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Showing Protein E3 ubiquitin-protein ligase UBR5 (HMDBP09286)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 4 metabolites
Identification
HMDB Protein ID HMDBP09286
Secondary Accession Numbers
  • 15115
Name E3 ubiquitin-protein ligase UBR5
Synonyms
  1. E3 ubiquitin-protein ligase, HECT domain-containing 1
  2. Hyperplastic discs protein homolog
  3. Progestin-induced protein
  4. hHYD
Gene Name UBR5
Protein Type Enzyme
Biological Properties
General Function Involved in acid-amino acid ligase activity
Specific Function E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific amino-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in maturation and/or transcriptional regulation of mRNA. May play a role in control of cell cycle progression. May have tumor suppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response. Plays an essential role in extraembryonic development
Pathways Not Available
Reactions Not Available
GO Classification
Component
cell part
intracellular
Function
ion binding
cation binding
metal ion binding
binding
catalytic activity
small conjugating protein ligase activity
transition metal ion binding
zinc ion binding
ligase activity
ligase activity, forming carbon-nitrogen bonds
acid-amino acid ligase activity
ubiquitin-protein ligase activity
nucleic acid binding
rna binding
Process
metabolic process
macromolecule metabolic process
macromolecule modification
protein modification process
Cellular Location
  1. Nucleus
Gene Properties
Chromosome Location Chromosome:8
Locus 8q22
SNPs UBR5
Gene Sequence 
>8400 bp
ATGACGTCCATCCATTTCGTGGTTCACCCGCTGCCGGGCACCGAGGACCAGCTCAATGAC
AGGTTACGAGAAGTTTCTGAGAAGCTGAACAAATATAATTTAAACAGCCACCCCCCTTTG
AATGTATTGGAACAGGCTACTATTAAACAGTGTGTGGTGGGACCAAATCATGCTGCCTTT
CTTCTTGAGGATGGTAGAGTTTGCAGGATTGGTTTTTCAGTACAGCCAGACAGATTGGAA
TTGGGTAAACCTGATAATAATGATGGGTCAAAGTTGAACAGCAACTCGGGGGCAGGGAGG
ACGTCAAGGCCTGGTAGGACAAGCGACTCTCCATGGTTTCTCTCAGGTTCTGAGACTCTA
GGCAGGCTGGCAGGCAACACCTTAGGAAGCCGCTGGAGTTCTGGAGTGGGTGGAAGTGGT
GGAGGATCCTCTGGTAGGTCATCAGCTGGAGCTCGAGATTCCCGCCGGCAGACTCGAGTT
ATTCGGACAGGACGGGATCGAGGGTCTGGGCTTTTGGGCAGTCAGCCCCAGCCAGTTATT
CCAGCATCTGTCATTCCAGAGGAGCTGATTTCACAGGCCCAAGTTGTTTTACAAGGCAAA
