Showing Protein Probable E3 ubiquitin-protein ligase TRIP12 (HMDBP09328)
Identification | |||||||||||||||
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HMDB Protein ID | HMDBP09328 | ||||||||||||||
Secondary Accession Numbers |
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Name | Probable E3 ubiquitin-protein ligase TRIP12 | ||||||||||||||
Synonyms |
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Gene Name | TRIP12 | ||||||||||||||
Protein Type | Enzyme | ||||||||||||||
Biological Properties | |||||||||||||||
General Function | Involved in binding | ||||||||||||||
Specific Function | Component of PA700, an ATP-dependent multisubunit protein that activates the proteolytic activities of the multifunctional proteinase (20S proteasome) of the 26S complex. Specifically interacts with the ligand binding domain of the thyroid hormone receptor (in a thyroid hormone T3-independent manner) and with retinoid X receptor (RXR). Could be E3 ubiquitin- protein ligase which accepts ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates | ||||||||||||||
Pathways | Not Available | ||||||||||||||
Reactions | Not Available | ||||||||||||||
GO Classification |
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Cellular Location | Not Available | ||||||||||||||
Gene Properties | |||||||||||||||
Chromosome Location | Chromosome:2 | ||||||||||||||
Locus | 2q36.3 | ||||||||||||||
SNPs | TRIP12 | ||||||||||||||
Gene Sequence |
>5979 bp ATGTCCAACCGGCCTAATAACAATCCAGGGGGGTCACTGCGACGTTCACAGAGGAACACT GCCGGGGCCCAACCACAAGACGACTCAATAGGAGGAAGAAGCTGCAGTTCATCATCTGCT GTGATAGTTCCACAACCAGAGGATCCAGACAGAGCCAATACTTCAGAAAGACAAAAAACG GGGCAGGTGCCTAAGAAAGACAATTCTCGAGGAGTGAAGCGCAGTGCTAGTCCAGACTAC AACAGGACCAATTCTCCTAGCTCTGCAAAAAAACCAAAAGCACTTCAGCATACTGAATCT CCCTCAGAAACAAATAAGCCACATAGTAAGTCAAAGAAGAGACATTTAGACCAGGAGCAA CAACTGAAATCTGCACAATCACCATCAACAAGCAAGGCTCATACCAGGAAGAGTGGGGCC ACTGGCGGTTCACGGAGTCAGAAAAGAAAAAGGACAGAGAGTTCTTGTGTAAAGAGTGGC TCCGGGTCTGAATCAACTGGTGCAGAAGAGAGATCTGCGAAACCTACCAAGCTGGCTTCA AAATCAGCCACCTCAGCCAAAGCTGGGTGTAGCACCATCACTGATTCTTCTTCTGCTGCC TCTACTTCCTCCTCGTCTTCTGCTGTAGCCTCGGCCTCCTCCACTGTACCACCAGGTGCC