Hmdb loader
Identification
HMDB Protein ID HMDBP09503
Secondary Accession Numbers
  • 15398
Name Serine/threonine-protein kinase ULK2
Synonyms
  1. Unc-51-like kinase 2
Gene Name ULK2
Protein Type Enzyme
Biological Properties
General Function Involved in protein kinase activity
Specific Function ATP + a protein = ADP + a phosphoprotein
Pathways Not Available
Reactions Not Available
GO Classification
Function
binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
protein binding
protein kinase activity
protein serine/threonine kinase activity
Process
phosphorus metabolic process
phosphate metabolic process
metabolic process
cellular process
biological regulation
regulation of biological process
cellular metabolic process
cell projection organization
cell projection morphogenesis
neuron projection morphogenesis
axonogenesis
regulation of cellular process
signal transduction
protein amino acid phosphorylation
phosphorylation
Cellular Location Not Available
Gene Properties
Chromosome Location Chromosome:1
Locus 17p11.2
SNPs ULK2
Gene Sequence
>3111 bp
ATGGAGGTGGTGGGTGACTTCGAGTACAGCAAGAGGGATCTCGTGGGACACGGGGCCTTC
GCCGTGGTCTTCCGGGGGCGGCACCGCCAGAAAACTGATTGGGAGGTAGCTATTAAAAGT
ATTAATAAAAAGAACTTGTCAAAATCACAAATACTGCTTGGAAAGGAAATTAAAATCTTA
AAGGAACTTCAGCATGAAAATATTGTAGCACTCTATGATGTTCAGGAATTACCCAACTCT
GTCTTTTTGGTGATGGAGTATTGCAATGGTGGAGACCTCGCAGATTATTTGCAAGCGAAA
GGGACTCTCAGTGAAGACACGATCAGAGTGTTTCTGCATCAGATTGCTGCTGCCATGCGA
ATCCTGCACAGCAAAGGAATCATCCACAGAGATCTCAAACCACAGAACATCTTGCTGTCC
TATGCCAATCGCAGAAAATCAAGTGTCAGTGGTATTCGCATCAAAATAGCGGATTTTGGT
TTTGCTCGTTACCTACATAGTAACATGATGGCTGCAACACTGTGTGGATCCCCGATGTAC
ATGGCTCCTGAGGTTATTATGTCTCAACATTATGATGCTAAGGCTGACTTGTGGAGCATA
GGAACAGTGATATACCAATGCCTAGTTGGAAAACCACCTTTTCAGGCCAATAGTCCTCAA
GACTTAAGGATGTTTTATGAAAAAAACAGGAGCTTAATGCCTAGTATTCCCAGAGAAACA
TCACCTTATTTGGCTAATCTCCTTTTGGGTTTGCTTCAGAGAAACCAAAAAGATAGAATG
GACTTTGAAGCATTTTTTAGCCATCCTTTTCTTGAGCAAGGTCCAGTAAAAAAATCTTGC
CCAGTTCCAGTGCCCATGTATTCTGGTTCTGTCTCTGGAAGCTCCTGTGGCAGCTCTCCA
TCTTGTCGTTTTGCTTCTCCACCATCCCTTCCAGATATGCAGCATATTCAGGAAGAAAAC
TTATCTTCCCCACCATTGGGTCCTCCCAACTATCTACAAGTTTCCAAAGATTCTGCCAGT
ACTAGTAGCAAGAACTCTTCTTGTGACACGGATGACTTTGTTTTGGTGCCACACAACATC
TCGTCAGACCACTCATGTGATATGCCAGTGGGGACTGCTGGCAGACGTGCTTCAAATGAA
TTCTTGGTGTGTGGAGGGCAGTGTCAGCCTACTGTGTCACCTCACAGCGAAACAGCACCA
ATTCCAGTTCCTACTCAAATAAGGAATTATCAGCGCATAGAGCAGAATCTTACATCTACT
GCCAGCTCAGGCACAAATGTACATGGTTCTCCAAGATCTGCAGTGGTACGAAGGTCCAAC
ACCAGCCCCATGGGCTTCCTCCGGCCGGGATCATGCTCCCCAGTACCAGCAGACACAGCA
CAGACAGTTGGACGAAGGCTCTCCACTGGGTCTTCTAGGCCTTACTCACCTTCCCCTTTG
GTTGGTACCATTCCTGAGCAATTCAGTCAGTGCTGCTGTGGGCATCCTCAGGGCCATGAC
TCCAGGAGTAGAAACTCCTCAGGTTCTCCAGTGCCACAAGCTCAGTCCCCACAGTCTCTC