TCCAGAAGTGTCATTATTCGAGAACTTCAGAGAACAAATCTTGATGTGAACCTTGCTGTA
AATAATTTACTTAGCCGGGATGATGAAGATGGAGATGATGGGGATGATACAGCCAGCGAA
TCTTATTTGCCTGGAGAGGATCTTATGTCTCTCCTTGATGCCGACATTCATTCTGCCCAC
CCAAGTGTCATTATTGATGCAGATGCCATGTTTTCTGAAGACATTAGCTATTTTGGTTAC
CCTTCTTTTCGTCGTTCATCACTTTCCAGGCTAGGCTCATCTCGAGTTCTCCTTCTTCCC
TTAGAGAGAGACTCTGAGCTGTTGCGTGAACGTGAATCCGTTTTACGTTTACGTGAACGA
AGGTGGCTTGATGGAGCCTCATTTGATAATGAAAGGGGTTCTACCAGCAAGGAAGGAGAG
CCAAACTTGGATAAGAAGAATACACCTGTTCAAAGTCCAGTATCTCTAGGAGAAGATTTG
CAGTGGTGGCCTGATAAGGATGGAACAAAATTCATCTGTATTGGGGCTCTGTATTCTGAA
CTTCTGGCTGTCAGCAGTAAAGGAGAACTTTATCAGTGGAAATGGAGTGAATCTGAGCCT
TACAGAAATGCCCAGAATCCTTCATTACATCATCCACGAGCAACATTTTTGGGGTTAACC
AATGAAAAGATAGTCCTCCTGTCTGCAAATAGCATAAGAGCAACTGTAGCTACAGAAAAT
AACAAGGTTGCTACATGGGTGGATGAAACTTTAAGTTCTGTGGCTTCTAAATTAGAGCAC
ACTGCTCAGACTTACTCTGAACTTCAAGGAGAGCGGATAGTTTCTTTACATTGCTGTGCC
CTTTACACCTGCGCTCAGCTGGAAAACAGTTTATATTGGTGGGGTGTAGTTCCTTTTAGT
CAAAGGAAGAAAATGTTAGAGAAAGCTAGAGCAAAAAATAAAAAGCCTAAATCCAGTGCT
GGTATTTCTTCAATGCCGAACATCACTGTTGGTACCCAGGTATGCTTGAGAAATAATCCT
CTTTATCATGCTGGAGCAGTTGCATTTTCAATTAGTGCTGGGATTCCTAAAGTTGGTGTC
TTAATGGAGTCAGTTTGGAATATGAATGACAGCTGTAGATTTCAACTTAGATCTCCTGAA
AGCTTGAAAAACATGGAAAAAGCTAGCAAAACTACTGAAGCTAAGCCTGAAAGTAAGCAG
GAGCCAGTGAAAACAGAAATGGGTCCTCCACCATCTCCAGCATCCACGTGTAGTGATGCA
TCCTCAATTGCCAGCAGTGCATCAATGCCATACAAACGACGACGGTCAACCCCTGCACCA
AAAGAAGAGGAAAAGGTGAATGAAGAGCAGTGGTCTCTTCGGGAAGTGGTTTTTGTGGAA
GATGTCAAGAATGTTCCTGTTGGCAAGGTGCTAAAAGTAGATGGTGCCTATGTTGCTGTA
AAATTTCCAGGAACCTCCAGTAATACTAACTGTCAGAACAGCTCTGGTCCAGATGCTGAC
CCTTCTTCTCTCCTGCAGGATTGTAGGTTACTTAGAATTGATGAATTGCAGGTTGTCAAA
ACTGGTGGAACACCGAAGGTTCCCGACTGTTTCCAAAGGACTCCTAAAAAGCTTTGTATA
CCTGAAAAAACAGAAATATTAGCAGTGAATGTAGATTCCAAAGGTGTTCATGCTGTTCTG
AAGACTGGAAATTGGGTACGATACTGTATCTTTGATCTTGCTACAGGAAAAGCAGAACAG
GAAAATAATTTTCCTACAAGCAGCATTGCTTTCCTTGGTCAGAATGAGAGGAATGTAGCC
ATTTTCACTGCTGGACAGGAATCTCCCATTATTCTTCGAGATGGAAATGGTACCATCTAC
CCAATGGCCAAAGATTGCATGGGAGGAATAAGGGATCCCGATTGGCTGGATCTTCCACCT
ATTAGTAGTCTTGGAATGGGTGTGCATTCTTTAATAAATCTTCCTGCCAATTCAACAATC
AAAAAGAAAGCTGCTGTTATCATCATGGCTGTAGAGAAACAAACCTTAATGCAACACATT
CTGCGCTGTGACTATGAGGCCTGTCGACAATATCTAATGAATCTTGAGCAAGCGGTTGTT
TTAGAGCAGAATCTACAGATGCTGCAGACATTCATCAGCCACAGATGTGATGGAAATCGA
