Hmdb loader
Identification
HMDB Protein ID HMDBP09366
Secondary Accession Numbers
  • 15230
Name Peptidoglycan recognition protein 3
Synonyms
  1. PGLYRPIalpha
  2. PGRP-I-alpha
  3. Peptidoglycan recognition protein I-alpha
  4. Peptidoglycan recognition protein intermediate alpha
Gene Name PGLYRP3
Protein Type Enzyme
Biological Properties
General Function Involved in N-acetylmuramoyl-L-alanine amidase activity
Specific Function Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity.
Pathways Not Available
Reactions
N-Acetylmuramoyl-Ala + Water → N-Acetylmuramate + L-Alanine details
GO Classification
Biological Process
detection of bacterium
growth of symbiont in host
negative regulation of interferon-gamma production
negative regulation of natural killer cell differentiation involved in immune response
peptidoglycan catabolic process
defense response to Gram-positive bacterium
innate immune response
Cellular Component
intracellular
extracellular region
membrane
Function
n-acetylmuramoyl-l-alanine amidase activity
binding
catalytic activity
hydrolase activity
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
protein binding
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
Molecular Function
N-acetylmuramoyl-L-alanine amidase activity
peptidoglycan binding
peptidoglycan receptor activity
zinc ion binding
Process
polysaccharide metabolic process
aminoglycan metabolic process
glycosaminoglycan metabolic process
peptidoglycan metabolic process
peptidoglycan catabolic process
metabolic process
primary metabolic process
carbohydrate metabolic process
Cellular Location
  1. Secreted
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs PGLYRP3
Gene Sequence
>1026 bp
ATGGGGACGCTGCCATGGCTTCTTGCCTTCTTCATTCTGGGTCTCCAGGCTTGGGATACT
CCCACCATCGTCTCCCGCAAGGAGTGGGGGGCAAGACCGCTCGCCTGCAGGGCCCTGCTG
ACCCTGCCTGTGGCCTACATCATCACAGACCAGCTCCCAGGGATGCAGTGCCAGCAGCAG
AGCGTTTGCAGCCAGATGCTGCGGGGGTTGCAGTCCCATTCCGTCTACACCATAGGCTGG
TGCGACGTGGCGTACAACTTCCTGGTTGGGGATGATGGCAGGGTGTATGAAGGTGTTGGC
TGGAACATCCAAGGCTTGCACACCCAGGGCTACAACAACATTTCCCTGGGCATCGCCTTC
TTTGGCAATAAGATAGGCAGCAGTCCCAGCCCTGCTGCCTTATCAGCTGCAGAGGGTCTG
ATCTCCTATGCCATCCAGAAGGGTCACCTGTCGCCCAGGTATATTCAGCCACTTCTTCTG
AAAGAAGAGACCTGCCTGGACCCTCAACATCCAGTGATGCCCAGGAAGGTTTGCCCCAAC
ATCATCAAACGATCTGCTTGGGAAGCCAGAGAGACACACTGCCCTAAAATGAACCTCCCA
GCCAAATATGTCATCATCATCCACACCGCTGGCACAAGCTGCACTGTATCCACAGACTGC
CAGACTGTCGTCCGAAACATACAGTCCTTTCACATGGACACACGGAACTTTTGTGACATT
GGATATCACTTCCTGGTGGGCCAGGATGGTGGCGTGTATGAAGGGGTTGGATGGCACATC
CAAGGCTCTCACACTTATGGATTCAACGATATTGCCCTAGGAATTGCCTTCATCGGCTAC
TTTGTAGAAAAGCCTCCAAATGCTGCAGCGCTGGAGGCGGCCCAGGACCTGATCCAGTGT
GCCGTGGTTGAGGGGTACCTGACTCCAAACTACCTGCTGATGGGCCACAGTGACGTGGTC
AACATCCTGTCCCCTGGGCAGGCTTTGTATAACATCATCAGCACCTGGCCTCATTTCAAG
CACTGA
Protein Properties
Number of Residues 341
Molecular Weight Not Available
Theoretical pI Not Available
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Peptidoglycan recognition protein 3
MGTLPWLLAFFILGLQAWDTPTIVSRKEWGARPLACRALLTLPVAYIITDQLPGMQCQQQ
SVCSQMLRGLQSHSVYTIGWCDVAYNFLVGDDGRVYEGVGWNIQGLHTQGYNNISLGIAF
FGNKIGSSPSPAALSAAEGLISYAIQKGHLSPRYIQPLLLKEETCLDPQHPVMPRKVCPN
IIKRSAWEARETHCPKMNLPAKYVIIIHTAGTSCTVSTDCQTVVRNIQSFHMDTRNFCDI
GYHFLVGQDGGVYEGVGWHIQGSHTYGFNDIALGIAFIGYFVEKPPNAAALEAAQDLIQC
AVVEGYLTPNYLLMGHSDVVNILSPGQALYNIISTWPHFKH
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q96LB9
UniProtKB/Swiss-Prot Entry Name PGRP3_HUMAN
PDB IDs
GenBank Gene ID AY035376
GeneCard ID PGLYRP3
GenAtlas ID PGLYRP3
HGNC ID HGNC:30014
References
General References
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  3. Liu C, Xu Z, Gupta D, Dziarski R: Peptidoglycan recognition proteins: a novel family of four human innate immunity pattern recognition molecules. J Biol Chem. 2001 Sep 14;276(37):34686-94. Epub 2001 Jul 18. [PubMed:11461926 ]
  4. Lu X, Wang M, Qi J, Wang H, Li X, Gupta D, Dziarski R: Peptidoglycan recognition proteins are a new class of human bactericidal proteins. J Biol Chem. 2006 Mar 3;281(9):5895-907. Epub 2005 Dec 14. [PubMed:16354652 ]
  5. Guan R, Malchiodi EL, Wang Q, Schuck P, Mariuzza RA: Crystal structure of the C-terminal peptidoglycan-binding domain of human peptidoglycan recognition protein Ialpha. J Biol Chem. 2004 Jul 23;279(30):31873-82. Epub 2004 May 12. [PubMed:15140887 ]
  6. Guan R, Roychowdhury A, Ember B, Kumar S, Boons GJ, Mariuzza RA: Structural basis for peptidoglycan binding by peptidoglycan recognition proteins. Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17168-73. Epub 2004 Nov 30. [PubMed:15572450 ]
  7. Guan R, Brown PH, Swaminathan CP, Roychowdhury A, Boons GJ, Mariuzza RA: Crystal structure of human peptidoglycan recognition protein I alpha bound to a muramyl pentapeptide from Gram-positive bacteria. Protein Sci. 2006 May;15(5):1199-206. [PubMed:16641493 ]