Hmdb loader
Identification
HMDB Protein ID HMDBP09309
Secondary Accession Numbers
  • 15141
Name E3 ubiquitin-protein ligase MARCH7
Synonyms
  1. Axotrophin
  2. MARCH-VII
  3. Membrane-associated RING finger protein 7
  4. Membrane-associated RING-CH protein VII
  5. RING finger protein 177
Gene Name MARCH7
Protein Type Enzyme
Biological Properties
General Function Involved in zinc ion binding
Specific Function E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates
Pathways Not Available
Reactions Not Available
GO Classification
Function
ion binding
cation binding
metal ion binding
binding
transition metal ion binding
zinc ion binding
Cellular Location Not Available
Gene Properties
Chromosome Location Chromosome:2
Locus 2q24.2
SNPs MARCH7
Gene Sequence
>2115 bp
ATGGAGTCTAAACCTTCAAGGATTCCAAGAAGAATTTCTGTTCAACCTTCCAGCTCCTTA
AGTGCTAGGATGATGTCTGGAAGCAGAGGAAGTAGTTTAAATGATACCTATCACTCAAGA
GACTCTTCATTTAGATTGGATTCTGAATATCAGTCTACATCAGCATCAGCATCTGCGTCA
CCATTTCAATCTGCATGGTATAGTGAATCTGAGATAACTCAGGGAGCACGCTCAAGATCG
CAGAACCAGCAACGGGATCATGATTCAAAAAGACCTAAACTTTCCTGTACAAACTGTACT
ACCTCAGCTGGGAGAAATGTTGGAAATGGTTTAAACACATTATCAGATTCATCTTGGAGG
CATAGTCAAGTTCCTAGATCTTCATCAATGGTACTTGGATCATTTGGAACAGACTTAATG
AGAGAGAGGAGAGATTTGGAGAGAAGAACAGATTCCTCTATTAGTAATCTTATGGATTAT
AGTCACCGAAGTGGTGATTTCACAACTTCATCATATGTTCAAGACAGAGTTCCTTCATAT
TCACAAGGAGCAAGACCAAAAGAAAACTCAATGAGCACTTTACAGTTGAATACATCATCC
ACAAACCACCAATTGCCTTCTGAACATCAGACCATACTAAGTTCTAGGGACTCCAGAAAT
TCTTTAAGATCAAATTTTTCTTCAAGAGAATCAGAATCTTCCCGAAGCAATACGCAGCCT
GGATTTTCTTACAGTTCAAGTAGAGATGAAGCCCCAATCATAAGCAATTCAGAAAGGGTT
GTTTCATCTCAAAGACCATTTCAAGAATCTTCTGACAATGAAGGTAGGCGGACAACGAGG
AGATTGCTGTCACGCATAGCTTCTAGCATGTCATCTACTTTTTTTTCACGAAGATCTAGT
CAGGATTCCTTGAATACAAGATCATTGAATTCTGAAAATTCTTACGTTTCTCCAAGAATC
TTGACAGCTTCACAGTCCCGTAGTAATGTACCATCAGCTTCTGAAGTTCCCGATAATAGG
GCATCTGAAGCTTCTCAGGGATTTCGATTTCTTAGGCGAAGATGGGGTTTGTCATCTCTT
AGCCACAATCATAGCTCTGAGTCAGATTCAGAAAATTTTAACCAAGAATCTGAAGGTAGA
AATACAGGACCATGGTTATCTTCCTCACTTAGAAATAGATGCACACCTTTGTTCTCTAGA
AGGAGGCGAGAGGGAAGAGATGAATCTTCAAGGATACCTACCTCTGATACATCATCTAGA
TCTCATATTTTTAGAAGAGAATCAAATGAAGTGGTTCACCTTGAAGCACAGAATGATCCT
CTTGGAGCTGCTGCCAACAGACCACAAGCATCTGCAGCATCAAGCAGTGCCACAACAGGT
GGCTCTACATCAGATTCGGCTCAAGGTGGAAGAAATACAGGAATATCAGGGATTCTTCCT
GGTTCCTTATTCCGGTTTGCAGTCCCTCCAGCACTTGGGAGTAATTTGACCGACAATGTC