AATATTTTGCATGCTTGTGTATCAGTTTGCTTTCCAACCAGCAATAAAGAAACTAAAGAA
GAAGAGGAAGCGGAGCGTTCTGAAAGAAATACATTTGCAGAAAGGCTTTCTGCTGTTGAG
GCCATTGCAAATGCAATATCAGTTGTTTCAAGTAATGGCCCAGGTAATCGGGCTGGATCA
TCAAGTAGCCGAAGTTTGAGATTACGGGAAATGATGAGACGTTCGTTGAGAGCAGCTGGT
TTGGGTAGACATGAAGCTGGAGCTTCATCCAGTGACCACCAGGATCCAGTTTCACCCCCC
ATAGCTCCCCCTAGTTGGGTTCCTGACCCTCCTGCGATGGATCCTGATGGTGACATTGAT
TTTATCCTGGCCCCCGCTGTGGGATCTCTTACCACAGCAGCAACCGGTACTGGTCAAGGA
CCAAGCACCTCCACTATTCCAGGTCCTTCCACAGAGCCATCTGTAGTAGAATCCAAGGAT
CGAAAGGCGAATGCTCATTTTATATTGAAATTGTTATGTGACAGTGTGGTTCTCCAGCCC
TATCTACGAGAACTTCTTTCTGCCAAGGATGCAAGAGGGATGACCCCATTTATGTCAGCT
GTAAGTGGCCGAGCTTATCCTGCTGCAATTACCATCTTAGAAACTGCTCAGAAAATTGCA
AAAGCTGAAATATCCTCAAGTGAAAAAGAGGAAGATGTATTCATGGGAATGGTTTGCCCA
TCAGGTACCAACCCTGATGACTCTCCTTTATATGTTTTATGTTGTAATGACACTTGCAGT
TTTACATGGACTGGAGCAGAGCACATTAACCAGGATATTTTTGAGTGTCGAACTTGTGGC
TTGCTGGAGTCACTGTGTTGTTGTACGGAATGTGCAAGGGTTTGTCATAAAGGTCATGAT
TGCAAACTCAAACGGACATCACCAACAGCCTACTGTGATTGTTGGGAGAAATGTAAATGT
AAAACTCTTATTGCTGGACAGAAATCTGCTCGTCTTGATCTACTTTATCGCCTGCTCACT
GCTACTAATCTGGTTACTCTGCCAAACAGCAGGGGAGAGCACCTCTTACTATTCTTAGTA
CAGACAGTCGCAAGGCAGACGGTGGAGCATTGTCAATACAGGCCACCTCGAATCAGGGAA
GATCGTAACCGAAAAACAGCCAGTCCTGAAGATTCAGATATGCCAGATCATGATTTAGAG
CCTCCAAGATTTGCCCAGCTTGCATTGGAGCGTGTTCTACAGGACTGGAATGCCTTGAAA
TCTATGATTATGTTTGGGTCGCAGGAGAATAAAGACCCTCTTAGTGCCAGCAGTAGAATA
GGCCATCTTTTGCCAGAAGAGCAAGTATACCTCAATCAGCAAAGTGGCACAATTCGGCTG
GACTGTTTCACTCATTGCCTTATAGTTAAGTGTACAGCAGATATTTTGCTTTTAGATACT
CTACTAGGTACACTAGTGAAAGAACTCCAAAACAAATATACACCTGGACGTAGAGAAGAA
GCTATTGCTGTGACAATGAGGTTTCTACGTTCAGTGGCAAGAGTTTTTGTTATTCTGAGT
GTGGAAATGGCTTCATCCAAAAAGAAAAACAACTTTATTCCACAGCCAATTGGAAAATGC
AAGCGTGTATTCCAAGCATTGCTACCTTACGCTGTGGAAGAATTGTGCAACGTAGCAGAG
TCACTGATTGTTCCTGTCAGAATGGGGATTGCTCGTCCAACTGCACCATTTACCCTGGCT
AGTACTAGCATAGATGCCATGCAGGGCAGTGAAGAATTATTTTCAGTGGAACCACTACCA
CCACGACCATCATCTGATCAGTCTAGCAGCTCCAGTCAGTCTCAGTCATCCTACATCATC
AGGAATCCACAGCAGAGGCGCATCAGCCAGTCACAGCCCGTTCGGGGCAGAGATGAAGAA
CAGGATGATATTGTTTCAGCAGATGTGGAAGAGGTTGAGGTGGTGGAGGGTGTGGCTGGA
GAAGAGGATCATCATGATGAACAGGAAGAACACGGGGAAGAAAATGCTGAGGCAGAGGGA
CAACATGATGAGCATGATGAAGACGGGAGTGATATGGAGCTGGACTTGTTAGCAGCAGCT
GAAACAGAAAGTGATAGTGAAAGTAACCACAGCAACCAAGATAATGCTAGTGGGCGCAGA
AGCGTTGTCACTGCAGCAACTGCTGGTTCAGAAGCAGGAGCAAGCAGTGTTCCTGCCTTC
