Hmdb loader

Showing Protein Aminopeptidase B (HMDBP10011)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP10011
Secondary Accession Numbers
  • 15948
Name Aminopeptidase B
Synonyms
  1. AP-B
  2. Arginine aminopeptidase
  3. Arginyl aminopeptidase
Gene Name RNPEP
Protein Type Enzyme
Biological Properties
General Function Involved in binding
Specific Function Exopeptidase which selectively removes arginine and/or lysine residues from the N-terminus of several peptide substrates including Arg(0)-Leu-enkephalin, Arg(0)-Met-enkephalin and Arg(- 1)-Lys(0)-somatostatin-14. Can hydrolyze leukotriene A4 (LTA-4) into leukotriene B4 (LTB-4)
Pathways Not Available
Reactions Not Available
GO Classification
Component
extracellular region part
extracellular space
Function
exopeptidase activity
aminopeptidase activity
ion binding
cation binding
metal ion binding
binding
catalytic activity
hydrolase activity
transition metal ion binding
zinc ion binding
peptidase activity
peptidase activity, acting on l-amino acid peptides
metallopeptidase activity
Process
metabolic process
macromolecule metabolic process
cellular metabolic process
organic acid metabolic process
oxoacid metabolic process
carboxylic acid metabolic process
monocarboxylic acid metabolic process
fatty acid metabolic process
leukotriene biosynthetic process
protein metabolic process
proteolysis
unsaturated fatty acid metabolic process
icosanoid metabolic process
leukotriene metabolic process
Cellular Location
  1. Secreted
Gene Properties
Chromosome Location Chromosome:1
Locus 1q32
SNPs RNPEP
Gene Sequence 
>1953 bp
ATGGCGAGCGGCGAGCATTCCCCCGGCAGCGGCGCGGCCCGGCGGCCGCTGCACTCCGCG
CAGGCTGTGGACGTGGCCTCGGCCTCCAACTTCCGGGCCTTTGAGCTGCTGCACTTGCAC
CTGGACCTGCGGGCTGAGTTCGGGCCTCCAGGGCCCGGCGCAGGGAGCCGGGGGCTGAGC
GGCACCGCGGTCCTGGACCTGCGCTGCCTGGAGCCCGAGGGCGCCGCCGAGCTGCGGCTG
GACTCGCACCCGTGCCTGGAGGTGACGGCGGCGGCGCTGCGGCGGGAGCGGCCCGGCTCG
GAGGAGCCGCCTGCGGAGCCCGTGAGCTTCTACACGCAGCCCTTCTCGCACTATGGCCAG
GCCCTGTGCGTGTCCTTCCCGCAGCCCTGCCGCGCCGCCGAGCGCCTCCAGGTGCTGCTC
ACCTACCGCGTCGGGGAGGGACCCGGGGTTTGCTGGTTGGCTCCCGAGCAGACAGCAGGA
AAGAAGAAGCCCTTCGTGTACACCCAGGGCCAGGCTGTCCTAAACCGGGCCTTCTTCCCT
TGCTTCGACACGCCTGCTGTTAAATACAAGTATTCAGCTCTTATTGAGGTCCCAGATGGC
TTCACAGCTGTGATGAGTGCTAGCACCTGGGAGAAGAGAGGTCCAAATAAGTTCTTCTTC
CAGATGTGTCAGCCCATCCCCTCCTATCTGATAGCTTTGGCCATCGGAGATCTGGTTTCG
GCTGAAGTTGGACCCAGGAGCCGGGTGTGGGCTGAGCCCTGCCTGATTGATGCTGCCAAG
GAGGAGTACAACGGGGTGATAGAAGAATTTTTGGCAACAGGAGAGAAGCTTTTTGGACCT
TATGTTTGGGGAAGGTATGACTTGCTCTTCATGCCACCGTCCTTTCCATTTGGAGGAATG