ATGATCACAGTAGATATTATTCCTTCAGGTTGGAATTCAGCTGATGGTAAAAGTGATAAA
ACTAAAAGTGCGCCTTCAAGAGATCCAGAAAGATTGCAGAAAATAAAAGAGAGCCTCCTT
TTAGAGGACTCAGAAGAAGAAGAAGGTGACTTATGTAGAATTTGTCAAATGGCAGCTGCA
TCATCATCTAATTTGCTGATAGAGCCATGCAAGTGCACAGGAAGTTTGCAGTATGTCCAC
CAAGACTGTATGAAAAAGTGGTTACAGGCCAAAATTAACTCTGGTTCTTCATTAGAAGCT
GTAACCACCTGTGAACTATGTAAAGAGAAGTTGGAGCTTAACCTGGAGGATTTTGATATT
CATGAACTACATAGAGCTCATGCAAATGAACAAGCTGAGTATGAGTTTATCAGCTCTGGT
CTCTACCTAGTGGTGTTATTGCACTTGTGCGAACAAAGCTTTTCTGATATGATGGGAAAT
ACAAATGAACCAAGCACACGTGTCCGATTTATTAACCTTGCAAGAACTCTTCAGGCACAT
ATGGAAGATCTCGAAACTTCAGAGGATGATTCCGAAGAAGACGGAGACCATAACAGGACA
TTTGATATTGCCTAA
Protein Properties
Number of Residues 704
Molecular Weight 78050.0
Theoretical pI 6.76
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>E3 ubiquitin-protein ligase MARCH7
MESKPSRIPRRISVQPSSSLSARMMSGSRGSSLNDTYHSRDSSFRLDSEYQSTSASASAS
PFQSAWYSESEITQGARSRSQNQQRDHDSKRPKLSCTNCTTSAGRNVGNGLNTLSDSSWR
HSQVPRSSSMVLGSFGTDLMRERRDLERRTDSSISNLMDYSHRSGDFTTSSYVQDRVPSY
SQGARPKENSMSTLQLNTSSTNHQLPSEHQTILSSRDSRNSLRSNFSSRESESSRSNTQP
GFSYSSSRDEAPIISNSERVVSSQRPFQESSDNEGRRTTRRLLSRIASSMSSTFFSRRSS
QDSLNTRSLNSENSYVSPRILTASQSRSNVPSASEVPDNRASEASQGFRFLRRRWGLSSL
SHNHSSESDSENFNQESEGRNTGPWLSSSLRNRCTPLFSRRRREGRDESSRIPTSDTSSR
SHIFRRESNEVVHLEAQNDPLGAAANRPQASAASSSATTGGSTSDSAQGGRNTGISGILP
GSLFRFAVPPALGSNLTDNVMITVDIIPSGWNSADGKSDKTKSAPSRDPERLQKIKESLL
LEDSEEEEGDLCRICQMAAASSSNLLIEPCKCTGSLQYVHQDCMKKWLQAKINSGSSLEA
VTTCELCKEKLELNLEDFDIHELHRAHANEQAEYEFISSGLYLVVLLHLCEQSFSDMMGN
TNEPSTRVRFINLARTLQAHMEDLETSEDDSEEDGDHNRTFDIA
GenBank ID Protein 62822392
UniProtKB/Swiss-Prot ID Q9H992
UniProtKB/Swiss-Prot Entry Name MARH7_HUMAN
PDB IDs Not Available
GenBank Gene ID AC009961
GeneCard ID MARCH7
GenAtlas ID MARCH7
HGNC ID HGNC:17393
References
General References
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  3. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  4. Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. [PubMed:18669648 ]
  5. Flierman D, Coleman CS, Pickart CM, Rapoport TA, Chau V: E2-25K mediates US11-triggered retro-translocation of MHC class I heavy chains in a permeabilized cell system. Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11589-94. Epub 2006 Jul 25. [PubMed:16868077 ]
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