TTTTCTGAAGATGATTCTCAATCGAATGACTCAAGTGATTCTGATAGCAGTAGTAGTCAG
AGTGACGACATAGAACAGGAGACCTTTATGCTTGATGAGCCATTAGAAAGAACCACAAAT
AGCTCCCATGCCAATGGTGCTGCCCAAGCTCCCCGTTCAATGCAGTGGGCTGTCCGCAAC
ACCCAGCATCAGCGAGCAGCCAGTACAGCCCCTTCCAGTACATCTACACCAGCAGCAAGT
TCAGCGGGTTTGATTTATATTGATCCTTCAAACTTACGCCGGAGTGGTACCATCAGTACA
AGTGCTGCAGCTGCAGCAGCTGCTTTGGAAGCTAGCAACGCCAGCAGTTACCTAACATCT
GCAAGCAGTTTAGCCAGGGCTTACAGCATTGTCATTAGACAAATCTCGGACTTGATGGGC
CTTATTCCTAAGTATAATCACCTAGTATACTCTCAGATTCCAGCAGCTGTGAAATTGACT
TACCAAGATGCAGTAAACTTACAGAACTATGTAGAAGAAAAGCTTATTCCCACTTGGAAC
TGGATGGTCAGTATTATGGATTCTACTGAAGCTCAATTACGTTATGGTTCTGCATTAGCA
TCTGCTGGTGATCCTGGACATCCAAATCATCCTCTTCACGCTTCTCAGAATTCAGCGAGA
AGAGAGAGGATGACTGCGCGAGAAGAAGCTAGCTTACGAACACTTGAAGGCAGACGACGT
GCCACCTTGCTTAGCGCCCGTCAAGGAATGATGTCTGCACGAGGAGACTTCCTAAATTAT
GCTCTGTCTCTAATGCGGTCTCATAATGATGAGCATTCTGATGTTCTTCCAGTTTTGGAT
GTTTGCTCATTGAAGCATGTGGCATATGTTTTTCAAGCACTTATATACTGGATTAAGGCA
ATGAATCAGCAGACAACATTGGATACACCTCAACTAGAACGCAAAAGGACGCGAGAACTC
TTGGAACTGGGTATTGATAATGAAGATTCAGAACATGAAAATGATGATGACACCAATCAA
AGTGCTACTTTGAATGATAAGGATGATGACTCTCTTCCTGCAGAAACTGGCCAAAACCAT
CCATTTTTCCGACGTTCAGACTCCATGACATTCCTTGGGTGTATACCCCCAAATCCATTT
GAAGTGCCTCTGGCTGAAGCCATCCCCTTGGCTGATCAGCCACATCTGTTGCAGCCAAAT
GCTAGAAAGGAGGATCTTTTTGGCCGTCCAAGTCAGGGTCTTTATTCTTCATCTGCCAGT
AGTGGGAAATGTTTAATGGAGGTTACAGTGGATAGAAACTGCCTAGAGGTTCTTCCAACA
AAAATGTCTTATGCTGCCAATCTGAAAAATGTAATGAACATGCAAAACCGGCAAAAAAAA
GAAGGGGAAGAACAGCCCGTGCTGCCAGAAGAAACTGAGAGTTCAAAACCAGGGCCATCT
GCTCATGATCTTGCTGCACAATTAAAAAGTAGCTTACTAGCAGAAATAGGACTTACTGAA
AGTGAAGGGCCACCTCTCACATCTTTCAGGCCACAGTGTAGCTTTATGGGAATGGTTATT
TCCCATGATATGCTGCTAGGACGTTGGCGCCTTTCTTTAGAACTGTTCGGCAGGGTATTC
ATGGAAGATGTTGGAGCAGAACCTGGATCAATCCTAACTGAATTGGGTGGTTTTGAGGTA
AAAGAATCAAAATTCCGCAGAGAAATGGAAAAACTGAGAAACCAGCAGTCAAGAGATTTG
TCACTAGAGGTTGATCGGGATCGAGATCTTCTCATTCAGCAGACTATGAGGCAGCTTAAC
AATCACTTTGGTCGAAGATGTGCTACTACACCAATGGCTGTACACAGAGTAAAAGTCACA
TTTAAGGATGAGCCAGGAGAGGGCAGTGGTGTAGCACGAAGTTTTTATACAGCCATTGCA
CAAGCATTTTTATCAAATGAAAAATTGCCAAATCTAGAGTGTATCCAAAATGCCAACAAA
GGCACCCACACAAGTTTAATGCAGAGATTAAGGAACCGAGGAGAGAGAGACCGGGAAAGG
GAGAGAGAAAGGGAAATGAGGAGGAGTAGTGGTTTGCGAGCAGGTTCTCGGAGGGACCGG
GATAGAGACTTTAGAAGACAGCTTTCCATCGACACTAGGCCCTTTAGACCAGCCTCTGAA
