Hmdb loader
Identification
HMDB Protein ID HMDBP09273
Secondary Accession Numbers
  • 15101
Name E3 ubiquitin-protein ligase MGRN1
Synonyms
  1. Mahogunin RING finger protein 1
  2. RING finger protein 156
Gene Name MGRN1
Protein Type Enzyme
Biological Properties
General Function Involved in protein binding
Specific Function E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to- lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination
Pathways Not Available
Reactions Not Available
GO Classification
Function
ion binding
cation binding
metal ion binding
binding
transition metal ion binding
zinc ion binding
protein binding
Cellular Location
  1. Cell membrane
  2. cytosol
  3. Isoform 4:Cytoplasm
Gene Properties
Chromosome Location Chromosome:1
Locus 16p13.3
SNPs MGRN1
Gene Sequence
>1659 bp
ATGGGCTCCATTCTCAGCCGCCGCATCGCGGGGGTGGAGGACATCGACATCCAGGCGAAC
TCGGCCTATCGCTACCCTCCGAAGTCCGGAAACTACTTTGCTTCGCACTTTTTCATGGGA
GGAGAGAAATTCGACACCCCCCACCCTGAAGGTTACCTCTTTGGAGAGAACATGGATCTG
AACTTCCTGGGCAGCCGCCCGGTCCAGTTTCCCTACGTCACTCCTGCCCCCCACGAGCCC
GTGAAGACGCTGCGGAGCCTGGTGAACATCCGCAAAGACTCCCTGCGGCTGGTGAGGTAC
AAAGACGATGCCGACAGCCCCACCGAGGACGGCGACAAGCCCCGGGTGCTCTACAGCCTG
GAGTTCACCTTCGACGCCGATGCCCGCGTGGCCATCACCATCTACTGCCAGGCATCGGAG
GAGTTCCTGAACGGCAGGGCAGTATACAGCCCCAAGAGCCCCTCGCTACAGTCCGAGACC
GTCCACTACAAGAGAGGGGTGAGCCAGCAGTTCTCCCTGCCCTCCTTCAAGATTGACTTC
TCGGAATGGAAGGATGACGAGCTGAACTTTGACCTGGACCGGGGCGTGTTTCCAGTAGTC
ATCCAGGCTGTGGTGGACGAAGGAGATGTGGTGGAAGTGACTGGCCACGCCCACGTGCTC
TTGGCTGCCTTTGAAAAGCACATGGACGGCAGCTTCTCTGTGAAGCCTTTAAAGCAGAAG
CAAATTGTGGACCGGGTCAGCTACCTCCTGCAGGAGATCTATGGCATTGAGAACAAGAAC
AACCAGGAGACCAAGCCCTCGGACGACGAGAACAGCGACAACAGCAACGAGTGTGTGGTG
TGCCTGTCCGACCTGCGGGACACGCTGATCCTGCCCTGCCGCCACCTGTGCCTCTGTACC
TCCTGCGCCGACACGCTGCGCTACCAGGCCAACAACTGCCCCATCTGCCGGCTGCCTTTC
CGGGCCCTCCTGCAGATCCGGGCGGTGCGGAAGAAGCCAGGAGCCCTGTCCCCCGTGTCC
TTCAGCCCCGTCCTGGCCCAGAGCCTGGAGCATGATGAGCACTCTTGTCCCTTTAAAAAA
TCAAAGCCGCACCCCGCCTCCCTGGCCAGCAAGAAACCTAAAAGGGAAACAAACTCTGAC
AGCGTCCCACCTGGCTACGAGCCCATCTCGCTGCTCGAGGCGCTCAACGGCCTCCGGGCT
GTCTCCCCGGCCATCCCCTCGGCCCCTCTTTATGAAGAAATCACCTATTCAGGCATCTCG
GACGGCCTGTCCCAGGCCAGCTGTCCCCTCGCGGCTATCGACCACATCCTGGACAGCAGC
CGCCAGAAGGGCAGGCCGCAGAGCAAGGCCCCCGACAGCACCCTACGGTCCCCGTCTTCC
CCCATCCACGAAGAGGATGAGGAGAAGCTCTCCGAGGACGTGGACGCCCCTCCCCCACTG
GGTGGCGCAGAGCTGGCCCTGCGGGAAAGCAGCTCCCCTGAGAGTTTCATAACAGAAGAG