TTATCGGGTGCTAGACTGCAGAGCGCCCCCACCCTCACTGACATCTATCAGAACAAGCAG
AAGCTCAGAAAACAGCACTCTGACCCCGTGTGCCCATCCCATACTGGGGCTGGGTACAGC
TACTCGCCTCAGCCCAGTCGGCCTGGCAGCCTTGGAACTTCTCCCACCAAGCACTTGGGG
TCCTCTCCACGGAGTTCTGACTGGTTCTTTAAAACTCCTTTGCCAACAATCATTGGCTCT
CCTACTAAGACCACAGCTCCTTTCAAAATCCCTAAAACTCAAGCATCTTCCAACCTGTTA
GCCTTGGTTACTCGTCATGGGCCTGCTGAAGAACAGTCGAAAGATGGGAATGAGCCACGG
GAATGTGCCCATTGCCTCTTAGTGCAAGGAAGTGAGAGGCAGCGGGCCGAGCAGCAGAGC
AAGGCAGTGTTTGGCAGATCTGTCAGTACCGGGAAGTTATCAGATCAACAAGGAAAGACT
CCTATATGTCGACATCAGGGCAGCACAGACAGTTTAAATACAGAACGACCAATGGATATA
GCTCCGGCAGGAGCCTGTGGTGGTGTTCTGGCACCTCCTGCAGGTACAGCAGCAAGTTCC
AAGGCTGTCCTCTTCACTGTAGGGTCTCCTCCACACAGTGCGGCAGCCCCCACTTGTACC
CACATGTTCCTTCGAACAAGAACAACCTCAGTGGGGCCCAGCAACTCCGGGGGCTCTCTT
TGTGCCATGAGTGGCCGCGTGTGCGTGGGGTCCCCGCCTGGCCCAGGCTTCGGCTCTTCC
CCTCCAGGAGCAGAGGCAGCTCCCAGCCTGAGATACGTGCCTTACGGTGCTTCACCCCCC
AGCCTAGAGGGGCTCATCACCTTTGAAGCCCCTGAACTGCCGGAGGAGACGCTGATGGAG
CGGGAACACACAGACACCTTACGCCATCTGAATGTGATGCTGATGTTCACTGAGTGTGTG
CTGGACCTGACAGCCATGAGGGGAGGAAACCCTGAGCTGTGCACATCTGCTGTGTCCTTG
TACCAGATCCAGGAGAGTGTGGTGGTGGACCAGATCAGTCAGCTGAGCAAAGACTGGGGG
CGGGTGGAGCAGCTGGTGTTGTACATGAAAGCAGCACAGCTGCTTGCGGCTTCTCTGCAT
CTTGCCAAAGCCCAGATCAAGTCCGGGAAACTGAGCCCATCCACAGCTGTGAAACAAGTT
GTCAAGAATCTGAACGAACGATATAAATTCTGCATCACCATGTGCAAGAAACTTACAGAA
AAGCTGAATCGATTCTTCTCTGACAAACAGAGGTTTATTGATGAAATCAACAGTGTGACT
GCAGAGAAACTCATCTATAATTGTGCTGTAGAAATGGTTCAGTCTGCAGCCCTGGATGAG
ATGTTTCAGCAGACCGAAGATATTGTTTATCGCTATCATAAGGCAGCCCTTCTTTTGGAA
GGCCTAAGTAGGATTCTACAGGACCCTGCAGATATTGAAAATGTGCATAAATATAAATGT
AGTATTGAGAGAAGACTGTCGGCGCTCTGCCATAGCACCGCAACCGTGTGA
Protein Properties
Number of Residues 1036
Molecular Weight 112693.2
Theoretical pI 8.62
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Serine/threonine-protein kinase ULK2
MEVVGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKIL
KELQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMR
ILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCGSPMY
MAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSIPRET
SPYLANLLLGLLQRNQKDRMDFEAFFSHPFLEQGPVKKSCPVPVPMYSGSVSGSSCGSSP
SCRFASPPSLPDMQHIQEENLSSPPLGPPNYLQVSKDSASTSSKNSSCDTDDFVLVPHNI
SSDHSCDMPVGTAGRRASNEFLVCGGQCQPTVSPHSETAPIPVPTQIRNYQRIEQNLTST
ASSGTNVHGSPRSAVVRRSNTSPMGFLRPGSCSPVPADTAQTVGRRLSTGSSRPYSPSPL
VGTIPEQFSQCCCGHPQGHDSRSRNSSGSPVPQAQSPQSLLSGARLQSAPTLTDIYQNKQ
KLRKQHSDPVCPSHTGAGYSYSPQPSRPGSLGTSPTKHLGSSPRSSDWFFKTPLPTIIGS
PTKTTAPFKIPKTQASSNLLALVTRHGPAEEQSKDGNEPRECAHCLLVQGSERQRAEQQS
KAVFGRSVSTGKLSDQQGKTPICRHQGSTDSLNTERPMDIAPAGACGGVLAPPAGTAASS
KAVLFTVGSPPHSAAAPTCTHMFLRTRTTSVGPSNSGGSLCAMSGRVCVGSPPGPGFGSS
PPGAEAAPSLRYVPYGASPPSLEGLITFEAPELPEETLMEREHTDTLRHLNVMLMFTECV