GGGAATCCTAGCGATGATCCTGAGCCTTTGCCAGCACATCGGCAGGCACTTGGAGAGAGG
CTTTATCCTCGTGTACAAGCAATGCAACCAGCATTTGCAAGTAAAATCACTGGCATGTTG
TTGGAATTATCCCCAGCTCAGCTGCTTCTCCTTCTAGCAAGTGAGGATTCTCTGAGAGCA
AGAGTGGATGAGGCCATGGAACTCATTATTGCACATGGACGGGAAAATGGAGCTGATAGT
ATCCTGGATCTTGGATTAGTAGACTCCTCAGAAAAGGTACAGCAGGAAAACCGAAAGCGC
CATGGCTCTAGTCGAAGTGTAGTAGATATGGATTTAGATGATACAGATGATGGTGATGAC
AATGCCCCTTTGTTTTACCAACCTGGGAAAAGAGGATTTTATACTCCAAGGCCTGGCAAG
AACACAGAAGCAAGGTTGAATTGTTTCAGAAACATTGGCAGGATTCTTGGACTATGTCTG
TTACAGAATGAACTATGTCCTATCACATTGAATAGACATGTAATTAAAGTATTGCTTGGT
AGAAAAGTCAATTGGCATGATTTTGCTTTTTTTGATCCTGTAATGTATGAGAGTTTGCGG
CAACTAATCCTCGCGTCTCAGAGTTCAGATGCTGATGCTGTTTTCTCAGCAATGGATTTG
GCATTTGCAATTGACCTGTGTAAAGAAGAAGGTGGAGGACAGGTTGAACTCATTCCTAAT
GGTGTAAATATACCAGTCACTCCACAGAATGTATATGAGTATGTGCGGAAATACGCAGAA
CACAGAATGTTGGTAGTTGCAGAACAGCCCTTACATGCAATGAGGAAAGGTCTACTAGAT
GTGCTTCCAAAAAATTCATTAGAAGATTTAACGGCAGAAGATTTTAGGCTTTTGGTAAAT
GGCTGCGGTGAAGTCAATGTGCAAATGCTGATCAGTTTTACCTCTTTCAATGATGAATCA
GGAGAAAATGCTGAGAAGCTTCTGCAGTTCAAGCGTTGGTTCTGGTCAATAGTAGAGAAG
ATGAGCATGACAGAACGACAAGATCTTGTTTACTTTTGGACATCAAGCCCATCACTGCCA
GCCAGTGAAGAAGGATTCCAGCCTATGCCCTCAATCACAATAAGACCACCAGATGACCAA
CATCTTCCTACTGCAAATACTTGCATTTCTCGACTTTACGTCCCACTCTATTCCTCTAAA
CAGATTCTCAAACAGAAATTGTTACTCGCCATTAAGACCAAGAATTTTGGTTTTGTGTAG
Protein Properties
Number of Residues 2799
Molecular Weight 309349.2
Theoretical pI 5.63
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence 
>E3 ubiquitin-protein ligase UBR5
MTSIHFVVHPLPGTEDQLNDRLREVSEKLNKYNLNSHPPLNVLEQATIKQCVVGPNHAAF
LLEDGRVCRIGFSVQPDRLELGKPDNNDGSKLNSNSGAGRTSRPGRTSDSPWFLSGSETL
GRLAGNTLGSRWSSGVGGSGGGSSGRSSAGARDSRRQTRVIRTGRDRGSGLLGSQPQPVI
PASVIPEELISQAQVVLQGKSRSVIIRELQRTNLDVNLAVNNLLSRDDEDGDDGDDTASE
SYLPGEDLMSLLDADIHSAHPSVIIDADAMFSEDISYFGYPSFRRSSLSRLGSSRVLLLP
LERDSELLRERESVLRLRERRWLDGASFDNERGSTSKEGEPNLDKKNTPVQSPVSLGEDL
QWWPDKDGTKFICIGALYSELLAVSSKGELYQWKWSESEPYRNAQNPSLHHPRATFLGLT
NEKIVLLSANSIRATVATENNKVATWVDETLSSVASKLEHTAQTYSELQGERIVSLHCCA
LYTCAQLENSLYWWGVVPFSQRKKMLEKARAKNKKPKSSAGISSMPNITVGTQVCLRNNP
LYHAGAVAFSISAGIPKVGVLMESVWNMNDSCRFQLRSPESLKNMEKASKTTEAKPESKQ
EPVKTEMGPPPSPASTCSDASSIASSASMPYKRRRSTPAPKEEEKVNEEQWSLREVVFVE
DVKNVPVGKVLKVDGAYVAVKFPGTSSNTNCQNSSGPDADPSSLLQDCRLLRIDELQVVK
