Human Metabolome Database: Showing Protein Poly(A) polymerase beta (Testis specific) (HMDBP09385)

Identification Biological properties Gene properties Protein properties External links References XML Show 3 metabolites

Identification

HMDB Protein ID

HMDBP09385

Secondary Accession Numbers

15255

Name

Poly(A) polymerase beta (Testis specific)

Synonyms

Not Available

Gene Name

PAPOLB

Protein Type

Enzyme

Biological Properties

General Function

Involved in nucleotidyltransferase activity

Specific Function

Not Available

Pathways

Not Available

Reactions

Not Available

GO Classification

Component
organelle
membrane-bounded organelle
intracellular membrane-bounded organelle
nucleus
Function
binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
nucleotidyltransferase activity
adenylyltransferase activity
nucleic acid binding
polynucleotide adenylyltransferase activity
rna binding
Process
rna metabolic process
macromolecule biosynthetic process
cellular macromolecule biosynthetic process
metabolic process
macromolecule metabolic process
cellular macromolecule metabolic process
rna processing
biosynthetic process
rna polyadenylation
transcription
rna 3'-end processing

Cellular Location

Cytoplasmic

Gene Properties

Chromosome Location

Chromosome:7

Locus

7p22.1

SNPs

PAPOLB

Gene Sequence

>1914 bp
ATGATGCCGTTTCCGGTGACAACCCAGGGACCACCGCAGCCGGCGCCGCCGCCGAATCGC
TACGGCGTCTCCTCGCCTATCAGTCTAGCGGTCCCCAAGGAGACGGACTGCCTCCTCACC
CAGAGGCTAATAGAAACCCTCAGGCCCTTCGGGGTCTTCGAAGAGGAAGAGGAACTGCAG
CGCAGGATTTTAGTTTTGGAAAAATTAAATAATCTGGTAAAGGAATGGATACGCGAAATC
AGTGAAAGCAAGAGTCTTCCCCAGTCTGTAATTGAAAACGTTGGAGGAAAGATTTTTACG
TTTGGCTCTTACAGATTAGGAGTACATACGAAAGGCGCAGATATTGACGCCTTGTGCGTT
GCACCAAGTCATGTGGATCGAAGCGACTTTTTCACCTCATTCTATGCTAAACTGAAACTA
CAGGAGGAAGTGAAAGATTTAAGGGCTGTCGAGGAGGCATTTGTGCCAGTTATCAAACTG
TGTTTTGATGGGATAGAGATTGATATTTTATTTGCAAGATTAGCACTACAGACTATTCCA
GAAGATTTGGACTTAAGAGATGACAGTCTACTTAAAAATTTAGACATTAGATGCATAAGA
AGCCTTAATGGTTGCCGGGTAACCGATGAAATTTTACATCTAGTGCCAAACATTGACAAC
TTCAGGCTGACTCTGAGAGCCATCAAACTGTGGGCCAAGTGCCACAATATCTATTCCAAT
ATATTAGGTTTCCTCGGAGGTGTTTCCTGGGCCATGCTAGTAGCAAGAACTTGTCAGCTT
TATCCAAATGCAGTAGCGTCAACTCTTGTACGGAAATTCTTCTTGGTATTTTCAGAATGG
GAATGGCCAAACCCAGTGTTACTGAAGGAGCCTGAAGAACGGAATCTTAATTTGCCTGTA
TGGGACCCAAGAGTAAATCCCAGTGATAGGTACCATCTTATGCCTATCATCACACCAGCA
TACCCACAGCAGAACTCCACATACAACGTGTCTATTTCAACCAGGATGGTCATGATTGAG
GAGTTTAAACAGGGGCTTGCTATCACACACGAGATTTTGCTAAGTAAGGCAGAGTGGTCC
AAACTCTTTGAAGCTCCAAGCTTCTTTCAAAAGTACAAGCATTATATTGTACTTCTGGCA
AGTGCATCAACAGAAAAACAACATTTAGAATGGGTGGGCTTGGTGGAATCAAAGATCCGA
ATCCTGGTTGGGAGCTTGGAGAAGAATGAATTTATTACACTGGCACATGTGAATCCACAG
TCATTTCCAGCACCCAAAGAAAATCCTGATATGGAAGAATTTCGTACAATGTGGGTGATT
GGGTTAGGGCTAAAAAAGCCAGATAATTCTGAAATTCTCAGCATTGATCTCACCTATGAT
ATCCAGTCTTTCACAGATACTGTTTATAGGCAAGCAGTGAATAGTAAGATGTTTGAGATG
GGTATGAAAATTACTGCAATGCATTTAAGAAGAAAGGAACTTCACCAGCTGCTGCCTCAT
CATGTGCTTCAGGACAAGAAAGCACACTCAACAGAAGGTAGAAGATTGACAGATTTGAAC
GACAGCAGCTTTGACTTGTCTGCAGGCTGTGAAAACAGCATGTCTGTGCCTTCATCTACT
AGCACTATGAAGACAGGCCCATTGATTAGCAGTTCTCAGGGTAGAAACAGTCCTGCCTTG
GCTGTAATGACAGCATCTGTGGCTAACATACAGGCTACTGAATTTTCCTTGCAACAGGTG
AATACCAATGAAAGTTCAGGGGTTGCATTAAACGAAAGTATTCCTCACGCTGTCTCTCAG
CCTGCCATTTCTCCATCACCAAAGGCCATGGTCGCCAGAGTTGTTTCTTCAACATGTCTC
ATAAGCCATCCAGACCTTCAGGAAACTCAGCAACAAACATATCTAATCCTATAG