GAGAACCCTTGTCTGACCTTTGTCACCCCCTGCCTGCTAGCTGGGGACCGCTCCTTGGCA
GATGTCATCATCCATGAGATCTCCCACAGTTGGTTTGGGAACCTGGTCACCAACGCCAAC
TGGGGTGAATTCTGGCTCAATGAAGGTTTCACCATGTACGCCCAGAGGAGGATCTCCACC
ATCCTCTTTGGCGCTGCGTACACCTGCTTGGAGGCTGCAACGGGGCGGGCTCTGCTGCGT
CAGCACATGGACATCACTGGAGAGGAAAACCCACTCAACAAGCTCCGCGTGAAGATTGAA
CCAGGCGTTGACCCGGACGACACCTATAATGAGACCCCCTACGAGAAAGGTTTCTGCTTT
GTCTCATACCTGGCCCACTTGGTGGGTGATCAGGATCAGTTTGACAGTTTTCTCAAGGCC
TATGTGCATGAATTCAAATTCCGAAGCATCTTAGCCGATGACTTTCTGGACTTCTACTTG
GAATATTTCCCTGAGCTTAAGAAAAAGAGAGTGGATATCATTCCAGGTTTTGAGTTTGAT
CGATGGCTGAATACCCCCGGCTGGCCCCCGTACCTCCCTGATCTCTCCCCTGGGGACTCA
CTCATGAAGCCTGCTGAAGAGCTAGCCCAACTGTGGGCAGCCGAGGAGCTGGACATGAAG
GCCATTGAAGCCGTGGCCATCTCTCCCTGGAAGACCTACCAGCTGGTCTACTTCCTGGAT
AAGATCCTCCAGAAATCCCCTCTCCCTCCTGGGAATGTGAAAAAACTTGGAGACACATAC
CCAAGTATCTCAAATGCCCGGAATGCAGAGCTCCGGCTGCGATGGGGCCAAATCGTCCTT
AAGAACGACCACCAGGAAGATTTCTGGAAAGTGAAGGAGTTCCTGCATAACCAGGGGAAG
CAGAAGTATACACTTCCGCTGTACCACGCAATGATGGGTGGCAGTGAGGTGGCCCAGACC
CTCGCCAAGGAGACTTTTGCATCCACCGCCTCCCAGCTCCACAGCAATGTTGTCAACTAT
GTCCAGCAGATCGTGGCACCCAAGGGCAGTTAG
Protein Properties
Number of Residues 650
Molecular Weight 72595.1
Theoretical pI 5.52
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence 
>Aminopeptidase B
MASGEHSPGSGAARRPLHSAQAVDVASASNFRAFELLHLHLDLRAEFGPPGPGAGSRGLS
GTAVLDLRCLEPEGAAELRLDSHPCLEVTAAALRRERPGSEEPPAEPVSFYTQPFSHYGQ
ALCVSFPQPCRAAERLQVLLTYRVGEGPGVCWLAPEQTAGKKKPFVYTQGQAVLNRAFFP
CFDTPAVKYKYSALIEVPDGFTAVMSASTWEKRGPNKFFFQMCQPIPSYLIALAIGDLVS
AEVGPRSRVWAEPCLIDAAKEEYNGVIEEFLATGEKLFGPYVWGRYDLLFMPPSFPFGGM
ENPCLTFVTPCLLAGDRSLADVIIHEISHSWFGNLVTNANWGEFWLNEGFTMYAQRRIST
ILFGAAYTCLEAATGRALLRQHMDITGEENPLNKLRVKIEPGVDPDDTYNETPYEKGFCF
VSYLAHLVGDQDQFDSFLKAYVHEFKFRSILADDFLDFYLEYFPELKKKRVDIIPGFEFD
RWLNTPGWPPYLPDLSPGDSLMKPAEELAQLWAAEELDMKAIEAVAISPWKTYQLVYFLD
KILQKSPLPPGNVKKLGDTYPSISNARNAELRLRWGQIVLKNDHQEDFWKVKEFLHNQGK
QKYTLPLYHAMMGGSEVAQTLAKETFASTASQLHSNVVNYVQQIVAPKGS
GenBank ID Protein 40316915
UniProtKB/Swiss-Prot ID Q9H4A4
UniProtKB/Swiss-Prot Entry Name AMPB_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_020216.3
GeneCard ID RNPEP
GenAtlas ID RNPEP
HGNC ID HGNC:10078
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M: Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science. 2009 Aug 14;325(5942):834-40. doi: 10.1126/science.1175371. Epub 2009 Jul 16. [PubMed:19608861 ]
  3. Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal Chem. 2009 Jun 1;81(11):4493-501. doi: 10.1021/ac9004309. [PubMed:19413330 ]
  4. Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. [PubMed:17974005 ]