Hmdb loader
Identification
HMDB Protein ID HMDBP09221
Secondary Accession Numbers
  • 15037
  • HMDBP09227
Name Dehydrodolichyl diphosphate synthase
Synonyms
  1. Dedol-PP synthase
  2. Cis-isoprenyltransferase
  3. Epididymis tissue protein Li 189m
  4. CIT
  5. Cis-IPTase
Gene Name DHDDS
Protein Type Enzyme
Biological Properties
General Function Involved in transferase activity, transferring alkyl or aryl (other than methyl) groups
Specific Function Catalyzes cis-prenyl chain elongation to produce the polyprenyl backbone of dolichol, a glycosyl carrier-lipid required for the biosynthesis of several classes of glycoprotein.
Pathways
  • protein glycosylation
  • Terpenoid backbone biosynthesis
Reactions
Farnesyl pyrophosphate + → Dehydrodolichol diphosphate + details
GO Classification
Biological Process
protein glycosylation
Cellular Component
endoplasmic reticulum membrane
Function
catalytic activity
transferase activity
transferase activity, transferring alkyl or aryl (other than methyl) groups
Molecular Function
transferase activity, transferring alkyl or aryl (other than methyl) groups
Process
physiological process
metabolism
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs DHDDS
Gene Sequence
>1002 bp
ATGTCATGGATCAAGGAAGGAGAGCTGTCACTTTGGGAGCGGTTCTGTGCCAACATCATA
AAGGCAGGCCCAATGCCGAAACACATTGCATTCATAATGGACGGGAACCGTCGCTATGCC
AAGAAGTGCCAGGTGGAGCGGCAGGAAGGCCACTCACAGGGCTTCAACAAGCTAGCTGAG
ACTCTGCGGTGGTGTTTGAACCTGGGCATCCTAGAGGTGACAGTCTACGCATTCAGCATT
GAGAACTTCAAACGCTCCAAGAGTGAGGTAGACGGGCTTATGGATCTGGCCCGGCAGAAG
TTCAGCCGCTTGATGGAAGAAAAGGAGAAACTGCAGAAGCATGGGGTGTGTATCCGGGTC
CTGGGCGATCTGCACTTGTTGCCCTTGGATCTCCAGGAGCTGATTGCACAAGCTGTACAG
GCCACGAAGAACTACAACAAGTGTTTCCTGAATGTCTGTTTTGCATACACATCCCGTCAT
GAGATCAGCAATGCTGTGAGAGAGATGGCCTGGGGGGTGGAGCAAGGCCTGTTGGATCCC
AGTGATATCTCTGAGTCTCTGCTTGATAAGTGCCTCTATACCAACCGCTCTCCTCATCCT
GACATCTTGATACGGACTTCTGGAGAAGTGCGGCTGAGTGACTTCTTGCTATGGCAGACC
TCTCACTCCTGCCTGGTGTTCCAACCCGTTCTGTGGCCAGAGTATACATTTTGGAACCTC
TTCGAGGCCATCCTGCAGTTCCAGATGAACCATAGCGTGCTTCAGAAGGCCCGAGACATG
TATGCAGAGGAGCGGAAGAGGCAGCAGCTGGAGAGGGACCAGGCTACAGTGACAGAGCAG
CTGCTGCGAGAGGGGCTCCAAGCCAGTGGGGACGCCCAGCTCCGAAGGACACGCTTGCAC
AAACTCTCGGCCAGACGGGAAGAGCGAGTCCAAGGCTTCCTGCAGGCCTTGGAACTCAAG
CGAGCTGACTGGCTGGCCCGTCTGGGCACTGCATCAGCCTGA
Protein Properties
Number of Residues 333
Molecular Weight Not Available
Theoretical pI Not Available
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Dehydrodolichyl diphosphate synthase
MSWIKEGELSLWERFCANIIKAGPMPKHIAFIMDGNRRYAKKCQVERQEGHSQGFNKLAE
TLRWCLNLGILEVTVYAFSIENFKRSKSEVDGLMDLARQKFSRLMEEKEKLQKHGVCIRV
LGDLHLLPLDLQELIAQAVQATKNYNKCFLNVCFAYTSRHEISNAVREMAWGVEQGLLDP
SDISESLLDKCLYTNRSPHPDILIRTSGEVRLSDFLLWQTSHSCLVFQPVLWPEYTFWNL
FEAILQFQMNHSVLQKARDMYAEERKRQQLERDQATVTEQLLREGLQASGDAQLRRTRLH
KLSARREERVQGFLQALELKRADWLARLGTASA
GenBank ID Protein 28557344
UniProtKB/Swiss-Prot ID Q86SQ9
UniProtKB/Swiss-Prot Entry Name DHDDS_HUMAN
PDB IDs Not Available
GenBank Gene ID AB090852
GeneCard ID DHDDS
GenAtlas ID DHDDS
HGNC ID HGNC:20603
References
General References
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