TGGTPKVPDCFQRTPKKLCIPEKTEILAVNVDSKGVHAVLKTGNWVRYCIFDLATGKAEQ
ENNFPTSSIAFLGQNERNVAIFTAGQESPIILRDGNGTIYPMAKDCMGGIRDPDWLDLPP
ISSLGMGVHSLINLPANSTIKKKAAVIIMAVEKQTLMQHILRCDYEACRQYLMNLEQAVV
LEQNLQMLQTFISHRCDGNRNILHACVSVCFPTSNKETKEEEEAERSERNTFAERLSAVE
AIANAISVVSSNGPGNRAGSSSSRSLRLREMMRRSLRAAGLGRHEAGASSSDHQDPVSPP
IAPPSWVPDPPAMDPDGDIDFILAPAVGSLTTAATGTGQGPSTSTIPGPSTEPSVVESKD
RKANAHFILKLLCDSVVLQPYLRELLSAKDARGMTPFMSAVSGRAYPAAITILETAQKIA
KAEISSSEKEEDVFMGMVCPSGTNPDDSPLYVLCCNDTCSFTWTGAEHINQDIFECRTCG
LLESLCCCTECARVCHKGHDCKLKRTSPTAYCDCWEKCKCKTLIAGQKSARLDLLYRLLT
ATNLVTLPNSRGEHLLLFLVQTVARQTVEHCQYRPPRIREDRNRKTASPEDSDMPDHDLE
PPRFAQLALERVLQDWNALKSMIMFGSQENKDPLSASSRIGHLLPEEQVYLNQQSGTIRL
DCFTHCLIVKCTADILLLDTLLGTLVKELQNKYTPGRREEAIAVTMRFLRSVARVFVILS
VEMASSKKKNNFIPQPIGKCKRVFQALLPYAVEELCNVAESLIVPVRMGIARPTAPFTLA
STSIDAMQGSEELFSVEPLPPRPSSDQSSSSSQSQSSYIIRNPQQRRISQSQPVRGRDEE
QDDIVSADVEEVEVVEGVAGEEDHHDEQEEHGEENAEAEGQHDEHDEDGSDMELDLLAAA
ETESDSESNHSNQDNASGRRSVVTAATAGSEAGASSVPAFFSEDDSQSNDSSDSDSSSSQ
SDDIEQETFMLDEPLERTTNSSHANGAAQAPRSMQWAVRNTQHQRAASTAPSSTSTPAAS
SAGLIYIDPSNLRRSGTISTSAAAAAAALEASNASSYLTSASSLARAYSIVIRQISDLMG
LIPKYNHLVYSQIPAAVKLTYQDAVNLQNYVEEKLIPTWNWMVSIMDSTEAQLRYGSALA
SAGDPGHPNHPLHASQNSARRERMTAREEASLRTLEGRRRATLLSARQGMMSARGDFLNY
ALSLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALIYWIKAMNQQTTLDTPQLERKRTREL
LELGIDNEDSEHENDDDTNQSATLNDKDDDSLPAETGQNHPFFRRSDSMTFLGCIPPNPF
EVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSSASSGKCLMEVTVDRNCLEVLPT
KMSYAANLKNVMNMQNRQKKEGEEQPVLPEETESSKPGPSAHDLAAQLKSSLLAEIGLTE
SEGPPLTSFRPQCSFMGMVISHDMLLGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEV
KESKFRREMEKLRNQQSRDLSLEVDRDRDLLIQQTMRQLNNHFGRRCATTPMAVHRVKVT
FKDEPGEGSGVARSFYTAIAQAFLSNEKLPNLECIQNANKGTHTSLMQRLRNRGERDRER
EREREMRRSSGLRAGSRRDRDRDFRRQLSIDTRPFRPASEGNPSDDPEPLPAHRQALGER
LYPRVQAMQPAFASKITGMLLELSPAQLLLLLASEDSLRARVDEAMELIIAHGRENGADS
ILDLGLVDSSEKVQQENRKRHGSSRSVVDMDLDDTDDGDDNAPLFYQPGKRGFYTPRPGK
NTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLR
QLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAE
HRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDES
GENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQ
HLPTANTCISRLYVPLYSSKQILKQKLLLAIKTKNFGFV
GenBank ID Protein 15147337
UniProtKB/Swiss-Prot ID O95071