AGAGTGAAACAAGGAAAAGATCAGAACAAGGCCAGGCGTTCCCGTTCAGCGTCCAGTCCC AGCCCCAGAAGAAGTAGCAGGGAAAAGGAACAGAGTAAAACTGGTGGCTCTTCAAAATTT GATTGGGCTGCTCGTTTCAGCCCTAAAGTTAGCCTTCCTAAAACAAAACTGTCTCTTCCA GGGTCTTCTAAGTCAGAGACATCAAAACCTGGACCTTCTGGATTACAGGCCAAATTAGCA AGTTTAAGAAAATCTACGAAGAAACGCAGTGAGTCTCCACCTGCTGAGCTCCCCAGTTTG AGGCGGAGCACACGCCAAAAGACCACGGGCTCCTGTGCTAGTACCAGTCGGCGAGGCTCT GGCCTGGGCAAAAGAGGAGCAGCTGAAGCTCGTCGACAGGAGAAAATGGCAGACCCTGAA AGCAACCAGGAGGCAGTAAATTCTTCAGCTGCTCGGACAGATGAAGCTCCCCAAGGAGCT GCAGGGGCTGTTGGCATGACCACCTCTGGGGAGAGTGAATCAGATGATTCCGAGATGGGA CGTTTGCAAGCTTTGTTAGAGGCAAGGGGTCTTCCCCCTCACCTATTTGGTCCTCTTGGT CCTCGGATGTCACAGCTTTTCCATAGAACAATTGGAAGTGGAGCTAGTTCTAAGGCCCAG CAGCTACTACAAGGATTGCAAGCCAGTGATGAAAGTCAACAGCTTCAGGCAGTTATTGAG ATGTGTCAGTTACTGGTCATGGGAAATGAGGAGACACTGGGAGGGTTTCCTGTCAAGAGT GTTGTTCCAGCTTTGATTACGTTACTTCAGATGGAGCACAATTTTGATATTATGAACCAT GCTTGTCGAGCCTTAACATACATGATGGAAGCACTTCCTCGATCTTCTGCTGTTGTAGTA GATGCTATTCCTGTCTTTTTAGAAAAGCTGCAAGTTATTCAGTGTATTGATGTGGCAGAG CAGGCCTTGACTGCCTTGGAGATGTTGTCACGGAGACATAGTAAAGCCATTCTACAGGCG GGTGGTTTGGCAGACTGCTTGCTGTACCTAGAATTCTTCAGCATAAATGCCCAAAGAAAT GCATTAGCAATTGCAGCTAATTGCTGCCAGAGTATCACGCCAGATGAATTTCATTTTGTG GCAGATTCACTCCCATTGCTAACCCAAAGGCTAACACATCAGGATAAAAAGTCAGTAGAA AGCACTTGCCTTTGTTTTGCACGCCTAGTGGACAACTTCCAGCATGAGGAGAATTTACTC CAGCAGGTTGCTTCCAAAGATCTGCTTACAAATGTTCAACAGCTGTTGGTAGTGACTCCA CCCATTTTAAGTTCTGGGATGTTTATAATGGTGGTTCGCATGTTTTCTCTGATGTGTTCC AACTGTCCAACTTTAGCTGTTCAACTTATGAAACAAAACATTGCAGAAACGCTTCACTTT CTCCTGTGTGGTGCCTCCAATGGAAGTTGTCAGGAACAGATTGATCTTGTTCCACGAAGC CCTCAAGAGTTGTATGAACTGACATCTCTGATTTGTGAACTTATGCCATGTTTACCAAAA GAAGGCATTTTTGCAGTTGATACCATGTTGAAGAAGGGAAATGCACAGAACACAGATGGT GCGATATGGCAGTGGCGTGATGATCGGGGCCTCTGGCATCCATATAACAGGATTGACAGC CGGATCATTGAGCAAATCAATGAGGACACGGGAACAGCACGTGCCATTCAGAGAAAACCT AACCCGTTAGCCAATAGTAACACTAGTGGATATTCAGAGTCAAAGAAGGATGATGCTCGA GCACAGCTTATGAAAGAGGATCCGGAACTGGCTAAGTCTTTTATTAAGACATTATTTGGT GTTCTTTATGAAGTGTATAGTTCCTCAGCAGGACCTGCGGTCAGACATAAGTGCCTTAGA GCAATTCTTAGGATAATTTATTTTGCGGATGCTGAACTTCTGAAGGATGTTCTGAAAAAT CATGCTGTTTCAAGTCACATTGCTTCCATGCTGTCAAGCCAAGACCTGAAGATAGTAGTG GGAGCACTTCAGATGGCAGAAATTTTAATGCAGAAGTTACCTGATATTTTTAGTGTTTAC