Hmdb loader
Identification
HMDB Protein ID HMDBP09301
Secondary Accession Numbers
  • 15131
Name E3 ubiquitin-protein ligase CCNB1IP1
Synonyms
  1. Cyclin-B1-interacting protein 1
  2. Human enhancer of invasion 10
Gene Name CCNB1IP1
Protein Type Enzyme
Biological Properties
General Function Involved in ligase activity
Specific Function E3 ubiquitin-protein ligase. Modulates cyclin B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis
Pathways Not Available
Reactions Not Available
GO Classification Not Available
Cellular Location
  1. Nucleus
  2. Chromosome
Gene Properties
Chromosome Location Chromosome:1
Locus 14q11.2
SNPs CCNB1IP1
Gene Sequence
>834 bp
ATGTCTTTGTGTGAAGACATGCTGCTTTGTAATTATCGAAAGTGTCGCATCAAACTCTCT
GGCTATGCATGGGTCACTGCCTGCTCTCACATCTTCTGTGATCAGCATGGCAGTGGTGAG
TTTAGTCGCTCACCAGCTATCTGTCCTGCCTGCAACAGTACCCTTTCTGGAAAGCTAGAT
ATTGTCCGCACAGAACTCAGTCCATCAGAGGAATATAAAGCTATGGTATTGGCAGGACTG
CGACCAGAGATCGTGTTGGACATTAGCTCCCGAGCGCTGGCCTTCTGGACATATCAGGTA
CATCAGGAACGTCTCTATCAAGAATACAATTTCAGCAAGGCTGAGGGCCATCTGAAACAG
ATGGAGAAGATATATACTCAGCAAATACAAAGCAAGGATGTAGAATTGACCTCTATGAAA
GGGGAGGTTACCTCCATGAAGAAAGTACTAGAAGAATACAAGAAAAAGTTCAGTGACATC
TCTGAGAAACTTATGGAGCGCAATCGTCAGTATCAAAAGCTCCAAGGCCTCTATGATAGC
CTTAGGCTACGAAACATCACTATTGCTAACCATGAAGGCACCCTTGAACCATCCATGATT
GCACAGTCTGGTGTTCTTGGCTTCCCATTAGGTAACAACTCCAAGTTTCCTTTGGATAAT
ACACCTGTTCGAAATCGGGGCGATGGAGATGGAGATTTTCAGTTCAGACCATTTTTTGCG
GGTTCTCCCACAGCACCTGAACCCAGCAACAGCTTTTTTAGTTTTGTCTCTCCAAGTCGT
GAATTAGAGCAGCAGCAAGTTTCTAGCAGGGCCTTCAAAGTAAAAAGAATTTGA
Protein Properties
Number of Residues 277
Molecular Weight 31543.7
Theoretical pI 8.46
Pfam Domain Function Not Available
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>E3 ubiquitin-protein ligase CCNB1IP1
MSLCEDMLLCNYRKCRIKLSGYAWVTACSHIFCDQHGSGEFSRSPAICPACNSTLSGKLD
IVRTELSPSEEYKAMVLAGLRPEIVLDISSRALAFWTYQVHQERLYQEYNFSKAEGHLKQ
MEKIYTQQIQSKDVELTSMKGEVTSMKKVLEEYKKKFSDISEKLMERNRQYQKLQGLYDS
LRLRNITIANHEGTLEPSMIAQSGVLGFPLGNNSKFPLDNTPVRNRGDGDGDFQFRPFFA
GSPTAPEPSNSFFSFVSPSRELEQQQVSSRAFKVKRI
GenBank ID Protein 7107350
UniProtKB/Swiss-Prot ID Q9NPC3
UniProtKB/Swiss-Prot Entry Name CIP1_HUMAN
PDB IDs Not Available
GenBank Gene ID AF216381
GeneCard ID CCNB1IP1
GenAtlas ID CCNB1IP1
HGNC ID HGNC:19437
References
General References
  1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [PubMed:14702039 ]
  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  3. Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. [PubMed:17974005 ]
  4. Toby GG, Gherraby W, Coleman TR, Golemis EA: A novel RING finger protein, human enhancer of invasion 10, alters mitotic progression through regulation of cyclin B levels. Mol Cell Biol. 2003 Mar;23(6):2109-22. [PubMed:12612082 ]