| Identification |
|---|
| HMDB Protein ID
| HMDBP09516 |
| Secondary Accession Numbers
| |
| Name
| Cyclin-dependent kinase-like 4 |
| Synonyms
|
Not Available
|
| Gene Name
| CDKL4 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein kinase activity |
| Specific Function
| ATP + a protein = ADP + a phosphoprotein |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Function |
| binding |
| catalytic activity |
| transferase activity |
| transferase activity, transferring phosphorus-containing groups |
| kinase activity |
| nucleoside binding |
| purine nucleoside binding |
| adenyl nucleotide binding |
| adenyl ribonucleotide binding |
| atp binding |
| protein kinase activity |
| protein serine/threonine kinase activity |
| Process |
| phosphorus metabolic process |
| phosphate metabolic process |
| metabolic process |
| cellular metabolic process |
| protein amino acid phosphorylation |
| phosphorylation |
|
| Cellular Location
|
- Cytoplasm (Probable)
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:2 |
| Locus
| 2p22.1 |
| SNPs
| CDKL4 |
| Gene Sequence
|
>948 bp
ATGGAAAAGTATGAAAAATTAGCTAAGACTGGAGAAGGGTCTTATGGGGTTGTATTCAAA
TGCAGAAACAAAACCTCTGGACAAGTAGTAGCTGTTAAAAAATTTGTGGAATCTGAAGAT
GATCCTGTTGTTAAGAAAATAGCACTAAGAGAAATACGTATGTTGAAGCAATTAAAACAT
CCAAATCTTGTGAACCTCATCGAGGTGTTCAGGAGAAAAAGGAAAATGCATTTAGTTTTT
GAATACTGTGATCATACACTTTTAAATGAGCTGGAAAGAAACCCAAATGGAGTTGCTGAT
GGAGTGATCAAAAGCGTATTATGGCAAACACTTCAAGCTCTTAATTTCTGTCATATACAT
AACTGTATTCACAGAGATATAAAACCTGAAAATATTCTAATAACTAAGCAAGGAATAATC
AAGATTTGTGACTTCGGGTTTGCACAAATTCTGATTCCAGGAGATGCCTACACCGATTAT
GTAGCTACGAGATGGTACCGAGCTCCTGAACTTCTTGTGGGAGATACTCAGTATGGTTCT
TCAGTCGATATATGGGCTATTGGTTGTGTTTTTGCAGAGCTCCTGACAGGCCAGCCACTG
TGGCCTGGAAAATCAGATGTGGACCAACTTTATCTGATAATCAGAACACTAGGAAAATTA
ATCCCAAGACATCAATCAATCTTTAAAAGTAACGGGTTTTTCCATGGCATCAGTATACCT
GAGCCAGAAGACATGGAAACTCTTGAGGAAAAGTTCTCAGATGTTCATCCTGTGGCTCTG
AACTTCATGAAGGGGTGTCTGAAGATGAATCCAGATGACAGATTAACCTGTTCCCAACTC
CTGGAGAGCTCCTACTTTGATTCTTTTCAAGAGGCCCAAATTAAAAGAAAAGCACGTAAT
GAAGGAAGAAACAGAAGACGCCAACAGGTACTTCCGCTCAAAAGTTAA
|
| Protein Properties |
|---|
| Number of Residues
| 315 |
| Molecular Weight
| 36222.7 |
| Theoretical pI
| 8.87 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Cyclin-dependent kinase-like 4
MEKYEKLAKTGEGSYGVVFKCRNKTSGQVVAVKKFVESEDDPVVKKIALREIRMLKQLKH
PNLVNLIEVFRRKRKMHLVFEYCDHTLLNELERNPNGVADGVIKSVLWQTLQALNFCHIH
NCIHRDIKPENILITKQGIIKICDFGFAQILIPGDAYTDYVATRWYRAPELLVGDTQYGS
SVDIWAIGCVFAELLTGQPLWPGKSDVDQLYLIIRTLGKLIPRHQSIFKSNGFFHGISIP
EPEDMETLEEKFSDVHPVALNFMKGCLKMNPDDRLTCSQLLESSYFDSFQEAQIKRKARN
EGRNRRRQQVLPLKS
|
| External Links |
|---|
| GenBank ID Protein
| 56790912 |
| UniProtKB/Swiss-Prot ID
| Q5MAI5 |
| UniProtKB/Swiss-Prot Entry Name
| CDKL4_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AY845084 |
| GeneCard ID
| CDKL4 |
| GenAtlas ID
| CDKL4 |
| HGNC ID
| HGNC:19287 |
| References |
|---|
| General References
| - Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, Davies H, Teague J, Butler A, Stevens C, Edkins S, O'Meara S, Vastrik I, Schmidt EE, Avis T, Barthorpe S, Bhamra G, Buck G, Choudhury B, Clements J, Cole J, Dicks E, Forbes S, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jenkinson A, Jones D, Menzies A, Mironenko T, Perry J, Raine K, Richardson D, Shepherd R, Small A, Tofts C, Varian J, Webb T, West S, Widaa S, Yates A, Cahill DP, Louis DN, Goldstraw P, Nicholson AG, Brasseur F, Looijenga L, Weber BL, Chiew YE, DeFazio A, Greaves MF, Green AR, Campbell P, Birney E, Easton DF, Chenevix-Trench G, Tan MH, Khoo SK, Teh BT, Yuen ST, Leung SY, Wooster R, Futreal PA, Stratton MR: Patterns of somatic mutation in human cancer genomes. Nature. 2007 Mar 8;446(7132):153-8. [PubMed:17344846 ]
|