TTCAGAAGAGAAGGTGTAATGCATCAAGTAAAACACTTAGCAGAATCAGAGTCTTTGTTG ACAAGTCCACCAAAGGCATGTACGAATGGATCGGGATCCATGGGATCCACAACTTCAGTC AGCAGTGGGACAGCCACAGCTGCCACTCATGCTGCAGCTGACTTGGGATCACCCAGCTTG CAGCACAGCAGGGATGATTCTTTAGATCTCAGCCCTCAAGGTCGATTAAGTGATGTTCTA AAGAGAAAACGACTGCCAAAACGAGGGCCAAGAAGGCCAAAGTACTCACCTCCAAGAGAT GATGACAAAGTAGACAATCAAGCTAAAAGCCCCACCACTACTCAGTCACCTAAATCTTCT TTCCTGGCAAGCTTGAATCCAAAAACATGGGGAAGGTTAAGTACACAGTCCAACAGCAAC AACATTGAGCCAGCACGGACTGCGGGAGGTAGTGGCCTTGCCAGGGCTGCCTCAAAGGAT ACCATCTCCAATAATAGAGAAAAAATTAAAGGTTGGATTAAGGAGCAGGCACATAAATTT GTAGAACGTTATTTCAGTTCTGAGAATATGGATGGAAGCAACCCTGCATTGAATGTCCTT CAGAGACTTTGTGCTGCAACCGAACAACTCAACCTCCAGGTGGATGGTGGAGCTGAGTGC CTTGTAGAAATCCGTAGCATAGTCTCAGAGTCAGATGTTTCATCATTTGAAATCCAACAT AGTGGATTTGTGAAGCAGCTGTTGCTTTATTTGACATCTAAAAGTGAAAAGGATGCTGTG AGCAGAGAGATCAGATTAAAGCGATTTCTTCATGTATTTTTTTCTTCTCCACTTCCTGGA GAAGAGCCCATTGGAAGAGTGGAACCAGTGGGTAATGCACCTTTGTTGGCATTAGTTCAC AAGATGAACAACTGCCTCAGCCAGATGGAACAATTTCCAGTCAAAGTACATGATTTCCCT AGTGGAAATGGGACAGGAGGCAGCTTTTCTCTCAACAGAGGATCACAGGCTTTAAAATTT TTCAACACACATCAATTAAAATGCCAGTTACAAAGGCATCCAGACTGTGCAAATGTGAAG CAGTGGAAGGGTGGACCTGTCAAGATTGACCCTCTGGCTTTGGTACAAGCCATCGAGAGA TACCTTGTAGTTAGAGGGTATGGAAGAGTAAGAGAAGATGATGAAGACAGCGATGACGAT GGATCAGATGAGGAAATAGATGAGTCTCTGGCTGCTCAGTTCCTAAATTCAGGAAATGTA AGACACAGGCTGCAGTTTTATATTGGAGAACATTTGCTGCCGTATAACATGACTGTGTAT CAGGCAGTACGGCAGTTTAGTATACAGGCTGAAGATGAAAGAGAATCCACAGATGATGAG AGCAATCCTCTAGGCAGAGCTGGTATTTGGACAAAGACTCATACAATATGGTATAAACCT GTGAGAGAGGATGAAGAAAGTAATAAAGATTGTGTTGGTGGTAAAAGAGGAAGAGCCCAA ACAGCTCCAACGAAAACTTCCCCTAGAAATGCAAAAAAGCATGATGAGTTATGGCACGAT GGAGTGTGCCCATCAGTATCAAATCCTTTAGAAGTTTACCTCATTCCCACACCACCTGAA AATATAACATTTGAAGACCCGTCATTAGATGTGATCCTTCTTTTAAGAGTTTTACATGCT ATCAGTCGATACTGGTATTACTTGTATGATAATGCAATGTGCAAGGAAATTATTCCAACT AGTGAATTTATTAACAGTAAGTTAACAGCAAAAGCAAATAGGCAACTTCAAGATCCTTTA GTAATCATGACAGGAAACATCCCAACATGGCTTACTGAGCTAGGAAAAACCTGCCCATTT TTCTTTCCTTTTGATACCCGGCAAATGCTTTTTTATGTAACTGCATTTGATCGGGACCGA GCAATGCAAAGATTACTTGATACCAACCCAGAAATCAACCAGTCTGATTCTCAAGATAGC AGAGTTGCACCTAGATTGGATAGAAAAAAACGTACTGTGAACCGAGAGGAGCTGCTGAAA CAGGCGGAGTCTGTGATGCAGGACCTCGGCAGCTCACGGGCCATGTTAGAAATCCAGTAT