LDLTAMRGGNPELCTSAVSLYQIQESVVVDQISQLSKDWGRVEQLVLYMKAAQLLAASLH
LAKAQIKSGKLSPSTAVKQVVKNLNERYKFCITMCKKLTEKLNRFFSDKQRFIDEINSVT
AEKLIYNCAVEMVQSAALDEMFQQTEDIVYRYHKAALLLEGLSRILQDPADIENVHKYKC
SIERRLSALCHSTATV
GenBank ID Protein 217330559
UniProtKB/Swiss-Prot ID Q8IYT8
UniProtKB/Swiss-Prot Entry Name ULK2_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_001142610.1
GeneCard ID ULK2
GenAtlas ID ULK2
HGNC ID HGNC:13480
References
General References
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  2. Zody MC, Garber M, Adams DJ, Sharpe T, Harrow J, Lupski JR, Nicholson C, Searle SM, Wilming L, Young SK, Abouelleil A, Allen NR, Bi W, Bloom T, Borowsky ML, Bugalter BE, Butler J, Chang JL, Chen CK, Cook A, Corum B, Cuomo CA, de Jong PJ, DeCaprio D, Dewar K, FitzGerald M, Gilbert J, Gibson R, Gnerre S, Goldstein S, Grafham DV, Grocock R, Hafez N, Hagopian DS, Hart E, Norman CH, Humphray S, Jaffe DB, Jones M, Kamal M, Khodiyar VK, LaButti K, Laird G, Lehoczky J, Liu X, Lokyitsang T, Loveland J, Lui A, Macdonald P, Major JE, Matthews L, Mauceli E, McCarroll SA, Mihalev AH, Mudge J, Nguyen C, Nicol R, O'Leary SB, Osoegawa K, Schwartz DC, Shaw-Smith C, Stankiewicz P, Steward C, Swarbreck D, Venkataraman V, Whittaker CA, Yang X, Zimmer AR, Bradley A, Hubbard T, Birren BW, Rogers J, Lander ES, Nusbaum C: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. Nature. 2006 Apr 20;440(7087):1045-9. [PubMed:16625196 ]
  3. Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, Davies H, Teague J, Butler A, Stevens C, Edkins S, O'Meara S, Vastrik I, Schmidt EE, Avis T, Barthorpe S, Bhamra G, Buck G, Choudhury B, Clements J, Cole J, Dicks E, Forbes S, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jenkinson A, Jones D, Menzies A, Mironenko T, Perry J, Raine K, Richardson D, Shepherd R, Small A, Tofts C, Varian J, Webb T, West S, Widaa S, Yates A, Cahill DP, Louis DN, Goldstraw P, Nicholson AG, Brasseur F, Looijenga L, Weber BL, Chiew YE, DeFazio A, Greaves MF, Green AR, Campbell P, Birney E, Easton DF, Chenevix-Trench G, Tan MH, Khoo SK, Teh BT, Yuen ST, Leung SY, Wooster R, Futreal PA, Stratton MR: Patterns of somatic mutation in human cancer genomes. Nature. 2007 Mar 8;446(7132):153-8. [PubMed:17344846 ]
  4. Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O: Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. DNA Res. 1998 Jun 30;5(3):169-76. [PubMed:9734811 ]
  5. Chan EY, Longatti A, McKnight NC, Tooze SA: Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism. Mol Cell Biol. 2009 Jan;29(1):157-71. doi: 10.1128/MCB.01082-08. Epub 2008 Oct 20. [PubMed:18936157 ]