UniProtKB/Swiss-Prot Entry Name UBR5_HUMAN
PDB IDs
GenBank Gene ID NM_015902.4
GeneCard ID UBR5
GenAtlas ID UBR5
HGNC ID HGNC:16806
References
General References
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  2. Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. Nat Biotechnol. 2005 Jan;23(1):94-101. Epub 2004 Dec 12. [PubMed:15592455 ]
  3. Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. [PubMed:18669648 ]
  4. Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal. 2009 Aug 18;2(84):ra46. doi: 10.1126/scisignal.2000007. [PubMed:19690332 ]
  5. Daub H, Olsen JV, Bairlein M, Gnad F, Oppermann FS, Korner R, Greff Z, Keri G, Stemmann O, Mann M: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol Cell. 2008 Aug 8;31(3):438-48. doi: 10.1016/j.molcel.2008.07.007. [PubMed:18691976 ]
  6. Oppermann FS, Gnad F, Olsen JV, Hornberger R, Greff Z, Keri G, Mann M, Daub H: Large-scale proteomics analysis of the human kinome. Mol Cell Proteomics. 2009 Jul;8(7):1751-64. doi: 10.1074/mcp.M800588-MCP200. Epub 2009 Apr 15. [PubMed:19369195 ]
  7. Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell. 2006 Nov 3;127(3):635-48. [PubMed:17081983 ]
  8. Zahedi RP, Lewandrowski U, Wiesner J, Wortelkamp S, Moebius J, Schutz C, Walter U, Gambaryan S, Sickmann A: Phosphoproteome of resting human platelets. J Proteome Res. 2008 Feb;7(2):526-34. Epub 2007 Dec 19. [PubMed:18088087 ]
  9. Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER 3rd, Hurov KE, Luo J, Bakalarski CE, Zhao Z, Solimini N, Lerenthal Y, Shiloh Y, Gygi SP, Elledge SJ: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science. 2007 May 25;316(5828):1160-6. [PubMed:17525332 ]
  10. Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. DNA Res. 2002 Jun 30;9(3):99-106. [PubMed:12168954 ]
  11. Cantin GT, Yi W, Lu B, Park SK, Xu T, Lee JD, Yates JR 3rd: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. J Proteome Res. 2008 Mar;7(3):1346-51. doi: 10.1021/pr0705441. Epub 2008 Jan 26. [PubMed:18220336 ]
  12. Kim JE, Tannenbaum SR, White FM: Global phosphoproteome of HT-29 human colon adenocarcinoma cells. J Proteome Res. 2005 Jul-Aug;4(4):1339-46. [PubMed:16083285 ]
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