Protein Properties

Number of Residues

637

Molecular Weight

71812.0

Theoretical pI

6.41

Pfam Domain Function

NTP_transf_2 (PF01909 )
PAP_central; (PF04928 )
PAP_RNA-bind (PF04926 )

Signals

None

Transmembrane Regions

None

Protein Sequence

>Poly(A) polymerase beta (Testis specific)
MMPFPVTTQGPPQPAPPPNRYGVSSPISLAVPKETDCLLTQRLIETLRPFGVFEEEEELQ
RRILVLEKLNNLVKEWIREISESKSLPQSVIENVGGKIFTFGSYRLGVHTKGADIDALCV
APSHVDRSDFFTSFYAKLKLQEEVKDLRAVEEAFVPVIKLCFDGIEIDILFARLALQTIP
EDLDLRDDSLLKNLDIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKCHNIYSN
ILGFLGGVSWAMLVARTCQLYPNAVASTLVRKFFLVFSEWEWPNPVLLKEPEERNLNLPV
WDPRVNPSDRYHLMPIITPAYPQQNSTYNVSISTRMVMIEEFKQGLAITHEILLSKAEWS
KLFEAPSFFQKYKHYIVLLASASTEKQHLEWVGLVESKIRILVGSLEKNEFITLAHVNPQ
SFPAPKENPDMEEFRTMWVIGLGLKKPDNSEILSIDLTYDIQSFTDTVYRQAVNSKMFEM
GMKITAMHLRRKELHQLLPHHVLQDKKAHSTEGRRLTDLNDSSFDLSAGCENSMSVPSST
STMKTGPLISSSQGRNSPALAVMTASVANIQATEFSLQQVNTNESSGVALNESIPHAVSQ
PAISPSPKAMVARVVSSTCLISHPDLQETQQQTYLIL

External Links

GenBank ID Protein

77874206

UniProtKB/Swiss-Prot ID

A4D1Z6

UniProtKB/Swiss-Prot Entry Name

A4D1Z6_HUMAN

PDB IDs

Not Available

GenBank Gene ID

GeneCard ID

GenAtlas ID

HGNC ID

References

General References

Scherer SW, Cheung J, MacDonald JR, Osborne LR, Nakabayashi K, Herbrick JA, Carson AR, Parker-Katiraee L, Skaug J, Khaja R, Zhang J, Hudek AK, Li M, Haddad M, Duggan GE, Fernandez BA, Kanematsu E, Gentles S, Christopoulos CC, Choufani S, Kwasnicka D, Zheng XH, Lai Z, Nusskern D, Zhang Q, Gu Z, Lu F, Zeesman S, Nowaczyk MJ, Teshima I, Chitayat D, Shuman C, Weksberg R, Zackai EH, Grebe TA, Cox SR, Kirkpatrick SJ, Rahman N, Friedman JM, Heng HH, Pelicci PG, Lo-Coco F, Belloni E, Shaffer LG, Pober B, Morton CC, Gusella JF, Bruns GA, Korf BR, Quade BJ, Ligon AH, Ferguson H, Higgins AW, Leach NT, Herrick SR, Lemyre E, Farra CG, Kim HG, Summers AM, Gripp KW, Roberts W, Szatmari P, Winsor EJ, Grzeschik KH, Teebi A, Minassian BA, Kere J, Armengol L, Pujana MA, Estivill X, Wilson MD, Koop BF, Tosi S, Moore GE, Boright AP, Zlotorynski E, Kerem B, Kroisel PM, Petek E, Oscier DG, Mould SJ, Dohner H, Dohner K, Rommens JM, Vincent JB, Venter JC, Li PW, Mural RJ, Adams MD, Tsui LC: Human chromosome 7: DNA sequence and biology. Science. 2003 May 2;300(5620):767-72. Epub 2003 Apr 10. [PubMed:12690205 ]