNDQLM
LLERTFLNPRAFPEERYYSHVLWAPSHGLRSHIPGLSNACSRARDTASGSEAWAEVQRQL
SIVVTALEGAAATLRPVADL
GenBank ID Protein 57232740
UniProtKB/Swiss-Prot ID Q9UQQ1
UniProtKB/Swiss-Prot Entry Name NALDL_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_005468.2
GeneCard ID NAALADL1
GenAtlas ID NAALADL1
HGNC ID HGNC:23536
References
General References
  1. Pangalos MN, Neefs JM, Somers M, Verhasselt P, Bekkers M, van der Helm L, Fraiponts E, Ashton D, Gordon RD: Isolation and expression of novel human glutamate carboxypeptidases with N-acetylated alpha-linked acidic dipeptidase and dipeptidyl peptidase IV activity. J Biol Chem. 1999 Mar 26;274(13):8470-83. [PubMed:10085079 ]
  2. Shneider BL, Thevananther S, Moyer MS, Walters HC, Rinaldo P, Devarajan P, Sun AQ, Dawson PA, Ananthanarayanan M: Cloning and characterization of a novel peptidase from rat and human ileum. J Biol Chem. 1997 Dec 5;272(49):31006-15. [PubMed:9388249 ]