GAAAATGAGGTTGGTACAGGTCTTGGGCCTACACTGGAGTTTTATGCGCTTGTATCTCAG GAACTACAGAGAGCTGACTTGGGTCTTTGGAGAGGTGAAGAAGTAACTCTTAGCAATCCA AAAGGGAGCCAAGAAGGGACCAAGTATATTCAAAACCTCCAGGGCCTGTTTGCGCTTCCC TTTGGTAGGACAGCAAAGCCAGCTCATATCGCAAAGGTTAAGATGAAGTTTCGCTTCTTA GGAAAATTAATGGCCAAGGCTATCATGGATTTCAGATTGGTGGACCTTCCCCTTGGCTTA CCCTTTTATAAATGGATGCTACGGCAAGAAACTTCACTGACATCACACGATTTGTTTGAC ATCGACCCAGTTGTAGCCAGATCAGTTTATCACCTAGAAGACATTGTCAGACAGAAGAAA AGACTTGAACAAGATAAATCCCAGACCAAAGAGAGTCTACAGTATGCATTAGAAACCTTG ACTATGAATGGCTGCTCAGTTGAAGATCTAGGACTGGATTTCACTCTGCCAGGGTTTCCC AATATCGAACTGAAGAAAGGAGGGAAGGATATACCAGTCACTATCCACAATTTAGAGGAG TATCTAAGACTGGTTATATTCTGGGCACTAAATGAAGGCGTTTCTAGGCAATTTGATTCG TTCAGAGATGGATTTGAATCAGTCTTCCCACTCAGTCATCTTCAGTACTTCTACCCGGAG GAACTGGATCAGCTCCTTTGTGGCAGTAAAGCAGACACTTGGGATGCAAAGACACTGATG GAATGCTGTAGGCCTGATCATGGTTATACTCATGACAGTCGGGCTGTGAAGTTTTTGTTT GAGATTCTCAGTAGTTTTGATAATGAGCAGCAGAGGTTATTTCTCCAGTTTGTGACTGGT AGCCCAAGATTGCCTGTTGGAGGATTCCGGAGTTTGAATCCACCTTTGACAATTGTCCGA AAGACGTTTGAATCAACAGAAAACCCAGATGACTTCTTGCCCTCTGTAATGACTTGTGTG AACTATCTTAAGTTGCCGGACTATTCAAGCATTGAGATAATGCGTGAAAAACTGTTGATA GCAGCAAGAGAAGGGCAGCAGTCGTTCCATCTTTCCTGA |
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Protein Properties | |||||||||||||||
Number of Residues | 1992 | ||||||||||||||
Molecular Weight | 220431.5 | ||||||||||||||
Theoretical pI | 8.64 | ||||||||||||||
Pfam Domain Function |
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Signals |
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Transmembrane Regions |
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Protein Sequence |
>Probable E3 ubiquitin-protein ligase TRIP12 MSNRPNNNPGGSLRRSQRNTAGAQPQDDSIGGRSCSSSSAVIVPQPEDPDRANTSERQKT GQVPKKDNSRGVKRSASPDYNRTNSPSSAKKPKALQHTESPSETNKPHSKSKKRHLDQEQ QLKSAQSPSTSKAHTRKSGATGGSRSQKRKRTESSCVKSGSGSESTGAEERSAKPTKLAS KSATSAKAGCSTITDSSSAASTSSSSSAVASASSTVPPGARVKQGKDQNKARRSRSASSP SPRRSSREKEQSKTGGSSKFDWAARFSPKVSLPKTKLSLPGSSKSETSKPGPSGLQAKLA SLRKSTKKRSESPPAELPSLRRSTRQKTTGSCASTSRRGSGLGKRGAAEARRQEKMADPE SNQEAVNSSAARTDEAPQGAAGAVGMTTSGESESDDSEMGRLQALLEARGLPPHLFGPLG