GTTGATGAGTCGTCGTCACCACAGCAAGGGACCCGAGCAGCTTCCATTGAGAATGTCCTG
CAGGACAGCAGCCCCGAGCACTGTGGCCGAGGCCCACCTGCTGACATCTACCTGCCAGCC
CTGGGGCCCGACTCCTGCTCTGTTGGTATAGACGAGTAA
Protein Properties
Number of Residues 552
Molecular Weight 60752.2
Theoretical pI 4.77
Pfam Domain Function Not Available
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>E3 ubiquitin-protein ligase MGRN1
MGSILSRRIAGVEDIDIQANSAYRYPPKSGNYFASHFFMGGEKFDTPHPEGYLFGENMDL
NFLGSRPVQFPYVTPAPHEPVKTLRSLVNIRKDSLRLVRYKDDADSPTEDGDKPRVLYSL
EFTFDADARVAITIYCQASEEFLNGRAVYSPKSPSLQSETVHYKRGVSQQFSLPSFKIDF
SEWKDDELNFDLDRGVFPVVIQAVVDEGDVVEVTGHAHVLLAAFEKHMDGSFSVKPLKQK
QIVDRVSYLLQEIYGIENKNNQETKPSDDENSDNSNECVVCLSDLRDTLILPCRHLCLCT
SCADTLRYQANNCPICRLPFRALLQIRAVRKKPGALSPVSFSPVLAQSLEHDEHSCPFKK
SKPHPASLASKKPKRETNSDSVPPGYEPISLLEALNGLRAVSPAIPSAPLYEEITYSGIS
DGLSQASCPLAAIDHILDSSRQKGRPQSKAPDSTLRSPSSPIHEEDEEKLSEDVDAPPPL
GGAELALRESSSPESFITEEVDESSSPQQGTRAASIENVLQDSSPEHCGRGPPADIYLPA
LGPDSCSVGIDE
GenBank ID Protein 214010236
UniProtKB/Swiss-Prot ID O60291
UniProtKB/Swiss-Prot Entry Name MGRN1_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_001142290.1
GeneCard ID MGRN1
GenAtlas ID MGRN1
HGNC ID HGNC:20254
References
General References
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  2. Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. [PubMed:18669648 ]
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  4. Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O: Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. DNA Res. 1998 Feb 28;5(1):31-9. [PubMed:9628581 ]
  5. Perez-Oliva AB, Olivares C, Jimenez-Cervantes C, Garcia-Borron JC: Mahogunin ring finger-1 (MGRN1) E3 ubiquitin ligase inhibits signaling from melanocortin receptor by competition with Galphas. J Biol Chem. 2009 Nov 13;284(46):31714-25. doi: 10.1074/jbc.M109.028100. Epub 2009 Sep 8. [PubMed:19737927 ]
  6. Kim BY, Olzmann JA, Barsh GS, Chin LS, Li L: Spongiform neurodegeneration-associated E3 ligase Mahogunin ubiquitylates TSG101 and regulates endosomal trafficking. Mol Biol Cell. 2007 Apr;18(4):1129-42. Epub 2007 Jan 17. [PubMed:17229889 ]
  7. Jiao J, Sun K, Walker WP, Bagher P, Cota CD, Gunn TM: Abnormal regulation of TSG101 in mice with spongiform neurodegeneration. Biochim Biophys Acta. 2009 Oct;1792(10):1027-35. doi: 10.1016/j.bbadis.2009.08.009. Epub 2009 Aug 22. [PubMed:19703557 ]