PRMSQLFHRTIGSGASSKAQQLLQGLQASDESQQLQAVIEMCQLLVMGNEETLGGFPVKS VVPALITLLQMEHNFDIMNHACRALTYMMEALPRSSAVVVDAIPVFLEKLQVIQCIDVAE QALTALEMLSRRHSKAILQAGGLADCLLYLEFFSINAQRNALAIAANCCQSITPDEFHFV ADSLPLLTQRLTHQDKKSVESTCLCFARLVDNFQHEENLLQQVASKDLLTNVQQLLVVTP PILSSGMFIMVVRMFSLMCSNCPTLAVQLMKQNIAETLHFLLCGASNGSCQEQIDLVPRS PQELYELTSLICELMPCLPKEGIFAVDTMLKKGNAQNTDGAIWQWRDDRGLWHPYNRIDS RIIEQINEDTGTARAIQRKPNPLANSNTSGYSESKKDDARAQLMKEDPELAKSFIKTLFG VLYEVYSSSAGPAVRHKCLRAILRIIYFADAELLKDVLKNHAVSSHIASMLSSQDLKIVV GALQMAEILMQKLPDIFSVYFRREGVMHQVKHLAESESLLTSPPKACTNGSGSMGSTTSV SSGTATAATHAAADLGSPSLQHSRDDSLDLSPQGRLSDVLKRKRLPKRGPRRPKYSPPRD DDKVDNQAKSPTTTQSPKSSFLASLNPKTWGRLSTQSNSNNIEPARTAGGSGLARAASKD TISNNREKIKGWIKEQAHKFVERYFSSENMDGSNPALNVLQRLCAATEQLNLQVDGGAEC LVEIRSIVSESDVSSFEIQHSGFVKQLLLYLTSKSEKDAVSREIRLKRFLHVFFSSPLPG EEPIGRVEPVGNAPLLALVHKMNNCLSQMEQFPVKVHDFPSGNGTGGSFSLNRGSQALKF FNTHQLKCQLQRHPDCANVKQWKGGPVKIDPLALVQAIERYLVVRGYGRVREDDEDSDDD GSDEEIDESLAAQFLNSGNVRHRLQFYIGEHLLPYNMTVYQAVRQFSIQAEDERESTDDE SNPLGRAGIWTKTHTIWYKPVREDEESNKDCVGGKRGRAQTAPTKTSPRNAKKHDELWHD GVCPSVSNPLEVYLIPTPPENITFEDPSLDVILLLRVLHAISRYWYYLYDNAMCKEIIPT SEFINSKLTAKANRQLQDPLVIMTGNIPTWLTELGKTCPFFFPFDTRQMLFYVTAFDRDR AMQRLLDTNPEINQSDSQDSRVAPRLDRKKRTVNREELLKQAESVMQDLGSSRAMLEIQY ENEVGTGLGPTLEFYALVSQELQRADLGLWRGEEVTLSNPKGSQEGTKYIQNLQGLFALP FGRTAKPAHIAKVKMKFRFLGKLMAKAIMDFRLVDLPLGLPFYKWMLRQETSLTSHDLFD IDPVVARSVYHLEDIVRQKKRLEQDKSQTKESLQYALETLTMNGCSVEDLGLDFTLPGFP NIELKKGGKDIPVTIHNLEEYLRLVIFWALNEGVSRQFDSFRDGFESVFPLSHLQYFYPE ELDQLLCGSKADTWDAKTLMECCRPDHGYTHDSRAVKFLFEILSSFDNEQQRLFLQFVTG SPRLPVGGFRSLNPPLTIVRKTFESTENPDDFLPSVMTCVNYLKLPDYSSIEIMREKLLI AAREGQQSFHLS |
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External Links | |||||||||||||||
GenBank ID Protein | 10863903 | ||||||||||||||
UniProtKB/Swiss-Prot ID | Q14669 | ||||||||||||||
UniProtKB/Swiss-Prot Entry Name | TRIPC_HUMAN | ||||||||||||||
PDB IDs | Not Available | ||||||||||||||
GenBank Gene ID | NM_004238.1 | ||||||||||||||
GeneCard ID | TRIP12 | ||||||||||||||
GenAtlas ID | TRIP12 | ||||||||||||||
HGNC ID | HGNC:12306 | ||||||||||||||
References | |||||||||||||||
General References |
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